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Q8R4C2

- RUFY2_MOUSE

UniProt

Q8R4C2 - RUFY2_MOUSE

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Protein
RUN and FYVE domain-containing protein 2
Gene
Rufy2, Kiaa1537
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri540 – 59859FYVE-type
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RUN and FYVE domain-containing protein 2
Alternative name(s):
Leucine zipper FYVE-finger protein
Short name:
LZ-FYVE
Gene namesi
Name:Rufy2
Synonyms:Kiaa1537
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1917682. Rufy2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 606606RUN and FYVE domain-containing protein 2
PRO_0000245831Add
BLAST

Proteomic databases

PaxDbiQ8R4C2.
PRIDEiQ8R4C2.

PTM databases

PhosphoSiteiQ8R4C2.

Expressioni

Developmental stagei

Expressed only at embryonic stages. Present at E12 in primordial lung, cartilage and otic capsule (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ8R4C2.
BgeeiQ8R4C2.
CleanExiMM_RUFY2.
GenevestigatoriQ8R4C2.

Interactioni

Subunit structurei

Interacts with BMX By similarity.

Protein-protein interaction databases

BioGridi214046. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8R4C2.
SMRiQ8R4C2. Positions 8-173, 478-599.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 169133RUN
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili210 – 26758 Reviewed prediction
Add
BLAST
Coiled coili294 – 515222 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 1 RUN domain.

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG270133.
GeneTreeiENSGT00550000074558.
HOGENOMiHOG000030913.
HOVERGENiHBG057053.
InParanoidiQ8R4C2.
OMAiLQECQSK.
OrthoDBiEOG722J98.
PhylomeDBiQ8R4C2.
TreeFamiTF323904.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004012. Run.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00593. RUN. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R4C2-1 [UniParc]FASTAAdd to Basket

« Hide

MATKDPTAVE RANLLNMAKL SIKGLIESAL SFGRTLDSDY PPLQQFFVVM    50
EHCLKHGLKG RKSFLSYNKT IWGPLELVEK LYPEAEEIGA SVRDLPGLKT 100
PLGRARAWLR LALMQKKMAD YLRCLIIQRE LLSEFYEYHA LMMEEEGAVI 150
VGLLVGLNVI DANLCVKGED LDSQVGVIDF SMYLKNEEEI GNKERNVQIA 200
AILDQKNYVE ELNRQLNSTV SSLHSRVDSL EKSNTKLIEE LAIAKNNIIK 250
LQEENHQLRS ENELILMRTR QHLEVTKVDV ETELQTYKHS RQGLDEMYND 300
ARRQLRDESQ LRQDVENELS VQVGMKHEME LAMKLLEKDI HEKQDTLIGL 350
RQQLEEVKAI NIEMYQRLQG SEDGLKEKNE IIARLEEKTN KITTAMRQLE 400
QRLQQAEKAQ KEAEAEDEKY AQECLSQSDS LQRQISQKEQ QLVQLETDLK 450
IEKEWRQTLQ EDLQKEKDVL SHLRHETQKV ISLKKEFLNL QDENQQLKRI 500
YQEQEQALQE LGSKLCESKL KIDDIKEANK ALQGLVWLKD KDATHCKLCE 550
KEFSLSKRKH HCRNCGEIFC NACSDNELPL PSSPKPVRVC DSCHAMLIQR 600
CSSNMP 606
Length:606
Mass (Da):70,093
Last modified:July 11, 2006 - v2
Checksum:i741EE7EA1E0A4EF2
GO

Sequence cautioni

The sequence BAD32473.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081Y → C in AAM18673. 1 Publication
Sequence conflicti435 – 4351I → V in AAM18673. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF484555 mRNA. Translation: AAM18673.1.
AK173195 mRNA. Translation: BAD32473.1. Different initiation.
CCDSiCCDS48582.1.
RefSeqiNP_081701.2. NM_027425.3.
UniGeneiMm.234587.
Mm.274784.

Genome annotation databases

EnsembliENSMUST00000119567; ENSMUSP00000113429; ENSMUSG00000020070.
GeneIDi70432.
KEGGimmu:70432.
UCSCiuc007fjn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF484555 mRNA. Translation: AAM18673.1 .
AK173195 mRNA. Translation: BAD32473.1 . Different initiation.
CCDSi CCDS48582.1.
RefSeqi NP_081701.2. NM_027425.3.
UniGenei Mm.234587.
Mm.274784.

3D structure databases

ProteinModelPortali Q8R4C2.
SMRi Q8R4C2. Positions 8-173, 478-599.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 214046. 1 interaction.

PTM databases

PhosphoSitei Q8R4C2.

Proteomic databases

PaxDbi Q8R4C2.
PRIDEi Q8R4C2.

Protocols and materials databases

DNASUi 70432.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000119567 ; ENSMUSP00000113429 ; ENSMUSG00000020070 .
GeneIDi 70432.
KEGGi mmu:70432.
UCSCi uc007fjn.1. mouse.

Organism-specific databases

CTDi 55680.
MGIi MGI:1917682. Rufy2.
Rougei Search...

Phylogenomic databases

eggNOGi NOG270133.
GeneTreei ENSGT00550000074558.
HOGENOMi HOG000030913.
HOVERGENi HBG057053.
InParanoidi Q8R4C2.
OMAi LQECQSK.
OrthoDBi EOG722J98.
PhylomeDBi Q8R4C2.
TreeFami TF323904.

Miscellaneous databases

ChiTaRSi RUFY2. mouse.
NextBioi 331611.
PROi Q8R4C2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8R4C2.
Bgeei Q8R4C2.
CleanExi MM_RUFY2.
Genevestigatori Q8R4C2.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR004012. Run.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01363. FYVE. 1 hit.
PF02759. RUN. 1 hit.
[Graphical view ]
SMARTi SM00064. FYVE. 1 hit.
SM00593. RUN. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "LZ-FYVE: a novel developmental stage-specific leucine zipper, FYVE-finger protein."
    Dunkelberg J.C., Gutierrez-Hartmann A.
    DNA Cell Biol. 20:403-412(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
    Tissue: Embryo.
  2. "Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking."
    Yang J., Kim O., Wu J., Qiu Y.
    J. Biol. Chem. 277:30219-30226(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRUFY2_MOUSE
AccessioniPrimary (citable) accession number: Q8R4C2
Secondary accession number(s): Q69ZH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: July 9, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi