Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8R4C2

- RUFY2_MOUSE

UniProt

Q8R4C2 - RUFY2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

RUN and FYVE domain-containing protein 2

Gene

Rufy2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri540 – 59859FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RUN and FYVE domain-containing protein 2
Alternative name(s):
Leucine zipper FYVE-finger protein
Short name:
LZ-FYVE
Gene namesi
Name:Rufy2
Synonyms:Kiaa1537
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1917682. Rufy2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 606606RUN and FYVE domain-containing protein 2PRO_0000245831Add
BLAST

Proteomic databases

MaxQBiQ8R4C2.
PaxDbiQ8R4C2.
PRIDEiQ8R4C2.

PTM databases

PhosphoSiteiQ8R4C2.

Expressioni

Developmental stagei

Expressed only at embryonic stages. Present at E12 in primordial lung, cartilage and otic capsule (at protein level).1 Publication

Gene expression databases

BgeeiQ8R4C2.
CleanExiMM_RUFY2.
ExpressionAtlasiQ8R4C2. baseline and differential.
GenevestigatoriQ8R4C2.

Interactioni

Subunit structurei

Interacts with BMX.By similarity

Protein-protein interaction databases

BioGridi214046. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8R4C2.
SMRiQ8R4C2. Positions 8-173, 478-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 169133RUNPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili210 – 26758Sequence AnalysisAdd
BLAST
Coiled coili294 – 515222Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 RUN domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri540 – 59859FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG270133.
GeneTreeiENSGT00550000074558.
HOGENOMiHOG000030913.
HOVERGENiHBG057053.
InParanoidiQ8R4C2.
OMAiLQECQSK.
OrthoDBiEOG722J98.
PhylomeDBiQ8R4C2.
TreeFamiTF323904.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004012. Run.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00593. RUN. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R4C2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATKDPTAVE RANLLNMAKL SIKGLIESAL SFGRTLDSDY PPLQQFFVVM
60 70 80 90 100
EHCLKHGLKG RKSFLSYNKT IWGPLELVEK LYPEAEEIGA SVRDLPGLKT
110 120 130 140 150
PLGRARAWLR LALMQKKMAD YLRCLIIQRE LLSEFYEYHA LMMEEEGAVI
160 170 180 190 200
VGLLVGLNVI DANLCVKGED LDSQVGVIDF SMYLKNEEEI GNKERNVQIA
210 220 230 240 250
AILDQKNYVE ELNRQLNSTV SSLHSRVDSL EKSNTKLIEE LAIAKNNIIK
260 270 280 290 300
LQEENHQLRS ENELILMRTR QHLEVTKVDV ETELQTYKHS RQGLDEMYND
310 320 330 340 350
ARRQLRDESQ LRQDVENELS VQVGMKHEME LAMKLLEKDI HEKQDTLIGL
360 370 380 390 400
RQQLEEVKAI NIEMYQRLQG SEDGLKEKNE IIARLEEKTN KITTAMRQLE
410 420 430 440 450
QRLQQAEKAQ KEAEAEDEKY AQECLSQSDS LQRQISQKEQ QLVQLETDLK
460 470 480 490 500
IEKEWRQTLQ EDLQKEKDVL SHLRHETQKV ISLKKEFLNL QDENQQLKRI
510 520 530 540 550
YQEQEQALQE LGSKLCESKL KIDDIKEANK ALQGLVWLKD KDATHCKLCE
560 570 580 590 600
KEFSLSKRKH HCRNCGEIFC NACSDNELPL PSSPKPVRVC DSCHAMLIQR

CSSNMP
Length:606
Mass (Da):70,093
Last modified:July 11, 2006 - v2
Checksum:i741EE7EA1E0A4EF2
GO

Sequence cautioni

The sequence BAD32473.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081Y → C in AAM18673. (PubMed:11877430)Curated
Sequence conflicti435 – 4351I → V in AAM18673. (PubMed:11877430)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF484555 mRNA. Translation: AAM18673.1.
AK173195 mRNA. Translation: BAD32473.1. Different initiation.
CCDSiCCDS48582.1.
RefSeqiNP_081701.2. NM_027425.3.
UniGeneiMm.234587.
Mm.274784.

Genome annotation databases

EnsembliENSMUST00000119567; ENSMUSP00000113429; ENSMUSG00000020070.
GeneIDi70432.
KEGGimmu:70432.
UCSCiuc007fjn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF484555 mRNA. Translation: AAM18673.1 .
AK173195 mRNA. Translation: BAD32473.1 . Different initiation.
CCDSi CCDS48582.1.
RefSeqi NP_081701.2. NM_027425.3.
UniGenei Mm.234587.
Mm.274784.

3D structure databases

ProteinModelPortali Q8R4C2.
SMRi Q8R4C2. Positions 8-173, 478-599.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 214046. 1 interaction.

PTM databases

PhosphoSitei Q8R4C2.

Proteomic databases

MaxQBi Q8R4C2.
PaxDbi Q8R4C2.
PRIDEi Q8R4C2.

Protocols and materials databases

DNASUi 70432.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000119567 ; ENSMUSP00000113429 ; ENSMUSG00000020070 .
GeneIDi 70432.
KEGGi mmu:70432.
UCSCi uc007fjn.1. mouse.

Organism-specific databases

CTDi 55680.
MGIi MGI:1917682. Rufy2.
Rougei Search...

Phylogenomic databases

eggNOGi NOG270133.
GeneTreei ENSGT00550000074558.
HOGENOMi HOG000030913.
HOVERGENi HBG057053.
InParanoidi Q8R4C2.
OMAi LQECQSK.
OrthoDBi EOG722J98.
PhylomeDBi Q8R4C2.
TreeFami TF323904.

Miscellaneous databases

ChiTaRSi RUFY2. mouse.
NextBioi 331611.
PROi Q8R4C2.
SOURCEi Search...

Gene expression databases

Bgeei Q8R4C2.
CleanExi MM_RUFY2.
ExpressionAtlasi Q8R4C2. baseline and differential.
Genevestigatori Q8R4C2.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR004012. Run.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01363. FYVE. 1 hit.
PF02759. RUN. 1 hit.
[Graphical view ]
SMARTi SM00064. FYVE. 1 hit.
SM00593. RUN. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "LZ-FYVE: a novel developmental stage-specific leucine zipper, FYVE-finger protein."
    Dunkelberg J.C., Gutierrez-Hartmann A.
    DNA Cell Biol. 20:403-412(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
    Tissue: Embryo.
  2. "Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking."
    Yang J., Kim O., Wu J., Qiu Y.
    J. Biol. Chem. 277:30219-30226(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRUFY2_MOUSE
AccessioniPrimary (citable) accession number: Q8R4C2
Secondary accession number(s): Q69ZH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: October 29, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3