Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8R4C2

- RUFY2_MOUSE

UniProt

Q8R4C2 - RUFY2_MOUSE

Protein

RUN and FYVE domain-containing protein 2

Gene

Rufy2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (11 Jul 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri540 – 59859FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RUN and FYVE domain-containing protein 2
    Alternative name(s):
    Leucine zipper FYVE-finger protein
    Short name:
    LZ-FYVE
    Gene namesi
    Name:Rufy2
    Synonyms:Kiaa1537
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1917682. Rufy2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 606606RUN and FYVE domain-containing protein 2PRO_0000245831Add
    BLAST

    Proteomic databases

    PaxDbiQ8R4C2.
    PRIDEiQ8R4C2.

    PTM databases

    PhosphoSiteiQ8R4C2.

    Expressioni

    Developmental stagei

    Expressed only at embryonic stages. Present at E12 in primordial lung, cartilage and otic capsule (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ8R4C2.
    BgeeiQ8R4C2.
    CleanExiMM_RUFY2.
    GenevestigatoriQ8R4C2.

    Interactioni

    Subunit structurei

    Interacts with BMX.By similarity

    Protein-protein interaction databases

    BioGridi214046. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R4C2.
    SMRiQ8R4C2. Positions 8-173, 478-599.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 169133RUNPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili210 – 26758Sequence AnalysisAdd
    BLAST
    Coiled coili294 – 515222Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
    Contains 1 RUN domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri540 – 59859FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG270133.
    GeneTreeiENSGT00550000074558.
    HOGENOMiHOG000030913.
    HOVERGENiHBG057053.
    InParanoidiQ8R4C2.
    OMAiLQECQSK.
    OrthoDBiEOG722J98.
    PhylomeDBiQ8R4C2.
    TreeFamiTF323904.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR004012. Run.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01363. FYVE. 1 hit.
    PF02759. RUN. 1 hit.
    [Graphical view]
    SMARTiSM00064. FYVE. 1 hit.
    SM00593. RUN. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS50826. RUN. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R4C2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATKDPTAVE RANLLNMAKL SIKGLIESAL SFGRTLDSDY PPLQQFFVVM    50
    EHCLKHGLKG RKSFLSYNKT IWGPLELVEK LYPEAEEIGA SVRDLPGLKT 100
    PLGRARAWLR LALMQKKMAD YLRCLIIQRE LLSEFYEYHA LMMEEEGAVI 150
    VGLLVGLNVI DANLCVKGED LDSQVGVIDF SMYLKNEEEI GNKERNVQIA 200
    AILDQKNYVE ELNRQLNSTV SSLHSRVDSL EKSNTKLIEE LAIAKNNIIK 250
    LQEENHQLRS ENELILMRTR QHLEVTKVDV ETELQTYKHS RQGLDEMYND 300
    ARRQLRDESQ LRQDVENELS VQVGMKHEME LAMKLLEKDI HEKQDTLIGL 350
    RQQLEEVKAI NIEMYQRLQG SEDGLKEKNE IIARLEEKTN KITTAMRQLE 400
    QRLQQAEKAQ KEAEAEDEKY AQECLSQSDS LQRQISQKEQ QLVQLETDLK 450
    IEKEWRQTLQ EDLQKEKDVL SHLRHETQKV ISLKKEFLNL QDENQQLKRI 500
    YQEQEQALQE LGSKLCESKL KIDDIKEANK ALQGLVWLKD KDATHCKLCE 550
    KEFSLSKRKH HCRNCGEIFC NACSDNELPL PSSPKPVRVC DSCHAMLIQR 600
    CSSNMP 606
    Length:606
    Mass (Da):70,093
    Last modified:July 11, 2006 - v2
    Checksum:i741EE7EA1E0A4EF2
    GO

    Sequence cautioni

    The sequence BAD32473.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti208 – 2081Y → C in AAM18673. (PubMed:11877430)Curated
    Sequence conflicti435 – 4351I → V in AAM18673. (PubMed:11877430)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF484555 mRNA. Translation: AAM18673.1.
    AK173195 mRNA. Translation: BAD32473.1. Different initiation.
    CCDSiCCDS48582.1.
    RefSeqiNP_081701.2. NM_027425.3.
    UniGeneiMm.234587.
    Mm.274784.

    Genome annotation databases

    EnsembliENSMUST00000119567; ENSMUSP00000113429; ENSMUSG00000020070.
    GeneIDi70432.
    KEGGimmu:70432.
    UCSCiuc007fjn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF484555 mRNA. Translation: AAM18673.1 .
    AK173195 mRNA. Translation: BAD32473.1 . Different initiation.
    CCDSi CCDS48582.1.
    RefSeqi NP_081701.2. NM_027425.3.
    UniGenei Mm.234587.
    Mm.274784.

    3D structure databases

    ProteinModelPortali Q8R4C2.
    SMRi Q8R4C2. Positions 8-173, 478-599.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 214046. 1 interaction.

    PTM databases

    PhosphoSitei Q8R4C2.

    Proteomic databases

    PaxDbi Q8R4C2.
    PRIDEi Q8R4C2.

    Protocols and materials databases

    DNASUi 70432.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000119567 ; ENSMUSP00000113429 ; ENSMUSG00000020070 .
    GeneIDi 70432.
    KEGGi mmu:70432.
    UCSCi uc007fjn.1. mouse.

    Organism-specific databases

    CTDi 55680.
    MGIi MGI:1917682. Rufy2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG270133.
    GeneTreei ENSGT00550000074558.
    HOGENOMi HOG000030913.
    HOVERGENi HBG057053.
    InParanoidi Q8R4C2.
    OMAi LQECQSK.
    OrthoDBi EOG722J98.
    PhylomeDBi Q8R4C2.
    TreeFami TF323904.

    Miscellaneous databases

    ChiTaRSi RUFY2. mouse.
    NextBioi 331611.
    PROi Q8R4C2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R4C2.
    Bgeei Q8R4C2.
    CleanExi MM_RUFY2.
    Genevestigatori Q8R4C2.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR004012. Run.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01363. FYVE. 1 hit.
    PF02759. RUN. 1 hit.
    [Graphical view ]
    SMARTi SM00064. FYVE. 1 hit.
    SM00593. RUN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS50826. RUN. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "LZ-FYVE: a novel developmental stage-specific leucine zipper, FYVE-finger protein."
      Dunkelberg J.C., Gutierrez-Hartmann A.
      DNA Cell Biol. 20:403-412(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
      Tissue: Embryo.
    2. "Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking."
      Yang J., Kim O., Wu J., Qiu Y.
      J. Biol. Chem. 277:30219-30226(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiRUFY2_MOUSE
    AccessioniPrimary (citable) accession number: Q8R4C2
    Secondary accession number(s): Q69ZH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3