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Q8R4C2 (RUFY2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RUN and FYVE domain-containing protein 2
Alternative name(s):
Leucine zipper FYVE-finger protein
Short name=LZ-FYVE
Gene names
Name:Rufy2
Synonyms:Kiaa1537
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length606 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with BMX By similarity.

Subcellular location

Nucleus Ref.1.

Developmental stage

Expressed only at embryonic stages. Present at E12 in primordial lung, cartilage and otic capsule (at protein level). Ref.1

Sequence similarities

Contains 1 FYVE-type zinc finger.

Contains 1 RUN domain.

Sequence caution

The sequence BAD32473.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentNucleus
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 606606RUN and FYVE domain-containing protein 2
PRO_0000245831

Regions

Domain37 – 169133RUN
Zinc finger540 – 59859FYVE-type
Coiled coil210 – 26758 Potential
Coiled coil294 – 515222 Potential

Experimental info

Sequence conflict2081Y → C in AAM18673. Ref.2
Sequence conflict4351I → V in AAM18673. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8R4C2 [UniParc].

Last modified July 11, 2006. Version 2.
Checksum: 741EE7EA1E0A4EF2

FASTA60670,093
        10         20         30         40         50         60 
MATKDPTAVE RANLLNMAKL SIKGLIESAL SFGRTLDSDY PPLQQFFVVM EHCLKHGLKG 

        70         80         90        100        110        120 
RKSFLSYNKT IWGPLELVEK LYPEAEEIGA SVRDLPGLKT PLGRARAWLR LALMQKKMAD 

       130        140        150        160        170        180 
YLRCLIIQRE LLSEFYEYHA LMMEEEGAVI VGLLVGLNVI DANLCVKGED LDSQVGVIDF 

       190        200        210        220        230        240 
SMYLKNEEEI GNKERNVQIA AILDQKNYVE ELNRQLNSTV SSLHSRVDSL EKSNTKLIEE 

       250        260        270        280        290        300 
LAIAKNNIIK LQEENHQLRS ENELILMRTR QHLEVTKVDV ETELQTYKHS RQGLDEMYND 

       310        320        330        340        350        360 
ARRQLRDESQ LRQDVENELS VQVGMKHEME LAMKLLEKDI HEKQDTLIGL RQQLEEVKAI 

       370        380        390        400        410        420 
NIEMYQRLQG SEDGLKEKNE IIARLEEKTN KITTAMRQLE QRLQQAEKAQ KEAEAEDEKY 

       430        440        450        460        470        480 
AQECLSQSDS LQRQISQKEQ QLVQLETDLK IEKEWRQTLQ EDLQKEKDVL SHLRHETQKV 

       490        500        510        520        530        540 
ISLKKEFLNL QDENQQLKRI YQEQEQALQE LGSKLCESKL KIDDIKEANK ALQGLVWLKD 

       550        560        570        580        590        600 
KDATHCKLCE KEFSLSKRKH HCRNCGEIFC NACSDNELPL PSSPKPVRVC DSCHAMLIQR 


CSSNMP 

« Hide

References

« Hide 'large scale' references
[1]"LZ-FYVE: a novel developmental stage-specific leucine zipper, FYVE-finger protein."
Dunkelberg J.C., Gutierrez-Hartmann A.
DNA Cell Biol. 20:403-412(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
Tissue: Embryo.
[2]"Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking."
Yang J., Kim O., Wu J., Qiu Y.
J. Biol. Chem. 277:30219-30226(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF484555 mRNA. Translation: AAM18673.1.
AK173195 mRNA. Translation: BAD32473.1. Different initiation.
RefSeqNP_081701.2. NM_027425.3.
UniGeneMm.234587.
Mm.274784.

3D structure databases

ProteinModelPortalQ8R4C2.
SMRQ8R4C2. Positions 8-173, 478-599.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid214046. 1 interaction.

PTM databases

PhosphoSiteQ8R4C2.

Proteomic databases

PaxDbQ8R4C2.
PRIDEQ8R4C2.

Protocols and materials databases

DNASU70432.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000119567; ENSMUSP00000113429; ENSMUSG00000020070.
GeneID70432.
KEGGmmu:70432.
UCSCuc007fjn.1. mouse.

Organism-specific databases

CTD55680.
MGIMGI:1917682. Rufy2.
RougeSearch...

Phylogenomic databases

eggNOGNOG270133.
GeneTreeENSGT00550000074558.
HOGENOMHOG000030913.
HOVERGENHBG057053.
InParanoidQ8R4C2.
OMALQECQSK.
OrthoDBEOG722J98.
PhylomeDBQ8R4C2.
TreeFamTF323904.

Gene expression databases

ArrayExpressQ8R4C2.
BgeeQ8R4C2.
CleanExMM_RUFY2.
GenevestigatorQ8R4C2.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR004012. Run.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF01363. FYVE. 1 hit.
PF02759. RUN. 1 hit.
[Graphical view]
SMARTSM00064. FYVE. 1 hit.
SM00593. RUN. 1 hit.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
PROSITEPS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRUFY2. mouse.
NextBio331611.
PROQ8R4C2.
SOURCESearch...

Entry information

Entry nameRUFY2_MOUSE
AccessionPrimary (citable) accession number: Q8R4C2
Secondary accession number(s): Q69ZH1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: April 16, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot