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Protein

RUN and FYVE domain-containing protein 2

Gene

Rufy2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri540 – 59859FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RUN and FYVE domain-containing protein 2
Alternative name(s):
Leucine zipper FYVE-finger protein
Short name:
LZ-FYVE
Gene namesi
Name:Rufy2
Synonyms:Kiaa1537
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917682. Rufy2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 606606RUN and FYVE domain-containing protein 2PRO_0000245831Add
BLAST

Proteomic databases

MaxQBiQ8R4C2.
PaxDbiQ8R4C2.
PRIDEiQ8R4C2.

PTM databases

PhosphoSiteiQ8R4C2.

Expressioni

Developmental stagei

Expressed only at embryonic stages. Present at E12 in primordial lung, cartilage and otic capsule (at protein level).1 Publication

Gene expression databases

BgeeiQ8R4C2.
CleanExiMM_RUFY2.
ExpressionAtlasiQ8R4C2. baseline and differential.
GenevisibleiQ8R4C2. MM.

Interactioni

Subunit structurei

Interacts with BMX.By similarity

Protein-protein interaction databases

BioGridi214046. 1 interaction.
STRINGi10090.ENSMUSP00000113429.

Structurei

3D structure databases

ProteinModelPortaliQ8R4C2.
SMRiQ8R4C2. Positions 8-173, 478-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 169133RUNPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili210 – 26758Sequence AnalysisAdd
BLAST
Coiled coili294 – 515222Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 RUN domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri540 – 59859FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG270133.
GeneTreeiENSGT00550000074558.
HOGENOMiHOG000030913.
HOVERGENiHBG057053.
InParanoidiQ8R4C2.
OMAiLQECQSK.
OrthoDBiEOG722J98.
PhylomeDBiQ8R4C2.
TreeFamiTF323904.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004012. Run.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00593. RUN. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R4C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKDPTAVE RANLLNMAKL SIKGLIESAL SFGRTLDSDY PPLQQFFVVM
60 70 80 90 100
EHCLKHGLKG RKSFLSYNKT IWGPLELVEK LYPEAEEIGA SVRDLPGLKT
110 120 130 140 150
PLGRARAWLR LALMQKKMAD YLRCLIIQRE LLSEFYEYHA LMMEEEGAVI
160 170 180 190 200
VGLLVGLNVI DANLCVKGED LDSQVGVIDF SMYLKNEEEI GNKERNVQIA
210 220 230 240 250
AILDQKNYVE ELNRQLNSTV SSLHSRVDSL EKSNTKLIEE LAIAKNNIIK
260 270 280 290 300
LQEENHQLRS ENELILMRTR QHLEVTKVDV ETELQTYKHS RQGLDEMYND
310 320 330 340 350
ARRQLRDESQ LRQDVENELS VQVGMKHEME LAMKLLEKDI HEKQDTLIGL
360 370 380 390 400
RQQLEEVKAI NIEMYQRLQG SEDGLKEKNE IIARLEEKTN KITTAMRQLE
410 420 430 440 450
QRLQQAEKAQ KEAEAEDEKY AQECLSQSDS LQRQISQKEQ QLVQLETDLK
460 470 480 490 500
IEKEWRQTLQ EDLQKEKDVL SHLRHETQKV ISLKKEFLNL QDENQQLKRI
510 520 530 540 550
YQEQEQALQE LGSKLCESKL KIDDIKEANK ALQGLVWLKD KDATHCKLCE
560 570 580 590 600
KEFSLSKRKH HCRNCGEIFC NACSDNELPL PSSPKPVRVC DSCHAMLIQR

CSSNMP
Length:606
Mass (Da):70,093
Last modified:July 11, 2006 - v2
Checksum:i741EE7EA1E0A4EF2
GO

Sequence cautioni

The sequence BAD32473.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081Y → C in AAM18673 (PubMed:11877430).Curated
Sequence conflicti435 – 4351I → V in AAM18673 (PubMed:11877430).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF484555 mRNA. Translation: AAM18673.1.
AK173195 mRNA. Translation: BAD32473.1. Different initiation.
CCDSiCCDS48582.1.
RefSeqiNP_081701.2. NM_027425.3.
UniGeneiMm.234587.
Mm.274784.

Genome annotation databases

EnsembliENSMUST00000119567; ENSMUSP00000113429; ENSMUSG00000020070.
GeneIDi70432.
KEGGimmu:70432.
UCSCiuc007fjn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF484555 mRNA. Translation: AAM18673.1.
AK173195 mRNA. Translation: BAD32473.1. Different initiation.
CCDSiCCDS48582.1.
RefSeqiNP_081701.2. NM_027425.3.
UniGeneiMm.234587.
Mm.274784.

3D structure databases

ProteinModelPortaliQ8R4C2.
SMRiQ8R4C2. Positions 8-173, 478-599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214046. 1 interaction.
STRINGi10090.ENSMUSP00000113429.

PTM databases

PhosphoSiteiQ8R4C2.

Proteomic databases

MaxQBiQ8R4C2.
PaxDbiQ8R4C2.
PRIDEiQ8R4C2.

Protocols and materials databases

DNASUi70432.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000119567; ENSMUSP00000113429; ENSMUSG00000020070.
GeneIDi70432.
KEGGimmu:70432.
UCSCiuc007fjn.1. mouse.

Organism-specific databases

CTDi55680.
MGIiMGI:1917682. Rufy2.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG270133.
GeneTreeiENSGT00550000074558.
HOGENOMiHOG000030913.
HOVERGENiHBG057053.
InParanoidiQ8R4C2.
OMAiLQECQSK.
OrthoDBiEOG722J98.
PhylomeDBiQ8R4C2.
TreeFamiTF323904.

Miscellaneous databases

ChiTaRSiRufy2. mouse.
NextBioi331611.
PROiQ8R4C2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R4C2.
CleanExiMM_RUFY2.
ExpressionAtlasiQ8R4C2. baseline and differential.
GenevisibleiQ8R4C2. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004012. Run.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00593. RUN. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "LZ-FYVE: a novel developmental stage-specific leucine zipper, FYVE-finger protein."
    Dunkelberg J.C., Gutierrez-Hartmann A.
    DNA Cell Biol. 20:403-412(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
    Tissue: Embryo.
  2. "Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking."
    Yang J., Kim O., Wu J., Qiu Y.
    J. Biol. Chem. 277:30219-30226(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRUFY2_MOUSE
AccessioniPrimary (citable) accession number: Q8R4C2
Secondary accession number(s): Q69ZH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: June 24, 2015
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.