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Protein

Calpain-5

Gene

Capn5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei81 – 811By similarity
Active sitei252 – 2521By similarity
Active sitei284 – 2841By similarity

GO - Molecular functioni

  1. calcium-dependent cysteine-type endopeptidase activity Source: GO_Central

GO - Biological processi

  1. granulosa cell differentiation Source: RGD
  2. luteinization Source: RGD
  3. ovarian follicle development Source: RGD
  4. proteolysis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC02.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-5 (EC:3.4.22.-)
Gene namesi
Name:Capn5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620084. Capn5.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. cytoplasm Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Calpain-5PRO_0000207715Add
BLAST

Proteomic databases

PaxDbiQ8R4C0.
PRIDEiQ8R4C0.

Expressioni

Gene expression databases

GenevestigatoriQ8R4C0.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019370.

Structurei

3D structure databases

ProteinModelPortaliQ8R4C0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 343318Calpain catalyticPROSITE-ProRule annotationAdd
BLAST
Domaini518 – 619102C2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni344 – 496153Domain IIIAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated
Contains 1 C2 domain.Curated
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG258770.
HOGENOMiHOG000232036.
HOVERGENiHBG001095.
InParanoidiQ8R4C0.
KOiK08574.
PhylomeDBiQ8R4C0.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00239. C2. 1 hit.
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R4C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSCTKAYEY QNYSALKRAC LRRKVLFEDP HFPASDDSLY YKGTPGPTVR
60 70 80 90 100
WKRPFDICDD PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV
110 120 130 140 150
IPDWKEQEWN PEKPDSYAGI FHFNFWRFGE WVDVVVDDRL PTVNNQLIYC
160 170 180 190 200
HSNSKNEFWC APVEKAYAKL AGCYQALDGG NTADALVDFT GGVSEPIDLT
210 220 230 240 250
EGDLATDEAK RSQLFERVLK VHSRGGLISA SIKAMTAADM ETRLACGLVK
260 270 280 290 300
GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERV WTGPWSDTSE
310 320 330 340 350
EWQKVSKSER EKMGVTVQDD GEFWMTYEDM CRYFTDIIKC RLINTSYLSI
360 370 380 390 400
HKTWEEARLR GAWTRHEDPQ QNRSGGCINH KDTFFQNPQY IFEVKKPEDE
410 420 430 440 450
VLICIQQRPK RSTRREGKGE NLAIGFDIYK VEENRQYRMH SLQHKAASSI
460 470 480 490 500
YINSRSVFLR TELPEGRYVI IPTTFEPGHT GELLLRVFTD VPSNCRELRL
510 520 530 540 550
DEPPRTCWSS LCGYPQQVTQ VHVLGAAGLK DSSTGANSYV IIKCEGEKVR
560 570 580 590 600
SAVQRGTSTP EYNVKGIFYR KKLSQPITVQ VWNNRVLKDE FLGQVHLKTA
610 620 630 640
PDDLQDLHSL HLQDRSGRQP SDLPGIVAVR VLCSASLTAV
Length:640
Mass (Da):73,065
Last modified:June 1, 2002 - v1
Checksum:i098A6CDA7799BC61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF484958 mRNA. Translation: AAL92024.1.
RefSeqiNP_604456.1. NM_134461.1.
UniGeneiRn.15526.

Genome annotation databases

GeneIDi171495.
KEGGirno:171495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF484958 mRNA. Translation: AAL92024.1.
RefSeqiNP_604456.1. NM_134461.1.
UniGeneiRn.15526.

3D structure databases

ProteinModelPortaliQ8R4C0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019370.

Protein family/group databases

MEROPSiC02.011.

Proteomic databases

PaxDbiQ8R4C0.
PRIDEiQ8R4C0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171495.
KEGGirno:171495.

Organism-specific databases

CTDi726.
RGDi620084. Capn5.

Phylogenomic databases

eggNOGiNOG258770.
HOGENOMiHOG000232036.
HOVERGENiHBG001095.
InParanoidiQ8R4C0.
KOiK08574.
PhylomeDBiQ8R4C0.

Miscellaneous databases

NextBioi622443.
PROiQ8R4C0.

Gene expression databases

GenevestigatoriQ8R4C0.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00239. C2. 1 hit.
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and normal expression profiling of rat calpain-5 by real-time PCR."
    Wang D.-S., McKinsey D., Pike B.R., DeFord M., Pineda J., Wang K.K.-W., Hayes R.L.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 277-283; 446-455 AND 566-572, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiCAN5_RAT
AccessioniPrimary (citable) accession number: Q8R4C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: June 1, 2002
Last modified: February 4, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.