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Q8R4C0 (CAN5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calpain-5

EC=3.4.22.-
Gene names
Name:Capn5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length640 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Broad endopeptidase specificity.

Sequence similarities

Belongs to the peptidase C2 family.

Contains 1 C2 domain.

Contains 1 calpain catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 640640Calpain-5
PRO_0000207715

Regions

Domain26 – 343318Calpain catalytic
Domain518 – 619102C2
Region344 – 496153Domain III

Sites

Active site811 By similarity
Active site2521 By similarity
Active site2841 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8R4C0 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 098A6CDA7799BC61

FASTA64073,065
        10         20         30         40         50         60 
MFSCTKAYEY QNYSALKRAC LRRKVLFEDP HFPASDDSLY YKGTPGPTVR WKRPFDICDD 

        70         80         90        100        110        120 
PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV IPDWKEQEWN PEKPDSYAGI 

       130        140        150        160        170        180 
FHFNFWRFGE WVDVVVDDRL PTVNNQLIYC HSNSKNEFWC APVEKAYAKL AGCYQALDGG 

       190        200        210        220        230        240 
NTADALVDFT GGVSEPIDLT EGDLATDEAK RSQLFERVLK VHSRGGLISA SIKAMTAADM 

       250        260        270        280        290        300 
ETRLACGLVK GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERV WTGPWSDTSE 

       310        320        330        340        350        360 
EWQKVSKSER EKMGVTVQDD GEFWMTYEDM CRYFTDIIKC RLINTSYLSI HKTWEEARLR 

       370        380        390        400        410        420 
GAWTRHEDPQ QNRSGGCINH KDTFFQNPQY IFEVKKPEDE VLICIQQRPK RSTRREGKGE 

       430        440        450        460        470        480 
NLAIGFDIYK VEENRQYRMH SLQHKAASSI YINSRSVFLR TELPEGRYVI IPTTFEPGHT 

       490        500        510        520        530        540 
GELLLRVFTD VPSNCRELRL DEPPRTCWSS LCGYPQQVTQ VHVLGAAGLK DSSTGANSYV 

       550        560        570        580        590        600 
IIKCEGEKVR SAVQRGTSTP EYNVKGIFYR KKLSQPITVQ VWNNRVLKDE FLGQVHLKTA 

       610        620        630        640 
PDDLQDLHSL HLQDRSGRQP SDLPGIVAVR VLCSASLTAV 

« Hide

References

[1]"Cloning and normal expression profiling of rat calpain-5 by real-time PCR."
Wang D.-S., McKinsey D., Pike B.R., DeFord M., Pineda J., Wang K.K.-W., Hayes R.L.
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[2]Lubec G., Kang S.U., Lubec S.
Submitted (SEP-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 277-283; 446-455 AND 566-572, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF484958 mRNA. Translation: AAL92024.1.
RefSeqNP_604456.1. NM_134461.1.
UniGeneRn.15526.

3D structure databases

ProteinModelPortalQ8R4C0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000019370.

Protein family/group databases

MEROPSC02.011.

Proteomic databases

PaxDbQ8R4C0.
PRIDEQ8R4C0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID171495.
KEGGrno:171495.

Organism-specific databases

CTD726.
RGD620084. Capn5.

Phylogenomic databases

eggNOGNOG258770.
HOGENOMHOG000232036.
HOVERGENHBG001095.
InParanoidQ8R4C0.
KOK08574.
PhylomeDBQ8R4C0.

Gene expression databases

GenevestigatorQ8R4C0.

Family and domain databases

Gene3D2.60.40.150. 1 hit.
InterProIPR000008. C2_dom.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamPF00168. C2. 1 hit.
PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSPR00704. CALPAIN.
SMARTSM00239. C2. 1 hit.
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio622443.
PROQ8R4C0.

Entry information

Entry nameCAN5_RAT
AccessionPrimary (citable) accession number: Q8R4C0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries