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Q8R4C0

- CAN5_RAT

UniProt

Q8R4C0 - CAN5_RAT

Protein

Calpain-5

Gene

Capn5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Broad endopeptidase specificity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei81 – 811By similarity
    Active sitei252 – 2521By similarity
    Active sitei284 – 2841By similarity

    GO - Molecular functioni

    1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome

    GO - Biological processi

    1. granulosa cell differentiation Source: RGD
    2. luteinization Source: RGD
    3. ovarian follicle development Source: RGD
    4. proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Protein family/group databases

    MEROPSiC02.011.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calpain-5 (EC:3.4.22.-)
    Gene namesi
    Name:Capn5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620084. Capn5.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. cytoplasm Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 640640Calpain-5PRO_0000207715Add
    BLAST

    Proteomic databases

    PaxDbiQ8R4C0.
    PRIDEiQ8R4C0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8R4C0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000019370.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R4C0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 343318Calpain catalyticPROSITE-ProRule annotationAdd
    BLAST
    Domaini518 – 619102C2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni344 – 496153Domain IIIAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C2 family.Curated
    Contains 1 C2 domain.Curated
    Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG258770.
    HOGENOMiHOG000232036.
    HOVERGENiHBG001095.
    InParanoidiQ8R4C0.
    KOiK08574.
    PhylomeDBiQ8R4C0.

    Family and domain databases

    Gene3Di2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view]
    PfamiPF00168. C2. 1 hit.
    PF01067. Calpain_III. 1 hit.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view]
    PRINTSiPR00704. CALPAIN.
    SMARTiSM00239. C2. 1 hit.
    SM00720. calpain_III. 1 hit.
    SM00230. CysPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF49758. SSF49758. 1 hit.
    PROSITEiPS50203. CALPAIN_CAT. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R4C0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSCTKAYEY QNYSALKRAC LRRKVLFEDP HFPASDDSLY YKGTPGPTVR    50
    WKRPFDICDD PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV 100
    IPDWKEQEWN PEKPDSYAGI FHFNFWRFGE WVDVVVDDRL PTVNNQLIYC 150
    HSNSKNEFWC APVEKAYAKL AGCYQALDGG NTADALVDFT GGVSEPIDLT 200
    EGDLATDEAK RSQLFERVLK VHSRGGLISA SIKAMTAADM ETRLACGLVK 250
    GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERV WTGPWSDTSE 300
    EWQKVSKSER EKMGVTVQDD GEFWMTYEDM CRYFTDIIKC RLINTSYLSI 350
    HKTWEEARLR GAWTRHEDPQ QNRSGGCINH KDTFFQNPQY IFEVKKPEDE 400
    VLICIQQRPK RSTRREGKGE NLAIGFDIYK VEENRQYRMH SLQHKAASSI 450
    YINSRSVFLR TELPEGRYVI IPTTFEPGHT GELLLRVFTD VPSNCRELRL 500
    DEPPRTCWSS LCGYPQQVTQ VHVLGAAGLK DSSTGANSYV IIKCEGEKVR 550
    SAVQRGTSTP EYNVKGIFYR KKLSQPITVQ VWNNRVLKDE FLGQVHLKTA 600
    PDDLQDLHSL HLQDRSGRQP SDLPGIVAVR VLCSASLTAV 640
    Length:640
    Mass (Da):73,065
    Last modified:June 1, 2002 - v1
    Checksum:i098A6CDA7799BC61
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF484958 mRNA. Translation: AAL92024.1.
    RefSeqiNP_604456.1. NM_134461.1.
    UniGeneiRn.15526.

    Genome annotation databases

    GeneIDi171495.
    KEGGirno:171495.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF484958 mRNA. Translation: AAL92024.1 .
    RefSeqi NP_604456.1. NM_134461.1.
    UniGenei Rn.15526.

    3D structure databases

    ProteinModelPortali Q8R4C0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000019370.

    Protein family/group databases

    MEROPSi C02.011.

    Proteomic databases

    PaxDbi Q8R4C0.
    PRIDEi Q8R4C0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 171495.
    KEGGi rno:171495.

    Organism-specific databases

    CTDi 726.
    RGDi 620084. Capn5.

    Phylogenomic databases

    eggNOGi NOG258770.
    HOGENOMi HOG000232036.
    HOVERGENi HBG001095.
    InParanoidi Q8R4C0.
    KOi K08574.
    PhylomeDBi Q8R4C0.

    Miscellaneous databases

    NextBioi 622443.
    PROi Q8R4C0.

    Gene expression databases

    Genevestigatori Q8R4C0.

    Family and domain databases

    Gene3Di 2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view ]
    Pfami PF00168. C2. 1 hit.
    PF01067. Calpain_III. 1 hit.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view ]
    PRINTSi PR00704. CALPAIN.
    SMARTi SM00239. C2. 1 hit.
    SM00720. calpain_III. 1 hit.
    SM00230. CysPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF49758. SSF49758. 1 hit.
    PROSITEi PS50203. CALPAIN_CAT. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and normal expression profiling of rat calpain-5 by real-time PCR."
      Wang D.-S., McKinsey D., Pike B.R., DeFord M., Pineda J., Wang K.K.-W., Hayes R.L.
      Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    2. Lubec G., Kang S.U., Lubec S.
      Submitted (SEP-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 277-283; 446-455 AND 566-572, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiCAN5_RAT
    AccessioniPrimary (citable) accession number: Q8R4C0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 12, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3