NACHT, LRR and PYD domains-containing protein 3

Preferred order of sections

Names and origin

Protein names

Recommended name:
NACHT, LRR and PYD domains-containing protein 3

Alternative name(s):
Cold autoinflammatory syndrome 1 protein homolog
Cryopyrin
Mast cell maturation-associated-inducible protein 1
PYRIN-containing APAF1-like protein 1

Gene names

Name:	Nlrp3
Synonyms:	Cias1, Mmig1, Nalp3, Pypaf1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1033 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA By similarity. Activates caspase-1 as part of the NALP3 inflammasome complex in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. Ref.6 Ref.7 Ref.8 Ref.9
Subunit structure	Interacts with PYCARD/ASC. Part of the NALP3 inflammasome complex which is involved in activation of caspase-1 and caspase-5, leading to processing of IL1B and IL18 By similarity. Interacts with PML By similarity.
Subcellular location	Cytoplasm Ref.1.
Tissue specificity	Widely expressed with high levels in peripheral blood leukocytes. Not detected in thymus. Ref.2 Ref.6
Disruption phenotype	Mice display lack of activation of caspase-1 in response to stimuli such as LPS and ATP, viral infection, bacterial and viral RNA, non-viral double-stranded RNA, nigericin, maitotoxin and the imidazoquinoline compounds R837 and R848. Ref.6 Ref.7 Ref.8 Ref.9
Miscellaneous	Expression is increased in mice with experimental atopic dermatitis.
Sequence similarities	Belongs to the NLRP family. Contains 1 DAPIN domain. Contains 9 LRR (leucine-rich) repeats. Contains 1 NACHT domain.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Leucine-rich repeat Repeat
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from mutant phenotype Ref.7. Source: MGI defense response to virus Inferred from mutant phenotype Ref.7. Source: MGI inflammatory response Inferred from sequence or structural similarity. Source: HGNC interleukin-1 secretion Inferred from mutant phenotype Ref.7. Source: MGI interleukin-18 production Inferred from mutant phenotype Ref.7. Source: MGI negative regulation of NF-kappaB import into nucleus Inferred from sequence or structural similarity. Source: HGNC negative regulation of NF-kappaB transcription factor activity Inferred from sequence or structural similarity. Source: HGNC negative regulation of inflammatory response Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of interleukin-1 beta secretion Inferred from sequence or structural similarity. Source: HGNC
Cellular_component	NLRP3 inflammasome complex Inferred from sequence or structural similarity. Source: UniProtKB cytosol Traceable author statement. Source: Reactome
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8R4B8-1) Also known as: MMIG-1a; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8R4B8-2) Also known as: MMIG-1b; The sequence of this isoform differs from the canonical sequence as follows: 888-944: Missing.

Isoform 3 (identifier: Q8R4B8-3) Also known as: MMIG-1c; The sequence of this isoform differs from the canonical sequence as follows: 774-830: Missing.

Isoform 4 (identifier: Q8R4B8-4) Also known as: MMIG-1d; The sequence of this isoform differs from the canonical sequence as follows: 830-1033: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1033

1033

NACHT, LRR and PYD domains-containing protein 3

PRO_0000080887

Regions

Domain

1 – 91

91

DAPIN

Domain

216 – 532

317

NACHT

Repeat

739 – 759

21

LRR 1

Repeat

768 – 789

22

LRR 2

Repeat

796 – 816

21

LRR 3

Repeat

825 – 846

22

LRR 4

Repeat

853 – 873

21

LRR 5

Repeat

882 – 903

22

LRR 6

Repeat

910 – 930

21

LRR 7

Repeat

939 – 960

22

LRR 8

Repeat

967 – 988

22

LRR 9

Nucleotide binding

222 – 229

8

ATP Potential

Natural variations

Alternative sequence

774 – 830

57

Missing in isoform 3.

VSP_014925

Alternative sequence

830 – 1033

204

Missing in isoform 4.

VSP_014926

Alternative sequence

888 – 944

57

Missing in isoform 2.

VSP_014927

Sequences

Sequence		Length	Mass (Da)
Isoform 1 (MMIG-1a) [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 5924690966B12117 Show »	FASTA	1,033	118,275
10 20 30 40 50 60 MTSVRCKLAQ YLEDLEDVDL KKFKMHLEDY PPEKGCIPVP RGQMEKADHL DLATLMIDFN 70 80 90 100 110 120 GEEKAWAMAV WIFAAINRRD LWEKAKKDQP EWNDTCTSHS SMVCQEDSLE EEWMGLLGYL 130 140 150 160 170 180 SRISICKKKK DYCKMYRRHV RSRFYSIKDR NARLGESVDL NSRYTQLQLV KEHPSKQERE 190 200 210 220 230 240 HELLTIGRTK MRDSPMSSLK LELLFEPEDG HSEPVHTVVF QGAAGIGKTI LARKIMLDWA 250 260 270 280 290 300 LGKLFKDKFD YLFFIHCREV SLRTPRSLAD LIVSCWPDPN PPVCKILRKP SRILFLMDGF 310 320 330 340 350 360 DELQGAFDEH IGEVCTDWQK AVRGDILLSS LIRKKLLPKA SLLITTRPVA LEKLQHLLDH 370 380 390 400 410 420 PRHVEILGFS EAKRKEYFFK YFSNELQARE AFRLIQENEV LFTMCFIPLV CWIVCTGLKQ 430 440 450 460 470 480 QMETGKSLAQ TSKTTTAVYV FFLSSLLQSR GGIEEHLFSD YLQGLCSLAA DGIWNQKILF 490 500 510 520 530 540 EECDLRKHGL QKTDVSAFLR MNVFQKEVDC ERFYSFSHMT FQEFFAAMYY LLEEEAEGET 550 560 570 580 590 600 VRKGPGGCSD LLNRDVKVLL ENYGKFEKGY LIFVVRFLFG LVNQERTSYL EKKLSCKISQ 610 620 630 640 650 660 QVRLELLKWI EVKAKAKKLQ WQPSQLELFY CLYEMQEEDF VQSAMDHFPK IEINLSTRMD 670 680 690 700 710 720 HVVSSFCIKN CHRVKTLSLG FFHNSPKEEE EERRGGRPLD QVQCVFPDTH VACSSRLVNC 730 740 750 760 770 780 CLTSSFCRGL FSSLSTNRSL TELDLSDNTL GDPGMRVLCE ALQHPGCNIQ RLWLGRCGLS 790 800 810 820 830 840 HQCCFDISSV LSSSQKLVEL DLSDNALGDF GIRLLCVGLK HLLCNLQKLW LVSCCLTSAC 850 860 870 880 890 900 CQDLALVLSS NHSLTRLYIG ENALGDSGVQ VLCEKMKDPQ CNLQKLGLVN SGLTSICCSA 910 920 930 940 950 960 LTSVLKTNQN FTHLYLRSNA LGDTGLRLLC EGLLHPDCKL QMLELDNCSL TSHSCWNLST 970 980 990 1000 1010 1020 ILTHNHSLRK LNLGNNDLGD LCVVTLCEVL KQQGCLLQSL QLGEMYLNRE TKRALEALQE 1030 EKPELTIVFE ISW « Hide
Isoform 2 (MMIG-1b) [UniParc]. Checksum: 01C3B9AC1D01C9D8 Show »	FASTA	976	112,073
10 20 30 40 50 60 MTSVRCKLAQ YLEDLEDVDL KKFKMHLEDY PPEKGCIPVP RGQMEKADHL DLATLMIDFN 70 80 90 100 110 120 GEEKAWAMAV WIFAAINRRD LWEKAKKDQP EWNDTCTSHS SMVCQEDSLE EEWMGLLGYL 130 140 150 160 170 180 SRISICKKKK DYCKMYRRHV RSRFYSIKDR NARLGESVDL NSRYTQLQLV KEHPSKQERE 190 200 210 220 230 240 HELLTIGRTK MRDSPMSSLK LELLFEPEDG HSEPVHTVVF QGAAGIGKTI LARKIMLDWA 250 260 270 280 290 300 LGKLFKDKFD YLFFIHCREV SLRTPRSLAD LIVSCWPDPN PPVCKILRKP SRILFLMDGF 310 320 330 340 350 360 DELQGAFDEH IGEVCTDWQK AVRGDILLSS LIRKKLLPKA SLLITTRPVA LEKLQHLLDH 370 380 390 400 410 420 PRHVEILGFS EAKRKEYFFK YFSNELQARE AFRLIQENEV LFTMCFIPLV CWIVCTGLKQ 430 440 450 460 470 480 QMETGKSLAQ TSKTTTAVYV FFLSSLLQSR GGIEEHLFSD YLQGLCSLAA DGIWNQKILF 490 500 510 520 530 540 EECDLRKHGL QKTDVSAFLR MNVFQKEVDC ERFYSFSHMT FQEFFAAMYY LLEEEAEGET 550 560 570 580 590 600 VRKGPGGCSD LLNRDVKVLL ENYGKFEKGY LIFVVRFLFG LVNQERTSYL EKKLSCKISQ 610 620 630 640 650 660 QVRLELLKWI EVKAKAKKLQ WQPSQLELFY CLYEMQEEDF VQSAMDHFPK IEINLSTRMD 670 680 690 700 710 720 HVVSSFCIKN CHRVKTLSLG FFHNSPKEEE EERRGGRPLD QVQCVFPDTH VACSSRLVNC 730 740 750 760 770 780 CLTSSFCRGL FSSLSTNRSL TELDLSDNTL GDPGMRVLCE ALQHPGCNIQ RLWLGRCGLS 790 800 810 820 830 840 HQCCFDISSV LSSSQKLVEL DLSDNALGDF GIRLLCVGLK HLLCNLQKLW LVSCCLTSAC 850 860 870 880 890 900 CQDLALVLSS NHSLTRLYIG ENALGDSGVQ VLCEKMKDPQ CNLQKLGLDN CSLTSHSCWN 910 920 930 940 950 960 LSTILTHNHS LRKLNLGNND LGDLCVVTLC EVLKQQGCLL QSLQLGEMYL NRETKRALEA 970 LQEEKPELTI VFEISW « Hide
Isoform 3 (MMIG-1c) [UniParc]. Checksum: C8D9FB1ECD871D5E Show »	FASTA	976	112,032
10 20 30 40 50 60 MTSVRCKLAQ YLEDLEDVDL KKFKMHLEDY PPEKGCIPVP RGQMEKADHL DLATLMIDFN 70 80 90 100 110 120 GEEKAWAMAV WIFAAINRRD LWEKAKKDQP EWNDTCTSHS SMVCQEDSLE EEWMGLLGYL 130 140 150 160 170 180 SRISICKKKK DYCKMYRRHV RSRFYSIKDR NARLGESVDL NSRYTQLQLV KEHPSKQERE 190 200 210 220 230 240 HELLTIGRTK MRDSPMSSLK LELLFEPEDG HSEPVHTVVF QGAAGIGKTI LARKIMLDWA 250 260 270 280 290 300 LGKLFKDKFD YLFFIHCREV SLRTPRSLAD LIVSCWPDPN PPVCKILRKP SRILFLMDGF 310 320 330 340 350 360 DELQGAFDEH IGEVCTDWQK AVRGDILLSS LIRKKLLPKA SLLITTRPVA LEKLQHLLDH 370 380 390 400 410 420 PRHVEILGFS EAKRKEYFFK YFSNELQARE AFRLIQENEV LFTMCFIPLV CWIVCTGLKQ 430 440 450 460 470 480 QMETGKSLAQ TSKTTTAVYV FFLSSLLQSR GGIEEHLFSD YLQGLCSLAA DGIWNQKILF 490 500 510 520 530 540 EECDLRKHGL QKTDVSAFLR MNVFQKEVDC ERFYSFSHMT FQEFFAAMYY LLEEEAEGET 550 560 570 580 590 600 VRKGPGGCSD LLNRDVKVLL ENYGKFEKGY LIFVVRFLFG LVNQERTSYL EKKLSCKISQ 610 620 630 640 650 660 QVRLELLKWI EVKAKAKKLQ WQPSQLELFY CLYEMQEEDF VQSAMDHFPK IEINLSTRMD 670 680 690 700 710 720 HVVSSFCIKN CHRVKTLSLG FFHNSPKEEE EERRGGRPLD QVQCVFPDTH VACSSRLVNC 730 740 750 760 770 780 CLTSSFCRGL FSSLSTNRSL TELDLSDNTL GDPGMRVLCE ALQHPGCNIQ RLWLVSCCLT 790 800 810 820 830 840 SACCQDLALV LSSNHSLTRL YIGENALGDS GVQVLCEKMK DPQCNLQKLG LVNSGLTSIC 850 860 870 880 890 900 CSALTSVLKT NQNFTHLYLR SNALGDTGLR LLCEGLLHPD CKLQMLELDN CSLTSHSCWN 910 920 930 940 950 960 LSTILTHNHS LRKLNLGNND LGDLCVVTLC EVLKQQGCLL QSLQLGEMYL NRETKRALEA 970 LQEEKPELTI VFEISW « Hide
Isoform 4 (MMIG-1d) [UniParc]. Checksum: 9F8A2ABC9CAE7004 Show »	FASTA	829	95,710
10 20 30 40 50 60 MTSVRCKLAQ YLEDLEDVDL KKFKMHLEDY PPEKGCIPVP RGQMEKADHL DLATLMIDFN 70 80 90 100 110 120 GEEKAWAMAV WIFAAINRRD LWEKAKKDQP EWNDTCTSHS SMVCQEDSLE EEWMGLLGYL 130 140 150 160 170 180 SRISICKKKK DYCKMYRRHV RSRFYSIKDR NARLGESVDL NSRYTQLQLV KEHPSKQERE 190 200 210 220 230 240 HELLTIGRTK MRDSPMSSLK LELLFEPEDG HSEPVHTVVF QGAAGIGKTI LARKIMLDWA 250 260 270 280 290 300 LGKLFKDKFD YLFFIHCREV SLRTPRSLAD LIVSCWPDPN PPVCKILRKP SRILFLMDGF 310 320 330 340 350 360 DELQGAFDEH IGEVCTDWQK AVRGDILLSS LIRKKLLPKA SLLITTRPVA LEKLQHLLDH 370 380 390 400 410 420 PRHVEILGFS EAKRKEYFFK YFSNELQARE AFRLIQENEV LFTMCFIPLV CWIVCTGLKQ 430 440 450 460 470 480 QMETGKSLAQ TSKTTTAVYV FFLSSLLQSR GGIEEHLFSD YLQGLCSLAA DGIWNQKILF 490 500 510 520 530 540 EECDLRKHGL QKTDVSAFLR MNVFQKEVDC ERFYSFSHMT FQEFFAAMYY LLEEEAEGET 550 560 570 580 590 600 VRKGPGGCSD LLNRDVKVLL ENYGKFEKGY LIFVVRFLFG LVNQERTSYL EKKLSCKISQ 610 620 630 640 650 660 QVRLELLKWI EVKAKAKKLQ WQPSQLELFY CLYEMQEEDF VQSAMDHFPK IEINLSTRMD 670 680 690 700 710 720 HVVSSFCIKN CHRVKTLSLG FFHNSPKEEE EERRGGRPLD QVQCVFPDTH VACSSRLVNC 730 740 750 760 770 780 CLTSSFCRGL FSSLSTNRSL TELDLSDNTL GDPGMRVLCE ALQHPGCNIQ RLWLGRCGLS 790 800 810 820 HQCCFDISSV LSSSQKLVEL DLSDNALGDF GIRLLCVGLK HLLCNLQKL « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Induction of PYPAF1 during in vitro maturation of mouse mast cells." Kikuchi-Yanoshita R., Taketomi Y., Koga K., Sugiki T., Atsumi Y., Saito T., Ishii S., Hisada M., Suzuki-Nishimura T., Uchida M.K., Moon T.-C., Chang H.-W., Sawada M., Inagaki N., Nagai H., Murakami M., Kudo I. J. Biochem. 134:699-709(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), SUBCELLULAR LOCATION. Strain: BALB/cJ.
[2]	"Structural, expression, and evolutionary analysis of mouse CIAS1." Anderson J.P., Mueller J.L., Rosengren S., Boyle D.L., Schaner P., Cannon S.B., Goodyear C.S., Hoffman H.M. Gene 338:25-34(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Strain: 129/Sv, BALB/c and C57BL/6.
[3]	"Murine NALPs: a family of proteins involved in inflammation." Martinon F., Hofmann K., Tschopp J. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: C57BL/6.
[4]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
[6]	"Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1." Sutterwala F.S., Ogura Y., Szczepanik M., Lara-Tejero M., Lichtenberger G.S., Grant E.P., Bertin J., Coyle A.J., Galan J.E., Askenase P.W., Flavell R.A. Immunity 24:317-327(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[7]	"Critical role for cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA." Kanneganti T.-D., Body-Malapel M., Amer A., Park J.-H., Whitfield J., Franchi L., Taraporewala Z.F., Miller D., Patton J.T., Inohara N., Nunez G. J. Biol. Chem. 281:36560-36568(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[8]	"Cryopyrin activates the inflammasome in response to toxins and ATP." Mariathasan S., Weiss D.S., Newton K., McBride J., O'Rourke K., Roose-Girma M., Lee W.P., Weinrauch Y., Monack D.M., Dixit V.M. Nature 440:228-232(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[9]	"Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3." Kanneganti T.-D., Oezoeren N., Body-Malapel M., Amer A., Park J.-H., Franchi L., Whitfield J., Barchet W., Colonna M., Vandenabeele P., Bertin J., Coyle A., Grant E.P., Akira S., Nunez G. Nature 440:233-236(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF486632 mRNA. Translation: AAL90874.1. AY495376 mRNA. Translation: AAS75794.1. AY495377 mRNA. Translation: AAS75795.1. AY337285 mRNA. Translation: AAR03540.1. AY337292 AY337291 Genomic DNA. Translation: AAR03541.1. AY337299 AY337298 Genomic DNA. Translation: AAR03542.1. AY337306 AY337305 Genomic DNA. Translation: AAR03543.1. AY355340 mRNA. Translation: AAR14737.1. AL592522 Genomic DNA. Translation: CAI24551.1. BC116174 mRNA. Translation: AAI16175.1. BC116175 mRNA. Translation: AAI16176.1.
IPI	IPI00153873. IPI00620168. IPI00620897. IPI00621784.
RefSeq	NP_665826.1. NM_145827.3.
UniGene	Mm.54174.
3D structure databases
ProteinModelPortal	Q8R4B8.
SMR	Q8R4B8. Positions 3-92, 716-1028.
ModBase	Search...
PTM databases
PhosphoSite	Q8R4B8.
Proteomic databases
PaxDb	Q8R4B8.
PRIDE	Q8R4B8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000079476; ENSMUSP00000078440; ENSMUSG00000032691. ENSMUST00000101148; ENSMUSP00000098707; ENSMUSG00000032691.
GeneID	216799.
KEGG	mmu:216799.
UCSC	uc007jeh.1. mouse.
Organism-specific databases
CTD	114548.
MGI	MGI:2653833. Nlrp3.
Phylogenomic databases
eggNOG	NOG82860.
GeneTree	ENSGT00700000104141.
HOGENOM	HOG000294064.
HOVERGEN	HBG063656.
InParanoid	Q8R4B8.
KO	K12800.
OMA	VNCCLTS.
OrthoDB	EOG4HX508.
Enzyme and pathway databases
Reactome	REACT_107772. Immune System.
Gene expression databases
ArrayExpress	Q8R4B8.
Bgee	Q8R4B8.
CleanEx	MM_NLRP3.
Genevestigator	Q8R4B8.
GermOnline	ENSMUSG00000032691. Mus musculus.
Family and domain databases
Gene3D	1.10.533.10. 1 hit.
InterPro	IPR004020. DAPIN. IPR011029. DEATH-like_dom. IPR001611. Leu-rich_rpt. IPR003590. Leu-rich_rpt_RNase_inh_sub-typ. IPR007111. NACHT_NTPase. [Graphical view]
Pfam	PF02758. PYRIN. 1 hit. [Graphical view]
SMART	SM00368. LRR_RI. 1 hit. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit.
PROSITE	PS50824. DAPIN. 1 hit. PS51450. LRR. 5 hits. PS50837. NACHT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	375328.
SOURCE	Search...

Entry information

Entry name

NALP3_MOUSE

Accession

Primary (citable) accession number: Q8R4B8
Secondary accession number(s): Q1JQ87, Q1JQ88, Q6JEL0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents