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Protein
Submitted name:

Cadherin 13

Gene

Cdh13

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. low-density lipoprotein particle binding Source: Ensembl

GO - Biological processi

  1. calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: Ensembl
  2. cell adhesion Source: RGD
  3. endothelial cell migration Source: Ensembl
  4. homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  5. keratinocyte proliferation Source: Ensembl
  6. lamellipodium assembly Source: Ensembl
  7. localization within membrane Source: Ensembl
  8. low-density lipoprotein particle mediated signaling Source: Ensembl
  9. mitotic cell cycle Source: RGD
  10. negative regulation of cell adhesion Source: Ensembl
  11. negative regulation of cell proliferation Source: Ensembl
  12. positive regulation of calcium-mediated signaling Source: Ensembl
  13. positive regulation of cell-matrix adhesion Source: Ensembl
  14. positive regulation of cell migration Source: Ensembl
  15. positive regulation of endothelial cell proliferation Source: Ensembl
  16. positive regulation of positive chemotaxis Source: Ensembl
  17. positive regulation of smooth muscle cell proliferation Source: Ensembl
  18. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  19. Rac protein signal transduction Source: Ensembl
  20. regulation of cell growth Source: RGD
  21. regulation of endocytosis Source: Ensembl
  22. regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
  23. response to organic substance Source: RGD
  24. Rho protein signal transduction Source: Ensembl
  25. single organismal cell-cell adhesion Source: RGD
  26. sprouting angiogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesionSAAS annotation

Keywords - Ligandi

CalciumUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cadherin 13Imported
Submitted name:
Protein Cdh13Imported
Submitted name:
T-cadherinImported
Gene namesi
Name:Cdh13Imported
ORF Names:rCG_51389Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 19

Organism-specific databases

RGDi619745. Cdh13.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. external side of plasma membrane Source: Ensembl
  3. extracellular space Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. neuron projection Source: Ensembl
  6. perinuclear region of cytoplasm Source: RGD
  7. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ8R490.

Structurei

3D structure databases

ProteinModelPortaliQ8R490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiNOG304703.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
KOiK06808.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR014868. Cadherin_pro_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R490-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPRTPLTLC VLLSQVLLVT SAGDLDCTPG FQQKVLHIHQ PAEFIEDQPV
60 70 80 90 100
LNLTFSDCKG NKKLHYEVSS PYFKVNSDGT LVAVRNITAV GRTLFVHART
110 120 130 140 150
PHAEDMAELV IVGGKDIQGS LQDIFKFART SPVPRQKRSI VVSPILIPEN
160 170 180 190 200
QRQPFPRDVG KVVDSDRPEG SKFRLTGKGV DQDPKGTFRI NENTGSVSVT
210 220 230 240 250
RTLDRETIAT YQLFVETTDA SGRTLEGPVP LEVIVIDQND NRPIFREGPY
260 270 280 290 300
IGHVMEGSPT GTTVMRMTAF DADDPATDNA LLRYNIRQQT PDKPSPNMFY
310 320 330 340 350
IDPEKGDIVT VVSPALLDRE TLENPKYELI IEAQDMAGLD VGLTGTATAT
360 370 380 390 400
IVIDDKNDHS PKFTKKEFQA TVEEGAVGVI VNLTVEDKDD PATGAWRAAY
410 420 430 440 450
TIINGNPGQS FEIHTNPQTN EGMLSVVKPL DYEISAFHTL LIKVENEDPL
460 470 480 490 500
VPDVSYGPSS TATVHITVLD VNEGPVFYPD PMMVTKQENI SVGSVLLTVN
510 520 530 540 550
ATDPDSLQHQ TIRYSVYKDP AGWLSINPIN GTVDTTAVLD RESPFVHNSV
560 570 580 590 600
YTALFLAIDS GNPPATGTGT LMITLEDVND NAPVIYPTVA EVCDDARNLS
610 620 630 640 650
VVILGASDKD LHPNTDPFKF EIHKQTVPDK VWKISKINNT HALVSLLQNL
660 670 680 690 700
NKANYNLPIM VTDSGKPPMT NITDLRVQVC SCKNSKVDCN AAGTLHLSLS
710
LLLLFSLLSL LSGL
Length:714
Mass (Da):78,086
Last modified:June 1, 2002 - v1
Checksum:i7E56142B8162F864
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06099055 Genomic DNA. No translation available.
AABR06099056 Genomic DNA. No translation available.
AABR06099057 Genomic DNA. No translation available.
AABR06099058 Genomic DNA. No translation available.
AABR06099059 Genomic DNA. No translation available.
AABR06099060 Genomic DNA. No translation available.
AABR06099061 Genomic DNA. No translation available.
AABR06099062 Genomic DNA. No translation available.
AABR06099063 Genomic DNA. No translation available.
AABR06099064 Genomic DNA. No translation available.
AABR06099065 Genomic DNA. No translation available.
AABR06099066 Genomic DNA. No translation available.
AABR06099067 Genomic DNA. No translation available.
AABR06099068 Genomic DNA. No translation available.
AABR06099069 Genomic DNA. No translation available.
AABR06099070 Genomic DNA. No translation available.
AABR06099071 Genomic DNA. No translation available.
AABR06099072 Genomic DNA. No translation available.
AABR06099073 Genomic DNA. No translation available.
AABR06099074 Genomic DNA. No translation available.
AABR06099075 Genomic DNA. No translation available.
AABR06099076 Genomic DNA. No translation available.
AABR06099077 Genomic DNA. No translation available.
AABR06099078 Genomic DNA. No translation available.
AABR06099079 Genomic DNA. No translation available.
AABR06099080 Genomic DNA. No translation available.
AABR06099081 Genomic DNA. No translation available.
AABR06099082 Genomic DNA. No translation available.
AABR06099083 Genomic DNA. No translation available.
AABR06099084 Genomic DNA. No translation available.
AABR06099085 Genomic DNA. No translation available.
AABR06099086 Genomic DNA. No translation available.
AABR06099087 Genomic DNA. No translation available.
AABR06099088 Genomic DNA. No translation available.
AABR06099089 Genomic DNA. No translation available.
AABR06099090 Genomic DNA. No translation available.
AABR06099091 Genomic DNA. No translation available.
AABR06099092 Genomic DNA. No translation available.
AABR06099093 Genomic DNA. No translation available.
AABR06099094 Genomic DNA. No translation available.
AABR06099095 Genomic DNA. No translation available.
AABR06099096 Genomic DNA. No translation available.
AABR06099097 Genomic DNA. No translation available.
AABR06099098 Genomic DNA. No translation available.
AABR06099099 Genomic DNA. No translation available.
AABR06099100 Genomic DNA. No translation available.
AABR06099101 Genomic DNA. No translation available.
AABR06099102 Genomic DNA. No translation available.
AABR06099103 Genomic DNA. No translation available.
AABR06099104 Genomic DNA. No translation available.
AABR06099105 Genomic DNA. No translation available.
BC085699 mRNA. Translation: AAH85699.1.
AF494095 mRNA. Translation: AAM14607.1.
CH473972 Genomic DNA. Translation: EDL92658.1.
RefSeqiNP_620244.1. NM_138889.2.
UniGeneiRn.23806.

Genome annotation databases

EnsembliENSRNOT00000077053; ENSRNOP00000068368; ENSRNOG00000014371.
GeneIDi192248.
KEGGirno:192248.
UCSCiRGD:619745. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06099055 Genomic DNA. No translation available.
AABR06099056 Genomic DNA. No translation available.
AABR06099057 Genomic DNA. No translation available.
AABR06099058 Genomic DNA. No translation available.
AABR06099059 Genomic DNA. No translation available.
AABR06099060 Genomic DNA. No translation available.
AABR06099061 Genomic DNA. No translation available.
AABR06099062 Genomic DNA. No translation available.
AABR06099063 Genomic DNA. No translation available.
AABR06099064 Genomic DNA. No translation available.
AABR06099065 Genomic DNA. No translation available.
AABR06099066 Genomic DNA. No translation available.
AABR06099067 Genomic DNA. No translation available.
AABR06099068 Genomic DNA. No translation available.
AABR06099069 Genomic DNA. No translation available.
AABR06099070 Genomic DNA. No translation available.
AABR06099071 Genomic DNA. No translation available.
AABR06099072 Genomic DNA. No translation available.
AABR06099073 Genomic DNA. No translation available.
AABR06099074 Genomic DNA. No translation available.
AABR06099075 Genomic DNA. No translation available.
AABR06099076 Genomic DNA. No translation available.
AABR06099077 Genomic DNA. No translation available.
AABR06099078 Genomic DNA. No translation available.
AABR06099079 Genomic DNA. No translation available.
AABR06099080 Genomic DNA. No translation available.
AABR06099081 Genomic DNA. No translation available.
AABR06099082 Genomic DNA. No translation available.
AABR06099083 Genomic DNA. No translation available.
AABR06099084 Genomic DNA. No translation available.
AABR06099085 Genomic DNA. No translation available.
AABR06099086 Genomic DNA. No translation available.
AABR06099087 Genomic DNA. No translation available.
AABR06099088 Genomic DNA. No translation available.
AABR06099089 Genomic DNA. No translation available.
AABR06099090 Genomic DNA. No translation available.
AABR06099091 Genomic DNA. No translation available.
AABR06099092 Genomic DNA. No translation available.
AABR06099093 Genomic DNA. No translation available.
AABR06099094 Genomic DNA. No translation available.
AABR06099095 Genomic DNA. No translation available.
AABR06099096 Genomic DNA. No translation available.
AABR06099097 Genomic DNA. No translation available.
AABR06099098 Genomic DNA. No translation available.
AABR06099099 Genomic DNA. No translation available.
AABR06099100 Genomic DNA. No translation available.
AABR06099101 Genomic DNA. No translation available.
AABR06099102 Genomic DNA. No translation available.
AABR06099103 Genomic DNA. No translation available.
AABR06099104 Genomic DNA. No translation available.
AABR06099105 Genomic DNA. No translation available.
BC085699 mRNA. Translation: AAH85699.1.
AF494095 mRNA. Translation: AAM14607.1.
CH473972 Genomic DNA. Translation: EDL92658.1.
RefSeqiNP_620244.1. NM_138889.2.
UniGeneiRn.23806.

3D structure databases

ProteinModelPortaliQ8R490.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000077053; ENSRNOP00000068368; ENSRNOG00000014371.
GeneIDi192248.
KEGGirno:192248.
UCSCiRGD:619745. rat.

Organism-specific databases

CTDi1012.
RGDi619745. Cdh13.

Phylogenomic databases

eggNOGiNOG304703.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
KOiK06808.

Miscellaneous databases

NextBioi622888.

Gene expression databases

GenevestigatoriQ8R490.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR014868. Cadherin_pro_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of rat T-cadherin."
    Niermann T., Schmutz S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeartImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. Ensembl
    Submitted (OCT-2014) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ8R490_RAT
AccessioniPrimary (citable) accession number: Q8R490
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: February 4, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.