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Protein

Cell adhesion molecule 4

Gene

Cadm4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 4
Alternative name(s):
Immunoglobulin superfamily member 4C
Short name:
IgSF4C
Nectin-like protein 4
Short name:
NECL-4
TSLC1-like protein 2
Gene namesi
Name:Cadm4
Synonyms:Igsf4c, Necl4, Tsll2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2449088. Cadm4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 324300ExtracellularSequence analysisAdd
BLAST
Transmembranei325 – 34521HelicalSequence analysisAdd
BLAST
Topological domaini346 – 38843CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 388368Cell adhesion molecule 4PRO_0000291981Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi44 ↔ 104PROSITE-ProRule annotation
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis
Disulfide bondi145 ↔ 199PROSITE-ProRule annotation
Disulfide bondi245 ↔ 291PROSITE-ProRule annotation
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence analysis
Modified residuei361 – 3611PhosphoserineCombined sources

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8R464.
PaxDbiQ8R464.
PRIDEiQ8R464.

PTM databases

iPTMnetiQ8R464.
PhosphoSiteiQ8R464.
SwissPalmiQ8R464.

Expressioni

Tissue specificityi

Expressed in the brain and several organs including the kidney and liver.1 Publication

Gene expression databases

BgeeiQ8R464.
CleanExiMM_CADM4.
GenevisibleiQ8R464. MM.

Interactioni

Subunit structurei

Monomer and homodimer.By similarity

Protein-protein interaction databases

IntActiQ8R464. 2 interactions.
MINTiMINT-4119117.
STRINGi10090.ENSMUSP00000066880.

Structurei

3D structure databases

ProteinModelPortaliQ8R464.
SMRiQ8R464. Positions 25-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 11999Ig-like V-typeAdd
BLAST
Domaini124 – 21996Ig-like C2-type 1Add
BLAST
Domaini224 – 30784Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKIN. Eukaryota.
ENOG410ZUF7. LUCA.
GeneTreeiENSGT00770000120518.
HOGENOMiHOG000036057.
HOVERGENiHBG057086.
InParanoidiQ8R464.
KOiK06783.
OMAiTGQEVQT.
OrthoDBiEOG7PVWPD.
PhylomeDBiQ8R464.
TreeFamiTF338300.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR028807. Cadm4.
IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view]
PANTHERiPTHR23277:SF50. PTHR23277:SF50. 1 hit.
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRARRFQWP LLLLWAAAAG PGTGQEVQTE NVTVAEGGVA EITCRLHQYD
60 70 80 90 100
GSIVVIQNPA RQTLFFNGTR ALKDERFQLE EFSPRRVRIR LSDARLEDEG
110 120 130 140 150
GYFCQLYTED THHQIATLTV LVAPENPVVE VREQAVEGGE VELSCLVPRS
160 170 180 190 200
RPAAVLRWYR DRKELKGVSS GQENGKVWSV ASTVRFRVDR KDDGGIVICE
210 220 230 240 250
AQNQALPSGH SKQTQYVLDV QYSPTARIHA SQAVVREGDT LVLTCAVTGN
260 270 280 290 300
PRPNQIRWNR GNESLPERAE AVGETLTLPG LVSADNGTYT CEAANKHGHA
310 320 330 340 350
RALYVLVVYD PGAVVEAQTS VPYAIVGGIL ALLVFLIICV LVGMVWCSVR
360 370 380
QKGSYLTHEA SGLDEQGEAR EAFLNGGDGH KRKEEFFI
Length:388
Mass (Da):42,723
Last modified:June 1, 2002 - v1
Checksum:i8E3A9DF1C3B9D23E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY059394 mRNA. Translation: AAL29692.1.
CCDSiCCDS20951.1.
RefSeqiNP_694752.1. NM_153112.3.
UniGeneiMm.178322.

Genome annotation databases

EnsembliENSMUST00000068023; ENSMUSP00000066880; ENSMUSG00000054793.
GeneIDi260299.
KEGGimmu:260299.
UCSCiuc009fps.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY059394 mRNA. Translation: AAL29692.1.
CCDSiCCDS20951.1.
RefSeqiNP_694752.1. NM_153112.3.
UniGeneiMm.178322.

3D structure databases

ProteinModelPortaliQ8R464.
SMRiQ8R464. Positions 25-302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R464. 2 interactions.
MINTiMINT-4119117.
STRINGi10090.ENSMUSP00000066880.

PTM databases

iPTMnetiQ8R464.
PhosphoSiteiQ8R464.
SwissPalmiQ8R464.

Proteomic databases

MaxQBiQ8R464.
PaxDbiQ8R464.
PRIDEiQ8R464.

Protocols and materials databases

DNASUi260299.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068023; ENSMUSP00000066880; ENSMUSG00000054793.
GeneIDi260299.
KEGGimmu:260299.
UCSCiuc009fps.1. mouse.

Organism-specific databases

CTDi199731.
MGIiMGI:2449088. Cadm4.

Phylogenomic databases

eggNOGiENOG410IKIN. Eukaryota.
ENOG410ZUF7. LUCA.
GeneTreeiENSGT00770000120518.
HOGENOMiHOG000036057.
HOVERGENiHBG057086.
InParanoidiQ8R464.
KOiK06783.
OMAiTGQEVQT.
OrthoDBiEOG7PVWPD.
PhylomeDBiQ8R464.
TreeFamiTF338300.

Miscellaneous databases

ChiTaRSiCadm4. mouse.
NextBioi392067.
PROiQ8R464.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R464.
CleanExiMM_CADM4.
GenevisibleiQ8R464. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR028807. Cadm4.
IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view]
PANTHERiPTHR23277:SF50. PTHR23277:SF50. 1 hit.
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2)."
    Fukami T., Satoh H., Williams Y.N., Masuda M., Fukuhara H., Maruyama T., Yageta M., Kuramochi M., Takamoto S., Murakami Y.
    Gene 323:11-18(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: 129/SvJ.
  2. "Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4."
    Williams Y.N., Masuda M., Sakurai-Yageta M., Maruyama T., Shibuya M., Murakami Y.
    Oncogene 25:1446-1453(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney and Spleen.

Entry informationi

Entry nameiCADM4_MOUSE
AccessioniPrimary (citable) accession number: Q8R464
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2002
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.