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Protein

Cell adhesion molecule 4

Gene

Cadm4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 4
Alternative name(s):
Immunoglobulin superfamily member 4C
Short name:
IgSF4C
Nectin-like protein 4
Short name:
NECL-4
TSLC1-like protein 2
Gene namesi
Name:Cadm4
Synonyms:Igsf4c, Necl4, Tsll2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2449088 Cadm4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 324ExtracellularSequence analysisAdd BLAST300
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 388CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000029198121 – 388Cell adhesion molecule 4Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi44 ↔ 104PROSITE-ProRule annotation
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 199PROSITE-ProRule annotation
Disulfide bondi245 ↔ 291PROSITE-ProRule annotation
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei361PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8R464
PaxDbiQ8R464
PeptideAtlasiQ8R464
PRIDEiQ8R464

PTM databases

iPTMnetiQ8R464
PhosphoSitePlusiQ8R464
SwissPalmiQ8R464

Expressioni

Tissue specificityi

Expressed in the brain and several organs including the kidney and liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000054793
CleanExiMM_CADM4
GenevisibleiQ8R464 MM

Interactioni

Subunit structurei

Monomer and homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8R464, 2 interactors
MINTiQ8R464
STRINGi10090.ENSMUSP00000066880

Structurei

3D structure databases

ProteinModelPortaliQ8R464
SMRiQ8R464
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 119Ig-like V-typeAdd BLAST99
Domaini124 – 219Ig-like C2-type 1Add BLAST96
Domaini224 – 307Ig-like C2-type 2Add BLAST84

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKIN Eukaryota
ENOG410ZUF7 LUCA
GeneTreeiENSGT00900000140811
HOGENOMiHOG000036057
HOVERGENiHBG057086
InParanoidiQ8R464
KOiK06783
OMAiTGQEVQT
OrthoDBiEOG091G0BHE
PhylomeDBiQ8R464
TreeFamiTF338300

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR028807 Cadm4
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR003585 Neurexin-like
PANTHERiPTHR23277:SF50 PTHR23277:SF50, 1 hit
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRARRFQWP LLLLWAAAAG PGTGQEVQTE NVTVAEGGVA EITCRLHQYD
60 70 80 90 100
GSIVVIQNPA RQTLFFNGTR ALKDERFQLE EFSPRRVRIR LSDARLEDEG
110 120 130 140 150
GYFCQLYTED THHQIATLTV LVAPENPVVE VREQAVEGGE VELSCLVPRS
160 170 180 190 200
RPAAVLRWYR DRKELKGVSS GQENGKVWSV ASTVRFRVDR KDDGGIVICE
210 220 230 240 250
AQNQALPSGH SKQTQYVLDV QYSPTARIHA SQAVVREGDT LVLTCAVTGN
260 270 280 290 300
PRPNQIRWNR GNESLPERAE AVGETLTLPG LVSADNGTYT CEAANKHGHA
310 320 330 340 350
RALYVLVVYD PGAVVEAQTS VPYAIVGGIL ALLVFLIICV LVGMVWCSVR
360 370 380
QKGSYLTHEA SGLDEQGEAR EAFLNGGDGH KRKEEFFI
Length:388
Mass (Da):42,723
Last modified:June 1, 2002 - v1
Checksum:i8E3A9DF1C3B9D23E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY059394 mRNA Translation: AAL29692.1
CCDSiCCDS20951.1
RefSeqiNP_694752.1, NM_153112.3
UniGeneiMm.178322

Genome annotation databases

EnsembliENSMUST00000068023; ENSMUSP00000066880; ENSMUSG00000054793
GeneIDi260299
KEGGimmu:260299
UCSCiuc009fps.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCADM4_MOUSE
AccessioniPrimary (citable) accession number: Q8R464
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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