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Protein

Interleukin-1 family member 10

Gene

Il1f10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2 (By similarity).By similarity

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 family member 10
Short name:
IL-1F10
Gene namesi
Name:Il1f10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2652548. Il1f10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Interleukin-1 family member 10PRO_0000153651Add
BLAST

Proteomic databases

PaxDbiQ8R459.
PRIDEiQ8R459.

Expressioni

Gene expression databases

BgeeiQ8R459.
CleanExiMM_IL1F10.
ExpressionAtlasiQ8R459. differential.
GenevisibleiQ8R459. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063004.

Structurei

3D structure databases

ProteinModelPortaliQ8R459.
SMRiQ8R459. Positions 12-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410IWY5. Eukaryota.
ENOG41118N6. LUCA.
GeneTreeiENSGT00530000062899.
HOGENOMiHOG000231506.
HOVERGENiHBG052099.
InParanoidiQ8R459.
KOiK05488.
OMAiAAWPGWF.
OrthoDBiEOG747PKM.
PhylomeDBiQ8R459.
TreeFamiTF300203.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR027164. IL-1_F10.
IPR000975. IL-1_fam.
IPR003297. IL-1RA/IL-36.
[Graphical view]
PANTHERiPTHR10078:SF8. PTHR10078:SF8. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01360. INTRLEUKIN1X.
SUPFAMiSSF50353. SSF50353. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSLPMARYY IIKDAHQKAL YTRNGQLLLG DPDSDNYSPE KVCILPNRGL
60 70 80 90 100
DRSKVPIFLG MQGGSCCLAC VKTREGPLLQ LEDVNIEDLY KGGEQTTRFT
110 120 130 140 150
FFQRSLGSAF RLEAAACPGW FLCGPAEPQQ PVQLTKESEP STHTEFYFEM

SR
Length:152
Mass (Da):17,078
Last modified:June 1, 2002 - v1
Checksum:i9AD03EB0C3C61D8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY071844 mRNA. Translation: AAL67155.1.
CCDSiCCDS15735.1.
RefSeqiNP_694717.1. NM_153077.2.
XP_006497893.1. XM_006497830.1.
UniGeneiMm.218750.

Genome annotation databases

EnsembliENSMUST00000058056; ENSMUSP00000063004; ENSMUSG00000046845.
GeneIDi215274.
KEGGimmu:215274.
UCSCiuc008iou.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY071844 mRNA. Translation: AAL67155.1.
CCDSiCCDS15735.1.
RefSeqiNP_694717.1. NM_153077.2.
XP_006497893.1. XM_006497830.1.
UniGeneiMm.218750.

3D structure databases

ProteinModelPortaliQ8R459.
SMRiQ8R459. Positions 12-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063004.

Proteomic databases

PaxDbiQ8R459.
PRIDEiQ8R459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058056; ENSMUSP00000063004; ENSMUSG00000046845.
GeneIDi215274.
KEGGimmu:215274.
UCSCiuc008iou.1. mouse.

Organism-specific databases

CTDi84639.
MGIiMGI:2652548. Il1f10.

Phylogenomic databases

eggNOGiENOG410IWY5. Eukaryota.
ENOG41118N6. LUCA.
GeneTreeiENSGT00530000062899.
HOGENOMiHOG000231506.
HOVERGENiHBG052099.
InParanoidiQ8R459.
KOiK05488.
OMAiAAWPGWF.
OrthoDBiEOG747PKM.
PhylomeDBiQ8R459.
TreeFamiTF300203.

Miscellaneous databases

NextBioi374658.
PROiQ8R459.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R459.
CleanExiMM_IL1F10.
ExpressionAtlasiQ8R459. differential.
GenevisibleiQ8R459. MM.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR027164. IL-1_F10.
IPR000975. IL-1_fam.
IPR003297. IL-1RA/IL-36.
[Graphical view]
PANTHERiPTHR10078:SF8. PTHR10078:SF8. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01360. INTRLEUKIN1X.
SUPFAMiSSF50353. SSF50353. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster / NIH.

Entry informationi

Entry nameiIL1FA_MOUSE
AccessioniPrimary (citable) accession number: Q8R459
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2002
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.