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Protein

Melanopsin

Gene

Opn4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal.1 Publication

GO - Molecular functioni

  • 11-cis retinal binding Source: UniProtKB
  • G-protein coupled photoreceptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Biological rhythms

Keywords - Ligandi

Chromophore

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.
R-RNO-419771. Opsins.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanopsin
Alternative name(s):
Opsin-4
Gene namesi
Name:Opn4Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi621701. Opn4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7272ExtracellularSequence analysisAdd
BLAST
Transmembranei73 – 9321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini94 – 10714CytoplasmicSequence analysisAdd
BLAST
Transmembranei108 – 12821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini129 – 14416ExtracellularSequence analysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini166 – 18823CytoplasmicSequence analysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini210 – 23829ExtracellularSequence analysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini260 – 29334CytoplasmicSequence analysisAdd
BLAST
Transmembranei294 – 31421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini315 – 35541ExtracellularSequence analysisAdd
BLAST
Transmembranei356 – 37217Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini373 – 474102CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474MelanopsinPRO_0000233062Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence analysis
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi143 ↔ 221PROSITE-ProRule annotation
Modified residuei337 – 3371N6-(retinylidene)lysineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8R456.
PRIDEiQ8R456.

PTM databases

iPTMnetiQ8R456.

Expressioni

Tissue specificityi

Eye; expressed in a photosensitive subset of retinal ganglion cells.1 Publication

Gene expression databases

GenevisibleiQ8R456. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015642.

Structurei

3D structure databases

ProteinModelPortaliQ8R456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000264261.
HOVERGENiHBG007871.
InParanoidiQ8R456.
KOiK04255.
OMAiKRWLFGE.
OrthoDBiEOG7CNZG2.
PhylomeDBiQ8R456.
TreeFamiTF324998.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSPSESRVP SSLTQDPSFT ASPALLQGIW NSTQNISVRV QLLSVSPTTP
60 70 80 90 100
GLQAAAWVPF PTVDVPDHAH YTLGTVILLV GLTGMLGNLT VIYTFCRNRG
110 120 130 140 150
LRTPANMLII NLAVSDFLMS FTQAPVFFAS SLYKKWLFGE TGCKFYAFCG
160 170 180 190 200
AVFGIVSMIT LTAIAMDRYL VITRPLATIG MRSKRRTALV LLGVWLYALA
210 220 230 240 250
WSLPPFFGWS AYVPEGLLTS CSWDYVTFTP LVRAYTMLLF CFVFFLPLLI
260 270 280 290 300
IIFCYIFIFR AIRETGRACE GCGESPLRRR QWQRLQSEWK MAKVALIVIL
310 320 330 340 350
LFVLSWAPYS TVALVGFAGY SHILTPYMSS VPAVIAKASA IHNPIIYAIT
360 370 380 390 400
HPKYRAAIAQ HLPCLGVLLG VSGQRSHPSL SYRSTHRSTL SSQSSDLSWI
410 420 430 440 450
SGQKRQESLG SESEVGWTDT ETTAAWGAAQ QASGQSFCSH DLEDGEVKAP
460 470
SSPQEQKSKT PKTKRHLPSL DRRM
Length:474
Mass (Da):52,407
Last modified:June 1, 2002 - v1
Checksum:i33C302113D41E5EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072689 mRNA. Translation: AAL61854.1.
RefSeqiNP_620215.1. NM_138860.1.
UniGeneiRn.54303.

Genome annotation databases

EnsembliENSRNOT00000091315; ENSRNOP00000069548; ENSRNOG00000053893.
GeneIDi192223.
KEGGirno:192223.
UCSCiRGD:621701. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072689 mRNA. Translation: AAL61854.1.
RefSeqiNP_620215.1. NM_138860.1.
UniGeneiRn.54303.

3D structure databases

ProteinModelPortaliQ8R456.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015642.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8R456.

Proteomic databases

PaxDbiQ8R456.
PRIDEiQ8R456.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000091315; ENSRNOP00000069548; ENSRNOG00000053893.
GeneIDi192223.
KEGGirno:192223.
UCSCiRGD:621701. rat.

Organism-specific databases

CTDi94233.
RGDi621701. Opn4.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000264261.
HOVERGENiHBG007871.
InParanoidiQ8R456.
KOiK04255.
OMAiKRWLFGE.
OrthoDBiEOG7CNZG2.
PhylomeDBiQ8R456.
TreeFamiTF324998.

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.
R-RNO-419771. Opsins.

Miscellaneous databases

PROiQ8R456.

Gene expression databases

GenevisibleiQ8R456. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity."
    Hattar S., Liao H.-W., Takao M., Berson D.M., Yau K.-W.
    Science 295:1065-1070(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-DawleyImported.
    Tissue: RetinaImported.

Entry informationi

Entry nameiOPN4_RAT
AccessioniPrimary (citable) accession number: Q8R456
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.