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Protein
Submitted name:

Potassium channel TWIK-2

Gene

KCNK6

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel TWIK-2Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:KCNK6Imported
Synonyms:Kcnk6Imported
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei93 – 112HelicalSequence analysisAdd BLAST20
Transmembranei124 – 148HelicalSequence analysisAdd BLAST25
Transmembranei168 – 193HelicalSequence analysisAdd BLAST26
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000012596.

Structurei

3D structure databases

ProteinModelPortaliQ8R453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 143Ion_trans_2InterPro annotationAdd BLAST58
Domaini180 – 256Ion_trans_2InterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
OMAiPAVIFAH.
OrthoDBiEOG091G0DIX.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR005409. 2pore_dom_K_chnl_TWIK2.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01587. TWIK2CHANNEL.
PR01586. TWIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q8R453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGALLAIA LVAYAAYLAL GALLVAWLER PHEARLRAEL GSLREQLLRR
60 70 80 90 100
SPCVEPPVLD AFVERVLAAG RLARSVLANA SGATNVSDPA WDFASALFFA
110 120 130 140 150
STLVTTVGYG YTTPLTDAGK GFSIAFALLG VPTTMLLLTA TAQHLALLTH
160 170 180 190 200
TPLSWLSFHW GWDPRRAARW HLAALLAVVM TTCFLVPAMV FAYLEEAWSF
210 220 230 240 250
LDAFYFCFIS LSTIGLGDYV PGEAPGQPYR ALYKVLVTVY LFLGLIAMML
260 270 280 290 300
VLQTFRHVSD LHGLTELILL PRPCPASLQE EEDDQVEIPD PQLDLHQRLS
310
ASSHNDYASI PR
Length:312
Mass (Da):34,297
Last modified:June 1, 2002 - v1
Checksum:iFDD8686D1348379C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02042201 Genomic DNA. No translation available.
AY075097 mRNA. Translation: AAL82796.1.
RefSeqiNP_001166234.1. NM_001172763.1.

Genome annotation databases

EnsembliENSCPOT00000014120; ENSCPOP00000012596; ENSCPOG00000013979.
GeneIDi100379284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02042201 Genomic DNA. No translation available.
AY075097 mRNA. Translation: AAL82796.1.
RefSeqiNP_001166234.1. NM_001172763.1.

3D structure databases

ProteinModelPortaliQ8R453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000012596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000014120; ENSCPOP00000012596; ENSCPOG00000013979.
GeneIDi100379284.

Organism-specific databases

CTDi9424.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
OMAiPAVIFAH.
OrthoDBiEOG091G0DIX.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR005409. 2pore_dom_K_chnl_TWIK2.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01587. TWIK2CHANNEL.
PR01586. TWIKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8R453_CAVPO
AccessioniPrimary (citable) accession number: Q8R453
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.