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Protein
Submitted name:

Potassium channel TWIK-2

Gene

KCNK6

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel TWIK-2Imported
Gene namesi
Name:KCNK6Imported
Synonyms:Kcnk6Imported
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei93 – 112HelicalSequence analysisAdd BLAST20
Transmembranei124 – 148HelicalSequence analysisAdd BLAST25
Transmembranei168 – 193HelicalSequence analysisAdd BLAST26
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSCPOG00000013979.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000012596.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 143Ion_trans_2InterPro annotationAdd BLAST58
Domaini180 – 256Ion_trans_2InterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
OMAiSHTDYAS.
OrthoDBiEOG091G0DIX.
TreeFamiTF313947.

Family and domain databases

InterProiView protein in InterPro
IPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR005409. 2pore_dom_K_chnl_TWIK2.
IPR013099. K_chnl_dom.
PfamiView protein in Pfam
PF07885. Ion_trans_2. 2 hits.
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01587. TWIK2CHANNEL.
PR01586. TWIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q8R453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGALLAIA LVAYAAYLAL GALLVAWLER PHEARLRAEL GSLREQLLRR
60 70 80 90 100
SPCVEPPVLD AFVERVLAAG RLARSVLANA SGATNVSDPA WDFASALFFA
110 120 130 140 150
STLVTTVGYG YTTPLTDAGK GFSIAFALLG VPTTMLLLTA TAQHLALLTH
160 170 180 190 200
TPLSWLSFHW GWDPRRAARW HLAALLAVVM TTCFLVPAMV FAYLEEAWSF
210 220 230 240 250
LDAFYFCFIS LSTIGLGDYV PGEAPGQPYR ALYKVLVTVY LFLGLIAMML
260 270 280 290 300
VLQTFRHVSD LHGLTELILL PRPCPASLQE EEDDQVEIPD PQLDLHQRLS
310
ASSHNDYASI PR
Length:312
Mass (Da):34,297
Last modified:June 1, 2002 - v1
Checksum:iFDD8686D1348379C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02042201 Genomic DNA. No translation available.
AY075097 mRNA. Translation: AAL82796.1.
RefSeqiNP_001166234.1. NM_001172763.1.

Genome annotation databases

EnsembliENSCPOT00000014120; ENSCPOP00000012596; ENSCPOG00000013979.
GeneIDi100379284.

Similar proteinsi

Entry informationi

Entry nameiQ8R453_CAVPO
AccessioniPrimary (citable) accession number: Q8R453
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported