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Protein

Monoglyceride lipase

Gene

Mgll

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.By similarity1 Publication

Miscellaneous

Requires non-ionic detergent for solubilization.
Short-term inhibition causes analgesia, while long-term inhibition causes tolerance to endocannabinoids acting on brain cannabinoid receptor CNR1, and a reduction in brain cannabinoid receptor CNR1 activity.By similarity

Catalytic activityi

Hydrolyzes glycerol monoesters of long-chain fatty acids.By similarity

Pathwayi: triacylglycerol degradation

This protein is involved in the pathway triacylglycerol degradation, which is part of Glycerolipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway triacylglycerol degradation and in Glycerolipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei122NucleophileBy similarity1
Active sitei239Charge relay systemBy similarity1
Active sitei269Charge relay systemBy similarity1

GO - Molecular functioni

  • acylglycerol lipase activity Source: UniProtKB
  • hydrolase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.1.23 5301
ReactomeiR-RNO-1482883 Acyl chain remodeling of DAG and TAG
R-RNO-426048 Arachidonate production from DAG
UniPathwayiUPA00256

Protein family/group databases

ESTHERiratno-MGLL Monoglyceridelipase_lysophospholip

Chemistry databases

SwissLipidsiSLP:000001427

Names & Taxonomyi

Protein namesi
Recommended name:
Monoglyceride lipaseCurated (EC:3.1.1.23By similarity)
Short name:
MGL
Alternative name(s):
Monoacylglycerol lipase
Short name:
MAGL
Gene namesi
Name:MgllImported
Synonyms:Mgl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi71039 Mgll

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3321

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912671 – 303Monoglyceride lipaseAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphothreonineBy similarity1
Modified residuei58Nitrated tyrosineBy similarity1
Modified residuei189PhosphoserineBy similarity1

Keywords - PTMi

Nitration, Phosphoprotein

Proteomic databases

PaxDbiQ8R431
PRIDEiQ8R431

PTM databases

iPTMnetiQ8R431
PhosphoSitePlusiQ8R431
SwissPalmiQ8R431

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in adipose tissue, adrenal gland, ovary, heart, spleen, lung, skeletal muscle, kidney and testis. Highly expressed throughout the brain.2 Publications

Gene expression databases

BgeeiENSRNOG00000014508
ExpressionAtlasiQ8R431 baseline and differential
GenevisibleiQ8R431 RN

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030271

Chemistry databases

BindingDBiQ8R431

Structurei

3D structure databases

ProteinModelPortaliQ8R431
SMRiQ8R431
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1455 Eukaryota
COG2267 LUCA
GeneTreeiENSGT00390000011364
HOGENOMiHOG000003227
HOVERGENiHBG049220
InParanoidiQ8R431
KOiK01054
PhylomeDBiQ8R431

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR022742 Hydrolase_4
PfamiView protein in Pfam
PF12146 Hydrolase_4, 1 hit
PRINTSiPR00111 ABHYDROLASE
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEASSPRRT PQNVPYQDLP HLVNADGQYL FCRYWKPSGT PKALIFVSHG
60 70 80 90 100
AGEHCGRYDE LAQMLKRLDM LVFAHDHVGH GQSEGERMVV SDFQVFVRDL
110 120 130 140 150
LQHVNTVQKD YPEVPVFLLG HSMGGAISIL AAAERPTHFS GMILISPLIL
160 170 180 190 200
ANPESASTLK VLAAKLLNFV LPNISLGRID SSVLSRNKSE VDLYNSDPLI
210 220 230 240 250
CHAGVKVCFG IQLLNAVSRV ERAMPRLTLP FLLLQGSADR LCDSKGAYLL
260 270 280 290 300
MESSPSQDKT LKMYEGAYHV LHKELPEVTN SVLHEINTWV SHRIAVAGAR

CLP
Length:303
Mass (Da):33,500
Last modified:June 1, 2002 - v1
Checksum:i49CD407D97A1A971
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081195 mRNA Translation: AAL87453.1
BC107920 mRNA Translation: AAI07921.1
RefSeqiNP_612511.1, NM_138502.2
UniGeneiRn.40396

Genome annotation databases

EnsembliENSRNOT00000029125; ENSRNOP00000030271; ENSRNOG00000014508
GeneIDi29254
KEGGirno:29254
UCSCiRGD:71039 rat

Similar proteinsi

Entry informationi

Entry nameiMGLL_RAT
AccessioniPrimary (citable) accession number: Q8R431
Secondary accession number(s): Q32PZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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