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Protein

CD109 antigen

Gene

Cd109

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Modulates negatively TGFB1 signaling in keratinocytes.By similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
  2. transforming growth factor beta binding Source: MGI

GO - Biological processi

  1. hair follicle development Source: MGI
  2. negative regulation of keratinocyte proliferation Source: MGI
  3. negative regulation of protein phosphorylation Source: MGI
  4. negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  5. negative regulation of wound healing Source: MGI
  6. osteoclast fusion Source: MGI
  7. regulation of keratinocyte differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI39.006.

Names & Taxonomyi

Protein namesi
Recommended name:
CD109 antigen
Alternative name(s):
GPI-anchored alpha-2 macroglobulin-related protein
CD_antigen: CD109
Gene namesi
Name:Cd109
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2445221. Cd109.

Subcellular locationi

Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cell surface Source: MGI
  3. extracellular space Source: InterPro
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 14191398CD109 antigenPRO_0000255947Add
BLAST
Propeptidei1420 – 144223Removed in mature formSequence AnalysisPRO_0000255948Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
Cross-linki923 ↔ 926Isoglutamyl cysteine thioester (Cys-Gln)By similarity
Glycosylationi1088 – 10881N-linked (GlcNAc...)Sequence Analysis
Lipidationi1419 – 14191GPI-anchor amidated alanineSequence Analysis

Post-translational modificationi

N-glycosylated.By similarity
2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Thioester bond

Proteomic databases

MaxQBiQ8R422.
PaxDbiQ8R422.
PRIDEiQ8R422.

PTM databases

PhosphoSiteiQ8R422.

Expressioni

Gene expression databases

BgeeiQ8R422.
CleanExiMM_CD109.
ExpressionAtlasiQ8R422. baseline and differential.
GenevestigatoriQ8R422.

Interactioni

Subunit structurei

Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091330.

Structurei

3D structure databases

ProteinModelPortaliQ8R422.
SMRiQ8R422. Positions 26-1414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni595 – 704110Bait region (approximate)By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

eggNOGiCOG2373.
GeneTreeiENSGT00760000118982.
HOGENOMiHOG000293132.
HOVERGENiHBG097839.
InParanoidiQ8R422.
KOiK06530.
OMAiCIIVYYI.
OrthoDBiEOG7PGDPR.
PhylomeDBiQ8R422.
TreeFamiTF313285.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSRRLLSAA HLLCLCAVAL AAPGSRFLVT APGIIRPGAN VTIGVDLLEN
60 70 80 90 100
SPPQVLVKAQ VFKIASNKSR SILEAEGVFH RGHFKTLVLP ALPLSSADKI
110 120 130 140 150
YELHINGQSE NEIVFSNRTR LTFESKSISV LIQTDKAFYK PKQEVKFRVL
160 170 180 190 200
TLCSDLKPYR TSVDIFIKDP KSNVIQQWFS QKGDLGVVSK TFQLSSNPIF
210 220 230 240 250
GDWSIQVQVN DQQYYQSFQV LEYVLPKFEV TVQTPLYCSL KSKQLNGSVI
260 270 280 290 300
AKYTYGKPVK GSLSLTFLPL SFWGKKKNIT KSFEINGFAN FSFDNYEMKK
310 320 330 340 350
VMNLKPLTDV SEGSYENVDP SFPGPAEIIA TVTESLTGIS RMASTNVFFK
360 370 380 390 400
QHDYIIEIFD YTTVLKPSLN FTATVKVSRS DGNQLTPEEI ENDLVTVVTQ
410 420 430 440 450
RKNNHPESQR DQEMDYIQTV NYTIPQNGII KIEFPVMSIS GELQLKAYFL
460 470 480 490 500
DGTSSVTVHS MFTSPSKTYI QLKTRDEYIK VGSPFDLMVS GNRQFKDLSY
510 520 530 540 550
MVISKGQLVA AGKQSSRTFS LTPEASWAPK ACIIAYYIAE DGEIINDILK
560 570 580 590 600
IPVQLVFENK VKLFWSKPTV KPSDKVSLRI SATQSDSLVG IVAVDKSVTL
610 620 630 640 650
MENSNSITME TMVHELELYN TEYYLGMFMN SFAVFQECGL WVLTDATLIR
660 670 680 690 700
DSIDEVYDTE EYSERFAEEN EANLVDFEDA SSVNNVHVRK NFPETWIWLD
710 720 730 740 750
AYMGSKIYEE FEVTVPDSIT SWVASAFVIS EDLGFGLTTV PAELQAFQPF
760 770 780 790 800
FLFLNLPYSV IRGEEFALEV SIVNYLKDTI KVVILIEESD SFDILMTSND
810 820 830 840 850
TNGTIYRKTV QVPRDNGVTL VFPIKPTHLG EIPITVTAAS PTASDAVTQT
860 870 880 890 900
IVVKPEGIEK SYSKSVLLDL TDSNVESKQQ SMRFSFPPDT VIGSERVQIT
910 920 930 940 950
AIGDILGSSI NGLSSLIRMP YGCGEQNMIY FAPNIYILDY LTKQKQLTVN
960 970 980 990 1000
LKEKALSYMR QGYQRELLYQ REDGSFSAFG DIDSSGSTWL SAFVLRCFLE
1010 1020 1030 1040 1050
ADYYIDIDQD VLHRTYTWLN AHKKFNGEFW EPGRVIHSEL QGGTKSPVTL
1060 1070 1080 1090 1100
TAYIVTSVLG YKKYQPNIDV QDSIKFLEFE FSRGISDNYT LAIISYALST
1110 1120 1130 1140 1150
VGSPKAEEAL NLLMQRSEKE GDTQFWLSSG PALSGSWQPR SVDIEIAAYA
1160 1170 1180 1190 1200
LLAHTLHHVS EGIPVMRWLI QQRNSLGGFV STQDTVVALK ALSEFSALVH
1210 1220 1230 1240 1250
KENTDIQLTV TGPGIPRSIH FRIDSQNLFL LHQEELHALD PITVNVSAHG
1260 1270 1280 1290 1300
SGFAICQLNV DYNVKGSGSS KRRRSTENQE VFDLDVIVNN EDDISHLNLN
1310 1320 1330 1340 1350
VCTSHLGSER TGMVLMEVNL LSGFSASSDS IPLSETLKKV EYDNGKLNLY
1360 1370 1380 1390 1400
LDSVNESQFC VNIPTVRDYK VSNIRDGSVS VMDYYEPRRQ AVRSYNTQVK
1410 1420 1430 1440
LSSCYLSPDT NCKSHTDGAT DSLRRSSSLL VFCSVLLYFV QH
Length:1,442
Mass (Da):161,659
Last modified:May 31, 2002 - v1
Checksum:iE2B9671B8EA5BAA7
GO

Sequence cautioni

The sequence BAC31190.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083458 mRNA. Translation: AAM00021.1.
BC052443 mRNA. Translation: AAH52443.1.
AK042169 mRNA. Translation: BAC31190.1. Different initiation.
CCDSiCCDS23365.1.
RefSeqiNP_694738.1. NM_153098.3.
UniGeneiMm.32955.

Genome annotation databases

EnsembliENSMUST00000093812; ENSMUSP00000091330; ENSMUSG00000046186.
GeneIDi235505.
KEGGimmu:235505.
UCSCiuc009qur.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083458 mRNA. Translation: AAM00021.1.
BC052443 mRNA. Translation: AAH52443.1.
AK042169 mRNA. Translation: BAC31190.1. Different initiation.
CCDSiCCDS23365.1.
RefSeqiNP_694738.1. NM_153098.3.
UniGeneiMm.32955.

3D structure databases

ProteinModelPortaliQ8R422.
SMRiQ8R422. Positions 26-1414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091330.

Protein family/group databases

MEROPSiI39.006.

PTM databases

PhosphoSiteiQ8R422.

Proteomic databases

MaxQBiQ8R422.
PaxDbiQ8R422.
PRIDEiQ8R422.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093812; ENSMUSP00000091330; ENSMUSG00000046186.
GeneIDi235505.
KEGGimmu:235505.
UCSCiuc009qur.2. mouse.

Organism-specific databases

CTDi135228.
MGIiMGI:2445221. Cd109.

Phylogenomic databases

eggNOGiCOG2373.
GeneTreeiENSGT00760000118982.
HOGENOMiHOG000293132.
HOVERGENiHBG097839.
InParanoidiQ8R422.
KOiK06530.
OMAiCIIVYYI.
OrthoDBiEOG7PGDPR.
PhylomeDBiQ8R422.
TreeFamiTF313285.

Miscellaneous databases

NextBioi382724.
PROiQ8R422.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R422.
CleanExiMM_CD109.
ExpressionAtlasiQ8R422. baseline and differential.
GenevestigatoriQ8R422.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of GPI-anchored alpha-2 macroglobulin-related protein."
    Hashimoto M., Ichihara M., Takahashi M.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1126-1442.
    Strain: C57BL/6J.
    Tissue: Thymus.

Entry informationi

Entry nameiCD109_MOUSE
AccessioniPrimary (citable) accession number: Q8R422
Secondary accession number(s): Q8BLT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 30, 2006
Last sequence update: May 31, 2002
Last modified: February 3, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.