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Q8R422 (CD109_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD109 antigen
Alternative name(s):
GPI-anchored alpha-2 macroglobulin-related protein
CD_antigen=CD109
Gene names
Name:Cd109
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1442 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Modulates negatively TGFB1 signaling in keratinocytes By similarity.

Subunit structure

Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner By similarity.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor By similarity.

Post-translational modification

N-glycosylated By similarity.

2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form By similarity.

Sequence similarities

Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification]

Sequence caution

The sequence BAC31190.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 14191398CD109 antigen
PRO_0000255947
Propeptide1420 – 144223Removed in mature form Potential
PRO_0000255948

Regions

Region595 – 704110Bait region (approximate) By similarity

Amino acid modifications

Lipidation14191GPI-anchor amidated alanine Potential
Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation2461N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation3701N-linked (GlcNAc...) Potential
Glycosylation4211N-linked (GlcNAc...) Potential
Glycosylation10881N-linked (GlcNAc...) Potential
Cross-link923 ↔ 926Isoglutamyl cysteine thioester (Cys-Gln) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8R422 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: E2B9671B8EA5BAA7

FASTA1,442161,659
        10         20         30         40         50         60 
MRSRRLLSAA HLLCLCAVAL AAPGSRFLVT APGIIRPGAN VTIGVDLLEN SPPQVLVKAQ 

        70         80         90        100        110        120 
VFKIASNKSR SILEAEGVFH RGHFKTLVLP ALPLSSADKI YELHINGQSE NEIVFSNRTR 

       130        140        150        160        170        180 
LTFESKSISV LIQTDKAFYK PKQEVKFRVL TLCSDLKPYR TSVDIFIKDP KSNVIQQWFS 

       190        200        210        220        230        240 
QKGDLGVVSK TFQLSSNPIF GDWSIQVQVN DQQYYQSFQV LEYVLPKFEV TVQTPLYCSL 

       250        260        270        280        290        300 
KSKQLNGSVI AKYTYGKPVK GSLSLTFLPL SFWGKKKNIT KSFEINGFAN FSFDNYEMKK 

       310        320        330        340        350        360 
VMNLKPLTDV SEGSYENVDP SFPGPAEIIA TVTESLTGIS RMASTNVFFK QHDYIIEIFD 

       370        380        390        400        410        420 
YTTVLKPSLN FTATVKVSRS DGNQLTPEEI ENDLVTVVTQ RKNNHPESQR DQEMDYIQTV 

       430        440        450        460        470        480 
NYTIPQNGII KIEFPVMSIS GELQLKAYFL DGTSSVTVHS MFTSPSKTYI QLKTRDEYIK 

       490        500        510        520        530        540 
VGSPFDLMVS GNRQFKDLSY MVISKGQLVA AGKQSSRTFS LTPEASWAPK ACIIAYYIAE 

       550        560        570        580        590        600 
DGEIINDILK IPVQLVFENK VKLFWSKPTV KPSDKVSLRI SATQSDSLVG IVAVDKSVTL 

       610        620        630        640        650        660 
MENSNSITME TMVHELELYN TEYYLGMFMN SFAVFQECGL WVLTDATLIR DSIDEVYDTE 

       670        680        690        700        710        720 
EYSERFAEEN EANLVDFEDA SSVNNVHVRK NFPETWIWLD AYMGSKIYEE FEVTVPDSIT 

       730        740        750        760        770        780 
SWVASAFVIS EDLGFGLTTV PAELQAFQPF FLFLNLPYSV IRGEEFALEV SIVNYLKDTI 

       790        800        810        820        830        840 
KVVILIEESD SFDILMTSND TNGTIYRKTV QVPRDNGVTL VFPIKPTHLG EIPITVTAAS 

       850        860        870        880        890        900 
PTASDAVTQT IVVKPEGIEK SYSKSVLLDL TDSNVESKQQ SMRFSFPPDT VIGSERVQIT 

       910        920        930        940        950        960 
AIGDILGSSI NGLSSLIRMP YGCGEQNMIY FAPNIYILDY LTKQKQLTVN LKEKALSYMR 

       970        980        990       1000       1010       1020 
QGYQRELLYQ REDGSFSAFG DIDSSGSTWL SAFVLRCFLE ADYYIDIDQD VLHRTYTWLN 

      1030       1040       1050       1060       1070       1080 
AHKKFNGEFW EPGRVIHSEL QGGTKSPVTL TAYIVTSVLG YKKYQPNIDV QDSIKFLEFE 

      1090       1100       1110       1120       1130       1140 
FSRGISDNYT LAIISYALST VGSPKAEEAL NLLMQRSEKE GDTQFWLSSG PALSGSWQPR 

      1150       1160       1170       1180       1190       1200 
SVDIEIAAYA LLAHTLHHVS EGIPVMRWLI QQRNSLGGFV STQDTVVALK ALSEFSALVH 

      1210       1220       1230       1240       1250       1260 
KENTDIQLTV TGPGIPRSIH FRIDSQNLFL LHQEELHALD PITVNVSAHG SGFAICQLNV 

      1270       1280       1290       1300       1310       1320 
DYNVKGSGSS KRRRSTENQE VFDLDVIVNN EDDISHLNLN VCTSHLGSER TGMVLMEVNL 

      1330       1340       1350       1360       1370       1380 
LSGFSASSDS IPLSETLKKV EYDNGKLNLY LDSVNESQFC VNIPTVRDYK VSNIRDGSVS 

      1390       1400       1410       1420       1430       1440 
VMDYYEPRRQ AVRSYNTQVK LSSCYLSPDT NCKSHTDGAT DSLRRSSSLL VFCSVLLYFV 


QH 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of GPI-anchored alpha-2 macroglobulin-related protein."
Hashimoto M., Ichihara M., Takahashi M.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1126-1442.
Strain: C57BL/6J.
Tissue: Thymus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY083458 mRNA. Translation: AAM00021.1.
BC052443 mRNA. Translation: AAH52443.1.
AK042169 mRNA. Translation: BAC31190.1. Different initiation.
CCDSCCDS23365.1.
RefSeqNP_694738.1. NM_153098.3.
UniGeneMm.32955.

3D structure databases

ProteinModelPortalQ8R422.
SMRQ8R422. Positions 26-1414.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000091330.

Protein family/group databases

MEROPSI39.006.

PTM databases

PhosphoSiteQ8R422.

Proteomic databases

MaxQBQ8R422.
PaxDbQ8R422.
PRIDEQ8R422.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000093812; ENSMUSP00000091330; ENSMUSG00000046186.
GeneID235505.
KEGGmmu:235505.
UCSCuc009qur.2. mouse.

Organism-specific databases

CTD135228.
MGIMGI:2445221. Cd109.

Phylogenomic databases

eggNOGCOG2373.
GeneTreeENSGT00750000117597.
HOGENOMHOG000293132.
HOVERGENHBG097839.
InParanoidQ8R422.
KOK06530.
OMARSYNSEV.
OrthoDBEOG7PGDPR.
PhylomeDBQ8R422.
TreeFamTF313285.

Gene expression databases

BgeeQ8R422.
CleanExMM_CD109.
GenevestigatorQ8R422.

Family and domain databases

Gene3D1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio382724.
PROQ8R422.
SOURCESearch...

Entry information

Entry nameCD109_MOUSE
AccessionPrimary (citable) accession number: Q8R422
Secondary accession number(s): Q8BLT6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot