Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CD109 antigen

Gene

Cd109

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates negatively TGFB1 signaling in keratinocytes.By similarity

GO - Molecular functioni

GO - Biological processi

  • hair follicle development Source: MGI
  • negative regulation of keratinocyte proliferation Source: MGI
  • negative regulation of protein phosphorylation Source: MGI
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • negative regulation of wound healing Source: MGI
  • osteoclast fusion Source: MGI
  • regulation of keratinocyte differentiation Source: MGI

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Protein family/group databases

MEROPSiI39.006

Names & Taxonomyi

Protein namesi
Recommended name:
CD109 antigen
Alternative name(s):
GPI-anchored alpha-2 macroglobulin-related protein
CD_antigen: CD109
Gene namesi
Name:Cd109
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2445221 Cd109

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000025594722 – 1419CD109 antigenAdd BLAST1398
PropeptideiPRO_00002559481420 – 1442Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
Cross-linki923 ↔ 926Isoglutamyl cysteine thioester (Cys-Gln)By similarity
Glycosylationi1088N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi1419GPI-anchor amidated alanineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity
2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Thioester bond

Proteomic databases

MaxQBiQ8R422
PaxDbiQ8R422
PRIDEiQ8R422

PTM databases

iPTMnetiQ8R422
PhosphoSitePlusiQ8R422
SwissPalmiQ8R422

Expressioni

Gene expression databases

BgeeiENSMUSG00000046186
CleanExiMM_CD109
ExpressionAtlasiQ8R422 baseline and differential
GenevisibleiQ8R422 MM

Interactioni

Subunit structurei

Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8R422, 1 interactor
STRINGi10090.ENSMUSP00000091330

Structurei

3D structure databases

ProteinModelPortaliQ8R422
SMRiQ8R422
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni595 – 704Bait region (approximate)By similarityAdd BLAST110

Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

eggNOGiKOG1366 Eukaryota
ENOG410XRED LUCA
GeneTreeiENSGT00760000118982
HOGENOMiHOG000293132
HOVERGENiHBG097839
InParanoidiQ8R422
KOiK06530
OMAiNVFFKQH
OrthoDBiEOG091G00F8
PhylomeDBiQ8R422
TreeFamiTF313285

Family and domain databases

Gene3Di2.60.40.10, 2 hits
2.60.40.690, 2 hits
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011626 A2M_comp
IPR002890 A2M_N
IPR011625 A2M_N_2
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR019565 MacrogloblnA2_thiol-ester-bond
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07678 A2M_comp, 1 hit
PF01835 A2M_N, 1 hit
PF07703 A2M_N_2, 1 hit
PF07677 A2M_recep, 1 hit
PF10569 Thiol-ester_cl, 1 hit
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SUPFAMiSSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSRRLLSAA HLLCLCAVAL AAPGSRFLVT APGIIRPGAN VTIGVDLLEN
60 70 80 90 100
SPPQVLVKAQ VFKIASNKSR SILEAEGVFH RGHFKTLVLP ALPLSSADKI
110 120 130 140 150
YELHINGQSE NEIVFSNRTR LTFESKSISV LIQTDKAFYK PKQEVKFRVL
160 170 180 190 200
TLCSDLKPYR TSVDIFIKDP KSNVIQQWFS QKGDLGVVSK TFQLSSNPIF
210 220 230 240 250
GDWSIQVQVN DQQYYQSFQV LEYVLPKFEV TVQTPLYCSL KSKQLNGSVI
260 270 280 290 300
AKYTYGKPVK GSLSLTFLPL SFWGKKKNIT KSFEINGFAN FSFDNYEMKK
310 320 330 340 350
VMNLKPLTDV SEGSYENVDP SFPGPAEIIA TVTESLTGIS RMASTNVFFK
360 370 380 390 400
QHDYIIEIFD YTTVLKPSLN FTATVKVSRS DGNQLTPEEI ENDLVTVVTQ
410 420 430 440 450
RKNNHPESQR DQEMDYIQTV NYTIPQNGII KIEFPVMSIS GELQLKAYFL
460 470 480 490 500
DGTSSVTVHS MFTSPSKTYI QLKTRDEYIK VGSPFDLMVS GNRQFKDLSY
510 520 530 540 550
MVISKGQLVA AGKQSSRTFS LTPEASWAPK ACIIAYYIAE DGEIINDILK
560 570 580 590 600
IPVQLVFENK VKLFWSKPTV KPSDKVSLRI SATQSDSLVG IVAVDKSVTL
610 620 630 640 650
MENSNSITME TMVHELELYN TEYYLGMFMN SFAVFQECGL WVLTDATLIR
660 670 680 690 700
DSIDEVYDTE EYSERFAEEN EANLVDFEDA SSVNNVHVRK NFPETWIWLD
710 720 730 740 750
AYMGSKIYEE FEVTVPDSIT SWVASAFVIS EDLGFGLTTV PAELQAFQPF
760 770 780 790 800
FLFLNLPYSV IRGEEFALEV SIVNYLKDTI KVVILIEESD SFDILMTSND
810 820 830 840 850
TNGTIYRKTV QVPRDNGVTL VFPIKPTHLG EIPITVTAAS PTASDAVTQT
860 870 880 890 900
IVVKPEGIEK SYSKSVLLDL TDSNVESKQQ SMRFSFPPDT VIGSERVQIT
910 920 930 940 950
AIGDILGSSI NGLSSLIRMP YGCGEQNMIY FAPNIYILDY LTKQKQLTVN
960 970 980 990 1000
LKEKALSYMR QGYQRELLYQ REDGSFSAFG DIDSSGSTWL SAFVLRCFLE
1010 1020 1030 1040 1050
ADYYIDIDQD VLHRTYTWLN AHKKFNGEFW EPGRVIHSEL QGGTKSPVTL
1060 1070 1080 1090 1100
TAYIVTSVLG YKKYQPNIDV QDSIKFLEFE FSRGISDNYT LAIISYALST
1110 1120 1130 1140 1150
VGSPKAEEAL NLLMQRSEKE GDTQFWLSSG PALSGSWQPR SVDIEIAAYA
1160 1170 1180 1190 1200
LLAHTLHHVS EGIPVMRWLI QQRNSLGGFV STQDTVVALK ALSEFSALVH
1210 1220 1230 1240 1250
KENTDIQLTV TGPGIPRSIH FRIDSQNLFL LHQEELHALD PITVNVSAHG
1260 1270 1280 1290 1300
SGFAICQLNV DYNVKGSGSS KRRRSTENQE VFDLDVIVNN EDDISHLNLN
1310 1320 1330 1340 1350
VCTSHLGSER TGMVLMEVNL LSGFSASSDS IPLSETLKKV EYDNGKLNLY
1360 1370 1380 1390 1400
LDSVNESQFC VNIPTVRDYK VSNIRDGSVS VMDYYEPRRQ AVRSYNTQVK
1410 1420 1430 1440
LSSCYLSPDT NCKSHTDGAT DSLRRSSSLL VFCSVLLYFV QH
Length:1,442
Mass (Da):161,659
Last modified:June 1, 2002 - v1
Checksum:iE2B9671B8EA5BAA7
GO

Sequence cautioni

The sequence BAC31190 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083458 mRNA Translation: AAM00021.1
BC052443 mRNA Translation: AAH52443.1
AK042169 mRNA Translation: BAC31190.1 Different initiation.
CCDSiCCDS23365.1
RefSeqiNP_694738.1, NM_153098.3
UniGeneiMm.32955

Genome annotation databases

EnsembliENSMUST00000093812; ENSMUSP00000091330; ENSMUSG00000046186
GeneIDi235505
KEGGimmu:235505
UCSCiuc009qur.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCD109_MOUSE
AccessioniPrimary (citable) accession number: Q8R422
Secondary accession number(s): Q8BLT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health