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Q8R422

- CD109_MOUSE

UniProt

Q8R422 - CD109_MOUSE

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Protein
CD109 antigen
Gene
Cd109
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Modulates negatively TGFB1 signaling in keratinocytes By similarity.

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI39.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD109 antigen
    Alternative name(s):
    GPI-anchored alpha-2 macroglobulin-related protein
    CD_antigen: CD109
    Gene namesi
    Name:Cd109
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2445221. Cd109.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. extracellular space Source: InterPro
    3. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121 By similarity
    Add
    BLAST
    Chaini22 – 14191398CD109 antigen
    PRO_0000255947Add
    BLAST
    Propeptidei1420 – 144223Removed in mature form Reviewed prediction
    PRO_0000255948Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi246 – 2461N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi278 – 2781N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi370 – 3701N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi421 – 4211N-linked (GlcNAc...) Reviewed prediction
    Cross-linki923 ↔ 926Isoglutamyl cysteine thioester (Cys-Gln) By similarity
    Glycosylationi1088 – 10881N-linked (GlcNAc...) Reviewed prediction
    Lipidationi1419 – 14191GPI-anchor amidated alanine Reviewed prediction

    Post-translational modificationi

    N-glycosylated By similarity.
    2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form By similarity.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Thioester bond

    Proteomic databases

    MaxQBiQ8R422.
    PaxDbiQ8R422.
    PRIDEiQ8R422.

    PTM databases

    PhosphoSiteiQ8R422.

    Expressioni

    Gene expression databases

    BgeeiQ8R422.
    CleanExiMM_CD109.
    GenevestigatoriQ8R422.

    Interactioni

    Subunit structurei

    Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner By similarity.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000091330.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R422.
    SMRiQ8R422. Positions 26-1414.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni595 – 704110Bait region (approximate) By similarity
    Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Bait region, Signal

    Phylogenomic databases

    eggNOGiCOG2373.
    GeneTreeiENSGT00750000117597.
    HOGENOMiHOG000293132.
    HOVERGENiHBG097839.
    InParanoidiQ8R422.
    KOiK06530.
    OMAiRSYNSEV.
    OrthoDBiEOG7PGDPR.
    PhylomeDBiQ8R422.
    TreeFamiTF313285.

    Family and domain databases

    Gene3Di1.50.10.20. 1 hit.
    2.60.40.690. 1 hit.
    InterProiIPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR014756. Ig_E-set.
    IPR001599. Macroglobln_a2.
    IPR019742. MacrogloblnA2_CS.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8R422-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSRRLLSAA HLLCLCAVAL AAPGSRFLVT APGIIRPGAN VTIGVDLLEN     50
    SPPQVLVKAQ VFKIASNKSR SILEAEGVFH RGHFKTLVLP ALPLSSADKI 100
    YELHINGQSE NEIVFSNRTR LTFESKSISV LIQTDKAFYK PKQEVKFRVL 150
    TLCSDLKPYR TSVDIFIKDP KSNVIQQWFS QKGDLGVVSK TFQLSSNPIF 200
    GDWSIQVQVN DQQYYQSFQV LEYVLPKFEV TVQTPLYCSL KSKQLNGSVI 250
    AKYTYGKPVK GSLSLTFLPL SFWGKKKNIT KSFEINGFAN FSFDNYEMKK 300
    VMNLKPLTDV SEGSYENVDP SFPGPAEIIA TVTESLTGIS RMASTNVFFK 350
    QHDYIIEIFD YTTVLKPSLN FTATVKVSRS DGNQLTPEEI ENDLVTVVTQ 400
    RKNNHPESQR DQEMDYIQTV NYTIPQNGII KIEFPVMSIS GELQLKAYFL 450
    DGTSSVTVHS MFTSPSKTYI QLKTRDEYIK VGSPFDLMVS GNRQFKDLSY 500
    MVISKGQLVA AGKQSSRTFS LTPEASWAPK ACIIAYYIAE DGEIINDILK 550
    IPVQLVFENK VKLFWSKPTV KPSDKVSLRI SATQSDSLVG IVAVDKSVTL 600
    MENSNSITME TMVHELELYN TEYYLGMFMN SFAVFQECGL WVLTDATLIR 650
    DSIDEVYDTE EYSERFAEEN EANLVDFEDA SSVNNVHVRK NFPETWIWLD 700
    AYMGSKIYEE FEVTVPDSIT SWVASAFVIS EDLGFGLTTV PAELQAFQPF 750
    FLFLNLPYSV IRGEEFALEV SIVNYLKDTI KVVILIEESD SFDILMTSND 800
    TNGTIYRKTV QVPRDNGVTL VFPIKPTHLG EIPITVTAAS PTASDAVTQT 850
    IVVKPEGIEK SYSKSVLLDL TDSNVESKQQ SMRFSFPPDT VIGSERVQIT 900
    AIGDILGSSI NGLSSLIRMP YGCGEQNMIY FAPNIYILDY LTKQKQLTVN 950
    LKEKALSYMR QGYQRELLYQ REDGSFSAFG DIDSSGSTWL SAFVLRCFLE 1000
    ADYYIDIDQD VLHRTYTWLN AHKKFNGEFW EPGRVIHSEL QGGTKSPVTL 1050
    TAYIVTSVLG YKKYQPNIDV QDSIKFLEFE FSRGISDNYT LAIISYALST 1100
    VGSPKAEEAL NLLMQRSEKE GDTQFWLSSG PALSGSWQPR SVDIEIAAYA 1150
    LLAHTLHHVS EGIPVMRWLI QQRNSLGGFV STQDTVVALK ALSEFSALVH 1200
    KENTDIQLTV TGPGIPRSIH FRIDSQNLFL LHQEELHALD PITVNVSAHG 1250
    SGFAICQLNV DYNVKGSGSS KRRRSTENQE VFDLDVIVNN EDDISHLNLN 1300
    VCTSHLGSER TGMVLMEVNL LSGFSASSDS IPLSETLKKV EYDNGKLNLY 1350
    LDSVNESQFC VNIPTVRDYK VSNIRDGSVS VMDYYEPRRQ AVRSYNTQVK 1400
    LSSCYLSPDT NCKSHTDGAT DSLRRSSSLL VFCSVLLYFV QH 1442
    Length:1,442
    Mass (Da):161,659
    Last modified:June 1, 2002 - v1
    Checksum:iE2B9671B8EA5BAA7
    GO

    Sequence cautioni

    The sequence BAC31190.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY083458 mRNA. Translation: AAM00021.1.
    BC052443 mRNA. Translation: AAH52443.1.
    AK042169 mRNA. Translation: BAC31190.1. Different initiation.
    CCDSiCCDS23365.1.
    RefSeqiNP_694738.1. NM_153098.3.
    UniGeneiMm.32955.

    Genome annotation databases

    EnsembliENSMUST00000093812; ENSMUSP00000091330; ENSMUSG00000046186.
    GeneIDi235505.
    KEGGimmu:235505.
    UCSCiuc009qur.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY083458 mRNA. Translation: AAM00021.1 .
    BC052443 mRNA. Translation: AAH52443.1 .
    AK042169 mRNA. Translation: BAC31190.1 . Different initiation.
    CCDSi CCDS23365.1.
    RefSeqi NP_694738.1. NM_153098.3.
    UniGenei Mm.32955.

    3D structure databases

    ProteinModelPortali Q8R422.
    SMRi Q8R422. Positions 26-1414.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000091330.

    Protein family/group databases

    MEROPSi I39.006.

    PTM databases

    PhosphoSitei Q8R422.

    Proteomic databases

    MaxQBi Q8R422.
    PaxDbi Q8R422.
    PRIDEi Q8R422.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000093812 ; ENSMUSP00000091330 ; ENSMUSG00000046186 .
    GeneIDi 235505.
    KEGGi mmu:235505.
    UCSCi uc009qur.2. mouse.

    Organism-specific databases

    CTDi 135228.
    MGIi MGI:2445221. Cd109.

    Phylogenomic databases

    eggNOGi COG2373.
    GeneTreei ENSGT00750000117597.
    HOGENOMi HOG000293132.
    HOVERGENi HBG097839.
    InParanoidi Q8R422.
    KOi K06530.
    OMAi RSYNSEV.
    OrthoDBi EOG7PGDPR.
    PhylomeDBi Q8R422.
    TreeFami TF313285.

    Miscellaneous databases

    NextBioi 382724.
    PROi Q8R422.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R422.
    CleanExi MM_CD109.
    Genevestigatori Q8R422.

    Family and domain databases

    Gene3Di 1.50.10.20. 1 hit.
    2.60.40.690. 1 hit.
    InterProi IPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR014756. Ig_E-set.
    IPR001599. Macroglobln_a2.
    IPR019742. MacrogloblnA2_CS.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Cloning and characterization of GPI-anchored alpha-2 macroglobulin-related protein."
      Hashimoto M., Ichihara M., Takahashi M.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1126-1442.
      Strain: C57BL/6J.
      Tissue: Thymus.

    Entry informationi

    Entry nameiCD109_MOUSE
    AccessioniPrimary (citable) accession number: Q8R422
    Secondary accession number(s): Q8BLT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: June 1, 2002
    Last modified: July 9, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi