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Q8R420

- ABCA3_MOUSE

UniProt

Q8R420 - ABCA3_MOUSE

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Protein

ATP-binding cassette sub-family A member 3

Gene
Abca3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi566 – 5738ATP 1 Reviewed prediction
Nucleotide bindingi1416 – 14238ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. response to glucocorticoid Source: Ensembl
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 3
Gene namesi
Name:Abca3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1351617. Abca3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221Helical; Reviewed predictionAdd
BLAST
Transmembranei261 – 28323Helical; Reviewed predictionAdd
BLAST
Transmembranei307 – 32721Helical; Reviewed predictionAdd
BLAST
Transmembranei344 – 36421Helical; Reviewed predictionAdd
BLAST
Transmembranei373 – 39321Helical; Reviewed predictionAdd
BLAST
Transmembranei405 – 42521Helical; Reviewed predictionAdd
BLAST
Transmembranei447 – 46721Helical; Reviewed predictionAdd
BLAST
Transmembranei925 – 94521Helical; Reviewed predictionAdd
BLAST
Transmembranei1100 – 112021Helical; Reviewed predictionAdd
BLAST
Transmembranei1144 – 116421Helical; Reviewed predictionAdd
BLAST
Transmembranei1183 – 120321Helical; Reviewed predictionAdd
BLAST
Transmembranei1213 – 123321Helical; Reviewed predictionAdd
BLAST
Transmembranei1245 – 126521Helical; Reviewed predictionAdd
BLAST
Transmembranei1310 – 133021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. alveolar lamellar body membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17041704ATP-binding cassette sub-family A member 3PRO_0000093294Add
BLAST

Proteomic databases

PaxDbiQ8R420.
PRIDEiQ8R420.

PTM databases

PhosphoSiteiQ8R420.

Expressioni

Gene expression databases

ArrayExpressiQ8R420.
BgeeiQ8R420.
GenevestigatoriQ8R420.

Interactioni

Protein-protein interaction databases

IntActiQ8R420. 1 interaction.
MINTiMINT-4086444.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini530 – 763234ABC transporter 1Add
BLAST
Domaini1381 – 1614234ABC transporter 2Add
BLAST

Domaini

Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
GeneTreeiENSGT00750000117526.
HOGENOMiHOG000006613.
HOVERGENiHBG050435.
InParanoidiQ3U3L4.
KOiK05643.
OMAiQPRNTLQ.
OrthoDBiEOG7RNJZ8.
TreeFamiTF105191.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR026969. ABCA3.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PTHR19229:SF98. PTHR19229:SF98. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R420-1 [UniParc]FASTAAdd to Basket

« Hide

MAVLRQLTLL LWKNYTLKKR KVLVTVLELF LPLLFSGILI WLRLKIQSEN     50
VPNATVYPDQ SIQELPLFFS FPPPGGTWEL AYVPSHSDAA RTITETVKRE 100
FMIKMRVHGF SSEKDFEDYI RYDNHSSSVL AAVVFEHSFN HSQDPLPLAV 150
KYHLRFSYTR RNYMWTQTGN IFLKETEGWH TTSLFPLFPS PGPREPSSPD 200
GGEPGYIREG FLAMQHAVDK AIMRYHANTS AQQLFQKLMV ITKRFPFPPY 250
ISDPFLIAIQ YQLPLLLMLS FTYTSLTIIR AVVQEKEKKL KEYMRMMGLN 300
SWLHWSAWFL MFFLFFLIVV SFMTLLFCVK VKKDIAVLSN SDPSLVLAFL 350
LCFAISSISF SFMVSTFFSK ANIAAAVGGF LYFFTYTPYF FVAPRYNWMT 400
LSQKLLSCLL SNVAMAMGAQ LIGKFEAKGT GIQWRDLLNP VNVDDNFCFG 450
QVLGMLLLDS ALYGLVTWYV EAVFPGQFGV PQPWHFFLMP SYWCGNPRTV 500
VGKEEEGSDP EKALRNEYFE AEPEDLVAGI KIKHLSKVFQ VGNKDKMGIR 550
DLTLNLYEGQ ITVLLGHNGA GKTTTMSLLT GLFPPTSGHA YIHGYEISQD 600
MAQIRKSLGL CPQHDVLFDN LTVAEHLYFY AQLKGLSLQK CPEEVKQMLH 650
ILSLEDKRDL RSKFLSGGMK RKLSIGIALI AGSKVLMLDE PTSGMDAVSR 700
RAIWDLLQQQ KSDRTVLLTT HFMDEADLLG DRIAILAKGE LQCCGSSLFL 750
KQKYGAGYHM TLVKEPHCNP EGISQLVHHH VPNAMLESHA GAELSFILPK 800
ESTHRFESLF AKLEKKQKEL GIASFGASVT TMEEVFLRVG KLVDTSMDIQ 850
AIQLPALQYQ HERRASDWAL DSNLCGVMDP TNGIGALIEE EEVLVKLNTG 900
LALHCQQFWA MFLKKAAYSW REWKMVAAQV LVPLTCLTLA LLAIHYTSEI 950
FDDPLLKLSL NEYGRTVVPF SVPGTSRLAQ QLSENLRDML QAERQEPREV 1000
LGDLEEFLVF RASVEGGGFN ERCLVATSFK DRGELTVVTA LFNNQAYHSP 1050
ATALAIVDNL LFKLLCGPQA SIEISNYPQP RNTLQVAKDH FNEGRKGFDI 1100
ALNLLIAMAF LASTFSILAV SERAVQAKHV QFVSGVHVAT FWFSALLWDL 1150
ISFLVPSLLL LVVFQAFNVH AFTRDGHMAD LLLLLMLYGW AIIPLMYLMS 1200
FFFSAASTAY TRLTIFNILS GIATFIMVTI MRIPAVKLEE LSRTLDHVFL 1250
VLPNHCLGMA VSNFYENYET RRYCTSSELA AHYCKKYNIQ YQESFYAWST 1300
PGVGKFVTSM AASGGIYLTL LFLIETNLLW RLRTFICAFR RRWTLAELQN 1350
RTSVLPEDQD VAEERSRILV PSLDSMLDTP LIINELSKVY DQRAPLLAVD 1400
RISLAVQKGE CFGLLGFNGA GKTTTFKMLT GEETITSGDA FVGGYSISSD 1450
IGKVRQRMGY CPQFDALLDH MTGREMLVMY ARLRGIPERL INACVENTLR 1500
GLLLEPHANK LVKTYSGGNK RKLSTGIALI GEPAVIFLDE PSTGMDPVAR 1550
RLLWDTVARA RESGKAIVIT SHSMEECEAL CTRLAIMVQG QFKCLGSPQH 1600
LKSKFGSGYS LQAKVRSEGK QDALEEFKAF VDLTFPGSIL EDEHQDMVHY 1650
HLPGCDLSWA KVFGILEKAK EKYGVDDYSV SQISLEQVFL SFAHLQPPTT 1700
EDGR 1704
Length:1,704
Mass (Da):191,971
Last modified:June 28, 2011 - v3
Checksum:i6741132D2CA30897
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti217 – 2171A → T in AAL99380. 1 Publication
Sequence conflicti446 – 4461N → D in AAL99380. 1 Publication
Sequence conflicti589 – 5891H → R in AAL99380. 1 Publication
Sequence conflicti693 – 6931S → P in AAL99380. 1 Publication
Sequence conflicti939 – 9391L → Q in AAL99380. 1 Publication
Sequence conflicti1069 – 10691Q → W in AAL99380. 1 Publication
Sequence conflicti1143 – 11431F → L in AAL99380. 1 Publication
Sequence conflicti1185 – 11851L → P in AAL99380. 1 Publication
Sequence conflicti1232 – 12321R → C in AAL99380. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY083616 mRNA. Translation: AAL99380.1.
AK154698 mRNA. Translation: BAE32771.1.
CCDSiCCDS37486.1.
RefSeqiNP_001034670.1. NM_001039581.2.
NP_038883.2. NM_013855.3.
XP_006524433.1. XM_006524370.1.
UniGeneiMm.239470.

Genome annotation databases

EnsembliENSMUST00000039013; ENSMUSP00000045285; ENSMUSG00000024130.
ENSMUST00000079594; ENSMUSP00000078544; ENSMUSG00000024130.
GeneIDi27410.
KEGGimmu:27410.
UCSCiuc008avm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY083616 mRNA. Translation: AAL99380.1 .
AK154698 mRNA. Translation: BAE32771.1 .
CCDSi CCDS37486.1.
RefSeqi NP_001034670.1. NM_001039581.2.
NP_038883.2. NM_013855.3.
XP_006524433.1. XM_006524370.1.
UniGenei Mm.239470.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8R420. 1 interaction.
MINTi MINT-4086444.

PTM databases

PhosphoSitei Q8R420.

Proteomic databases

PaxDbi Q8R420.
PRIDEi Q8R420.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039013 ; ENSMUSP00000045285 ; ENSMUSG00000024130 .
ENSMUST00000079594 ; ENSMUSP00000078544 ; ENSMUSG00000024130 .
GeneIDi 27410.
KEGGi mmu:27410.
UCSCi uc008avm.1. mouse.

Organism-specific databases

CTDi 21.
MGIi MGI:1351617. Abca3.

Phylogenomic databases

eggNOGi COG1131.
GeneTreei ENSGT00750000117526.
HOGENOMi HOG000006613.
HOVERGENi HBG050435.
InParanoidi Q3U3L4.
KOi K05643.
OMAi QPRNTLQ.
OrthoDBi EOG7RNJZ8.
TreeFami TF105191.

Enzyme and pathway databases

Reactomei REACT_197984. ABCA transporters in lipid homeostasis.

Miscellaneous databases

NextBioi 305426.
PROi Q8R420.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8R420.
Bgeei Q8R420.
Genevestigatori Q8R420.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR026969. ABCA3.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR19229. PTHR19229. 1 hit.
PTHR19229:SF98. PTHR19229:SF98. 1 hit.
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mus musculus ABCA3 cDNA."
    Gray J.M., Zhao M., Fisher A.B., Shuman H.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.

Entry informationi

Entry nameiABCA3_MOUSE
AccessioniPrimary (citable) accession number: Q8R420
Secondary accession number(s): Q3U3L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi