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Q8R420

- ABCA3_MOUSE

UniProt

Q8R420 - ABCA3_MOUSE

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Protein

ATP-binding cassette sub-family A member 3

Gene

Abca3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi566 – 5738ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1416 – 14238ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 3
Gene namesi
Name:Abca3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1351617. Abca3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Transmembranei261 – 28323HelicalSequence AnalysisAdd
BLAST
Transmembranei307 – 32721HelicalSequence AnalysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence AnalysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence AnalysisAdd
BLAST
Transmembranei405 – 42521HelicalSequence AnalysisAdd
BLAST
Transmembranei447 – 46721HelicalSequence AnalysisAdd
BLAST
Transmembranei925 – 94521HelicalSequence AnalysisAdd
BLAST
Transmembranei1100 – 112021HelicalSequence AnalysisAdd
BLAST
Transmembranei1144 – 116421HelicalSequence AnalysisAdd
BLAST
Transmembranei1183 – 120321HelicalSequence AnalysisAdd
BLAST
Transmembranei1213 – 123321HelicalSequence AnalysisAdd
BLAST
Transmembranei1245 – 126521HelicalSequence AnalysisAdd
BLAST
Transmembranei1310 – 133021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. alveolar lamellar body membrane Source: MGI
  2. extracellular space Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17041704ATP-binding cassette sub-family A member 3PRO_0000093294Add
BLAST

Proteomic databases

MaxQBiQ8R420.
PaxDbiQ8R420.
PRIDEiQ8R420.

PTM databases

PhosphoSiteiQ8R420.

Expressioni

Gene expression databases

BgeeiQ8R420.
ExpressionAtlasiQ8R420. baseline and differential.
GenevestigatoriQ8R420.

Interactioni

Protein-protein interaction databases

IntActiQ8R420. 1 interaction.
MINTiMINT-4086444.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini530 – 763234ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini1381 – 1614234ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Domaini

Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.By similarity

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
GeneTreeiENSGT00760000118965.
HOGENOMiHOG000006613.
HOVERGENiHBG050435.
InParanoidiQ8R420.
KOiK05643.
OMAiQPRNTLQ.
OrthoDBiEOG7RNJZ8.
TreeFamiTF105191.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR026969. ABCA3.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PTHR19229:SF98. PTHR19229:SF98. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R420-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVLRQLTLL LWKNYTLKKR KVLVTVLELF LPLLFSGILI WLRLKIQSEN
60 70 80 90 100
VPNATVYPDQ SIQELPLFFS FPPPGGTWEL AYVPSHSDAA RTITETVKRE
110 120 130 140 150
FMIKMRVHGF SSEKDFEDYI RYDNHSSSVL AAVVFEHSFN HSQDPLPLAV
160 170 180 190 200
KYHLRFSYTR RNYMWTQTGN IFLKETEGWH TTSLFPLFPS PGPREPSSPD
210 220 230 240 250
GGEPGYIREG FLAMQHAVDK AIMRYHANTS AQQLFQKLMV ITKRFPFPPY
260 270 280 290 300
ISDPFLIAIQ YQLPLLLMLS FTYTSLTIIR AVVQEKEKKL KEYMRMMGLN
310 320 330 340 350
SWLHWSAWFL MFFLFFLIVV SFMTLLFCVK VKKDIAVLSN SDPSLVLAFL
360 370 380 390 400
LCFAISSISF SFMVSTFFSK ANIAAAVGGF LYFFTYTPYF FVAPRYNWMT
410 420 430 440 450
LSQKLLSCLL SNVAMAMGAQ LIGKFEAKGT GIQWRDLLNP VNVDDNFCFG
460 470 480 490 500
QVLGMLLLDS ALYGLVTWYV EAVFPGQFGV PQPWHFFLMP SYWCGNPRTV
510 520 530 540 550
VGKEEEGSDP EKALRNEYFE AEPEDLVAGI KIKHLSKVFQ VGNKDKMGIR
560 570 580 590 600
DLTLNLYEGQ ITVLLGHNGA GKTTTMSLLT GLFPPTSGHA YIHGYEISQD
610 620 630 640 650
MAQIRKSLGL CPQHDVLFDN LTVAEHLYFY AQLKGLSLQK CPEEVKQMLH
660 670 680 690 700
ILSLEDKRDL RSKFLSGGMK RKLSIGIALI AGSKVLMLDE PTSGMDAVSR
710 720 730 740 750
RAIWDLLQQQ KSDRTVLLTT HFMDEADLLG DRIAILAKGE LQCCGSSLFL
760 770 780 790 800
KQKYGAGYHM TLVKEPHCNP EGISQLVHHH VPNAMLESHA GAELSFILPK
810 820 830 840 850
ESTHRFESLF AKLEKKQKEL GIASFGASVT TMEEVFLRVG KLVDTSMDIQ
860 870 880 890 900
AIQLPALQYQ HERRASDWAL DSNLCGVMDP TNGIGALIEE EEVLVKLNTG
910 920 930 940 950
LALHCQQFWA MFLKKAAYSW REWKMVAAQV LVPLTCLTLA LLAIHYTSEI
960 970 980 990 1000
FDDPLLKLSL NEYGRTVVPF SVPGTSRLAQ QLSENLRDML QAERQEPREV
1010 1020 1030 1040 1050
LGDLEEFLVF RASVEGGGFN ERCLVATSFK DRGELTVVTA LFNNQAYHSP
1060 1070 1080 1090 1100
ATALAIVDNL LFKLLCGPQA SIEISNYPQP RNTLQVAKDH FNEGRKGFDI
1110 1120 1130 1140 1150
ALNLLIAMAF LASTFSILAV SERAVQAKHV QFVSGVHVAT FWFSALLWDL
1160 1170 1180 1190 1200
ISFLVPSLLL LVVFQAFNVH AFTRDGHMAD LLLLLMLYGW AIIPLMYLMS
1210 1220 1230 1240 1250
FFFSAASTAY TRLTIFNILS GIATFIMVTI MRIPAVKLEE LSRTLDHVFL
1260 1270 1280 1290 1300
VLPNHCLGMA VSNFYENYET RRYCTSSELA AHYCKKYNIQ YQESFYAWST
1310 1320 1330 1340 1350
PGVGKFVTSM AASGGIYLTL LFLIETNLLW RLRTFICAFR RRWTLAELQN
1360 1370 1380 1390 1400
RTSVLPEDQD VAEERSRILV PSLDSMLDTP LIINELSKVY DQRAPLLAVD
1410 1420 1430 1440 1450
RISLAVQKGE CFGLLGFNGA GKTTTFKMLT GEETITSGDA FVGGYSISSD
1460 1470 1480 1490 1500
IGKVRQRMGY CPQFDALLDH MTGREMLVMY ARLRGIPERL INACVENTLR
1510 1520 1530 1540 1550
GLLLEPHANK LVKTYSGGNK RKLSTGIALI GEPAVIFLDE PSTGMDPVAR
1560 1570 1580 1590 1600
RLLWDTVARA RESGKAIVIT SHSMEECEAL CTRLAIMVQG QFKCLGSPQH
1610 1620 1630 1640 1650
LKSKFGSGYS LQAKVRSEGK QDALEEFKAF VDLTFPGSIL EDEHQDMVHY
1660 1670 1680 1690 1700
HLPGCDLSWA KVFGILEKAK EKYGVDDYSV SQISLEQVFL SFAHLQPPTT

EDGR
Length:1,704
Mass (Da):191,971
Last modified:June 28, 2011 - v3
Checksum:i6741132D2CA30897
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti217 – 2171A → T in AAL99380. 1 PublicationCurated
Sequence conflicti446 – 4461N → D in AAL99380. 1 PublicationCurated
Sequence conflicti589 – 5891H → R in AAL99380. 1 PublicationCurated
Sequence conflicti693 – 6931S → P in AAL99380. 1 PublicationCurated
Sequence conflicti939 – 9391L → Q in AAL99380. 1 PublicationCurated
Sequence conflicti1069 – 10691Q → W in AAL99380. 1 PublicationCurated
Sequence conflicti1143 – 11431F → L in AAL99380. 1 PublicationCurated
Sequence conflicti1185 – 11851L → P in AAL99380. 1 PublicationCurated
Sequence conflicti1232 – 12321R → C in AAL99380. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083616 mRNA. Translation: AAL99380.1.
AK154698 mRNA. Translation: BAE32771.1.
CCDSiCCDS37486.1.
RefSeqiNP_001034670.1. NM_001039581.2.
NP_038883.2. NM_013855.3.
XP_006524433.1. XM_006524370.1.
UniGeneiMm.239470.

Genome annotation databases

EnsembliENSMUST00000039013; ENSMUSP00000045285; ENSMUSG00000024130.
ENSMUST00000079594; ENSMUSP00000078544; ENSMUSG00000024130.
GeneIDi27410.
KEGGimmu:27410.
UCSCiuc008avm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083616 mRNA. Translation: AAL99380.1 .
AK154698 mRNA. Translation: BAE32771.1 .
CCDSi CCDS37486.1.
RefSeqi NP_001034670.1. NM_001039581.2.
NP_038883.2. NM_013855.3.
XP_006524433.1. XM_006524370.1.
UniGenei Mm.239470.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8R420. 1 interaction.
MINTi MINT-4086444.

PTM databases

PhosphoSitei Q8R420.

Proteomic databases

MaxQBi Q8R420.
PaxDbi Q8R420.
PRIDEi Q8R420.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039013 ; ENSMUSP00000045285 ; ENSMUSG00000024130 .
ENSMUST00000079594 ; ENSMUSP00000078544 ; ENSMUSG00000024130 .
GeneIDi 27410.
KEGGi mmu:27410.
UCSCi uc008avm.1. mouse.

Organism-specific databases

CTDi 21.
MGIi MGI:1351617. Abca3.

Phylogenomic databases

eggNOGi COG1131.
GeneTreei ENSGT00760000118965.
HOGENOMi HOG000006613.
HOVERGENi HBG050435.
InParanoidi Q8R420.
KOi K05643.
OMAi QPRNTLQ.
OrthoDBi EOG7RNJZ8.
TreeFami TF105191.

Enzyme and pathway databases

Reactomei REACT_197984. ABCA transporters in lipid homeostasis.

Miscellaneous databases

ChiTaRSi Abca3. mouse.
NextBioi 305426.
PROi Q8R420.
SOURCEi Search...

Gene expression databases

Bgeei Q8R420.
ExpressionAtlasi Q8R420. baseline and differential.
Genevestigatori Q8R420.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR026969. ABCA3.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR19229. PTHR19229. 1 hit.
PTHR19229:SF98. PTHR19229:SF98. 1 hit.
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mus musculus ABCA3 cDNA."
    Gray J.M., Zhao M., Fisher A.B., Shuman H.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.

Entry informationi

Entry nameiABCA3_MOUSE
AccessioniPrimary (citable) accession number: Q8R420
Secondary accession number(s): Q3U3L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 28, 2011
Last modified: November 26, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3