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Q8R420

- ABCA3_MOUSE

UniProt

Q8R420 - ABCA3_MOUSE

Protein

ATP-binding cassette sub-family A member 3

Gene

Abca3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 3 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi566 – 5738ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1416 – 14238ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. response to glucocorticoid Source: Ensembl
    2. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family A member 3
    Gene namesi
    Name:Abca3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1351617. Abca3.

    Subcellular locationi

    GO - Cellular componenti

    1. alveolar lamellar body membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17041704ATP-binding cassette sub-family A member 3PRO_0000093294Add
    BLAST

    Proteomic databases

    PaxDbiQ8R420.
    PRIDEiQ8R420.

    PTM databases

    PhosphoSiteiQ8R420.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8R420.
    BgeeiQ8R420.
    GenevestigatoriQ8R420.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8R420. 1 interaction.
    MINTiMINT-4086444.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei261 – 28323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei307 – 32721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei344 – 36421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei373 – 39321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei405 – 42521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei447 – 46721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei925 – 94521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1100 – 112021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1144 – 116421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1183 – 120321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1213 – 123321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1245 – 126521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1310 – 133021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini530 – 763234ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1381 – 1614234ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.By similarity

    Sequence similaritiesi

    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1131.
    GeneTreeiENSGT00750000117526.
    HOGENOMiHOG000006613.
    HOVERGENiHBG050435.
    InParanoidiQ3U3L4.
    KOiK05643.
    OMAiQPRNTLQ.
    OrthoDBiEOG7RNJZ8.
    TreeFamiTF105191.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR026969. ABCA3.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR19229. PTHR19229. 1 hit.
    PTHR19229:SF98. PTHR19229:SF98. 1 hit.
    PfamiPF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R420-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVLRQLTLL LWKNYTLKKR KVLVTVLELF LPLLFSGILI WLRLKIQSEN     50
    VPNATVYPDQ SIQELPLFFS FPPPGGTWEL AYVPSHSDAA RTITETVKRE 100
    FMIKMRVHGF SSEKDFEDYI RYDNHSSSVL AAVVFEHSFN HSQDPLPLAV 150
    KYHLRFSYTR RNYMWTQTGN IFLKETEGWH TTSLFPLFPS PGPREPSSPD 200
    GGEPGYIREG FLAMQHAVDK AIMRYHANTS AQQLFQKLMV ITKRFPFPPY 250
    ISDPFLIAIQ YQLPLLLMLS FTYTSLTIIR AVVQEKEKKL KEYMRMMGLN 300
    SWLHWSAWFL MFFLFFLIVV SFMTLLFCVK VKKDIAVLSN SDPSLVLAFL 350
    LCFAISSISF SFMVSTFFSK ANIAAAVGGF LYFFTYTPYF FVAPRYNWMT 400
    LSQKLLSCLL SNVAMAMGAQ LIGKFEAKGT GIQWRDLLNP VNVDDNFCFG 450
    QVLGMLLLDS ALYGLVTWYV EAVFPGQFGV PQPWHFFLMP SYWCGNPRTV 500
    VGKEEEGSDP EKALRNEYFE AEPEDLVAGI KIKHLSKVFQ VGNKDKMGIR 550
    DLTLNLYEGQ ITVLLGHNGA GKTTTMSLLT GLFPPTSGHA YIHGYEISQD 600
    MAQIRKSLGL CPQHDVLFDN LTVAEHLYFY AQLKGLSLQK CPEEVKQMLH 650
    ILSLEDKRDL RSKFLSGGMK RKLSIGIALI AGSKVLMLDE PTSGMDAVSR 700
    RAIWDLLQQQ KSDRTVLLTT HFMDEADLLG DRIAILAKGE LQCCGSSLFL 750
    KQKYGAGYHM TLVKEPHCNP EGISQLVHHH VPNAMLESHA GAELSFILPK 800
    ESTHRFESLF AKLEKKQKEL GIASFGASVT TMEEVFLRVG KLVDTSMDIQ 850
    AIQLPALQYQ HERRASDWAL DSNLCGVMDP TNGIGALIEE EEVLVKLNTG 900
    LALHCQQFWA MFLKKAAYSW REWKMVAAQV LVPLTCLTLA LLAIHYTSEI 950
    FDDPLLKLSL NEYGRTVVPF SVPGTSRLAQ QLSENLRDML QAERQEPREV 1000
    LGDLEEFLVF RASVEGGGFN ERCLVATSFK DRGELTVVTA LFNNQAYHSP 1050
    ATALAIVDNL LFKLLCGPQA SIEISNYPQP RNTLQVAKDH FNEGRKGFDI 1100
    ALNLLIAMAF LASTFSILAV SERAVQAKHV QFVSGVHVAT FWFSALLWDL 1150
    ISFLVPSLLL LVVFQAFNVH AFTRDGHMAD LLLLLMLYGW AIIPLMYLMS 1200
    FFFSAASTAY TRLTIFNILS GIATFIMVTI MRIPAVKLEE LSRTLDHVFL 1250
    VLPNHCLGMA VSNFYENYET RRYCTSSELA AHYCKKYNIQ YQESFYAWST 1300
    PGVGKFVTSM AASGGIYLTL LFLIETNLLW RLRTFICAFR RRWTLAELQN 1350
    RTSVLPEDQD VAEERSRILV PSLDSMLDTP LIINELSKVY DQRAPLLAVD 1400
    RISLAVQKGE CFGLLGFNGA GKTTTFKMLT GEETITSGDA FVGGYSISSD 1450
    IGKVRQRMGY CPQFDALLDH MTGREMLVMY ARLRGIPERL INACVENTLR 1500
    GLLLEPHANK LVKTYSGGNK RKLSTGIALI GEPAVIFLDE PSTGMDPVAR 1550
    RLLWDTVARA RESGKAIVIT SHSMEECEAL CTRLAIMVQG QFKCLGSPQH 1600
    LKSKFGSGYS LQAKVRSEGK QDALEEFKAF VDLTFPGSIL EDEHQDMVHY 1650
    HLPGCDLSWA KVFGILEKAK EKYGVDDYSV SQISLEQVFL SFAHLQPPTT 1700
    EDGR 1704
    Length:1,704
    Mass (Da):191,971
    Last modified:June 28, 2011 - v3
    Checksum:i6741132D2CA30897
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti217 – 2171A → T in AAL99380. 1 PublicationCurated
    Sequence conflicti446 – 4461N → D in AAL99380. 1 PublicationCurated
    Sequence conflicti589 – 5891H → R in AAL99380. 1 PublicationCurated
    Sequence conflicti693 – 6931S → P in AAL99380. 1 PublicationCurated
    Sequence conflicti939 – 9391L → Q in AAL99380. 1 PublicationCurated
    Sequence conflicti1069 – 10691Q → W in AAL99380. 1 PublicationCurated
    Sequence conflicti1143 – 11431F → L in AAL99380. 1 PublicationCurated
    Sequence conflicti1185 – 11851L → P in AAL99380. 1 PublicationCurated
    Sequence conflicti1232 – 12321R → C in AAL99380. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY083616 mRNA. Translation: AAL99380.1.
    AK154698 mRNA. Translation: BAE32771.1.
    CCDSiCCDS37486.1.
    RefSeqiNP_001034670.1. NM_001039581.2.
    NP_038883.2. NM_013855.3.
    XP_006524433.1. XM_006524370.1.
    UniGeneiMm.239470.

    Genome annotation databases

    EnsembliENSMUST00000039013; ENSMUSP00000045285; ENSMUSG00000024130.
    ENSMUST00000079594; ENSMUSP00000078544; ENSMUSG00000024130.
    GeneIDi27410.
    KEGGimmu:27410.
    UCSCiuc008avm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY083616 mRNA. Translation: AAL99380.1 .
    AK154698 mRNA. Translation: BAE32771.1 .
    CCDSi CCDS37486.1.
    RefSeqi NP_001034670.1. NM_001039581.2.
    NP_038883.2. NM_013855.3.
    XP_006524433.1. XM_006524370.1.
    UniGenei Mm.239470.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8R420. 1 interaction.
    MINTi MINT-4086444.

    PTM databases

    PhosphoSitei Q8R420.

    Proteomic databases

    PaxDbi Q8R420.
    PRIDEi Q8R420.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039013 ; ENSMUSP00000045285 ; ENSMUSG00000024130 .
    ENSMUST00000079594 ; ENSMUSP00000078544 ; ENSMUSG00000024130 .
    GeneIDi 27410.
    KEGGi mmu:27410.
    UCSCi uc008avm.1. mouse.

    Organism-specific databases

    CTDi 21.
    MGIi MGI:1351617. Abca3.

    Phylogenomic databases

    eggNOGi COG1131.
    GeneTreei ENSGT00750000117526.
    HOGENOMi HOG000006613.
    HOVERGENi HBG050435.
    InParanoidi Q3U3L4.
    KOi K05643.
    OMAi QPRNTLQ.
    OrthoDBi EOG7RNJZ8.
    TreeFami TF105191.

    Enzyme and pathway databases

    Reactomei REACT_197984. ABCA transporters in lipid homeostasis.

    Miscellaneous databases

    NextBioi 305426.
    PROi Q8R420.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R420.
    Bgeei Q8R420.
    Genevestigatori Q8R420.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR026969. ABCA3.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR19229. PTHR19229. 1 hit.
    PTHR19229:SF98. PTHR19229:SF98. 1 hit.
    Pfami PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mus musculus ABCA3 cDNA."
      Gray J.M., Zhao M., Fisher A.B., Shuman H.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.

    Entry informationi

    Entry nameiABCA3_MOUSE
    AccessioniPrimary (citable) accession number: Q8R420
    Secondary accession number(s): Q3U3L4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3