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Q8R418

- DICER_MOUSE

UniProt

Q8R418 - DICER_MOUSE

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Protein

Endoribonuclease Dicer

Gene
Dicer1, Dicer, Mdcr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes By similarity.1 Publication
Isoform 2: More active than isoform 1 to process long double-stranded RNA into siRNAs. Responsible for the accumulation of endogenous siRNAs observed in mouse oocytes compared to somatic cells and it regulates meiotic spindle organization in female germline.1 Publication

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Binds 2 magnesium or manganese ions per subunit Inferred.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1316 – 13161Magnesium or manganese 1 By similarity
Metal bindingi1395 – 13951Magnesium or manganese 1 By similarity
Metal bindingi1398 – 13981Magnesium or manganese 1 By similarity
Metal bindingi1699 – 16991Magnesium or manganese 2
Sitei1800 – 18001Important for activity
Metal bindingi1804 – 18041Magnesium or manganese 2
Metal bindingi1807 – 18071Magnesium or manganese 2

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. miRNA binding Source: MGI
  5. protein binding Source: UniProtKB
  6. ribonuclease III activity Source: UniProtKB

GO - Biological processi

  1. anatomical structure development Source: MGI
  2. angiogenesis Source: MGI
  3. branching morphogenesis of an epithelial tube Source: MGI
  4. cardiac muscle cell development Source: MGI
  5. cell proliferation Source: MGI
  6. cerebral cortex development Source: MGI
  7. defense response to virus Source: MGI
  8. digestive tract development Source: MGI
  9. embryonic hindlimb morphogenesis Source: MGI
  10. embryonic limb morphogenesis Source: MGI
  11. epidermis morphogenesis Source: MGI
  12. hair follicle cell proliferation Source: MGI
  13. hair follicle development Source: MGI
  14. hair follicle morphogenesis Source: MGI
  15. inner ear receptor cell development Source: MGI
  16. intestinal epithelial cell development Source: MGI
  17. lung development Source: MGI
  18. meiotic spindle organization Source: UniProtKB
  19. mRNA stabilization Source: MGI
  20. multicellular organism growth Source: MGI
  21. negative regulation of Schwann cell proliferation Source: BHF-UCL
  22. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  23. nerve development Source: BHF-UCL
  24. neuron projection morphogenesis Source: BHF-UCL
  25. olfactory bulb interneuron differentiation Source: MGI
  26. peripheral nervous system myelin formation Source: BHF-UCL
  27. positive regulation of gene expression Source: MGI
  28. positive regulation of miRNA metabolic process Source: MGI
  29. positive regulation of myelination Source: BHF-UCL
  30. positive regulation of Schwann cell differentiation Source: BHF-UCL
  31. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  32. post-embryonic development Source: MGI
  33. pre-miRNA processing Source: UniProtKB
  34. production of miRNAs involved in gene silencing by miRNA Source: BHF-UCL
  35. production of siRNA involved in RNA interference Source: UniProtKB
  36. regulation of cell cycle Source: MGI
  37. regulation of cell differentiation Source: MGI
  38. regulation of enamel mineralization Source: MGI
  39. regulation of gene expression Source: MGI
  40. regulation of miRNA metabolic process Source: MGI
  41. regulation of myelination Source: MGI
  42. regulation of neurogenesis Source: MGI
  43. regulation of neuron differentiation Source: MGI
  44. regulation of Notch signaling pathway Source: BHF-UCL
  45. regulation of odontogenesis of dentin-containing tooth Source: MGI
  46. regulation of oligodendrocyte differentiation Source: MGI
  47. regulation of protein phosphorylation Source: BHF-UCL
  48. regulation of RNA metabolic process Source: MGI
  49. regulation of viral genome replication Source: MGI
  50. reproductive structure development Source: MGI
  51. RNA phosphodiester bond hydrolysis Source: GOC
  52. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
  53. RNA processing Source: MGI
  54. rRNA catabolic process Source: InterPro
  55. spinal cord motor neuron differentiation Source: MGI
  56. spindle assembly Source: MGI
  57. spleen development Source: MGI
  58. stem cell maintenance Source: MGI
  59. targeting of mRNA for destruction involved in RNA interference Source: UniProtKB
  60. zygote asymmetric cell division Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Helicase, Hydrolase, Nuclease

Keywords - Biological processi

RNA-mediated gene silencing

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endoribonuclease Dicer (EC:3.1.26.3)
Alternative name(s):
Double-strand-specific ribonuclease mDCR-1
Gene namesi
Name:Dicer1
Synonyms:Dicer, Mdcr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2177178. Dicer1.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. RISC complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Isoform 2: Mice lacking isoform 2 are viable and males are fertile. However, females are sterile, their oocytes displaying meiotic spindle defects.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1800 – 18001K → A, R, S or T: Loss of activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19161916Endoribonuclease DicerUniRule annotationPRO_0000180471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei413 – 4131Phosphoserine By similarity
Modified residuei415 – 4151Phosphoserine By similarity
Modified residuei1016 – 10161Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8R418.
PaxDbiQ8R418.
PRIDEiQ8R418.

PTM databases

PhosphoSiteiQ8R418.

Expressioni

Tissue specificityi

Isoform 1 is expressed in a wide variety of tissues. Isoform 2 is specifically expressed in oocytes during their growth (at protein level).1 Publication

Gene expression databases

CleanExiMM_DICER1.
GenevestigatoriQ8R418.

Interactioni

Subunit structurei

Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2; DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9, AGO1, PIWIL1 and PRKRA. Associates with the 60S ribosome. Interacts with BCDIN3D By similarity.

Protein-protein interaction databases

DIPiDIP-29721N.
IntActiQ8R418. 2 interactions.

Structurei

Secondary structure

1
1916
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1649 – 16568
Turni1657 – 16593
Helixi1660 – 16678
Helixi1674 – 16818
Helixi1696 – 171621
Helixi1723 – 173311
Helixi1736 – 174510
Helixi1748 – 17503
Helixi1757 – 177418
Helixi1800 – 181617
Helixi1821 – 184222
Helixi1847 – 18548
Turni1856 – 18583
Beta strandi1859 – 18613
Beta strandi1872 – 18787
Turni1879 – 18813
Beta strandi1882 – 18909
Helixi1891 – 190818

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3C4BX-ray1.68A1648-1910[»]
3C4TX-ray2.80A1648-1910[»]
ProteinModelPortaliQ8R418.
SMRiQ8R418. Positions 766-1063, 1648-1910.

Miscellaneous databases

EvolutionaryTraceiQ8R418.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 227177Helicase ATP-bindingAdd
BLAST
Domaini433 – 602170Helicase C-terminalAdd
BLAST
Domaini630 – 72293Dicer dsRNA-binding foldAdd
BLAST
Domaini891 – 1042152PAZAdd
BLAST
Domaini1276 – 1403128RNase III 1Add
BLAST
Domaini1660 – 1818159RNase III 2Add
BLAST
Domaini1843 – 190866DRBMAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni256 – 595340Required for interaction with PRKRA and TARBP2 By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi175 – 1784DECH boxUniRule annotation

Sequence similaritiesi

Contains 1 PAZ domain.
Contains 2 RNase III domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1111.
HOGENOMiHOG000001567.
HOVERGENiHBG107811.
InParanoidiQ8R419.
PhylomeDBiQ8R418.

Family and domain databases

Gene3Di1.10.1520.10. 4 hits.
3.30.160.20. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00104. RNase_III.
InterProiIPR005034. Dicer_dimerisation_dom.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014720. dsRNA-bd_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR003100. PAZ_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF02170. PAZ. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00358. DSRM. 1 hit.
SM00490. HELICc. 1 hit.
SM00949. PAZ. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 4 hits.
PROSITEiPS51327. DICER_DSRBF. 1 hit.
PS50137. DS_RBD. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50821. PAZ. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. Align

Isoform 1 (identifier: Q8R418-1) [UniParc]FASTAAdd to Basket

Also known as: DicerS

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKSPALQPLS MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE     50
LLEAALDHNT IVCLNTGSGK TFIAVLLTKE LAHQIRGDLN PHAKRTVFLV 100
NSANQVAQQV SAVRTHSDLK VGEYSDLEVN ASWTKERWSQ EFTKHQVLIM 150
TCYVALTVLK NGYLSLSDIN LLVFDECHLA ILDHPYREIM KLCESCPSCP 200
RILGLTASIL NGKCDPEELE EKIQKLERIL RSDAETATDL VVLDRYTSQP 250
CEIVVDCGPF TDRSGLYERL LMELEAALDF INDCNVAVHS KERDSTLISK 300
QILSDCRAVL VVLGPWCADK VAGMMVRELQ KYIKHEQEEL HRKFLLFTDT 350
LLRKIHALCE EYFSPASLDL KYVTPKVMKL LEILRKYKPY ERQQFESVEW 400
YNNRNQDNYV SWSDSEDDDD DEEIEEKEKP ETNFPSPFTN ILCGIIFVER 450
RYTAVVLNRL IKEAGKQDPE LAYISSNFIT GHGIGKNQPR SKQMEAEFRK 500
QEEVLRKFRA HETNLLIATS VVEEGVDIPK CNLVVRFDLP TEYRSYVQSK 550
GRARAPISNY VMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSADGAEAD 600
VHAGVDDEDA FPPYVLRPDD GGPRVTINTA IGHINRYCAR LPSDPFTHLA 650
PKCRTRELPD GTFYSTLYLP INSPLRASIV GPPMDSVRLA ERVVALICCE 700
KLHKIGELDE HLMPVGKETV KYEEELDLHD EEETSVPGRP GSTKRRQCYP 750
KAIPECLRES YPKPDQPCYL YVIGMVLTTP LPDELNFRRR KLYPPEDTTR 800
CFGILTAKPI PQIPHFPVYT RSGEVTISIE LKKSGFTLSQ QMLELITRLH 850
QYIFSHILRL EKPALEFKPT GAESAYCVLP LNVVNDSGTL DIDFKFMEDI 900
EKSEARIGIP STKYSKETPF VFKLEDYQDA VIIPRYRNFD QPHRFYVADV 950
YTDLTPLSKF PSPEYETFAE YYKTKYNLDL TNLNQPLLDV DHTSSRLNLL 1000
TPRHLNQKGK ALPLSSAEKR KAKWESLQNK QILVPELCAI HPIPASLWRK 1050
AVCLPSILYR LHCLLTAEEL RAQTASDAGV GVRSLPVDFR YPNLDFGWKK 1100
SIDSKSFIST CNSSLAESDN YCKHSTTVVP EHAAHQGATR PSLENHDQMS 1150
VNCKRLPAES PAKLQSEVST DLTAINGLSY NKNLANGSYD LVNRDFCQGN 1200
QLNYFKQEIP VQPTTSYPIQ NLYNYENQPK PSNECPLLSN TYLDGNANTS 1250
TSDGSPAVST MPAMMNAVKA LKDRMDSEQS PSVGYSSRTL GPNPGLILQA 1300
LTLSNASDGF NLERLEMLGD SFLKHAITTY LFCTYPDAHE GRLSYMRSKK 1350
VSNCNLYRLG KKKGLPSRMV VSIFDPPVNW LPPGYVVNQD KSNSEKWEKD 1400
EMTKDCLLAN GKLGEACEEE EDLTWRAPKE EAEDEDDFLE YDQEHIQFID 1450
SMLMGSGAFV RKISLSPFSA SDSAYEWKMP KKASLGSMPF ASGLEDFDYS 1500
SWDAMCYLDP SKAVEEDDFV VGFWNPSEEN CGVDTGKQSI SYDLHTEQCI 1550
ADKSIADCVE ALLGCYLTSC GERAAQLFLC SLGLKVLPVI KRTSREKALD 1600
PAQENGSSQQ KSLSGSCAAP VGPRSSAGKD LEYGCLKIPP RCMFDHPDAE 1650
KTLNHLISGF ETFEKKINYR FKNKAYLLQA FTHASYHYNT ITDCYQRLEF 1700
LGDAILDYLI TKHLYEDPRQ HSPGVLTDLR SALVNNTIFA SLAVKYDYHK 1750
YFKAVSPELF HVIDDFVKFQ LEKNEMQGMD SELRRSEEDE EKEEDIEVPK 1800
AMGDIFESLA GAIYMDSGMS LEVVWQVYYP MMQPLIEKFS ANVPRSPVRE 1850
LLEMEPETAK FSPAERTYDG KVRVTVEVVG KGKFKGVGRS YRIAKSAAAR 1900
RALRSLKANQ PQVPNS 1916
Length:1,916
Mass (Da):216,821
Last modified:September 1, 2009 - v3
Checksum:iD97EA17922D7E79C
GO
Isoform 2 (identifier: Q8R418-2) [UniParc]FASTAAdd to Basket

Also known as: DicerO

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: MKSPALQPLS...TATDLVVLDR → MSRDTEV

Note: An MT-C retrotransposon in intron 6 of the mouse DICER gene functions as a promoter producing a transcript lacking exons 1 to 6. A new alternative first exon is directly derived from the retrotransposon.

Show »
Length:1,678
Mass (Da):190,213
Checksum:i4F445FDFB774C3EB
GO

Sequence cautioni

The sequence AAM21495.1 differs from that shown. Reason: Frameshift at position 8.
The sequence BAC15765.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 245245MKSPA…VVLDR → MSRDTEV in isoform 2. VSP_053586Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → L in BAC15765. 1 Publication
Sequence conflicti107 – 1071A → C in AAM21495. 1 Publication
Sequence conflicti167 – 1671S → P in BAC15765. 1 Publication
Sequence conflicti289 – 2891H → Y in AAM21495. 1 Publication
Sequence conflicti610 – 6101A → T in BAC15765. 1 Publication
Sequence conflicti759 – 7591E → D in AAM21495. 1 Publication
Sequence conflicti837 – 8371T → I in AAM21495. 1 Publication
Sequence conflicti888 – 8881G → S in AAL84638. 1 Publication
Sequence conflicti965 – 9651Y → C in BAC15765. 1 Publication
Sequence conflicti993 – 9931T → A in BAC15765. 1 Publication
Sequence conflicti1090 – 10901R → G in BAC15765. 1 Publication
Sequence conflicti1110 – 11101T → S in BAC15765. 1 Publication
Sequence conflicti1336 – 13361P → H in AAL84638. 1 Publication
Sequence conflicti1619 – 16191A → S in AAL84637. 1 Publication
Sequence conflicti1619 – 16191A → S in BAC15765. 1 Publication
Sequence conflicti1860 – 18601K → E in BAC15765. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF484523 Genomic DNA. Translation: AAL84637.1.
AF484524 Genomic DNA. Translation: AAL84638.1.
AB081470 mRNA. Translation: BAC15765.1. Different initiation.
AF430845 mRNA. Translation: AAM21495.1. Frameshift.
UniGeneiMm.21135.

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF484523 Genomic DNA. Translation: AAL84637.1 .
AF484524 Genomic DNA. Translation: AAL84638.1 .
AB081470 mRNA. Translation: BAC15765.1 . Different initiation.
AF430845 mRNA. Translation: AAM21495.1 . Frameshift.
UniGenei Mm.21135.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3C4B X-ray 1.68 A 1648-1910 [» ]
3C4T X-ray 2.80 A 1648-1910 [» ]
ProteinModelPortali Q8R418.
SMRi Q8R418. Positions 766-1063, 1648-1910.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29721N.
IntActi Q8R418. 2 interactions.

PTM databases

PhosphoSitei Q8R418.

Proteomic databases

MaxQBi Q8R418.
PaxDbi Q8R418.
PRIDEi Q8R418.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:2177178. Dicer1.

Phylogenomic databases

eggNOGi COG1111.
HOGENOMi HOG000001567.
HOVERGENi HBG107811.
InParanoidi Q8R419.
PhylomeDBi Q8R418.

Miscellaneous databases

EvolutionaryTracei Q8R418.
PROi Q8R418.
SOURCEi Search...

Gene expression databases

CleanExi MM_DICER1.
Genevestigatori Q8R418.

Family and domain databases

Gene3Di 1.10.1520.10. 4 hits.
3.30.160.20. 1 hit.
3.40.50.300. 2 hits.
HAMAPi MF_00104. RNase_III.
InterProi IPR005034. Dicer_dimerisation_dom.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014720. dsRNA-bd_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR003100. PAZ_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF02170. PAZ. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00358. DSRM. 1 hit.
SM00490. HELICc. 1 hit.
SM00949. PAZ. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view ]
SUPFAMi SSF101690. SSF101690. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 4 hits.
PROSITEi PS51327. DICER_DSRBF. 1 hit.
PS50137. DS_RBD. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50821. PAZ. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of a mouse cDNA encoding Dicer, a ribonuclease III ortholog involved in RNA interference."
    Nicholson R.H., Nicholson A.W.
    Mamm. Genome 13:67-73(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-1916.
    Strain: C57BL/6J.
  2. "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors."
    Doi N., Zenno S., Ueda R., Ohki-Hamazaki H., Ui-Tei K., Saigo K.
    Curr. Biol. 13:41-46(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "RNAi and expression of retrotransposons MuERV-L and IAP in preimplantation mouse embryos."
    Svoboda P., Stein P., Anger M., Bernstein E., Hannon G.J., Schultz R.M.
    Dev. Biol. 269:276-285(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: Czech II.
  4. "A retrotransposon-driven dicer isoform directs endogenous small interfering RNA production in mouse oocytes."
    Flemr M., Malik R., Franke V., Nejepinska J., Sedlacek R., Vlahovicek K., Svoboda P.
    Cell 155:807-816(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF ISOFORM 2, FUNCTION (ISOFORMS 1 AND 2), DISRUPTION PHENOTYPE (ISOFORM 2), TISSUE SPECIFICITY (ISOFORMS 1 AND 2).
  5. "Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage."
    Du Z., Lee J.K., Tjhen R., Stroud R.M., James T.L.
    Proc. Natl. Acad. Sci. U.S.A. 105:2391-2396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.68 ANGSTROMS) OF 1647-1910, MUTAGENESIS OF LYS-1800.

Entry informationi

Entry nameiDICER_MOUSE
AccessioniPrimary (citable) accession number: Q8R418
Secondary accession number(s): Q8R419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: September 1, 2009
Last modified: September 3, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi