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Protein

Endoribonuclease Dicer

Gene

Dicer1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity).By similarity
Isoform 2: More active than isoform 1 to process long double-stranded RNA into siRNAs. Responsible for the accumulation of endogenous siRNAs observed in mouse oocytes compared to somatic cells and it regulates meiotic spindle organization in female germline.

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.

Cofactori

Mg2+Curated, Mn2+CuratedNote: Binds 2 magnesium or manganese ions per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi1316Magnesium or manganese 1By similarity1
Metal bindingi1395Magnesium or manganese 1By similarity1
Metal bindingi1398Magnesium or manganese 1By similarity1
Metal bindingi1699Magnesium or manganese 21
Sitei1800Important for activity1
Metal bindingi1804Magnesium or manganese 21
Metal bindingi1807Magnesium or manganese 21

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi64 – 71ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

  • anatomical structure development Source: MGI
  • angiogenesis Source: MGI
  • apoptotic DNA fragmentation Source: GO_Central
  • branching morphogenesis of an epithelial tube Source: MGI
  • cardiac muscle cell development Source: MGI
  • cardiac neural crest cell development involved in outflow tract morphogenesis Source: MGI
  • cartilage development Source: MGI
  • cell proliferation Source: MGI
  • cerebral cortex development Source: MGI
  • chromatin silencing at centromere outer repeat region Source: MGI
  • conversion of ds siRNA to ss siRNA Source: MGI
  • conversion of ds siRNA to ss siRNA involved in RNA interference Source: MGI
  • defense response to virus Source: MGI
  • digestive tract development Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • epidermis morphogenesis Source: MGI
  • ganglion development Source: MGI
  • hair follicle cell proliferation Source: MGI
  • hair follicle development Source: MGI
  • hair follicle morphogenesis Source: MGI
  • inner ear receptor cell development Source: MGI
  • intestinal epithelial cell development Source: MGI
  • lung development Source: MGI
  • meiotic spindle organization Source: UniProtKB
  • miRNA loading onto RISC involved in gene silencing by miRNA Source: MGI
  • mRNA stabilization Source: MGI
  • multicellular organism growth Source: MGI
  • myoblast differentiation involved in skeletal muscle regeneration Source: MGI
  • negative regulation of glial cell proliferation Source: MGI
  • negative regulation of Schwann cell proliferation Source: BHF-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • nerve development Source: BHF-UCL
  • neuron projection morphogenesis Source: BHF-UCL
  • olfactory bulb interneuron differentiation Source: MGI
  • peripheral nervous system myelin formation Source: BHF-UCL
  • positive regulation of gene expression Source: BHF-UCL
  • positive regulation of miRNA metabolic process Source: MGI
  • positive regulation of myelination Source: BHF-UCL
  • positive regulation of Schwann cell differentiation Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • post-embryonic development Source: MGI
  • pre-miRNA processing Source: UniProtKB
  • production of miRNAs involved in gene silencing by miRNA Source: BHF-UCL
  • production of siRNA involved in RNA interference Source: UniProtKB
  • regulation of cell cycle Source: MGI
  • regulation of cell differentiation Source: MGI
  • regulation of enamel mineralization Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of inflammatory response Source: MGI
  • regulation of miRNA metabolic process Source: MGI
  • regulation of muscle cell apoptotic process Source: MGI
  • regulation of myelination Source: MGI
  • regulation of neurogenesis Source: MGI
  • regulation of neuron differentiation Source: MGI
  • regulation of Notch signaling pathway Source: BHF-UCL
  • regulation of odontogenesis of dentin-containing tooth Source: MGI
  • regulation of oligodendrocyte differentiation Source: MGI
  • regulation of protein phosphorylation Source: BHF-UCL
  • regulation of regulatory T cell differentiation Source: MGI
  • regulation of RNA metabolic process Source: MGI
  • regulation of stem cell differentiation Source: MGI
  • regulation of viral genome replication Source: MGI
  • reproductive structure development Source: MGI
  • RNA interference Source: MGI
  • RNA phosphodiester bond hydrolysis, endonucleolytic Source: MGI
  • RNA processing Source: MGI
  • rRNA catabolic process Source: InterPro
  • siRNA loading onto RISC involved in RNA interference Source: MGI
  • spinal cord motor neuron differentiation Source: MGI
  • spindle assembly Source: MGI
  • spleen development Source: MGI
  • stem cell population maintenance Source: MGI
  • targeting of mRNA for destruction involved in RNA interference Source: UniProtKB
  • zygote asymmetric cell division Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Helicase, Hydrolase, Nuclease

Keywords - Biological processi

RNA-mediated gene silencing

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BRENDAi3.1.26.3. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoribonuclease Dicer (EC:3.1.26.3)
Alternative name(s):
Double-strand-specific ribonuclease mDCR-1
Gene namesi
Name:Dicer1
Synonyms:Dicer, Mdcr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2177178. Dicer1.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • chromosome, centromeric outer repeat region Source: GOC
  • cytoplasm Source: UniProtKB
  • micro-ribonucleoprotein complex Source: MGI
  • nucleus Source: GO_Central
  • RISC complex Source: GO_Central
  • RISC-loading complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Isoform 2: Mice lacking isoform 2 are viable and males are fertile. However, females are sterile, their oocytes displaying meiotic spindle defects.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1800K → A, R, S or T: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001804711 – 1916Endoribonuclease DicerAdd BLAST1916

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei413PhosphoserineBy similarity1
Modified residuei415PhosphoserineBy similarity1
Modified residuei1016PhosphoserineBy similarity1
Modified residuei1160PhosphoserineBy similarity1
Modified residuei1456PhosphoserineBy similarity1
Modified residuei1464PhosphoserineCombined sources1
Modified residuei1466PhosphoserineBy similarity1
Modified residuei1862PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R418.
PaxDbiQ8R418.
PeptideAtlasiQ8R418.
PRIDEiQ8R418.

PTM databases

iPTMnetiQ8R418.
PhosphoSitePlusiQ8R418.

Expressioni

Tissue specificityi

Isoform 1 is expressed in a wide variety of tissues. Isoform 2 is specifically expressed in oocytes during their growth (at protein level).

Gene expression databases

CleanExiMM_DICER1.

Interactioni

Subunit structurei

Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2; DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9, AGO1, PIWIL1 and PRKRA. Interacts with AGO2, TARBP2, EIF6, MOV10 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). Interacts with BCDIN3D (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-29721N.
IntActiQ8R418. 2 interactors.
STRINGi10090.ENSMUSP00000043676.

Structurei

Secondary structure

11916
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1649 – 1656Combined sources8
Turni1657 – 1659Combined sources3
Helixi1660 – 1667Combined sources8
Helixi1674 – 1681Combined sources8
Helixi1696 – 1716Combined sources21
Helixi1723 – 1733Combined sources11
Helixi1736 – 1745Combined sources10
Helixi1748 – 1750Combined sources3
Helixi1757 – 1774Combined sources18
Helixi1800 – 1816Combined sources17
Helixi1821 – 1842Combined sources22
Helixi1847 – 1854Combined sources8
Turni1856 – 1858Combined sources3
Beta strandi1859 – 1861Combined sources3
Beta strandi1872 – 1878Combined sources7
Turni1879 – 1881Combined sources3
Beta strandi1882 – 1890Combined sources9
Helixi1891 – 1908Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C4BX-ray1.68A1648-1910[»]
3C4TX-ray2.80A1648-1910[»]
ProteinModelPortaliQ8R418.
SMRiQ8R418.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8R418.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 227Helicase ATP-bindingAdd BLAST177
Domaini433 – 602Helicase C-terminalAdd BLAST170
Domaini630 – 722Dicer dsRNA-binding foldAdd BLAST93
Domaini891 – 1042PAZAdd BLAST152
Domaini1276 – 1403RNase III 1Add BLAST128
Domaini1660 – 1818RNase III 2Add BLAST159
Domaini1843 – 1908DRBMAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni256 – 595Required for interaction with PRKRA and TARBP2By similarityAdd BLAST340

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi175 – 178DECH box4

Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.Curated
Contains 1 helicase ATP-binding domain.Curated
Contains 1 helicase C-terminal domain.Curated
Contains 1 PAZ domain.Curated
Contains 2 RNase III domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0701. Eukaryota.
COG0571. LUCA.
COG1111. LUCA.
HOGENOMiHOG000001567.
HOVERGENiHBG107811.
InParanoidiQ8R418.
PhylomeDBiQ8R418.

Family and domain databases

CDDicd00593. RIBOc. 2 hits.
Gene3Di1.10.1520.10. 4 hits.
3.30.160.20. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00104. RNase_III. 1 hit.
InterProiIPR005034. Dicer_dimerisation_dom.
IPR014720. dsRBD_dom.
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR003100. PAZ_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PfamiPF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF02170. PAZ. 1 hit.
PF04851. ResIII. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00358. DSRM. 1 hit.
SM00490. HELICc. 1 hit.
SM00949. PAZ. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 4 hits.
PROSITEiPS51327. DICER_DSRBF. 1 hit.
PS50137. DS_RBD. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50821. PAZ. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket

Isoform 1 (identifier: Q8R418-1) [UniParc]FASTAAdd to basket
Also known as: DicerS

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSPALQPLS MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE
60 70 80 90 100
LLEAALDHNT IVCLNTGSGK TFIAVLLTKE LAHQIRGDLN PHAKRTVFLV
110 120 130 140 150
NSANQVAQQV SAVRTHSDLK VGEYSDLEVN ASWTKERWSQ EFTKHQVLIM
160 170 180 190 200
TCYVALTVLK NGYLSLSDIN LLVFDECHLA ILDHPYREIM KLCESCPSCP
210 220 230 240 250
RILGLTASIL NGKCDPEELE EKIQKLERIL RSDAETATDL VVLDRYTSQP
260 270 280 290 300
CEIVVDCGPF TDRSGLYERL LMELEAALDF INDCNVAVHS KERDSTLISK
310 320 330 340 350
QILSDCRAVL VVLGPWCADK VAGMMVRELQ KYIKHEQEEL HRKFLLFTDT
360 370 380 390 400
LLRKIHALCE EYFSPASLDL KYVTPKVMKL LEILRKYKPY ERQQFESVEW
410 420 430 440 450
YNNRNQDNYV SWSDSEDDDD DEEIEEKEKP ETNFPSPFTN ILCGIIFVER
460 470 480 490 500
RYTAVVLNRL IKEAGKQDPE LAYISSNFIT GHGIGKNQPR SKQMEAEFRK
510 520 530 540 550
QEEVLRKFRA HETNLLIATS VVEEGVDIPK CNLVVRFDLP TEYRSYVQSK
560 570 580 590 600
GRARAPISNY VMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSADGAEAD
610 620 630 640 650
VHAGVDDEDA FPPYVLRPDD GGPRVTINTA IGHINRYCAR LPSDPFTHLA
660 670 680 690 700
PKCRTRELPD GTFYSTLYLP INSPLRASIV GPPMDSVRLA ERVVALICCE
710 720 730 740 750
KLHKIGELDE HLMPVGKETV KYEEELDLHD EEETSVPGRP GSTKRRQCYP
760 770 780 790 800
KAIPECLRES YPKPDQPCYL YVIGMVLTTP LPDELNFRRR KLYPPEDTTR
810 820 830 840 850
CFGILTAKPI PQIPHFPVYT RSGEVTISIE LKKSGFTLSQ QMLELITRLH
860 870 880 890 900
QYIFSHILRL EKPALEFKPT GAESAYCVLP LNVVNDSGTL DIDFKFMEDI
910 920 930 940 950
EKSEARIGIP STKYSKETPF VFKLEDYQDA VIIPRYRNFD QPHRFYVADV
960 970 980 990 1000
YTDLTPLSKF PSPEYETFAE YYKTKYNLDL TNLNQPLLDV DHTSSRLNLL
1010 1020 1030 1040 1050
TPRHLNQKGK ALPLSSAEKR KAKWESLQNK QILVPELCAI HPIPASLWRK
1060 1070 1080 1090 1100
AVCLPSILYR LHCLLTAEEL RAQTASDAGV GVRSLPVDFR YPNLDFGWKK
1110 1120 1130 1140 1150
SIDSKSFIST CNSSLAESDN YCKHSTTVVP EHAAHQGATR PSLENHDQMS
1160 1170 1180 1190 1200
VNCKRLPAES PAKLQSEVST DLTAINGLSY NKNLANGSYD LVNRDFCQGN
1210 1220 1230 1240 1250
QLNYFKQEIP VQPTTSYPIQ NLYNYENQPK PSNECPLLSN TYLDGNANTS
1260 1270 1280 1290 1300
TSDGSPAVST MPAMMNAVKA LKDRMDSEQS PSVGYSSRTL GPNPGLILQA
1310 1320 1330 1340 1350
LTLSNASDGF NLERLEMLGD SFLKHAITTY LFCTYPDAHE GRLSYMRSKK
1360 1370 1380 1390 1400
VSNCNLYRLG KKKGLPSRMV VSIFDPPVNW LPPGYVVNQD KSNSEKWEKD
1410 1420 1430 1440 1450
EMTKDCLLAN GKLGEACEEE EDLTWRAPKE EAEDEDDFLE YDQEHIQFID
1460 1470 1480 1490 1500
SMLMGSGAFV RKISLSPFSA SDSAYEWKMP KKASLGSMPF ASGLEDFDYS
1510 1520 1530 1540 1550
SWDAMCYLDP SKAVEEDDFV VGFWNPSEEN CGVDTGKQSI SYDLHTEQCI
1560 1570 1580 1590 1600
ADKSIADCVE ALLGCYLTSC GERAAQLFLC SLGLKVLPVI KRTSREKALD
1610 1620 1630 1640 1650
PAQENGSSQQ KSLSGSCAAP VGPRSSAGKD LEYGCLKIPP RCMFDHPDAE
1660 1670 1680 1690 1700
KTLNHLISGF ETFEKKINYR FKNKAYLLQA FTHASYHYNT ITDCYQRLEF
1710 1720 1730 1740 1750
LGDAILDYLI TKHLYEDPRQ HSPGVLTDLR SALVNNTIFA SLAVKYDYHK
1760 1770 1780 1790 1800
YFKAVSPELF HVIDDFVKFQ LEKNEMQGMD SELRRSEEDE EKEEDIEVPK
1810 1820 1830 1840 1850
AMGDIFESLA GAIYMDSGMS LEVVWQVYYP MMQPLIEKFS ANVPRSPVRE
1860 1870 1880 1890 1900
LLEMEPETAK FSPAERTYDG KVRVTVEVVG KGKFKGVGRS YRIAKSAAAR
1910
RALRSLKANQ PQVPNS
Length:1,916
Mass (Da):216,821
Last modified:September 1, 2009 - v3
Checksum:iD97EA17922D7E79C
GO
Isoform 2 (identifier: Q8R418-2) [UniParc]FASTAAdd to basket
Also known as: DicerO

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: MKSPALQPLS...TATDLVVLDR → MSRDTEV

Note: An MT-C retrotransposon in intron 6 of the mouse DICER gene functions as a promoter producing a transcript lacking exons 1 to 6. A new alternative first exon is directly derived from the retrotransposon.
Show »
Length:1,678
Mass (Da):190,213
Checksum:i4F445FDFB774C3EB
GO

Sequence cautioni

The sequence AAM21495 differs from that shown. Reason: Frameshift at position 8.Curated
The sequence BAC15765 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC15765 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → L in BAC15765 (PubMed:12526743).Curated1
Sequence conflicti107A → C in AAM21495 (PubMed:15081373).Curated1
Sequence conflicti167S → P in BAC15765 (PubMed:12526743).Curated1
Sequence conflicti289H → Y in AAM21495 (PubMed:15081373).Curated1
Sequence conflicti610A → T in BAC15765 (PubMed:12526743).Curated1
Sequence conflicti759E → D in AAM21495 (PubMed:15081373).Curated1
Sequence conflicti837T → I in AAM21495 (PubMed:15081373).Curated1
Sequence conflicti888G → S in AAL84638 (PubMed:11889553).Curated1
Sequence conflicti965Y → C in BAC15765 (PubMed:12526743).Curated1
Sequence conflicti993T → A in BAC15765 (PubMed:12526743).Curated1
Sequence conflicti1090R → G in BAC15765 (PubMed:12526743).Curated1
Sequence conflicti1110T → S in BAC15765 (PubMed:12526743).Curated1
Sequence conflicti1336P → H in AAL84638 (PubMed:11889553).Curated1
Sequence conflicti1619A → S in AAL84637 (PubMed:11889553).Curated1
Sequence conflicti1619A → S in BAC15765 (PubMed:12526743).Curated1
Sequence conflicti1860K → E in BAC15765 (PubMed:12526743).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0535861 – 245MKSPA…VVLDR → MSRDTEV in isoform 2. CuratedAdd BLAST245

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF484523 Genomic DNA. Translation: AAL84637.1.
AF484524 Genomic DNA. Translation: AAL84638.1.
AB081470 mRNA. Translation: BAC15765.1. Different initiation.
AF430845 mRNA. Translation: AAM21495.1. Frameshift.
UniGeneiMm.21135.

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF484523 Genomic DNA. Translation: AAL84637.1.
AF484524 Genomic DNA. Translation: AAL84638.1.
AB081470 mRNA. Translation: BAC15765.1. Different initiation.
AF430845 mRNA. Translation: AAM21495.1. Frameshift.
UniGeneiMm.21135.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C4BX-ray1.68A1648-1910[»]
3C4TX-ray2.80A1648-1910[»]
ProteinModelPortaliQ8R418.
SMRiQ8R418.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29721N.
IntActiQ8R418. 2 interactors.
STRINGi10090.ENSMUSP00000043676.

PTM databases

iPTMnetiQ8R418.
PhosphoSitePlusiQ8R418.

Proteomic databases

EPDiQ8R418.
PaxDbiQ8R418.
PeptideAtlasiQ8R418.
PRIDEiQ8R418.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2177178. Dicer1.

Phylogenomic databases

eggNOGiKOG0701. Eukaryota.
COG0571. LUCA.
COG1111. LUCA.
HOGENOMiHOG000001567.
HOVERGENiHBG107811.
InParanoidiQ8R418.
PhylomeDBiQ8R418.

Enzyme and pathway databases

BRENDAi3.1.26.3. 3474.

Miscellaneous databases

EvolutionaryTraceiQ8R418.
PROiQ8R418.
SOURCEiSearch...

Gene expression databases

CleanExiMM_DICER1.

Family and domain databases

CDDicd00593. RIBOc. 2 hits.
Gene3Di1.10.1520.10. 4 hits.
3.30.160.20. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00104. RNase_III. 1 hit.
InterProiIPR005034. Dicer_dimerisation_dom.
IPR014720. dsRBD_dom.
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR003100. PAZ_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PfamiPF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF02170. PAZ. 1 hit.
PF04851. ResIII. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00358. DSRM. 1 hit.
SM00490. HELICc. 1 hit.
SM00949. PAZ. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 4 hits.
PROSITEiPS51327. DICER_DSRBF. 1 hit.
PS50137. DS_RBD. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50821. PAZ. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDICER_MOUSE
AccessioniPrimary (citable) accession number: Q8R418
Secondary accession number(s): Q8R419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: September 1, 2009
Last modified: November 2, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-11 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.