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Protein

Prokineticin receptor 1

Gene

Prokr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
  • neuropeptide Y receptor activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prokineticin receptor 1
Short name:
PK-R1
Alternative name(s):
G-protein coupled receptor 73
G-protein coupled receptor ZAQ
Gene namesi
Name:Prokr1
Synonyms:Gpr73, Pkr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi708443. Prokr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62ExtracellularSequence analysisAdd BLAST62
Transmembranei63 – 83Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini84 – 98CytoplasmicSequence analysisAdd BLAST15
Transmembranei99 – 119Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini120 – 145ExtracellularSequence analysisAdd BLAST26
Transmembranei146 – 166Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini167 – 179CytoplasmicSequence analysisAdd BLAST13
Transmembranei180 – 200Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini201 – 232ExtracellularSequence analysisAdd BLAST32
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini254 – 282CytoplasmicSequence analysisAdd BLAST29
Transmembranei283 – 303Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini304 – 322ExtracellularSequence analysisAdd BLAST19
Transmembranei323 – 343Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini344 – 393CytoplasmicSequence analysisAdd BLAST50

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700811 – 393Prokineticin receptor 1Add BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi137 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8R416.
PRIDEiQ8R416.

PTM databases

PhosphoSitePlusiQ8R416.

Expressioni

Tissue specificityi

Widely expressed in peripheral tissues with the highest level in the spleen and moderate levels in the adipose tissues, thymus, lung, kidney, testis, uterus and small intestine.

Gene expression databases

BgeeiENSRNOG00000009556.
GenevisibleiQ8R416. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012913.

Structurei

3D structure databases

ProteinModelPortaliQ8R416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00820000127076.
HOGENOMiHOG000231664.
HOVERGENiHBG039631.
InParanoidiQ8R416.
KOiK08379.
OMAiNFIFITA.
OrthoDBiEOG091G086Y.
PhylomeDBiQ8R416.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METTVGTLGE NTTNTFTDFF SARDGSGAET SPLPFTFSYG DYDMPSDEEE
60 70 80 90 100
DVTNSRTFFA AKIVIGMALV GIMLVCGIGN FIFITALARY KKLRNLTNLL
110 120 130 140 150
IANLAISDFL VAIVCCPFEM DYYVVRQLSW EHGHVLCASV NYLRTVSLYV
160 170 180 190 200
STNALLAIAI DRYLAIVHPL RPRMKCQTAA GLIFLVWSVS ILIAIPAAYF
210 220 230 240 250
TTETVLVIVE SQEKIFCGQI WPVDQQFYYR SYFLLVFGLE FVGPVIAMTL
260 270 280 290 300
CYARVSRELW FKAVPGFQTE QIRRRLRCRR RTVLGLVCVL SAYVLCWAPF
310 320 330 340 350
YGFTIVRDFF PSVFVKEKHY LTAFYVVECI AMSNSMINTL CFVTVRNNTS
360 370 380 390
KYLKRILRLQ WRASPSGSKA SADLDLRTTG IPATEEVDCI RLK
Length:393
Mass (Da):44,507
Last modified:June 1, 2002 - v1
Checksum:iC75EC72B97E503A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY089974 mRNA. Translation: AAM11890.1.
AB158419 mRNA. Translation: BAE16991.1.
AB158420 mRNA. Translation: BAE16992.1.
RefSeqiNP_620433.1. NM_138977.1.
XP_006236883.1. XM_006236821.3.
UniGeneiRn.82759.

Genome annotation databases

EnsembliENSRNOT00000012913; ENSRNOP00000012913; ENSRNOG00000009556.
GeneIDi192648.
KEGGirno:192648.
UCSCiRGD:708443. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY089974 mRNA. Translation: AAM11890.1.
AB158419 mRNA. Translation: BAE16991.1.
AB158420 mRNA. Translation: BAE16992.1.
RefSeqiNP_620433.1. NM_138977.1.
XP_006236883.1. XM_006236821.3.
UniGeneiRn.82759.

3D structure databases

ProteinModelPortaliQ8R416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012913.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8R416.

Proteomic databases

PaxDbiQ8R416.
PRIDEiQ8R416.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012913; ENSRNOP00000012913; ENSRNOG00000009556.
GeneIDi192648.
KEGGirno:192648.
UCSCiRGD:708443. rat.

Organism-specific databases

CTDi10887.
RGDi708443. Prokr1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00820000127076.
HOGENOMiHOG000231664.
HOVERGENiHBG039631.
InParanoidiQ8R416.
KOiK08379.
OMAiNFIFITA.
OrthoDBiEOG091G086Y.
PhylomeDBiQ8R416.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ8R416.

Gene expression databases

BgeeiENSRNOG00000009556.
GenevisibleiQ8R416. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKR1_RAT
AccessioniPrimary (citable) accession number: Q8R416
Secondary accession number(s): Q4AEG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.