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Protein

Prokineticin receptor 2

Gene

Prokr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
  • neuropeptide Y receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prokineticin receptor 2
Short name:
PK-R2
Alternative name(s):
G-protein coupled receptor 73-like 1
G-protein coupled receptor I5E
Gene namesi
Name:Prokr2
Synonyms:Gpr73l1, Pkr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708445. Prokr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454ExtracellularSequence analysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini76 – 8914CytoplasmicSequence analysisAdd
BLAST
Transmembranei90 – 11021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini111 – 13626ExtracellularSequence analysisAdd
BLAST
Transmembranei137 – 15721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini158 – 17013CytoplasmicSequence analysisAdd
BLAST
Transmembranei171 – 19121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini192 – 22231ExtracellularSequence analysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini244 – 27229CytoplasmicSequence analysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini294 – 31219ExtracellularSequence analysisAdd
BLAST
Transmembranei313 – 33321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini334 – 38350CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Prokineticin receptor 2PRO_0000070085Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis
Disulfide bondi128 ↔ 207PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8R415.
PRIDEiQ8R415.

PTM databases

PhosphoSiteiQ8R415.

Expressioni

Tissue specificityi

Abundantly expressed in the CNS and reproductive organs with the highest levels in the cerebrum, cerebellum, testis and ovary.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028889.

Structurei

3D structure databases

ProteinModelPortaliQ8R415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000231664.
HOVERGENiHBG039631.
InParanoidiQ8R415.
KOiK08380.
PhylomeDBiQ8R415.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDQNGNTSF APDLNPPQDH VSLLPLNYSY GDYDIPLDDD EDVTKTQTFF
60 70 80 90 100
AAKIVIGVAL AGIMLVCGVG NFVFIAALAR YKKLRNLTNL LIANLAISDF
110 120 130 140 150
LVAIVCCPFE MDYYVVRQLS WEHGHVLCAS VNYLRTVSLY VSTNALLAIA
160 170 180 190 200
IDRYLAIVHP LKRMNYQTAS FLIALVWMVS ILIAIPSAYF TTETILVIVK
210 220 230 240 250
NQEKLFCGQI WPVDQQLYYK SYFLFVFGLE FVGPVVTMTL CYARISQELW
260 270 280 290 300
FKAVPGFQTE QIRKRLRCRR KTVLLLMGIL TAYVLCWAPF YGFTIVRDFF
310 320 330 340 350
PTLVVKEKHY LTAFYVVECI AMSNSMINTI CFVTVKNNTM KYFKKMLLLH
360 370 380
WRPSHYGSKS SADLDLKTSG VPATEEVDCI RLK
Length:383
Mass (Da):43,603
Last modified:July 19, 2003 - v2
Checksum:i477C501099535B93
GO

Sequence cautioni

The sequence AAM11891.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY089975 mRNA. Translation: AAM11891.1. Different initiation.
RefSeqiNP_620434.1. NM_138978.1.
UniGeneiRn.82760.

Genome annotation databases

GeneIDi192649.
KEGGirno:192649.
UCSCiRGD:708445. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY089975 mRNA. Translation: AAM11891.1. Different initiation.
RefSeqiNP_620434.1. NM_138978.1.
UniGeneiRn.82760.

3D structure databases

ProteinModelPortaliQ8R415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028889.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8R415.

Proteomic databases

PaxDbiQ8R415.
PRIDEiQ8R415.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi192649.
KEGGirno:192649.
UCSCiRGD:708445. rat.

Organism-specific databases

CTDi128674.
RGDi708445. Prokr2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000231664.
HOVERGENiHBG039631.
InParanoidiQ8R415.
KOiK08380.
PhylomeDBiQ8R415.

Miscellaneous databases

NextBioi623085.
PROiQ8R415.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors."
    Masuda Y., Takatsu Y., Terao Y., Kumano S., Ishibashi Y., Suenaga M., Abe M., Fukusumi S., Watanabe T., Shintani Y., Yamada T., Hinuma S., Inatomi N., Ohtaki T., Onda H., Fujino M.
    Biochem. Biophys. Res. Commun. 293:396-402(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiPKR2_RAT
AccessioniPrimary (citable) accession number: Q8R415
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: May 11, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.