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Protein

Prokineticin-1

Gene

Prok1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prokineticin-1
Alternative name(s):
Endocrine-gland-derived vascular endothelial growth factor
Short name:
EG-VEGF
Gene namesi
Name:Prok1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620898. Prok1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 10586Prokineticin-1PRO_0000025808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 38By similarity
Disulfide bondi32 ↔ 50By similarity
Disulfide bondi37 ↔ 78By similarity
Disulfide bondi60 ↔ 86By similarity
Disulfide bondi80 ↔ 96By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8R414.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018201.
GenevisibleiQ8R414. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024519.

Structurei

3D structure databases

ProteinModelPortaliQ8R414.
SMRiQ8R414. Positions 20-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AVIT (prokineticin) family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYYQ. Eukaryota.
ENOG4111YK9. LUCA.
GeneTreeiENSGT00390000014799.
HOGENOMiHOG000004848.
HOVERGENiHBG031845.
InParanoidiQ8R414.
OMAiRKRQHHT.
OrthoDBiEOG091G0U3L.
PhylomeDBiQ8R414.
TreeFamiTF332732.

Family and domain databases

InterProiIPR009523. Prokineticin.
IPR023569. Prokineticin_domain.
[Graphical view]
PANTHERiPTHR18821. PTHR18821. 1 hit.
PfamiPF06607. Prokineticin. 1 hit.
[Graphical view]
ProDomiPD059788. Prokineticin. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R414-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGAVQVFIM LLLATVSDCA VITGACERDV QCGAGTCCAI SLWLRGLRLC
60 70 80 90 100
TPLGREGEEC HPGSHKIPFF RKRQHHTCPC SPSLLCSRFP DGRYRCSQDL

KNVNF
Length:105
Mass (Da):11,643
Last modified:June 1, 2002 - v1
Checksum:i8DF0C42122B1C5B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY089983 mRNA. Translation: AAM09104.1.
RefSeqiNP_620206.1. NM_138851.1.
UniGeneiRn.82757.

Genome annotation databases

EnsembliENSRNOT00000024519; ENSRNOP00000024519; ENSRNOG00000018201.
GeneIDi192205.
KEGGirno:192205.
UCSCiRGD:620898. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY089983 mRNA. Translation: AAM09104.1.
RefSeqiNP_620206.1. NM_138851.1.
UniGeneiRn.82757.

3D structure databases

ProteinModelPortaliQ8R414.
SMRiQ8R414. Positions 20-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024519.

Proteomic databases

PaxDbiQ8R414.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024519; ENSRNOP00000024519; ENSRNOG00000018201.
GeneIDi192205.
KEGGirno:192205.
UCSCiRGD:620898. rat.

Organism-specific databases

CTDi84432.
RGDi620898. Prok1.

Phylogenomic databases

eggNOGiENOG410IYYQ. Eukaryota.
ENOG4111YK9. LUCA.
GeneTreeiENSGT00390000014799.
HOGENOMiHOG000004848.
HOVERGENiHBG031845.
InParanoidiQ8R414.
OMAiRKRQHHT.
OrthoDBiEOG091G0U3L.
PhylomeDBiQ8R414.
TreeFamiTF332732.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ8R414.

Gene expression databases

BgeeiENSRNOG00000018201.
GenevisibleiQ8R414. RN.

Family and domain databases

InterProiIPR009523. Prokineticin.
IPR023569. Prokineticin_domain.
[Graphical view]
PANTHERiPTHR18821. PTHR18821. 1 hit.
PfamiPF06607. Prokineticin. 1 hit.
[Graphical view]
ProDomiPD059788. Prokineticin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiPROK1_RAT
AccessioniPrimary (citable) accession number: Q8R414
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.