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Protein

Prokineticin-1

Gene

Prok1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Mitogen
Biological processAngiogenesis

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prokineticin-1
Alternative name(s):
Endocrine-gland-derived vascular endothelial growth factor
Short name:
EG-VEGF
Gene namesi
Name:Prok1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620898 Prok1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002580820 – 105Prokineticin-1Add BLAST86

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 38By similarity
Disulfide bondi32 ↔ 50By similarity
Disulfide bondi37 ↔ 78By similarity
Disulfide bondi60 ↔ 86By similarity
Disulfide bondi80 ↔ 96By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8R414

Expressioni

Gene expression databases

BgeeiENSRNOG00000018201
GenevisibleiQ8R414 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024519

Structurei

3D structure databases

ProteinModelPortaliQ8R414
SMRiQ8R414
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AVIT (prokineticin) family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYYQ Eukaryota
ENOG4111YK9 LUCA
GeneTreeiENSGT00390000014799
HOGENOMiHOG000004848
HOVERGENiHBG031845
InParanoidiQ8R414
OMAiMCTPLGQ
OrthoDBiEOG091G0U3L
PhylomeDBiQ8R414
TreeFamiTF332732

Family and domain databases

InterProiView protein in InterPro
IPR009523 Prokineticin
IPR023569 Prokineticin_domain
PANTHERiPTHR18821 PTHR18821, 1 hit
PfamiView protein in Pfam
PF06607 Prokineticin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD059788 Prokineticin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R414-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGAVQVFIM LLLATVSDCA VITGACERDV QCGAGTCCAI SLWLRGLRLC
60 70 80 90 100
TPLGREGEEC HPGSHKIPFF RKRQHHTCPC SPSLLCSRFP DGRYRCSQDL

KNVNF
Length:105
Mass (Da):11,643
Last modified:June 1, 2002 - v1
Checksum:i8DF0C42122B1C5B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY089983 mRNA Translation: AAM09104.1
RefSeqiNP_620206.1, NM_138851.1
XP_017446090.1, XM_017590601.1
UniGeneiRn.82757

Genome annotation databases

EnsembliENSRNOT00000024519; ENSRNOP00000024519; ENSRNOG00000018201
GeneIDi192205
KEGGirno:192205
UCSCiRGD:620898 rat

Similar proteinsi

Entry informationi

Entry nameiPROK1_RAT
AccessioniPrimary (citable) accession number: Q8R414
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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