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Protein

Prokineticin-2

Gene

Prok2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide
Biological processBiological rhythms

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prokineticin-2
Short name:
PK2
Gene namesi
Name:Prok2
Synonyms:Bv8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620280 Prok2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1949485

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002581127 – 107Prokineticin-2Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 45By similarity
Disulfide bondi39 ↔ 57By similarity
Disulfide bondi44 ↔ 85By similarity
Disulfide bondi67 ↔ 93By similarity
Disulfide bondi87 ↔ 103By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed at high levels in testis and at lower levels in brain, lung, ovary, spleen, thymus and uterus.

Inductioni

Activated by CLOCK and BMAL1 heterodimers and light; inhibited by period genes (PER1, PER2 and PER3) and cryptochrome genes (CRY1 and CRY2).Curated

Gene expression databases

BgeeiENSRNOG00000010898
ExpressionAtlasiQ8R413 baseline and differential
GenevisibleiQ8R413 RN

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD

Structurei

3D structure databases

ProteinModelPortaliQ8R413
SMRiQ8R413
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AVIT (prokineticin) family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000014799
HOGENOMiHOG000004848
HOVERGENiHBG031845
InParanoidiQ8R413

Family and domain databases

InterProiView protein in InterPro
IPR009523 Prokineticin
IPR023569 Prokineticin_domain
PANTHERiPTHR18821 PTHR18821, 1 hit
PfamiView protein in Pfam
PF06607 Prokineticin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD059788 Prokineticin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDPRCAPLL LLLLLPLLLT PPAGDAAVIT GACDKDSQCG GGMCCAVSIW
60 70 80 90 100
VKSIRICTPM GQVGDSCHPL TRKVPFWGRR MHHTCPCLPG LACLRTSFNR

FICLARK
Length:107
Mass (Da):11,594
Last modified:June 1, 2002 - v1
Checksum:iBDFF316CDCB5FED0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY089984 mRNA Translation: AAM09105.1
RefSeqiNP_620207.1, NM_138852.1
UniGeneiRn.211872

Genome annotation databases

EnsembliENSRNOT00000015075; ENSRNOP00000015075; ENSRNOG00000010898
GeneIDi192206
KEGGirno:192206
UCSCiRGD:620280 rat

Similar proteinsi

Entry informationi

Entry nameiPROK2_RAT
AccessioniPrimary (citable) accession number: Q8R413
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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