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Protein

Prokineticin-2

Gene

Prok2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Keywords - Biological processi

Biological rhythms

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prokineticin-2
Short name:
PK2
Gene namesi
Name:Prok2
Synonyms:Bv8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620280. Prok2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1949485.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002581127 – 107Prokineticin-2Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 45By similarity
Disulfide bondi39 ↔ 57By similarity
Disulfide bondi44 ↔ 85By similarity
Disulfide bondi67 ↔ 93By similarity
Disulfide bondi87 ↔ 103By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8R413.

Expressioni

Tissue specificityi

Expressed at high levels in testis and at lower levels in brain, lung, ovary, spleen, thymus and uterus.

Inductioni

Activated by CLOCK and BMAL1 heterodimers and light; inhibited by period genes (PER1, PER2 and PER3) and cryptochrome genes (CRY1 and CRY2).Curated

Gene expression databases

BgeeiENSRNOG00000010898.
ExpressionAtlasiQ8R413. baseline and differential.
GenevisibleiQ8R413. RN.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD

Structurei

3D structure databases

ProteinModelPortaliQ8R413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AVIT (prokineticin) family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000014799.
HOGENOMiHOG000004848.
HOVERGENiHBG031845.
InParanoidiQ8R413.

Family and domain databases

InterProiIPR009523. Prokineticin.
IPR023569. Prokineticin_domain.
[Graphical view]
PANTHERiPTHR18821. PTHR18821. 1 hit.
PfamiPF06607. Prokineticin. 1 hit.
[Graphical view]
ProDomiPD059788. Prokineticin. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDPRCAPLL LLLLLPLLLT PPAGDAAVIT GACDKDSQCG GGMCCAVSIW
60 70 80 90 100
VKSIRICTPM GQVGDSCHPL TRKVPFWGRR MHHTCPCLPG LACLRTSFNR

FICLARK
Length:107
Mass (Da):11,594
Last modified:June 1, 2002 - v1
Checksum:iBDFF316CDCB5FED0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY089984 mRNA. Translation: AAM09105.1.
RefSeqiNP_620207.1. NM_138852.1.
UniGeneiRn.211872.

Genome annotation databases

EnsembliENSRNOT00000015075; ENSRNOP00000015075; ENSRNOG00000010898.
GeneIDi192206.
KEGGirno:192206.
UCSCiRGD:620280. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY089984 mRNA. Translation: AAM09105.1.
RefSeqiNP_620207.1. NM_138852.1.
UniGeneiRn.211872.

3D structure databases

ProteinModelPortaliQ8R413.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL1949485.

Proteomic databases

PRIDEiQ8R413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015075; ENSRNOP00000015075; ENSRNOG00000010898.
GeneIDi192206.
KEGGirno:192206.
UCSCiRGD:620280. rat.

Organism-specific databases

CTDi60675.
RGDi620280. Prok2.

Phylogenomic databases

GeneTreeiENSGT00390000014799.
HOGENOMiHOG000004848.
HOVERGENiHBG031845.
InParanoidiQ8R413.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ8R413.

Gene expression databases

BgeeiENSRNOG00000010898.
ExpressionAtlasiQ8R413. baseline and differential.
GenevisibleiQ8R413. RN.

Family and domain databases

InterProiIPR009523. Prokineticin.
IPR023569. Prokineticin_domain.
[Graphical view]
PANTHERiPTHR18821. PTHR18821. 1 hit.
PfamiPF06607. Prokineticin. 1 hit.
[Graphical view]
ProDomiPD059788. Prokineticin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiPROK2_RAT
AccessioniPrimary (citable) accession number: Q8R413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: October 5, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.