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Protein

Interferon alpha-inducible protein 27-like protein 2A

Gene

Ifi27l2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

  • aging Source: MGI
  • response to virus Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-inducible protein 27-like protein 2A
Alternative name(s):
Interferon-stimulated gene 12 protein
Short name:
ISG12
Gene namesi
Name:Ifi27l2a
Synonyms:Ifi27, Isg12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1924183. Ifi27l2a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821HelicalSequence analysisAdd
BLAST
Transmembranei67 – 8923HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 9066Interferon alpha-inducible protein 27-like protein 2APRO_0000416107Add
BLAST

Proteomic databases

PaxDbiQ8R412.

Expressioni

Gene expression databases

BgeeiQ8R412.
GenevisibleiQ8R412. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054698.

Structurei

3D structure databases

ProteinModelPortaliQ8R412.
SMRiQ8R412. Positions 23-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IFI6/IFI27 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002592.
HOGENOMiHOG000112988.
InParanoidiQ8R412.
OMAiSSAMAEC.
TreeFamiTF340510.

Family and domain databases

InterProiIPR009311. IFI6/IFI27.
[Graphical view]
PANTHERiPTHR16932. PTHR16932. 1 hit.
PfamiPF06140. Ifi-6-16. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGTLFGSAI GGALAVAGAP VALAAMGFTG TGIAAASIAA KMMSAAAIAN
60 70 80 90
GGGVAAGSLV ATLQSAGVLG LSTSTNAILG AAGAAVGALL
Length:90
Mass (Da):7,929
Last modified:June 1, 2002 - v1
Checksum:iE4EEE1E956031607
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160503 mRNA. Translation: BAE35827.1.
AC154347 Genomic DNA. No translation available.
CH466549 Genomic DNA. Translation: EDL18827.1.
BC100588 mRNA. Translation: AAI00589.1.
AY090098 mRNA. Translation: AAM10443.1.
BN000231 mRNA. Translation: CAE00398.1.
CCDSiCCDS49153.1.
RefSeqiNP_084079.1. NM_029803.3.
UniGeneiMm.271275.
Mm.446878.

Genome annotation databases

EnsembliENSMUST00000055071; ENSMUSP00000054698; ENSMUSG00000079017.
GeneIDi76933.
KEGGimmu:76933.
UCSCiuc007ovn.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160503 mRNA. Translation: BAE35827.1.
AC154347 Genomic DNA. No translation available.
CH466549 Genomic DNA. Translation: EDL18827.1.
BC100588 mRNA. Translation: AAI00589.1.
AY090098 mRNA. Translation: AAM10443.1.
BN000231 mRNA. Translation: CAE00398.1.
CCDSiCCDS49153.1.
RefSeqiNP_084079.1. NM_029803.3.
UniGeneiMm.271275.
Mm.446878.

3D structure databases

ProteinModelPortaliQ8R412.
SMRiQ8R412. Positions 23-90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054698.

Proteomic databases

PaxDbiQ8R412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055071; ENSMUSP00000054698; ENSMUSG00000079017.
GeneIDi76933.
KEGGimmu:76933.
UCSCiuc007ovn.3. mouse.

Organism-specific databases

CTDi76933.
MGIiMGI:1924183. Ifi27l2a.

Phylogenomic databases

GeneTreeiENSGT00390000002592.
HOGENOMiHOG000112988.
InParanoidiQ8R412.
OMAiSSAMAEC.
TreeFamiTF340510.

Miscellaneous databases

ChiTaRSiIfi27l2a. mouse.
NextBioi346113.
PROiQ8R412.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R412.
GenevisibleiQ8R412. MM.

Family and domain databases

InterProiIPR009311. IFI6/IFI27.
[Graphical view]
PANTHERiPTHR16932. PTHR16932. 1 hit.
PfamiPF06140. Ifi-6-16. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Age-dependent resistance to lethal alphavirus encephalitis in mice: analysis of gene expression in the central nervous system and identification of a novel interferon-inducible protective gene, mouse ISG12."
    Labrada L., Liang X.H., Zheng W., Johnston C., Levine B.
    J. Virol. 76:11688-11703(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  6. "Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12."
    Parker N., Porter A.C.G.
    BMC Genomics 5:8-8(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiIF27A_MOUSE
AccessioniPrimary (citable) accession number: Q8R412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 1, 2002
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.