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Protein

MICOS complex subunit MIC13

Gene

Mic13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MINOS1/MIC10 into the MICOS complex.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC13By similarity
Gene namesi
Name:Mic13By similarity
Synonyms:Qil1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2442174. 2410015M20Rik.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 26HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899871 – 119MICOS complex subunit MIC13Add BLAST119

Proteomic databases

EPDiQ8R404.
MaxQBiQ8R404.
PaxDbiQ8R404.
PeptideAtlasiQ8R404.
PRIDEiQ8R404.
TopDownProteomicsiQ8R404.

PTM databases

iPTMnetiQ8R404.
PhosphoSitePlusiQ8R404.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049760.
CleanExiMM_2410015M20RIK.
GenevisibleiQ8R404. MM.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOO/MIC26, QIL1/MIC13, APOOL/MIC27 and IMMT/MIC60. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex.By similarity

Protein-protein interaction databases

IntActiQ8R404. 1 interactor.
STRINGi10090.ENSMUSP00000052908.

Family & Domainsi

Sequence similaritiesi

Belongs to the MICOS complex subunit Mic13 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J44B. Eukaryota.
ENOG410YRP1. LUCA.
GeneTreeiENSGT00390000002629.
HOGENOMiHOG000154052.
HOVERGENiHBG107278.
InParanoidiQ8R404.
OMAiPPKFNFH.
OrthoDBiEOG091G0WKK.
PhylomeDBiQ8R404.
TreeFamiTF343386.

Family and domain databases

InterProiView protein in InterPro
IPR026769. Mic13.
PANTHERiPTHR31816. PTHR31816. 1 hit.
PfamiView protein in Pfam
PF15884. QIL1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R404-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVARVWSLMR FLIKGSVAGG AVYLVYDQEL LGPSDKSEAA LRKAEEVVPP
60 70 80 90 100
AMYQFSQYVC QQTGLEMPQL PTPPKIKFPN FRDSWNSGII SVMSALSVAP
110
SKAREYSKEG WEYLKEHSK
Length:119
Mass (Da):13,373
Last modified:June 1, 2002 - v1
Checksum:i4F8DED9CAAFEACDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY091637 mRNA. Translation: AAM14633.1.
AF501666 Genomic DNA. Translation: AAM22184.1.
AK075942 mRNA. Translation: BAC36071.1.
AK075961 mRNA. Translation: BAC36083.1.
BC056164 mRNA. Translation: AAH56164.1.
CCDSiCCDS28908.1.
RefSeqiNP_694792.1. NM_153152.3.
UniGeneiMm.34002.

Genome annotation databases

EnsembliENSMUST00000052832; ENSMUSP00000052908; ENSMUSG00000049760.
GeneIDi224904.
KEGGimmu:224904.
UCSCiuc008dcl.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMIC13_MOUSE
AccessioniPrimary (citable) accession number: Q8R404
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: June 1, 2002
Last modified: September 27, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families