Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

MICOS complex subunit MIC13

Gene

Mic13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MINOS1/MIC10 into the MICOS complex.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC13By similarity
Gene namesi
Name:Mic13By similarity
Synonyms:Qil1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2442174 2410015M20Rik

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 26HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899871 – 119MICOS complex subunit MIC13Add BLAST119

Proteomic databases

EPDiQ8R404
MaxQBiQ8R404
PaxDbiQ8R404
PeptideAtlasiQ8R404
PRIDEiQ8R404
TopDownProteomicsiQ8R404

PTM databases

iPTMnetiQ8R404
PhosphoSitePlusiQ8R404

Expressioni

Gene expression databases

BgeeiENSMUSG00000049760
CleanExiMM_2410015M20RIK
GenevisibleiQ8R404 MM

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOO/MIC26, QIL1/MIC13, APOOL/MIC27 and IMMT/MIC60. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex.By similarity

Protein-protein interaction databases

IntActiQ8R404, 1 interactor
STRINGi10090.ENSMUSP00000052908

Family & Domainsi

Sequence similaritiesi

Belongs to the MICOS complex subunit Mic13 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J44B Eukaryota
ENOG410YRP1 LUCA
GeneTreeiENSGT00390000002629
HOGENOMiHOG000154052
HOVERGENiHBG107278
InParanoidiQ8R404
OMAiPPKFNFH
OrthoDBiEOG091G0WKK
PhylomeDBiQ8R404
TreeFamiTF343386

Family and domain databases

InterProiView protein in InterPro
IPR026769 Mic13
PANTHERiPTHR31816 PTHR31816, 1 hit
PfamiView protein in Pfam
PF15884 QIL1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R404-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVARVWSLMR FLIKGSVAGG AVYLVYDQEL LGPSDKSEAA LRKAEEVVPP
60 70 80 90 100
AMYQFSQYVC QQTGLEMPQL PTPPKIKFPN FRDSWNSGII SVMSALSVAP
110
SKAREYSKEG WEYLKEHSK
Length:119
Mass (Da):13,373
Last modified:June 1, 2002 - v1
Checksum:i4F8DED9CAAFEACDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY091637 mRNA Translation: AAM14633.1
AF501666 Genomic DNA Translation: AAM22184.1
AK075942 mRNA Translation: BAC36071.1
AK075961 mRNA Translation: BAC36083.1
BC056164 mRNA Translation: AAH56164.1
CCDSiCCDS28908.1
RefSeqiNP_694792.1, NM_153152.3
UniGeneiMm.34002

Genome annotation databases

EnsembliENSMUST00000052832; ENSMUSP00000052908; ENSMUSG00000049760
GeneIDi224904
KEGGimmu:224904
UCSCiuc008dcl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMIC13_MOUSE
AccessioniPrimary (citable) accession number: Q8R404
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health