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Reviewed, UniProtKB/Swiss-Prot Q8R3Z5 (CACB1_MOUSE)

Last modified May 26, 2009. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Voltage-dependent L-type calcium channel subunit beta-1
      Short name=CAB1
Alternative name(s):
    Calcium channel voltage-dependent subunit beta 1
Gene names
Name: Cacnb1
Synonyms: Cacnlb1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length597 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting By similarity.

Subunit structure

The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma By similarity. Interacts with JSRP1.

Subcellular location

Cell membrane › sarcolemma; Peripheral membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the calcium channel beta subunit family.

Contains 1 SH3 domain.

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Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8R3Z5-1)

Also known as: Beta 1B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8R3Z5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     210-216: AKQKQKS → GNEMTNFAFELDPLELEEEEAELGEHGGSAKTSVSSVTTPPPHGKRIPFFKK
     444-444: Q → QVQVLTSLRRNLSFWGGLEASPRGGDAVAQPQEHAM
Isoform 3 (identifier: Q8R3Z5-3)

Also known as: Beta 1C;

The sequence of this isoform differs from the canonical sequence as follows:
     445-479: GPYLASGDQPLDRATGEHASVHEYPGELGQPPGLY → VQVLTSLRRNLSFWGGLEASPRGGDAVAQPQEHAM
     480-597: Missing.
Isoform 4 (identifier: Q8R3Z5-4)

Also known as: Beta 1A;

The sequence of this isoform differs from the canonical sequence as follows:
     210-216: AKQKQKS → GNEMTNFAFELDPLELEEEEAELGEHGGSAKTSVSSVTTPPPHGKRIPFFKK
     480-597: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 597597Voltage-dependent L-type calcium channel subunit beta-1
PRO_0000144047

Regions

Domain100 – 16970SH3

Amino acid modifications

Modified residue1861Phosphoserine Ref.6
Modified residue4181Phosphothreonine By similarity
Modified residue4991Phosphothreonine Ref.5

Natural variations

Alternative sequence210 – 2167AKQKQKS → GNEMTNFAFELDPLELEEEE AELGEHGGSAKTSVSSVTTP PPHGKRIPFFKK in isoform 2 and isoform 4.
VSP_010726
Alternative sequence4441Q → QVQVLTSLRRNLSFWGGLEA SPRGGDAVAQPQEHAM in isoform 2.
VSP_010727
Alternative sequence445 – 47935GPYLA…PPGLY → VQVLTSLRRNLSFWGGLEAS PRGGDAVAQPQEHAM in isoform 3.
VSP_010728
Alternative sequence480 – 597118Missing in isoform 3 and isoform 4.
VSP_010729

Experimental info

Sequence conflict4851L → P in BAC80138. Ref.2
Sequence conflict5961T → I in BAC80138. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Beta 1B) [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: B912CEB24A6BAFB9

FASTA59765,486
        10         20         30         40         50         60 
MVQKSGMSRG PYPPSQEIPM EVFDPSPQGK YSKRKGRFKR SDGSTSSDTT SNSFVRQGSA 

        70         80         90        100        110        120 
ESYTSRPSDS DVSLEEDREA LRKEAERQAL AQLEKAKTKP VAFAVRTNVG YNPSPGDEVP 

       130        140        150        160        170        180 
VQGVAITFEP KDFLHIKEKY NNDWWIGRLV KEGCEVGFIP SPVKLDSLRL LQEQTLRQNR 

       190        200        210        220        230        240 
LSSSKSGDNS SSSLGDVVTG TRRPTPPASA KQKQKSTEHV PPYDVVPSMR PIILVGPSLK 

       250        260        270        280        290        300 
GYEVTDMMQK ALFDFLKHRF DGRISITRVT ADISLAKRSV LNNPSKHIII ERSNTRSSLA 

       310        320        330        340        350        360 
EVQSEIERIF ELARTLQLVA LDADTINHPA QLSKTSLAPI IVYIKITSPK VLQRLIKSRG 

       370        380        390        400        410        420 
KSQSKHLNVQ IAASEKLAQC PPEMFDIILD ENQLEDACEH LAEYLEAYWK ATHPPSSTPP 

       430        440        450        460        470        480 
NPLLNRTMAT AALAASPAPV SNLQGPYLAS GDQPLDRATG EHASVHEYPG ELGQPPGLYP 

       490        500        510        520        530        540 
SNHPLGRAGT LRALSRQDTF DADTPGSRNS AYTEPGDSCV DMETDPSEGP GPGDPAGGGT 

       550        560        570        580        590 
PPARQGSWED EEDYEEEMTD NRNRGRNKAR YCAEGGGPVL GRNKNELEGW GQGVYTR

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Isoform 2.

Checksum: C14AB2E0BFD9CC25
Show »

FASTA67774,118
Isoform 3 (Beta 1C).

Checksum: 1050A2010A4BF7D5
Show »

FASTA47952,947
Isoform 4 (Beta 1A).

Checksum: 7E2D857F81CE1EFD
Show »

FASTA52457,718

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References

« Hide 'large scale' references
[1]"The Mus musculus cDNA sequence of the skeletal muscle beta 1-A isoform of the L-type calcium channel."
Powers P.A., Ahern C.A., Iacovelli J.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1; 3 AND 4).
Strain: BALB/c.
Tissue: Skeletal muscle.
[2]"Structures of the murine genes for the beta1- and beta4-Subunits of the voltage-dependent calcium channel."
Murakami M., Miyoshi I., Suzuki T., Sasano H., Iijima T.
J. Mol. Neurosci. 21:13-22(2003) [PubMed: 14500989] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2), ALTERNATIVE SPLICING.
[3]"The mouse voltage-gated calcium channel beta 1 subunit, partial cDNA sequence."
Hildenbrand J., Ammon H.P.T., Wahl M.A.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 9-109.
Strain: NMRI.
Tissue: Brain.
[4]"The junctional SR protein JP-45 affects the functional expression of the voltage-dependent Ca2+ channel Cav1.1."
Anderson A.A., Altafaj X., Zheng Z., Wang Z.-M., Delbono O., Ronjat M., Treves S., Zorzato F.
J. Cell Sci. 119:2145-2155(2006) [PubMed: 16638807] [Abstract]
Cited for: INTERACTION WITH JSRP1.
[5]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed: 16452087] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-499, MASS SPECTROMETRY.
Tissue: Brain.
[6]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, MASS SPECTROMETRY.
Tissue: Brain cortex.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF322905 mRNA. Translation: AAG42829.1.
AY094172 mRNA. Translation: AAM11473.1.
AY094173 mRNA. Translation: AAM11474.1.
AB100389 Genomic DNA. Translation: BAC80138.1.
AF068898 mRNA. Translation: AAC19386.1.
IPIIPI00321850.
IPI00421276.
IPI00421277.
IPI00421278.
UniGeneMm.41252

3D structure databases

SMRQ8R3Z5. Positions 74-417.
ModBaseSearch...

Protein-protein interaction databases

IntActQ8R3Z5. 2 interactions.

Protein family/group databases

TCDB8.A.22.1.1. Ca2+ channel auxiliary subunit beta types 1-4 (CCA-beta) family.

PTM databases

PhosphoSiteQ8R3Z5.

Proteomic databases

PRIDEQ8R3Z5.

Genome annotation databases

EnsemblENSMUSG00000020882. Mus musculus. [Contig view]

Organism-specific databases

MGIMGI:102522. Cacnb1.

Phylogenomic databases

HOGENOMQ8R3Z5.
HOVERGENQ8R3Z5.

Gene expression databases

ArrayExpressQ8R3Z5.
BgeeQ8R3Z5.
GermOnlineENSMUSG00000020882. Mus musculus.

Family and domain databases

InterProIPR008145. Guanylt/Ca.
IPR001452. SH3_domain.
IPR005443. VDCC_L_b1su.
IPR000584. VDCC_L_bsu.
[Graphical view]
PANTHERPTHR11824. Ca_channel_B. 1 hit.
PfamPF00774. Ca_channel_B. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR01626. LCACHANNELB.
PR01627. LCACHANNELB1.
ProDomPD000066. SH3. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00072. GuKc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
PROSITEPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio280796.
SOURCESearch...

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Entry information

Entry nameCACB1_MOUSE
AccessionPrimary (citable) accession number: Q8R3Z5
Secondary accession number(s): O88517 expand/collapse secondary AC list , Q7TPF2, Q8R3Z6, Q9EPT9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 1, 2002
Last modified: May 26, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents