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Protein

Endophilin-B2

Gene

Sh3glb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Endophilin-B2
Alternative name(s):
SH3 domain-containing GRB2-like protein B2
Gene namesi
Name:Sh3glb2
Synonyms:Kiaa1848
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2385131. Sh3glb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Endophilin-B2PRO_0000146756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei10 – 101PhosphoserineBy similarity
Modified residuei400 – 4001PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8R3V5.
PaxDbiQ8R3V5.
PeptideAtlasiQ8R3V5.
PRIDEiQ8R3V5.

2D gel databases

REPRODUCTION-2DPAGEQ8R3V5.

PTM databases

iPTMnetiQ8R3V5.
PhosphoSiteiQ8R3V5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026860.
CleanExiMM_SH3GLB2.
ExpressionAtlasiQ8R3V5. baseline and differential.
GenevisibleiQ8R3V5. MM.

Interactioni

Subunit structurei

Homodimer, and heterodimer with SH3GLB1.By similarity

Protein-protein interaction databases

IntActiQ8R3V5. 2 interactions.
MINTiMINT-4134619.
STRINGi10090.ENSMUSP00000028214.

Structurei

3D structure databases

ProteinModelPortaliQ8R3V5.
SMRiQ8R3V5. Positions 18-232, 339-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 287264BARPROSITE-ProRule annotationAdd
BLAST
Domaini340 – 40061SH3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2727Membrane-binding amphipathic helixBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili205 – 23430Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the endophilin family.Curated
Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG3725. Eukaryota.
ENOG410XPA6. LUCA.
GeneTreeiENSGT00550000074464.
HOGENOMiHOG000232056.
HOVERGENiHBG054448.
InParanoidiQ8R3V5.
KOiK11248.
PhylomeDBiQ8R3V5.
TreeFamiTF313281.

Family and domain databases

Gene3Di1.20.1270.60. 2 hits.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q8R3V5-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFNMKKLAS DAGIFFTRAV QFTEEKFGQA EKTELDAHFE NLLARADSTK
60 70 80 90 100
NWTERILRQT EVLLQPNPSA RVEEFLYEKL DRKVPSRVTN GELLAQYMAE
110 120 130 140 150
AASELGPSTP YGKTLIKVSE AEKRLGAAER DFIHTASLSF LTPLRNFLEG
160 170 180 190 200
DWKTISKERR LLQNRRLDLD ACKARLKKAK AAEAKATTVP DFQETRPRNY
210 220 230 240 250
ILSASASALW NDEVDKAEQE LRVAQTEFDR QAEVTRLLLE GISSTHVNHL
260 270 280 290 300
RCLHEFVKSQ TTYYAQCYRH MLDLQKQLGS SQGAIFPGTF VGTTEPASPP
310 320 330 340 350
LSSTSPTTTA ATMPVVPTGA VLAPPEEAAL CLEEVAPPAS GTRKARVLYD
360 370 380 390 400
YEAADSSELA LLADELITVY SLPGMDPDWL IGERGNKKGK VPVTYLELLS
Length:400
Mass (Da):44,503
Last modified:October 23, 2007 - v2
Checksum:i0614F451F4B4370F
GO
Isoform 1 (identifier: Q8R3V5-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-285: SSQGAI → R

Show »
Length:395
Mass (Da):44,116
Checksum:iC36C19585EE15DD8
GO
Isoform 3 (identifier: Q8R3V5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-208: Missing.

Note: No experimental confirmation available.
Show »
Length:379
Mass (Da):42,198
Checksum:i0FC6AEA93E40C276
GO

Sequence cautioni

The sequence AAH28859 differs from that shown.Intron retention.Curated
The sequence BAC98265 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71K → N in AAL24820 (Ref. 1) Curated
Sequence conflicti332 – 3321L → M in BAE31195 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei188 – 20821Missing in isoform 3. 1 PublicationVSP_009280Add
BLAST
Alternative sequencei280 – 2856SSQGAI → R in isoform 1. 4 PublicationsVSP_028795

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426314 mRNA. Translation: AAL24820.1.
AK129455 Transcribed RNA. Translation: BAC98265.2. Different initiation.
AK152409 mRNA. Translation: BAE31195.1.
AK155248 mRNA. Translation: BAE33146.1.
AK167762 mRNA. Translation: BAE39795.1.
AL954388 Genomic DNA. Translation: CAM23166.1.
AL954388 Genomic DNA. Translation: CAM23168.1.
BC024477 mRNA. Translation: AAH24477.1.
BC028859 mRNA. Translation: AAH28859.1. Sequence problems.
CCDSiCCDS15879.1. [Q8R3V5-1]
CCDS71020.1. [Q8R3V5-4]
RefSeqiNP_001276638.1. NM_001289709.1. [Q8R3V5-4]
NP_647463.1. NM_139302.2. [Q8R3V5-1]
XP_006498002.1. XM_006497939.1. [Q8R3V5-3]
UniGeneiMm.33343.

Genome annotation databases

EnsembliENSMUST00000028214; ENSMUSP00000028214; ENSMUSG00000026860. [Q8R3V5-1]
ENSMUST00000100215; ENSMUSP00000097788; ENSMUSG00000026860. [Q8R3V5-4]
ENSMUST00000163668; ENSMUSP00000131545; ENSMUSG00000026860. [Q8R3V5-3]
GeneIDi227700.
KEGGimmu:227700.
UCSCiuc008jcc.2. mouse. [Q8R3V5-1]
uc008jcd.2. mouse. [Q8R3V5-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426314 mRNA. Translation: AAL24820.1.
AK129455 Transcribed RNA. Translation: BAC98265.2. Different initiation.
AK152409 mRNA. Translation: BAE31195.1.
AK155248 mRNA. Translation: BAE33146.1.
AK167762 mRNA. Translation: BAE39795.1.
AL954388 Genomic DNA. Translation: CAM23166.1.
AL954388 Genomic DNA. Translation: CAM23168.1.
BC024477 mRNA. Translation: AAH24477.1.
BC028859 mRNA. Translation: AAH28859.1. Sequence problems.
CCDSiCCDS15879.1. [Q8R3V5-1]
CCDS71020.1. [Q8R3V5-4]
RefSeqiNP_001276638.1. NM_001289709.1. [Q8R3V5-4]
NP_647463.1. NM_139302.2. [Q8R3V5-1]
XP_006498002.1. XM_006497939.1. [Q8R3V5-3]
UniGeneiMm.33343.

3D structure databases

ProteinModelPortaliQ8R3V5.
SMRiQ8R3V5. Positions 18-232, 339-400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R3V5. 2 interactions.
MINTiMINT-4134619.
STRINGi10090.ENSMUSP00000028214.

PTM databases

iPTMnetiQ8R3V5.
PhosphoSiteiQ8R3V5.

2D gel databases

REPRODUCTION-2DPAGEQ8R3V5.

Proteomic databases

MaxQBiQ8R3V5.
PaxDbiQ8R3V5.
PeptideAtlasiQ8R3V5.
PRIDEiQ8R3V5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028214; ENSMUSP00000028214; ENSMUSG00000026860. [Q8R3V5-1]
ENSMUST00000100215; ENSMUSP00000097788; ENSMUSG00000026860. [Q8R3V5-4]
ENSMUST00000163668; ENSMUSP00000131545; ENSMUSG00000026860. [Q8R3V5-3]
GeneIDi227700.
KEGGimmu:227700.
UCSCiuc008jcc.2. mouse. [Q8R3V5-1]
uc008jcd.2. mouse. [Q8R3V5-4]

Organism-specific databases

CTDi56904.
MGIiMGI:2385131. Sh3glb2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3725. Eukaryota.
ENOG410XPA6. LUCA.
GeneTreeiENSGT00550000074464.
HOGENOMiHOG000232056.
HOVERGENiHBG054448.
InParanoidiQ8R3V5.
KOiK11248.
PhylomeDBiQ8R3V5.
TreeFamiTF313281.

Miscellaneous databases

ChiTaRSiSh3glb2. mouse.
PROiQ8R3V5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026860.
CleanExiMM_SH3GLB2.
ExpressionAtlasiQ8R3V5. baseline and differential.
GenevisibleiQ8R3V5. MM.

Family and domain databases

Gene3Di1.20.1270.60. 2 hits.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHLB2_MOUSE
AccessioniPrimary (citable) accession number: Q8R3V5
Secondary accession number(s): Q3TIQ1
, Q3U2J4, Q3U824, Q8K140, Q91ZI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 23, 2007
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.