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Q8R3U8

- Q8R3U8_MOUSE

UniProt

Q8R3U8 - Q8R3U8_MOUSE

Protein
Submitted name:

Mapkapk2 protein

Gene

Mapkapk2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. protein serine/threonine kinase activity Source: Ensembl

    GO - Biological processi

    1. 3'-UTR-mediated mRNA stabilization Source: Ensembl
    2. cellular response to vascular endothelial growth factor stimulus Source: Ensembl
    3. G2 DNA damage checkpoint Source: Ensembl
    4. inner ear development Source: MGI
    5. mRNA stabilization Source: MGI
    6. peptidyl-serine phosphorylation Source: Ensembl
    7. regulation of tumor necrosis factor production Source: Ensembl
    8. response to cytokine Source: Ensembl
    9. vascular endothelial growth factor receptor signaling pathway Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Mapkapk2 proteinImported
    Gene namesi
    Name:Mapkapk2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:109298. Mapkapk2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8R3U8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8R3U8.
    BgeeiQ8R3U8.
    GenevestigatoriQ8R3U8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000016672.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R3U8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG106948.
    InParanoidiQ8R3U8.

    Family and domain databases

    Gene3Di4.10.1170.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR027442. MAPKAPK_C.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8R3U8-1 [UniParc]FASTAAdd to Basket

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    LTTPCYTPYY VAPEVLGPEK YDKSCDMWSL GVIMYILLCG YPPFYSNHGL    50
    AISPGMKTRI RMGQYEFPNP EWSEVSEEVK MLIRNLLKTE PTQRMTITEF 100
    MNHPWIMQST KVPQTPLHTS RVLKEDKERW EDVKEEMTSA LATMRVDYEQ 150
    IKIKKIEDAS NPLLLKRRKK ARAVEDAALA H 181
    Length:181
    Mass (Da):21,070
    Last modified:June 1, 2002 - v1
    Checksum:iE603176BDB1443C9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC024559 mRNA. Translation: AAH24559.1.
    UniGeneiMm.221235.
    Mm.490983.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC024559 mRNA. Translation: AAH24559.1 .
    UniGenei Mm.221235.
    Mm.490983.

    3D structure databases

    ProteinModelPortali Q8R3U8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000016672.

    Proteomic databases

    PRIDEi Q8R3U8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:109298. Mapkapk2.

    Phylogenomic databases

    HOVERGENi HBG106948.
    InParanoidi Q8R3U8.

    Miscellaneous databases

    ChiTaRSi MAPKAPK2. mouse.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R3U8.
    Bgeei Q8R3U8.
    Genevestigatori Q8R3U8.

    Family and domain databases

    Gene3Di 4.10.1170.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR027442. MAPKAPK_C.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N-3Imported.
      Tissue: Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by biopsy.Imported.

    Entry informationi

    Entry nameiQ8R3U8_MOUSE
    AccessioniPrimary (citable) accession number: Q8R3U8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)