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Protein
Submitted name:

Mapkapk2 protein

Gene

Mapkapk2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. calcium-dependent protein serine/threonine kinase activity Source: GO_Central
  3. calmodulin binding Source: GO_Central
  4. calmodulin-dependent protein kinase activity Source: GO_Central
  5. mitogen-activated protein kinase binding Source: GO_Central
  6. protein serine/threonine kinase activity Source: MGI
  7. signal transducer activity Source: GO_Central

GO - Biological processi

  1. 3'-UTR-mediated mRNA stabilization Source: MGI
  2. cellular response to DNA damage stimulus Source: MGI
  3. cellular response to vascular endothelial growth factor stimulus Source: MGI
  4. G2 DNA damage checkpoint Source: Ensembl
  5. inner ear development Source: MGI
  6. MAPK cascade Source: GO_Central
  7. mRNA stabilization Source: MGI
  8. p38MAPK cascade Source: MGI
  9. peptidyl-serine phosphorylation Source: MGI
  10. positive regulation of tumor necrosis factor biosynthetic process Source: MGI
  11. protein autophosphorylation Source: GO_Central
  12. regulation of tumor necrosis factor production Source: MGI
  13. response to cytokine Source: MGI
  14. vascular endothelial growth factor receptor signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Mapkapk2 proteinImported
Gene namesi
Name:Mapkapk2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:109298. Mapkapk2.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: MGI
  2. cytoplasm Source: MGI
  3. extracellular vesicular exosome Source: MGI
  4. nucleoplasm Source: MGI
  5. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8R3U8.

Expressioni

Gene expression databases

BgeeiQ8R3U8.
ExpressionAtlasiQ8R3U8. baseline and differential.
GenevestigatoriQ8R3U8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016672.

Structurei

3D structure databases

ProteinModelPortaliQ8R3U8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG106948.

Family and domain databases

Gene3Di4.10.1170.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR027442. MAPKAPK_C.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8R3U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LTTPCYTPYY VAPEVLGPEK YDKSCDMWSL GVIMYILLCG YPPFYSNHGL
60 70 80 90 100
AISPGMKTRI RMGQYEFPNP EWSEVSEEVK MLIRNLLKTE PTQRMTITEF
110 120 130 140 150
MNHPWIMQST KVPQTPLHTS RVLKEDKERW EDVKEEMTSA LATMRVDYEQ
160 170 180
IKIKKIEDAS NPLLLKRRKK ARAVEDAALA H
Length:181
Mass (Da):21,070
Last modified:June 1, 2002 - v1
Checksum:iE603176BDB1443C9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024559 mRNA. Translation: AAH24559.1.
UniGeneiMm.221235.
Mm.490983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024559 mRNA. Translation: AAH24559.1.
UniGeneiMm.221235.
Mm.490983.

3D structure databases

ProteinModelPortaliQ8R3U8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016672.

Chemistry

BindingDBiQ8R3U8.

Proteomic databases

PRIDEiQ8R3U8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109298. Mapkapk2.

Phylogenomic databases

HOVERGENiHBG106948.

Miscellaneous databases

ChiTaRSiMapkapk2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R3U8.
ExpressionAtlasiQ8R3U8. baseline and differential.
GenevestigatoriQ8R3U8.

Family and domain databases

Gene3Di4.10.1170.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR027442. MAPKAPK_C.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3Imported.
    Tissue: Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by biopsy.Imported.

Entry informationi

Entry nameiQ8R3U8_MOUSE
AccessioniPrimary (citable) accession number: Q8R3U8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: April 29, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.