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Protein

Syntaxin-binding protein 6

Gene

Stxbp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 6
Gene namesi
Name:Stxbp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2384963. Stxbp6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 210209Syntaxin-binding protein 6PRO_0000206783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8R3T5.
PaxDbiQ8R3T5.
PRIDEiQ8R3T5.

PTM databases

iPTMnetiQ8R3T5.
PhosphoSiteiQ8R3T5.

Expressioni

Gene expression databases

CleanExiMM_STXBP6.

Interactioni

Subunit structurei

Part of a ternary complex containing SNAP25 and STX1A that can be dissociated by NAPA and NSF. Interacts with STX4A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052639.

Structurei

3D structure databases

ProteinModelPortaliQ8R3T5.
SMRiQ8R3T5. Positions 155-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini151 – 21060v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410INFF. Eukaryota.
ENOG410ZU11. LUCA.
HOGENOMiHOG000132986.
HOVERGENiHBG059039.
InParanoidiQ8R3T5.
PhylomeDBiQ8R3T5.

Family and domain databases

InterProiIPR028258. Sec3-PIP2_bind.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF15277. Sec3-PIP2_bind. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
SMARTiSM01313. Sec3-PIP2_bind. 1 hit.
[Graphical view]
PROSITEiPS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R3T5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKSAISKE IFAPLDERML GAVQVKRRTK KKIPFLATGG QGEYLTYICL
60 70 80 90 100
SVTNKKPTQA SITKVKQFEG STSFVRRSQW MLEQLRQVNG IDPNRDSAEF
110 120 130 140 150
DLLFENAFDQ WVASTASEKC TFFQILHHTC QRYLTDRKPE FINCQSKIMG
160 170 180 190 200
GNSILHSAAD SVTSAVQKAS QALNERGERL GRAEEKTEDM KNSAQQFAET
210
AHKLAMKHKC
Length:210
Mass (Da):23,671
Last modified:June 1, 2002 - v1
Checksum:i7C116A9F7FAFC2D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024598 mRNA. Translation: AAH24598.1.
CCDSiCCDS25898.1.
UniGeneiMm.285400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024598 mRNA. Translation: AAH24598.1.
CCDSiCCDS25898.1.
UniGeneiMm.285400.

3D structure databases

ProteinModelPortaliQ8R3T5.
SMRiQ8R3T5. Positions 155-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052639.

PTM databases

iPTMnetiQ8R3T5.
PhosphoSiteiQ8R3T5.

Proteomic databases

MaxQBiQ8R3T5.
PaxDbiQ8R3T5.
PRIDEiQ8R3T5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2384963. Stxbp6.

Phylogenomic databases

eggNOGiENOG410INFF. Eukaryota.
ENOG410ZU11. LUCA.
HOGENOMiHOG000132986.
HOVERGENiHBG059039.
InParanoidiQ8R3T5.
PhylomeDBiQ8R3T5.

Miscellaneous databases

ChiTaRSiStxbp6. mouse.
PROiQ8R3T5.
SOURCEiSearch...

Gene expression databases

CleanExiMM_STXBP6.

Family and domain databases

InterProiIPR028258. Sec3-PIP2_bind.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF15277. Sec3-PIP2_bind. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
SMARTiSM01313. Sec3-PIP2_bind. 1 hit.
[Graphical view]
PROSITEiPS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTXB6_MOUSE
AccessioniPrimary (citable) accession number: Q8R3T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.