Q8R3S6 (EXOC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Exocyst complex component 1

Alternative name(s):
Exocyst complex component Sec3

Gene names

Name:	Exoc1
Synonyms:	Sec3, Sec3l1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	894 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane By similarity.
Subunit structure	The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 By similarity.
Sequence similarities	Belongs to the SEC3 family.

Ontologies

Keywords
Biological process	Exocytosis Protein transport Transport
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	exocytosis Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 894	893	Exocyst complex component 1		PRO_0000118914
Regions
	Coiled coil	152 – 199	48	Potential
	Coiled coil	205 – 259	55	Potential
Amino acid modifications
	Modified residue	471	1	Phosphothreonine By similarity
	Modified residue	473	1	Phosphoserine By similarity
	Modified residue	487	1	Phosphoserine By similarity
	Modified residue	501	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	329	1	V → I in AAH24678. Ref.2
	Sequence conflict	561	1	L → S in AAH24678. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8R3S6 [UniParc]. Last modified July 27, 2011. Version 4. Checksum: 50CA79A8F56091E7	FASTA	894	101,889
	10 20 30 40 50 60 MTAIKHALQR DIFTPNDERL LSIVNVCKAG KKKKNCFLCA TVTTERPVQV KVVKVKKSDK 70 80 90 100 110 120 GDFYKRQIAW ALRDLAVVDA KDAIKENPEF DLHFEKVYKW VASSTAEKNA FISCIWKLNQ 130 140 150 160 170 180 RYLRKKIDFV NVSSQLLEES VPSGENQSVA GGDEEAVDEY QELNAREEQD IEIMMEGCEC 190 200 210 220 230 240 AISNAEAFAE KLSRELQVLD GANIQSIMAS EKQVNTLMQL LDEALTEVDQ IELKLSSYEE 250 260 270 280 290 300 MLQSVKEQMD QISESNHLIH LSNTNNVKLL SEIEFLVNHM DLAKGHIKAL QEGDLVSSRG 310 320 330 340 350 360 IEACTNAADA LLQCMNVALR PGHDMLLAVK QQQQRFSDLR EHFARRLASH LNNVFVQQGH 370 380 390 400 410 420 DQSSTLAQHS VELTLPNHHP FHRDLLRYAK LMEWLKSTDY GKYEGLTKNY MDYLSRLYER 430 440 450 460 470 480 EIKDFFEVAK MKMTGTSKES KKFATLPRKE SAVKQETESL HGSSGKLTGS TSSLNKLSVQ 490 500 510 520 530 540 SSGSRRSQSS SLLDMGNMSA SDLDVADRTK FDKIFEQVLS ELEPLCLAEQ DFISKFFKLQ 550 560 570 580 590 600 QHQNMSASMT EAEDLDGGSL LRQHSSGTLL PVSSEKDMIR QMMIKIFRCI EPELNNLIAL 610 620 630 640 650 660 GDKVDSFNSL YMLVKMSHHV WTAQNVDPAS FLSTTLGNVL VTVKRNFDKC ISNQIRQMEE 670 680 690 700 710 720 VKISKKSKVG ILPFVAEFEE FAGLAESIFK NAERRGDLDK AYTKLIRGVF INVEKVANES 730 740 750 760 770 780 QKTPRDVVMM ENFHHIFATL SRLKISCLEA EKKEAKQKYT DHLQSYVIYS LGQPLEKLNH 790 800 810 820 830 840 FFEGVEARVA QGIREEEVSY QLAFNKQELR KVIKEYPGKE VKKGLDNLYK KVDKHLCEEE 850 860 870 880 890 NLLQVVWHSM QDEFIRQYKH FEGLIARCYP GSGVTMEFTI QDILDYCSSI AQSH

References

[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC127332 Genomic DNA. No translation available. BC024678 mRNA. Translation: AAH24678.1.
IPI	IPI00876325.
UniGene	Mm.403233.
3D structure databases
ProteinModelPortal	Q8R3S6.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4134019.
PTM databases
PhosphoSite	Q8R3S6.
Proteomic databases
PaxDb	Q8R3S6.
PRIDE	Q8R3S6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000087133; ENSMUSP00000084373; ENSMUSG00000036435.
UCSC	uc008xva.1. mouse.
Organism-specific databases
MGI	MGI:2445020. Exoc1.
Phylogenomic databases
eggNOG	NOG260089.
GeneTree	ENSGT00530000063494.
HOGENOM	HOG000247048.
HOVERGEN	HBG056730.
OrthoDB	EOG4BZN1W.
Enzyme and pathway databases
Reactome	REACT_147847. Translocation of Glut4 to the Plasma Membrane. REACT_88307. Membrane Trafficking.
Gene expression databases
ArrayExpress	Q8R3S6.
Bgee	Q8R3S6.
CleanEx	MM_EXOC1.
Genevestigator	Q8R3S6.
GermOnline	ENSMUSG00000036435. Mus musculus.
Family and domain databases
InterPro	IPR019160. Exocyst_Exoc1. [Graphical view]
Pfam	PF09763. Sec3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

EXOC1_MOUSE

Accession

Primary (citable) accession number: Q8R3S6
Secondary accession number(s): E9QQ24

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2002
Last sequence update:	July 27, 2011
Last modified:	May 29, 2013
This is version 69 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program