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Protein

Aspartoacylase

Gene

Aspa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter (By similarity).By similarity

Catalytic activityi

N-acyl-L-aspartate + H2O = a carboxylate + L-aspartate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi20ZincBy similarity1
Metal bindingi23ZincBy similarity1
Binding sitei62SubstrateBy similarity1
Metal bindingi115ZincBy similarity1
Active sitei177By similarity1
Binding sitei177SubstrateBy similarity1
Binding sitei287SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • acetate metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.5.1.15. 3474.
ReactomeiR-MMU-70614. Amino acid synthesis and interconversion (transamination).

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartoacylase (EC:3.5.1.15)
Alternative name(s):
Aminoacylase-2
Short name:
ACY-2
Gene namesi
Name:Aspa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:87914. Aspa.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: UniProtKB
  • extracellular exosome Source: MGI
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002168731 – 312AspartoacylaseAdd BLAST312

Proteomic databases

MaxQBiQ8R3P0.
PaxDbiQ8R3P0.
PeptideAtlasiQ8R3P0.
PRIDEiQ8R3P0.

PTM databases

iPTMnetiQ8R3P0.
PhosphoSitePlusiQ8R3P0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020774.
CleanExiMM_ASPA.
ExpressionAtlasiQ8R3P0. baseline and differential.
GenevisibleiQ8R3P0. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ8R3P0. 1 interactor.
MINTiMINT-4086826.
STRINGi10090.ENSMUSP00000021119.

Structurei

3D structure databases

ProteinModelPortaliQ8R3P0.
SMRiQ8R3P0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni69 – 70Substrate bindingBy similarity2
Regioni163 – 167Substrate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IERR. Eukaryota.
COG2988. LUCA.
GeneTreeiENSGT00390000001189.
HOGENOMiHOG000232489.
HOVERGENiHBG004172.
InParanoidiQ8R3P0.
KOiK01437.
OMAiNFNEGKE.
OrthoDBiEOG091G0BL6.
PhylomeDBiQ8R3P0.
TreeFamiTF328708.

Family and domain databases

HAMAPiMF_00704. Aspartoacylase. 1 hit.
InterProiIPR016708. Aspartoacylase.
IPR007036. Aste_AspA.
[Graphical view]
PfamiPF04952. AstE_AspA. 1 hit.
[Graphical view]
PIRSFiPIRSF018001. Aspartoacylase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R3P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSCVAKEPI KKIAIFGGTH GNELTGVFLV THWLRNGTEV HRAGLDVKPF
60 70 80 90 100
ITNPRAVEKC TRYIDCDLNR VFDLENLSKE MSEDLPYEVR RAQEINHLFG
110 120 130 140 150
PKNSDDAYDL VFDLHNTTSN MGCTLILEDS RNDFLIQMFH YIKTCMAPLP
160 170 180 190 200
CSVYLIEHPS LKYATTRSIA KYPVGIEVGP QPHGVLRADI LDQMRKMIKH
210 220 230 240 250
ALDFIQHFNE GKEFPPCSID VYKIMEKVDY PRNESGDMAA VIHPNLQDQD
260 270 280 290 300
WKPLHPGDPV FVSLDGKVIP LGGDCTVYPV FVNEAAYYEK KEAFAKTTKL
310
TLSAKSIRST LH
Length:312
Mass (Da):35,345
Last modified:May 1, 2007 - v2
Checksum:iF09E710CC3107108
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110L → I in AAF76459 (PubMed:10837925).Curated1
Sequence conflicti110L → I in AAH24934 (PubMed:15489334).Curated1
Sequence conflicti153V → G in BAB25624 (PubMed:16141072).Curated1
Sequence conflicti160S → L in BAB25624 (PubMed:16141072).Curated1
Sequence conflicti275C → Y in BAB25624 (PubMed:16141072).Curated1
Sequence conflicti312H → P in AAF76459 (PubMed:10837925).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212998 mRNA. Translation: AAF76459.1.
AK002859 mRNA. Translation: BAB22412.1.
AK008354 mRNA. Translation: BAB25624.1.
AL645739 Genomic DNA. Translation: CAI24567.1.
BC024934 mRNA. Translation: AAH24934.1.
CCDSiCCDS25005.1.
RefSeqiNP_075602.2. NM_023113.5.
XP_006532073.2. XM_006532010.3.
XP_006532074.1. XM_006532011.2.
XP_006532075.1. XM_006532012.3.
UniGeneiMm.293574.

Genome annotation databases

EnsembliENSMUST00000021119; ENSMUSP00000021119; ENSMUSG00000020774.
ENSMUST00000184572; ENSMUSP00000139318; ENSMUSG00000020774.
GeneIDi11484.
KEGGimmu:11484.
UCSCiuc007kal.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212998 mRNA. Translation: AAF76459.1.
AK002859 mRNA. Translation: BAB22412.1.
AK008354 mRNA. Translation: BAB25624.1.
AL645739 Genomic DNA. Translation: CAI24567.1.
BC024934 mRNA. Translation: AAH24934.1.
CCDSiCCDS25005.1.
RefSeqiNP_075602.2. NM_023113.5.
XP_006532073.2. XM_006532010.3.
XP_006532074.1. XM_006532011.2.
XP_006532075.1. XM_006532012.3.
UniGeneiMm.293574.

3D structure databases

ProteinModelPortaliQ8R3P0.
SMRiQ8R3P0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R3P0. 1 interactor.
MINTiMINT-4086826.
STRINGi10090.ENSMUSP00000021119.

PTM databases

iPTMnetiQ8R3P0.
PhosphoSitePlusiQ8R3P0.

Proteomic databases

MaxQBiQ8R3P0.
PaxDbiQ8R3P0.
PeptideAtlasiQ8R3P0.
PRIDEiQ8R3P0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021119; ENSMUSP00000021119; ENSMUSG00000020774.
ENSMUST00000184572; ENSMUSP00000139318; ENSMUSG00000020774.
GeneIDi11484.
KEGGimmu:11484.
UCSCiuc007kal.2. mouse.

Organism-specific databases

CTDi443.
MGIiMGI:87914. Aspa.

Phylogenomic databases

eggNOGiENOG410IERR. Eukaryota.
COG2988. LUCA.
GeneTreeiENSGT00390000001189.
HOGENOMiHOG000232489.
HOVERGENiHBG004172.
InParanoidiQ8R3P0.
KOiK01437.
OMAiNFNEGKE.
OrthoDBiEOG091G0BL6.
PhylomeDBiQ8R3P0.
TreeFamiTF328708.

Enzyme and pathway databases

BRENDAi3.5.1.15. 3474.
ReactomeiR-MMU-70614. Amino acid synthesis and interconversion (transamination).

Miscellaneous databases

PROiQ8R3P0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020774.
CleanExiMM_ASPA.
ExpressionAtlasiQ8R3P0. baseline and differential.
GenevisibleiQ8R3P0. MM.

Family and domain databases

HAMAPiMF_00704. Aspartoacylase. 1 hit.
InterProiIPR016708. Aspartoacylase.
IPR007036. Aste_AspA.
[Graphical view]
PfamiPF04952. AstE_AspA. 1 hit.
[Graphical view]
PIRSFiPIRSF018001. Aspartoacylase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACY2_MOUSE
AccessioniPrimary (citable) accession number: Q8R3P0
Secondary accession number(s): Q5SV07
, Q9D876, Q9DCE2, Q9JIN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.