Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8R3L5

- SO3A1_MOUSE

UniProt

Q8R3L5 - SO3A1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Solute carrier organic anion transporter family member 3A1

Gene

Slco3a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent transport of organic anions. Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin.By similarity

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_210189. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 3A1
Alternative name(s):
MJAM
Organic anion-transporting polypeptide D
Short name:
OATP-D
Sodium-independent organic anion transporter D
Solute carrier family 21 member 11
Gene namesi
Name:Slco3a1
Synonyms:Oatp3a1, Oatpd, Slc21a11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1351867. Slco3a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei41 – 6020Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 7919ExtracellularSequence AnalysisAdd
BLAST
Transmembranei80 – 10021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini101 – 1066CytoplasmicSequence Analysis
Transmembranei107 – 13125Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini132 – 17443ExtracellularSequence AnalysisAdd
BLAST
Transmembranei175 – 20329Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini204 – 22219CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini244 – 26118ExtracellularSequence AnalysisAdd
BLAST
Transmembranei262 – 28625Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini287 – 34458CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei345 – 36622Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini367 – 38620ExtracellularSequence AnalysisAdd
BLAST
Transmembranei387 – 41024Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini411 – 4144CytoplasmicSequence Analysis
Transmembranei415 – 43824Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini439 – 539101ExtracellularSequence AnalysisAdd
BLAST
Transmembranei540 – 56223Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini563 – 5719CytoplasmicSequence Analysis
Transmembranei572 – 59726Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini598 – 63033ExtracellularSequence AnalysisAdd
BLAST
Transmembranei631 – 64818Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini649 – 70557CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710Solute carrier organic anion transporter family member 3A1PRO_0000191065Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi471 ↔ 497PROSITE-ProRule annotation
Disulfide bondi475 ↔ 486PROSITE-ProRule annotation
Disulfide bondi477 ↔ 501PROSITE-ProRule annotation
Glycosylationi502 – 5021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8R3L5.
PaxDbiQ8R3L5.
PRIDEiQ8R3L5.

PTM databases

PhosphoSiteiQ8R3L5.

Expressioni

Tissue specificityi

Widely expressed.

Inductioni

By androgens in kidney and lung.

Gene expression databases

BgeeiQ8R3L5.
ExpressionAtlasiQ8R3L5. baseline and differential.
GenevestigatoriQ8R3L5.

Structurei

3D structure databases

ProteinModelPortaliQ8R3L5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini465 – 51349Kazal-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 326Poly-Lys

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320775.
GeneTreeiENSGT00760000119014.
HOVERGENiHBG098539.
InParanoidiQ8R3L5.
KOiK14353.
OMAiPANQTHR.
OrthoDBiEOG7GQXV6.
PhylomeDBiQ8R3L5.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8R3L5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM
60 70 80 90 100
LAQGTVGAYL VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG
110 120 130 140 150
ARGHRPRLIG CGGIVMALGA LLSALPEFLT HQYKYEAGEI RWGAEGRDVC
160 170 180 190 200
ATNGSSSDEG PDPDLICRNR TATNMMYLLL IGAQVLLGIG ATPVQPLGVS
210 220 230 240 250
YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY VDAVFIDTSN
260 270 280 290 300
LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSDPGMESE
310 320 330 340 350
QAMLPEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV
360 370 380 390 400
FTCIVLAACM EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC
410 420 430 440 450
LGIFLGGLLV KKLSLSALGA IRMAMLVNLV STACYVSFLF LGCDTGPVAG
460 470 480 490 500
VTVRYGNNSA RGSALDPYSP CNNNCECQTD SFTPVCGADG ITYLSACFAG
510 520 530 540 550
CNSTNLTGCA CLTTVPPENA SVVPGKCPSP GCQEAFLTFL CVMCVCSLIG
560 570 580 590 600
AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST
610 620 630 640 650
CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK
660 670 680 690 700
NYKRYIKNHE GGLSTSEFFA STLTLDNLGR DPVPAHQTHR TKFIYNLEDH
710
EWCENMESVL
Length:710
Mass (Da):76,763
Last modified:June 1, 2002 - v1
Checksum:iAC89FB5026441C59
GO
Isoform 2 (identifier: Q8R3L5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-692: EFFASTLTLDNLGRDPVPAHQTHRTK → TEYQDIETEKTCPESQSPSEDSFVRS
     693-710: Missing.

Show »
Length:692
Mass (Da):74,551
Checksum:iE1EE6BC60FA23A43
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71G → D in AAF35370. 1 PublicationCurated
Sequence conflicti14 – 141R → G in BAE38670. (PubMed:16141072)Curated
Sequence conflicti138 – 1381G → V in AAF35370. 1 PublicationCurated
Sequence conflicti143 – 1431G → E in AAF35370. 1 PublicationCurated
Sequence conflicti147 – 1471R → T in AAF35370. 1 PublicationCurated
Sequence conflicti159 – 1602EG → DR in AAF35370. 1 PublicationCurated
Sequence conflicti178 – 1781L → M in AAF35370. 1 PublicationCurated
Sequence conflicti428 – 4281N → K in AAF35370. 1 PublicationCurated
Sequence conflicti603 – 6031F → L in AAF35370. 1 PublicationCurated
Sequence conflicti681 – 6811D → G in BAE31259. (PubMed:16141072)Curated
Sequence conflicti687 – 6871Q → L in BAE31259. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei667 – 69226EFFAS…THRTK → TEYQDIETEKTCPESQSPSE DSFVRS in isoform 2. 2 PublicationsVSP_036839Add
BLAST
Alternative sequencei693 – 71018Missing in isoform 2. 2 PublicationsVSP_036840Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226324 mRNA. Translation: AAF35370.1.
AK020010 mRNA. Translation: BAB31965.1.
AK037938 mRNA. Translation: BAC29904.1.
AK152488 mRNA. Translation: BAE31259.1.
AK166266 mRNA. Translation: BAE38670.1.
BC025059 mRNA. Translation: AAH25059.1.
BC094464 mRNA. Translation: AAH94464.1.
CCDSiCCDS21366.1. [Q8R3L5-2]
CCDS21367.1. [Q8R3L5-1]
RefSeqiNP_001033732.1. NM_001038643.1. [Q8R3L5-2]
NP_076397.2. NM_023908.2. [Q8R3L5-1]
UniGeneiMm.425467.

Genome annotation databases

EnsembliENSMUST00000026897; ENSMUSP00000026897; ENSMUSG00000025790. [Q8R3L5-1]
ENSMUST00000098371; ENSMUSP00000095973; ENSMUSG00000025790. [Q8R3L5-2]
GeneIDi108116.
KEGGimmu:108116.
UCSCiuc009hwf.1. mouse. [Q8R3L5-2]
uc009hwg.1. mouse. [Q8R3L5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226324 mRNA. Translation: AAF35370.1 .
AK020010 mRNA. Translation: BAB31965.1 .
AK037938 mRNA. Translation: BAC29904.1 .
AK152488 mRNA. Translation: BAE31259.1 .
AK166266 mRNA. Translation: BAE38670.1 .
BC025059 mRNA. Translation: AAH25059.1 .
BC094464 mRNA. Translation: AAH94464.1 .
CCDSi CCDS21366.1. [Q8R3L5-2 ]
CCDS21367.1. [Q8R3L5-1 ]
RefSeqi NP_001033732.1. NM_001038643.1. [Q8R3L5-2 ]
NP_076397.2. NM_023908.2. [Q8R3L5-1 ]
UniGenei Mm.425467.

3D structure databases

ProteinModelPortali Q8R3L5.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8R3L5.

Proteomic databases

MaxQBi Q8R3L5.
PaxDbi Q8R3L5.
PRIDEi Q8R3L5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026897 ; ENSMUSP00000026897 ; ENSMUSG00000025790 . [Q8R3L5-1 ]
ENSMUST00000098371 ; ENSMUSP00000095973 ; ENSMUSG00000025790 . [Q8R3L5-2 ]
GeneIDi 108116.
KEGGi mmu:108116.
UCSCi uc009hwf.1. mouse. [Q8R3L5-2 ]
uc009hwg.1. mouse. [Q8R3L5-1 ]

Organism-specific databases

CTDi 28232.
MGIi MGI:1351867. Slco3a1.

Phylogenomic databases

eggNOGi NOG320775.
GeneTreei ENSGT00760000119014.
HOVERGENi HBG098539.
InParanoidi Q8R3L5.
KOi K14353.
OMAi PANQTHR.
OrthoDBi EOG7GQXV6.
PhylomeDBi Q8R3L5.
TreeFami TF317540.

Enzyme and pathway databases

Reactomei REACT_210189. Transport of organic anions.

Miscellaneous databases

ChiTaRSi Slco3a1. mouse.
NextBioi 360100.
PROi Q8R3L5.
SOURCEi Search...

Gene expression databases

Bgeei Q8R3L5.
ExpressionAtlasi Q8R3L5. baseline and differential.
Genevestigatori Q8R3L5.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view ]
PANTHERi PTHR11388. PTHR11388. 1 hit.
Pfami PF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view ]
SMARTi SM00280. KAZAL. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 4 hits.
TIGRFAMsi TIGR00805. oat. 1 hit.
PROSITEi PS51465. KAZAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mus musculus organic anion transporting polypeptide MJAM."
    Isern J., Menoyo A., Melia M.J., Meseguer A.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-710 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Macrophage, Mammary gland and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-710 (ISOFORM 2).
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSO3A1_MOUSE
AccessioniPrimary (citable) accession number: Q8R3L5
Secondary accession number(s): Q3TLX2
, Q3U7W0, Q505P2, Q544H3, Q9CTV3, Q9JKV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2002
Last modified: November 26, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3