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Q8R3L5

- SO3A1_MOUSE

UniProt

Q8R3L5 - SO3A1_MOUSE

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Protein
Solute carrier organic anion transporter family member 3A1
Gene
Slco3a1, Oatp3a1, Oatpd, Slc21a11
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent transport of organic anions By similarity. Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin By similarity.

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_210189. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 3A1
Alternative name(s):
MJAM
Organic anion-transporting polypeptide D
Short name:
OATP-D
Sodium-independent organic anion transporter D
Solute carrier family 21 member 11
Gene namesi
Name:Slco3a1
Synonyms:Oatp3a1, Oatpd, Slc21a11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1351867. Slco3a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei41 – 6020Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini61 – 7919Extracellular Reviewed prediction
Add
BLAST
Transmembranei80 – 10021Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini101 – 1066Cytoplasmic Reviewed prediction
Transmembranei107 – 13125Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini132 – 17443Extracellular Reviewed prediction
Add
BLAST
Transmembranei175 – 20329Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini204 – 22219Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei223 – 24321Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini244 – 26118Extracellular Reviewed prediction
Add
BLAST
Transmembranei262 – 28625Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini287 – 34458Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei345 – 36622Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini367 – 38620Extracellular Reviewed prediction
Add
BLAST
Transmembranei387 – 41024Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini411 – 4144Cytoplasmic Reviewed prediction
Transmembranei415 – 43824Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini439 – 539101Extracellular Reviewed prediction
Add
BLAST
Transmembranei540 – 56223Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini563 – 5719Cytoplasmic Reviewed prediction
Transmembranei572 – 59726Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini598 – 63033Extracellular Reviewed prediction
Add
BLAST
Transmembranei631 – 64818Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini649 – 70557Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710Solute carrier organic anion transporter family member 3A1
PRO_0000191065Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi153 – 1531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi169 – 1691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi381 – 3811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi457 – 4571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi471 ↔ 497 By similarity
Disulfide bondi475 ↔ 486 By similarity
Disulfide bondi477 ↔ 501 By similarity
Glycosylationi502 – 5021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi505 – 5051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi519 – 5191N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8R3L5.
PRIDEiQ8R3L5.

PTM databases

PhosphoSiteiQ8R3L5.

Expressioni

Tissue specificityi

Widely expressed.

Inductioni

By androgens in kidney and lung.

Gene expression databases

ArrayExpressiQ8R3L5.
BgeeiQ8R3L5.
GenevestigatoriQ8R3L5.

Structurei

3D structure databases

ProteinModelPortaliQ8R3L5.
SMRiQ8R3L5. Positions 474-500.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini465 – 51349Kazal-like
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 326Poly-Lys

Sequence similaritiesi

Contains 1 Kazal-like domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320775.
GeneTreeiENSGT00740000114981.
HOVERGENiHBG098539.
InParanoidiQ3U7W0.
KOiK14353.
OMAiPANQTHR.
OrthoDBiEOG7GQXV6.
PhylomeDBiQ8R3L5.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8R3L5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM    50
LAQGTVGAYL VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG 100
ARGHRPRLIG CGGIVMALGA LLSALPEFLT HQYKYEAGEI RWGAEGRDVC 150
ATNGSSSDEG PDPDLICRNR TATNMMYLLL IGAQVLLGIG ATPVQPLGVS 200
YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY VDAVFIDTSN 250
LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSDPGMESE 300
QAMLPEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV 350
FTCIVLAACM EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC 400
LGIFLGGLLV KKLSLSALGA IRMAMLVNLV STACYVSFLF LGCDTGPVAG 450
VTVRYGNNSA RGSALDPYSP CNNNCECQTD SFTPVCGADG ITYLSACFAG 500
CNSTNLTGCA CLTTVPPENA SVVPGKCPSP GCQEAFLTFL CVMCVCSLIG 550
AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST 600
CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK 650
NYKRYIKNHE GGLSTSEFFA STLTLDNLGR DPVPAHQTHR TKFIYNLEDH 700
EWCENMESVL 710
Length:710
Mass (Da):76,763
Last modified:June 1, 2002 - v1
Checksum:iAC89FB5026441C59
GO
Isoform 2 (identifier: Q8R3L5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-692: EFFASTLTLDNLGRDPVPAHQTHRTK → TEYQDIETEKTCPESQSPSEDSFVRS
     693-710: Missing.

Show »
Length:692
Mass (Da):74,551
Checksum:iE1EE6BC60FA23A43
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei667 – 69226EFFAS…THRTK → TEYQDIETEKTCPESQSPSE DSFVRS in isoform 2.
VSP_036839Add
BLAST
Alternative sequencei693 – 71018Missing in isoform 2.
VSP_036840Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71G → D in AAF35370. 1 Publication
Sequence conflicti14 – 141R → G in BAE38670. 1 Publication
Sequence conflicti138 – 1381G → V in AAF35370. 1 Publication
Sequence conflicti143 – 1431G → E in AAF35370. 1 Publication
Sequence conflicti147 – 1471R → T in AAF35370. 1 Publication
Sequence conflicti159 – 1602EG → DR in AAF35370. 1 Publication
Sequence conflicti178 – 1781L → M in AAF35370. 1 Publication
Sequence conflicti428 – 4281N → K in AAF35370. 1 Publication
Sequence conflicti603 – 6031F → L in AAF35370. 1 Publication
Sequence conflicti681 – 6811D → G in BAE31259. 1 Publication
Sequence conflicti687 – 6871Q → L in BAE31259. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF226324 mRNA. Translation: AAF35370.1.
AK020010 mRNA. Translation: BAB31965.1.
AK037938 mRNA. Translation: BAC29904.1.
AK152488 mRNA. Translation: BAE31259.1.
AK166266 mRNA. Translation: BAE38670.1.
BC025059 mRNA. Translation: AAH25059.1.
BC094464 mRNA. Translation: AAH94464.1.
CCDSiCCDS21366.1. [Q8R3L5-2]
CCDS21367.1. [Q8R3L5-1]
RefSeqiNP_001033732.1. NM_001038643.1. [Q8R3L5-2]
NP_076397.2. NM_023908.2. [Q8R3L5-1]
UniGeneiMm.425467.

Genome annotation databases

EnsembliENSMUST00000026897; ENSMUSP00000026897; ENSMUSG00000025790. [Q8R3L5-1]
ENSMUST00000098371; ENSMUSP00000095973; ENSMUSG00000025790. [Q8R3L5-2]
GeneIDi108116.
KEGGimmu:108116.
UCSCiuc009hwf.1. mouse. [Q8R3L5-2]
uc009hwg.1. mouse. [Q8R3L5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF226324 mRNA. Translation: AAF35370.1 .
AK020010 mRNA. Translation: BAB31965.1 .
AK037938 mRNA. Translation: BAC29904.1 .
AK152488 mRNA. Translation: BAE31259.1 .
AK166266 mRNA. Translation: BAE38670.1 .
BC025059 mRNA. Translation: AAH25059.1 .
BC094464 mRNA. Translation: AAH94464.1 .
CCDSi CCDS21366.1. [Q8R3L5-2 ]
CCDS21367.1. [Q8R3L5-1 ]
RefSeqi NP_001033732.1. NM_001038643.1. [Q8R3L5-2 ]
NP_076397.2. NM_023908.2. [Q8R3L5-1 ]
UniGenei Mm.425467.

3D structure databases

ProteinModelPortali Q8R3L5.
SMRi Q8R3L5. Positions 474-500.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8R3L5.

Proteomic databases

PaxDbi Q8R3L5.
PRIDEi Q8R3L5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026897 ; ENSMUSP00000026897 ; ENSMUSG00000025790 . [Q8R3L5-1 ]
ENSMUST00000098371 ; ENSMUSP00000095973 ; ENSMUSG00000025790 . [Q8R3L5-2 ]
GeneIDi 108116.
KEGGi mmu:108116.
UCSCi uc009hwf.1. mouse. [Q8R3L5-2 ]
uc009hwg.1. mouse. [Q8R3L5-1 ]

Organism-specific databases

CTDi 28232.
MGIi MGI:1351867. Slco3a1.

Phylogenomic databases

eggNOGi NOG320775.
GeneTreei ENSGT00740000114981.
HOVERGENi HBG098539.
InParanoidi Q3U7W0.
KOi K14353.
OMAi PANQTHR.
OrthoDBi EOG7GQXV6.
PhylomeDBi Q8R3L5.
TreeFami TF317540.

Enzyme and pathway databases

Reactomei REACT_210189. Transport of organic anions.

Miscellaneous databases

ChiTaRSi SLCO3A1. mouse.
NextBioi 360100.
PROi Q8R3L5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8R3L5.
Bgeei Q8R3L5.
Genevestigatori Q8R3L5.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view ]
PANTHERi PTHR11388. PTHR11388. 1 hit.
Pfami PF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view ]
SMARTi SM00280. KAZAL. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 4 hits.
TIGRFAMsi TIGR00805. oat. 1 hit.
PROSITEi PS51465. KAZAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mus musculus organic anion transporting polypeptide MJAM."
    Isern J., Menoyo A., Melia M.J., Meseguer A.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-710 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Macrophage, Mammary gland and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-710 (ISOFORM 2).
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSO3A1_MOUSE
AccessioniPrimary (citable) accession number: Q8R3L5
Secondary accession number(s): Q3TLX2
, Q3U7W0, Q505P2, Q544H3, Q9CTV3, Q9JKV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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