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Protein

Solute carrier organic anion transporter family member 3A1

Gene

Slco3a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions. Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-879518. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 3A1
Alternative name(s):
MJAM
Organic anion-transporting polypeptide D
Short name:
OATP-D
Sodium-independent organic anion transporter D
Solute carrier family 21 member 11
Gene namesi
Name:Slco3a1
Synonyms:Oatp3a1, Oatpd, Slc21a11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1351867. Slco3a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
Transmembranei41 – 60Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini61 – 79ExtracellularSequence analysisAdd BLAST19
Transmembranei80 – 100Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini101 – 106CytoplasmicSequence analysis6
Transmembranei107 – 131Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini132 – 174ExtracellularSequence analysisAdd BLAST43
Transmembranei175 – 203Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini204 – 222CytoplasmicSequence analysisAdd BLAST19
Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini244 – 261ExtracellularSequence analysisAdd BLAST18
Transmembranei262 – 286Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini287 – 344CytoplasmicSequence analysisAdd BLAST58
Transmembranei345 – 366Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini367 – 386ExtracellularSequence analysisAdd BLAST20
Transmembranei387 – 410Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini411 – 414CytoplasmicSequence analysis4
Transmembranei415 – 438Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini439 – 539ExtracellularSequence analysisAdd BLAST101
Transmembranei540 – 562Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini563 – 571CytoplasmicSequence analysis9
Transmembranei572 – 597Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini598 – 630ExtracellularSequence analysisAdd BLAST33
Transmembranei631 – 648Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini649 – 705CytoplasmicSequence analysisAdd BLAST57

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910651 – 710Solute carrier organic anion transporter family member 3A1Add BLAST710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi153N-linked (GlcNAc...)Sequence analysis1
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi381N-linked (GlcNAc...)Sequence analysis1
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi471 ↔ 497PROSITE-ProRule annotation
Disulfide bondi475 ↔ 486PROSITE-ProRule annotation
Disulfide bondi477 ↔ 501PROSITE-ProRule annotation
Glycosylationi502N-linked (GlcNAc...)Sequence analysis1
Glycosylationi505N-linked (GlcNAc...)Sequence analysis1
Glycosylationi519N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8R3L5.
PRIDEiQ8R3L5.

PTM databases

iPTMnetiQ8R3L5.
PhosphoSitePlusiQ8R3L5.

Expressioni

Tissue specificityi

Widely expressed.

Inductioni

By androgens in kidney and lung.

Gene expression databases

BgeeiENSMUSG00000025790.
ExpressionAtlasiQ8R3L5. baseline and differential.
GenevisibleiQ8R3L5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026897.

Structurei

3D structure databases

ProteinModelPortaliQ8R3L5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini465 – 513Kazal-likePROSITE-ProRule annotationAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 32Poly-Lys6

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOVERGENiHBG098539.
InParanoidiQ8R3L5.
KOiK14353.
OMAiLKSSAFV.
OrthoDBiEOG091G03A9.
PhylomeDBiQ8R3L5.
TreeFamiTF317540.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R3L5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM
60 70 80 90 100
LAQGTVGAYL VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG
110 120 130 140 150
ARGHRPRLIG CGGIVMALGA LLSALPEFLT HQYKYEAGEI RWGAEGRDVC
160 170 180 190 200
ATNGSSSDEG PDPDLICRNR TATNMMYLLL IGAQVLLGIG ATPVQPLGVS
210 220 230 240 250
YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY VDAVFIDTSN
260 270 280 290 300
LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSDPGMESE
310 320 330 340 350
QAMLPEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV
360 370 380 390 400
FTCIVLAACM EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC
410 420 430 440 450
LGIFLGGLLV KKLSLSALGA IRMAMLVNLV STACYVSFLF LGCDTGPVAG
460 470 480 490 500
VTVRYGNNSA RGSALDPYSP CNNNCECQTD SFTPVCGADG ITYLSACFAG
510 520 530 540 550
CNSTNLTGCA CLTTVPPENA SVVPGKCPSP GCQEAFLTFL CVMCVCSLIG
560 570 580 590 600
AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST
610 620 630 640 650
CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK
660 670 680 690 700
NYKRYIKNHE GGLSTSEFFA STLTLDNLGR DPVPAHQTHR TKFIYNLEDH
710
EWCENMESVL
Length:710
Mass (Da):76,763
Last modified:June 1, 2002 - v1
Checksum:iAC89FB5026441C59
GO
Isoform 2 (identifier: Q8R3L5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-692: EFFASTLTLDNLGRDPVPAHQTHRTK → TEYQDIETEKTCPESQSPSEDSFVRS
     693-710: Missing.

Show »
Length:692
Mass (Da):74,551
Checksum:iE1EE6BC60FA23A43
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7G → D in AAF35370 (Ref. 1) Curated1
Sequence conflicti14R → G in BAE38670 (PubMed:16141072).Curated1
Sequence conflicti138G → V in AAF35370 (Ref. 1) Curated1
Sequence conflicti143G → E in AAF35370 (Ref. 1) Curated1
Sequence conflicti147R → T in AAF35370 (Ref. 1) Curated1
Sequence conflicti159 – 160EG → DR in AAF35370 (Ref. 1) Curated2
Sequence conflicti178L → M in AAF35370 (Ref. 1) Curated1
Sequence conflicti428N → K in AAF35370 (Ref. 1) Curated1
Sequence conflicti603F → L in AAF35370 (Ref. 1) Curated1
Sequence conflicti681D → G in BAE31259 (PubMed:16141072).Curated1
Sequence conflicti687Q → L in BAE31259 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036839667 – 692EFFAS…THRTK → TEYQDIETEKTCPESQSPSE DSFVRS in isoform 2. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_036840693 – 710Missing in isoform 2. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226324 mRNA. Translation: AAF35370.1.
AK020010 mRNA. Translation: BAB31965.1.
AK037938 mRNA. Translation: BAC29904.1.
AK152488 mRNA. Translation: BAE31259.1.
AK166266 mRNA. Translation: BAE38670.1.
BC025059 mRNA. Translation: AAH25059.1.
BC094464 mRNA. Translation: AAH94464.1.
CCDSiCCDS21366.1. [Q8R3L5-2]
CCDS21367.1. [Q8R3L5-1]
RefSeqiNP_001033732.1. NM_001038643.1. [Q8R3L5-2]
NP_076397.2. NM_023908.2. [Q8R3L5-1]
UniGeneiMm.425467.

Genome annotation databases

EnsembliENSMUST00000026897; ENSMUSP00000026897; ENSMUSG00000025790. [Q8R3L5-1]
ENSMUST00000098371; ENSMUSP00000095973; ENSMUSG00000025790. [Q8R3L5-2]
GeneIDi108116.
KEGGimmu:108116.
UCSCiuc009hwf.1. mouse. [Q8R3L5-2]
uc009hwg.1. mouse. [Q8R3L5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226324 mRNA. Translation: AAF35370.1.
AK020010 mRNA. Translation: BAB31965.1.
AK037938 mRNA. Translation: BAC29904.1.
AK152488 mRNA. Translation: BAE31259.1.
AK166266 mRNA. Translation: BAE38670.1.
BC025059 mRNA. Translation: AAH25059.1.
BC094464 mRNA. Translation: AAH94464.1.
CCDSiCCDS21366.1. [Q8R3L5-2]
CCDS21367.1. [Q8R3L5-1]
RefSeqiNP_001033732.1. NM_001038643.1. [Q8R3L5-2]
NP_076397.2. NM_023908.2. [Q8R3L5-1]
UniGeneiMm.425467.

3D structure databases

ProteinModelPortaliQ8R3L5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026897.

PTM databases

iPTMnetiQ8R3L5.
PhosphoSitePlusiQ8R3L5.

Proteomic databases

PaxDbiQ8R3L5.
PRIDEiQ8R3L5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026897; ENSMUSP00000026897; ENSMUSG00000025790. [Q8R3L5-1]
ENSMUST00000098371; ENSMUSP00000095973; ENSMUSG00000025790. [Q8R3L5-2]
GeneIDi108116.
KEGGimmu:108116.
UCSCiuc009hwf.1. mouse. [Q8R3L5-2]
uc009hwg.1. mouse. [Q8R3L5-1]

Organism-specific databases

CTDi28232.
MGIiMGI:1351867. Slco3a1.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOVERGENiHBG098539.
InParanoidiQ8R3L5.
KOiK14353.
OMAiLKSSAFV.
OrthoDBiEOG091G03A9.
PhylomeDBiQ8R3L5.
TreeFamiTF317540.

Enzyme and pathway databases

ReactomeiR-MMU-879518. Transport of organic anions.

Miscellaneous databases

ChiTaRSiSlco3a1. mouse.
PROiQ8R3L5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025790.
ExpressionAtlasiQ8R3L5. baseline and differential.
GenevisibleiQ8R3L5. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO3A1_MOUSE
AccessioniPrimary (citable) accession number: Q8R3L5
Secondary accession number(s): Q3TLX2
, Q3U7W0, Q505P2, Q544H3, Q9CTV3, Q9JKV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.