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Q8R3L5 (SO3A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier organic anion transporter family member 3A1
Alternative name(s):
MJAM
Organic anion-transporting polypeptide D
Short name=OATP-D
Sodium-independent organic anion transporter D
Solute carrier family 21 member 11
Gene names
Name:Slco3a1
Synonyms:Oatp3a1, Oatpd, Slc21a11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length710 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the Na+-independent transport of organic anions By similarity. Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Widely expressed.

Induction

By androgens in kidney and lung.

Sequence similarities

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]

Contains 1 Kazal-like domain.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_procession transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8R3L5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8R3L5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     667-692: EFFASTLTLDNLGRDPVPAHQTHRTK → TEYQDIETEKTCPESQSPSEDSFVRS
     693-710: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 710710Solute carrier organic anion transporter family member 3A1
PRO_0000191065

Regions

Topological domain1 – 4040Cytoplasmic Potential
Transmembrane41 – 6020Helical; Name=1; Potential
Topological domain61 – 7919Extracellular Potential
Transmembrane80 – 10021Helical; Name=2; Potential
Topological domain101 – 1066Cytoplasmic Potential
Transmembrane107 – 13125Helical; Name=3; Potential
Topological domain132 – 17443Extracellular Potential
Transmembrane175 – 20329Helical; Name=4; Potential
Topological domain204 – 22219Cytoplasmic Potential
Transmembrane223 – 24321Helical; Name=5; Potential
Topological domain244 – 26118Extracellular Potential
Transmembrane262 – 28625Helical; Name=6; Potential
Topological domain287 – 34458Cytoplasmic Potential
Transmembrane345 – 36622Helical; Name=7; Potential
Topological domain367 – 38620Extracellular Potential
Transmembrane387 – 41024Helical; Name=8; Potential
Topological domain411 – 4144Cytoplasmic Potential
Transmembrane415 – 43824Helical; Name=9; Potential
Topological domain439 – 539101Extracellular Potential
Transmembrane540 – 56223Helical; Name=10; Potential
Topological domain563 – 5719Cytoplasmic Potential
Transmembrane572 – 59726Helical; Name=11; Potential
Topological domain598 – 63033Extracellular Potential
Transmembrane631 – 64818Helical; Name=12; Potential
Topological domain649 – 70557Cytoplasmic Potential
Domain465 – 51349Kazal-like
Compositional bias27 – 326Poly-Lys

Amino acid modifications

Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation3811N-linked (GlcNAc...) Potential
Glycosylation4571N-linked (GlcNAc...) Potential
Glycosylation5021N-linked (GlcNAc...) Potential
Glycosylation5051N-linked (GlcNAc...) Potential
Glycosylation5191N-linked (GlcNAc...) Potential
Disulfide bond471 ↔ 497 By similarity
Disulfide bond475 ↔ 486 By similarity
Disulfide bond477 ↔ 501 By similarity

Natural variations

Alternative sequence667 – 69226EFFAS…THRTK → TEYQDIETEKTCPESQSPSE DSFVRS in isoform 2.
VSP_036839
Alternative sequence693 – 71018Missing in isoform 2.
VSP_036840

Experimental info

Sequence conflict71G → D in AAF35370. Ref.1
Sequence conflict141R → G in BAE38670. Ref.2
Sequence conflict1381G → V in AAF35370. Ref.1
Sequence conflict1431G → E in AAF35370. Ref.1
Sequence conflict1471R → T in AAF35370. Ref.1
Sequence conflict159 – 1602EG → DR in AAF35370. Ref.1
Sequence conflict1781L → M in AAF35370. Ref.1
Sequence conflict4281N → K in AAF35370. Ref.1
Sequence conflict6031F → L in AAF35370. Ref.1
Sequence conflict6811D → G in BAE31259. Ref.2
Sequence conflict6871Q → L in BAE31259. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: AC89FB5026441C59

FASTA71076,763
        10         20         30         40         50         60 
MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM LAQGTVGAYL 

        70         80         90        100        110        120 
VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG ARGHRPRLIG CGGIVMALGA 

       130        140        150        160        170        180 
LLSALPEFLT HQYKYEAGEI RWGAEGRDVC ATNGSSSDEG PDPDLICRNR TATNMMYLLL 

       190        200        210        220        230        240 
IGAQVLLGIG ATPVQPLGVS YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY 

       250        260        270        280        290        300 
VDAVFIDTSN LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSDPGMESE 

       310        320        330        340        350        360 
QAMLPEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV FTCIVLAACM 

       370        380        390        400        410        420 
EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC LGIFLGGLLV KKLSLSALGA 

       430        440        450        460        470        480 
IRMAMLVNLV STACYVSFLF LGCDTGPVAG VTVRYGNNSA RGSALDPYSP CNNNCECQTD 

       490        500        510        520        530        540 
SFTPVCGADG ITYLSACFAG CNSTNLTGCA CLTTVPPENA SVVPGKCPSP GCQEAFLTFL 

       550        560        570        580        590        600 
CVMCVCSLIG AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST 

       610        620        630        640        650        660 
CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK NYKRYIKNHE 

       670        680        690        700        710 
GGLSTSEFFA STLTLDNLGR DPVPAHQTHR TKFIYNLEDH EWCENMESVL 

« Hide

Isoform 2 [UniParc].

Checksum: E1EE6BC60FA23A43
Show »

FASTA69274,551

References

« Hide 'large scale' references
[1]"Mus musculus organic anion transporting polypeptide MJAM."
Isern J., Menoyo A., Melia M.J., Meseguer A.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Kidney.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-710 (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Macrophage, Mammary gland and Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-710 (ISOFORM 2).
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF226324 mRNA. Translation: AAF35370.1.
AK020010 mRNA. Translation: BAB31965.1.
AK037938 mRNA. Translation: BAC29904.1.
AK152488 mRNA. Translation: BAE31259.1.
AK166266 mRNA. Translation: BAE38670.1.
BC025059 mRNA. Translation: AAH25059.1.
BC094464 mRNA. Translation: AAH94464.1.
RefSeqNP_001033732.1. NM_001038643.1.
NP_076397.2. NM_023908.2.
UniGeneMm.425467.

3D structure databases

ProteinModelPortalQ8R3L5.
SMRQ8R3L5. Positions 213-238, 474-529.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8R3L5.

Proteomic databases

PaxDbQ8R3L5.
PRIDEQ8R3L5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026897; ENSMUSP00000026897; ENSMUSG00000025790. [Q8R3L5-1]
ENSMUST00000098371; ENSMUSP00000095973; ENSMUSG00000025790. [Q8R3L5-2]
GeneID108116.
KEGGmmu:108116.
UCSCuc009hwf.1. mouse. [Q8R3L5-2]
uc009hwg.1. mouse. [Q8R3L5-1]

Organism-specific databases

CTD28232.
MGIMGI:1351867. Slco3a1.

Phylogenomic databases

eggNOGNOG320775.
GeneTreeENSGT00740000114981.
HOVERGENHBG098539.
InParanoidQ3U7W0.
KOK14353.
OMAPANQTHR.
OrthoDBEOG7GQXV6.
PhylomeDBQ8R3L5.
TreeFamTF317540.

Gene expression databases

ArrayExpressQ8R3L5.
BgeeQ8R3L5.
GenevestigatorQ8R3L5.

Family and domain databases

InterProIPR002350. Kazal_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERPTHR11388. PTHR11388. 1 hit.
PfamPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 4 hits.
TIGRFAMsTIGR00805. oat. 1 hit.
PROSITEPS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLCO3A1. mouse.
NextBio360100.
PROQ8R3L5.
SOURCESearch...

Entry information

Entry nameSO3A1_MOUSE
AccessionPrimary (citable) accession number: Q8R3L5
Secondary accession number(s): Q3TLX2 expand/collapse secondary AC list , Q3U7W0, Q505P2, Q544H3, Q9CTV3, Q9JKV0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot