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Q8R3L5

- SO3A1_MOUSE

UniProt

Q8R3L5 - SO3A1_MOUSE

Protein

Solute carrier organic anion transporter family member 3A1

Gene

Slco3a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Mediates the Na+-independent transport of organic anions. Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin.By similarity

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_210189. Transport of organic anions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 3A1
    Alternative name(s):
    MJAM
    Organic anion-transporting polypeptide D
    Short name:
    OATP-D
    Sodium-independent organic anion transporter D
    Solute carrier family 21 member 11
    Gene namesi
    Name:Slco3a1
    Synonyms:Oatp3a1, Oatpd, Slc21a11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1351867. Slco3a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 710710Solute carrier organic anion transporter family member 3A1PRO_0000191065Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi471 ↔ 497PROSITE-ProRule annotation
    Disulfide bondi475 ↔ 486PROSITE-ProRule annotation
    Disulfide bondi477 ↔ 501PROSITE-ProRule annotation
    Glycosylationi502 – 5021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8R3L5.
    PRIDEiQ8R3L5.

    PTM databases

    PhosphoSiteiQ8R3L5.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Inductioni

    By androgens in kidney and lung.

    Gene expression databases

    ArrayExpressiQ8R3L5.
    BgeeiQ8R3L5.
    GenevestigatoriQ8R3L5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R3L5.
    SMRiQ8R3L5. Positions 474-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini61 – 7919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini101 – 1066CytoplasmicSequence Analysis
    Topological domaini132 – 17443ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini204 – 22219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini244 – 26118ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini287 – 34458CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini367 – 38620ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini411 – 4144CytoplasmicSequence Analysis
    Topological domaini439 – 539101ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini563 – 5719CytoplasmicSequence Analysis
    Topological domaini598 – 63033ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini649 – 70557CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6020Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei107 – 13125Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei175 – 20329Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei223 – 24321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 28625Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei345 – 36622Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei387 – 41024Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei415 – 43824Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei540 – 56223Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei572 – 59726Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei631 – 64818Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini465 – 51349Kazal-likePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 326Poly-Lys

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320775.
    GeneTreeiENSGT00740000114981.
    HOVERGENiHBG098539.
    InParanoidiQ3U7W0.
    KOiK14353.
    OMAiPANQTHR.
    OrthoDBiEOG7GQXV6.
    PhylomeDBiQ8R3L5.
    TreeFamiTF317540.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SMARTiSM00280. KAZAL. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 4 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8R3L5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM    50
    LAQGTVGAYL VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG 100
    ARGHRPRLIG CGGIVMALGA LLSALPEFLT HQYKYEAGEI RWGAEGRDVC 150
    ATNGSSSDEG PDPDLICRNR TATNMMYLLL IGAQVLLGIG ATPVQPLGVS 200
    YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY VDAVFIDTSN 250
    LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSDPGMESE 300
    QAMLPEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV 350
    FTCIVLAACM EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC 400
    LGIFLGGLLV KKLSLSALGA IRMAMLVNLV STACYVSFLF LGCDTGPVAG 450
    VTVRYGNNSA RGSALDPYSP CNNNCECQTD SFTPVCGADG ITYLSACFAG 500
    CNSTNLTGCA CLTTVPPENA SVVPGKCPSP GCQEAFLTFL CVMCVCSLIG 550
    AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST 600
    CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK 650
    NYKRYIKNHE GGLSTSEFFA STLTLDNLGR DPVPAHQTHR TKFIYNLEDH 700
    EWCENMESVL 710
    Length:710
    Mass (Da):76,763
    Last modified:June 1, 2002 - v1
    Checksum:iAC89FB5026441C59
    GO
    Isoform 2 (identifier: Q8R3L5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         667-692: EFFASTLTLDNLGRDPVPAHQTHRTK → TEYQDIETEKTCPESQSPSEDSFVRS
         693-710: Missing.

    Show »
    Length:692
    Mass (Da):74,551
    Checksum:iE1EE6BC60FA23A43
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71G → D in AAF35370. 1 PublicationCurated
    Sequence conflicti14 – 141R → G in BAE38670. (PubMed:16141072)Curated
    Sequence conflicti138 – 1381G → V in AAF35370. 1 PublicationCurated
    Sequence conflicti143 – 1431G → E in AAF35370. 1 PublicationCurated
    Sequence conflicti147 – 1471R → T in AAF35370. 1 PublicationCurated
    Sequence conflicti159 – 1602EG → DR in AAF35370. 1 PublicationCurated
    Sequence conflicti178 – 1781L → M in AAF35370. 1 PublicationCurated
    Sequence conflicti428 – 4281N → K in AAF35370. 1 PublicationCurated
    Sequence conflicti603 – 6031F → L in AAF35370. 1 PublicationCurated
    Sequence conflicti681 – 6811D → G in BAE31259. (PubMed:16141072)Curated
    Sequence conflicti687 – 6871Q → L in BAE31259. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei667 – 69226EFFAS…THRTK → TEYQDIETEKTCPESQSPSE DSFVRS in isoform 2. 2 PublicationsVSP_036839Add
    BLAST
    Alternative sequencei693 – 71018Missing in isoform 2. 2 PublicationsVSP_036840Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF226324 mRNA. Translation: AAF35370.1.
    AK020010 mRNA. Translation: BAB31965.1.
    AK037938 mRNA. Translation: BAC29904.1.
    AK152488 mRNA. Translation: BAE31259.1.
    AK166266 mRNA. Translation: BAE38670.1.
    BC025059 mRNA. Translation: AAH25059.1.
    BC094464 mRNA. Translation: AAH94464.1.
    CCDSiCCDS21366.1. [Q8R3L5-2]
    CCDS21367.1. [Q8R3L5-1]
    RefSeqiNP_001033732.1. NM_001038643.1. [Q8R3L5-2]
    NP_076397.2. NM_023908.2. [Q8R3L5-1]
    UniGeneiMm.425467.

    Genome annotation databases

    EnsembliENSMUST00000026897; ENSMUSP00000026897; ENSMUSG00000025790. [Q8R3L5-1]
    ENSMUST00000098371; ENSMUSP00000095973; ENSMUSG00000025790. [Q8R3L5-2]
    GeneIDi108116.
    KEGGimmu:108116.
    UCSCiuc009hwf.1. mouse. [Q8R3L5-2]
    uc009hwg.1. mouse. [Q8R3L5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF226324 mRNA. Translation: AAF35370.1 .
    AK020010 mRNA. Translation: BAB31965.1 .
    AK037938 mRNA. Translation: BAC29904.1 .
    AK152488 mRNA. Translation: BAE31259.1 .
    AK166266 mRNA. Translation: BAE38670.1 .
    BC025059 mRNA. Translation: AAH25059.1 .
    BC094464 mRNA. Translation: AAH94464.1 .
    CCDSi CCDS21366.1. [Q8R3L5-2 ]
    CCDS21367.1. [Q8R3L5-1 ]
    RefSeqi NP_001033732.1. NM_001038643.1. [Q8R3L5-2 ]
    NP_076397.2. NM_023908.2. [Q8R3L5-1 ]
    UniGenei Mm.425467.

    3D structure databases

    ProteinModelPortali Q8R3L5.
    SMRi Q8R3L5. Positions 474-500.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8R3L5.

    Proteomic databases

    PaxDbi Q8R3L5.
    PRIDEi Q8R3L5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026897 ; ENSMUSP00000026897 ; ENSMUSG00000025790 . [Q8R3L5-1 ]
    ENSMUST00000098371 ; ENSMUSP00000095973 ; ENSMUSG00000025790 . [Q8R3L5-2 ]
    GeneIDi 108116.
    KEGGi mmu:108116.
    UCSCi uc009hwf.1. mouse. [Q8R3L5-2 ]
    uc009hwg.1. mouse. [Q8R3L5-1 ]

    Organism-specific databases

    CTDi 28232.
    MGIi MGI:1351867. Slco3a1.

    Phylogenomic databases

    eggNOGi NOG320775.
    GeneTreei ENSGT00740000114981.
    HOVERGENi HBG098539.
    InParanoidi Q3U7W0.
    KOi K14353.
    OMAi PANQTHR.
    OrthoDBi EOG7GQXV6.
    PhylomeDBi Q8R3L5.
    TreeFami TF317540.

    Enzyme and pathway databases

    Reactomei REACT_210189. Transport of organic anions.

    Miscellaneous databases

    ChiTaRSi SLCO3A1. mouse.
    NextBioi 360100.
    PROi Q8R3L5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R3L5.
    Bgeei Q8R3L5.
    Genevestigatori Q8R3L5.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view ]
    PANTHERi PTHR11388. PTHR11388. 1 hit.
    Pfami PF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 4 hits.
    TIGRFAMsi TIGR00805. oat. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mus musculus organic anion transporting polypeptide MJAM."
      Isern J., Menoyo A., Melia M.J., Meseguer A.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Kidney.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-710 (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Macrophage, Mammary gland and Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-710 (ISOFORM 2).
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiSO3A1_MOUSE
    AccessioniPrimary (citable) accession number: Q8R3L5
    Secondary accession number(s): Q3TLX2
    , Q3U7W0, Q505P2, Q544H3, Q9CTV3, Q9JKV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3