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Q8R3J5

- CHAC1_MOUSE

UniProt

Q8R3J5 - CHAC1_MOUSE

Protein

Cation transport regulator-like protein 1

Gene

Chac1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (13 Jun 2012)
      Previous versions | rss
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    Functioni

    Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade.1 Publication

    GO - Molecular functioni

    1. Notch binding Source: UniProtKB

    GO - Biological processi

    1. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
    2. negative regulation of Notch signaling pathway Source: UniProtKB
    3. negative regulation of protein processing Source: UniProtKB
    4. neurogenesis Source: UniProtKB
    5. Notch signaling pathway Source: UniProtKB-KW
    6. response to unfolded protein Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Neurogenesis, Notch signaling pathway, Unfolded protein response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cation transport regulator-like protein 1
    Alternative name(s):
    Blocks Notch protein
    Short name:
    Botch
    Gene namesi
    Name:Chac1
    Synonyms:Botch
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1916315. Chac1.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Golgi apparatustrans-Golgi network 1 Publication

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 223223Cation transport regulator-like protein 1PRO_0000239011Add
    BLAST

    Proteomic databases

    PRIDEiQ8R3J5.

    PTM databases

    PhosphoSiteiQ8R3J5.

    Expressioni

    Tissue specificityi

    Widely expressed, with high expression in forebrain and anterior spinal cord. Expressed at intermediate level in the dorsal aorta and heart. Present throughout adult brain (at protein level).1 Publication

    Gene expression databases

    BgeeiQ8R3J5.
    CleanExiMM_CHAC1.
    GenevestigatoriQ8R3J5.

    Interactioni

    Subunit structurei

    Interacts with NOTCH1 (via extracellular region).1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R3J5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ChaC family.Curated

    Phylogenomic databases

    eggNOGiCOG3703.
    GeneTreeiENSGT00390000003855.
    HOGENOMiHOG000264264.
    HOVERGENiHBG056733.
    InParanoidiQ8R3J5.
    KOiK07232.
    OMAiGTMKQES.
    OrthoDBiEOG7F7W9F.
    TreeFamiTF313048.

    Family and domain databases

    Gene3Di3.10.490.10. 1 hit.
    InterProiIPR013024. Butirosin_synth_BtrG-like.
    IPR006840. ChaC.
    [Graphical view]
    PANTHERiPTHR12192. PTHR12192. 1 hit.
    PfamiPF04752. ChaC. 1 hit.
    [Graphical view]
    SUPFAMiSSF110857. SSF110857. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8R3J5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQESASQST PPPSLSPAPS SAQPSWGDGD PQALWIFGYG SLVWKPDFAY    50
    SDSRVGFVRG YSRRFWQGDT FHRGSDKMPG RVVTLLEDRE GCTWGVAYQV 100
    RGEQVNEALK YLNVREAVLG GYDTKEVTFY PQDTPDQPLT ALAYVATPQN 150
    PGYLGPAPEE VIATQILACR GFSGHNLEYL LRLADFMQLC GPQAQDEHLE 200
    AIVDAVGTLL PCSYLPEQPL ALT 223
    Length:223
    Mass (Da):24,547
    Last modified:June 13, 2012 - v2
    Checksum:i2DF793150C1C3B67
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251S → F in AAH25169. (PubMed:15489334)Curated
    Sequence conflicti89 – 891R → H in AAH25169. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007378 mRNA. Translation: BAB24997.1.
    AK032218 mRNA. Translation: BAC27764.1.
    AL929318 Genomic DNA. Translation: CAM25343.1.
    BC025169 mRNA. Translation: AAH25169.1.
    CCDSiCCDS16601.1.
    RefSeqiNP_081205.1. NM_026929.4.
    UniGeneiMm.35083.

    Genome annotation databases

    EnsembliENSMUST00000028780; ENSMUSP00000028780; ENSMUSG00000027313.
    GeneIDi69065.
    KEGGimmu:69065.
    UCSCiuc008lts.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007378 mRNA. Translation: BAB24997.1 .
    AK032218 mRNA. Translation: BAC27764.1 .
    AL929318 Genomic DNA. Translation: CAM25343.1 .
    BC025169 mRNA. Translation: AAH25169.1 .
    CCDSi CCDS16601.1.
    RefSeqi NP_081205.1. NM_026929.4.
    UniGenei Mm.35083.

    3D structure databases

    ProteinModelPortali Q8R3J5.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8R3J5.

    Proteomic databases

    PRIDEi Q8R3J5.

    Protocols and materials databases

    DNASUi 69065.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028780 ; ENSMUSP00000028780 ; ENSMUSG00000027313 .
    GeneIDi 69065.
    KEGGi mmu:69065.
    UCSCi uc008lts.3. mouse.

    Organism-specific databases

    CTDi 79094.
    MGIi MGI:1916315. Chac1.

    Phylogenomic databases

    eggNOGi COG3703.
    GeneTreei ENSGT00390000003855.
    HOGENOMi HOG000264264.
    HOVERGENi HBG056733.
    InParanoidi Q8R3J5.
    KOi K07232.
    OMAi GTMKQES.
    OrthoDBi EOG7F7W9F.
    TreeFami TF313048.

    Miscellaneous databases

    NextBioi 328512.
    PROi Q8R3J5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R3J5.
    CleanExi MM_CHAC1.
    Genevestigatori Q8R3J5.

    Family and domain databases

    Gene3Di 3.10.490.10. 1 hit.
    InterProi IPR013024. Butirosin_synth_BtrG-like.
    IPR006840. ChaC.
    [Graphical view ]
    PANTHERi PTHR12192. PTHR12192. 1 hit.
    Pfami PF04752. ChaC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110857. SSF110857. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Olfactory bulb and Pancreas.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH NOTCH1.

    Entry informationi

    Entry nameiCHAC1_MOUSE
    AccessioniPrimary (citable) accession number: Q8R3J5
    Secondary accession number(s): A2AV63, Q9D944
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3