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Q8R3J5 (CHAC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cation transport regulator-like protein 1
Alternative name(s):
Blocks Notch protein
Short name=Botch
Gene names
Name:Chac1
Synonyms:Botch
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Ref.4

Subunit structure

Interacts with NOTCH1 (via extracellular region). Ref.4

Subcellular location

Cytoplasmcytosol By similarity. Golgi apparatustrans-Golgi network Ref.4.

Tissue specificity

Widely expressed, with high expression in forebrain and anterior spinal cord. Expressed at intermediate level in the dorsal aorta and heart. Present throughout adult brain (at protein level). Ref.4

Sequence similarities

Belongs to the ChaC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223Cation transport regulator-like protein 1
PRO_0000239011

Experimental info

Sequence conflict251S → F in AAH25169. Ref.3
Sequence conflict891R → H in AAH25169. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8R3J5 [UniParc].

Last modified June 13, 2012. Version 2.
Checksum: 2DF793150C1C3B67

FASTA22324,547
        10         20         30         40         50         60 
MKQESASQST PPPSLSPAPS SAQPSWGDGD PQALWIFGYG SLVWKPDFAY SDSRVGFVRG 

        70         80         90        100        110        120 
YSRRFWQGDT FHRGSDKMPG RVVTLLEDRE GCTWGVAYQV RGEQVNEALK YLNVREAVLG 

       130        140        150        160        170        180 
GYDTKEVTFY PQDTPDQPLT ALAYVATPQN PGYLGPAPEE VIATQILACR GFSGHNLEYL 

       190        200        210        220 
LRLADFMQLC GPQAQDEHLE AIVDAVGTLL PCSYLPEQPL ALT 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Olfactory bulb and Pancreas.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[4]"Botch promotes neurogenesis by antagonizing Notch."
Chi Z., Zhang J., Tokunaga A., Harraz M.M., Byrne S.T., Dolinko A., Xu J., Blackshaw S., Gaiano N., Dawson T.M., Dawson V.L.
Dev. Cell 22:707-720(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH NOTCH1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK007378 mRNA. Translation: BAB24997.1.
AK032218 mRNA. Translation: BAC27764.1.
AL929318 Genomic DNA. Translation: CAM25343.1.
BC025169 mRNA. Translation: AAH25169.1.
RefSeqNP_081205.1. NM_026929.4.
UniGeneMm.35083.

3D structure databases

ProteinModelPortalQ8R3J5.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8R3J5.

Proteomic databases

PRIDEQ8R3J5.

Protocols and materials databases

DNASU69065.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028780; ENSMUSP00000028780; ENSMUSG00000027313.
GeneID69065.
KEGGmmu:69065.
UCSCuc008lts.3. mouse.

Organism-specific databases

CTD79094.
MGIMGI:1916315. Chac1.

Phylogenomic databases

eggNOGCOG3703.
GeneTreeENSGT00390000003855.
HOGENOMHOG000264264.
HOVERGENHBG056733.
InParanoidQ8R3J5.
KOK07232.
OMAGTMKQES.
OrthoDBEOG7F7W9F.
TreeFamTF313048.

Gene expression databases

BgeeQ8R3J5.
CleanExMM_CHAC1.
GenevestigatorQ8R3J5.

Family and domain databases

Gene3D3.10.490.10. 1 hit.
InterProIPR013024. Butirosin_synth_BtrG-like.
IPR006840. ChaC.
[Graphical view]
PANTHERPTHR12192. PTHR12192. 1 hit.
PfamPF04752. ChaC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio328512.
PROQ8R3J5.
SOURCESearch...

Entry information

Entry nameCHAC1_MOUSE
AccessionPrimary (citable) accession number: Q8R3J5
Secondary accession number(s): A2AV63, Q9D944
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 13, 2012
Last modified: February 19, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot