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Q8R3J5

- CHAC1_MOUSE

UniProt

Q8R3J5 - CHAC1_MOUSE

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Protein
Cation transport regulator-like protein 1
Gene
Chac1, Botch
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade.1 Publication

GO - Molecular functioni

  1. Notch binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. Notch signaling pathway Source: UniProtKB-KW
  2. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
  3. negative regulation of Notch signaling pathway Source: UniProtKB
  4. negative regulation of protein processing Source: UniProtKB
  5. neurogenesis Source: UniProtKB
  6. response to unfolded protein Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Neurogenesis, Notch signaling pathway, Unfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
Cation transport regulator-like protein 1
Alternative name(s):
Blocks Notch protein
Short name:
Botch
Gene namesi
Name:Chac1
Synonyms:Botch
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1916315. Chac1.

Subcellular locationi

Cytoplasmcytosol By similarity. Golgi apparatustrans-Golgi network 1 Publication

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Cation transport regulator-like protein 1
PRO_0000239011Add
BLAST

Proteomic databases

PRIDEiQ8R3J5.

PTM databases

PhosphoSiteiQ8R3J5.

Expressioni

Tissue specificityi

Widely expressed, with high expression in forebrain and anterior spinal cord. Expressed at intermediate level in the dorsal aorta and heart. Present throughout adult brain (at protein level).1 Publication

Gene expression databases

BgeeiQ8R3J5.
CleanExiMM_CHAC1.
GenevestigatoriQ8R3J5.

Interactioni

Subunit structurei

Interacts with NOTCH1 (via extracellular region).1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8R3J5.

Family & Domainsi

Sequence similaritiesi

Belongs to the ChaC family.

Phylogenomic databases

eggNOGiCOG3703.
GeneTreeiENSGT00390000003855.
HOGENOMiHOG000264264.
HOVERGENiHBG056733.
InParanoidiQ8R3J5.
KOiK07232.
OMAiGTMKQES.
OrthoDBiEOG7F7W9F.
TreeFamiTF313048.

Family and domain databases

Gene3Di3.10.490.10. 1 hit.
InterProiIPR013024. Butirosin_synth_BtrG-like.
IPR006840. ChaC.
[Graphical view]
PANTHERiPTHR12192. PTHR12192. 1 hit.
PfamiPF04752. ChaC. 1 hit.
[Graphical view]
SUPFAMiSSF110857. SSF110857. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R3J5-1 [UniParc]FASTAAdd to Basket

« Hide

MKQESASQST PPPSLSPAPS SAQPSWGDGD PQALWIFGYG SLVWKPDFAY    50
SDSRVGFVRG YSRRFWQGDT FHRGSDKMPG RVVTLLEDRE GCTWGVAYQV 100
RGEQVNEALK YLNVREAVLG GYDTKEVTFY PQDTPDQPLT ALAYVATPQN 150
PGYLGPAPEE VIATQILACR GFSGHNLEYL LRLADFMQLC GPQAQDEHLE 200
AIVDAVGTLL PCSYLPEQPL ALT 223
Length:223
Mass (Da):24,547
Last modified:June 13, 2012 - v2
Checksum:i2DF793150C1C3B67
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251S → F in AAH25169. 1 Publication
Sequence conflicti89 – 891R → H in AAH25169. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007378 mRNA. Translation: BAB24997.1.
AK032218 mRNA. Translation: BAC27764.1.
AL929318 Genomic DNA. Translation: CAM25343.1.
BC025169 mRNA. Translation: AAH25169.1.
CCDSiCCDS16601.1.
RefSeqiNP_081205.1. NM_026929.4.
UniGeneiMm.35083.

Genome annotation databases

EnsembliENSMUST00000028780; ENSMUSP00000028780; ENSMUSG00000027313.
GeneIDi69065.
KEGGimmu:69065.
UCSCiuc008lts.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007378 mRNA. Translation: BAB24997.1 .
AK032218 mRNA. Translation: BAC27764.1 .
AL929318 Genomic DNA. Translation: CAM25343.1 .
BC025169 mRNA. Translation: AAH25169.1 .
CCDSi CCDS16601.1.
RefSeqi NP_081205.1. NM_026929.4.
UniGenei Mm.35083.

3D structure databases

ProteinModelPortali Q8R3J5.
ModBasei Search...

PTM databases

PhosphoSitei Q8R3J5.

Proteomic databases

PRIDEi Q8R3J5.

Protocols and materials databases

DNASUi 69065.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028780 ; ENSMUSP00000028780 ; ENSMUSG00000027313 .
GeneIDi 69065.
KEGGi mmu:69065.
UCSCi uc008lts.3. mouse.

Organism-specific databases

CTDi 79094.
MGIi MGI:1916315. Chac1.

Phylogenomic databases

eggNOGi COG3703.
GeneTreei ENSGT00390000003855.
HOGENOMi HOG000264264.
HOVERGENi HBG056733.
InParanoidi Q8R3J5.
KOi K07232.
OMAi GTMKQES.
OrthoDBi EOG7F7W9F.
TreeFami TF313048.

Miscellaneous databases

NextBioi 328512.
PROi Q8R3J5.
SOURCEi Search...

Gene expression databases

Bgeei Q8R3J5.
CleanExi MM_CHAC1.
Genevestigatori Q8R3J5.

Family and domain databases

Gene3Di 3.10.490.10. 1 hit.
InterProi IPR013024. Butirosin_synth_BtrG-like.
IPR006840. ChaC.
[Graphical view ]
PANTHERi PTHR12192. PTHR12192. 1 hit.
Pfami PF04752. ChaC. 1 hit.
[Graphical view ]
SUPFAMi SSF110857. SSF110857. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Olfactory bulb and Pancreas.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH NOTCH1.

Entry informationi

Entry nameiCHAC1_MOUSE
AccessioniPrimary (citable) accession number: Q8R3J5
Secondary accession number(s): A2AV63, Q9D944
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 13, 2012
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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