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Protein

Transcription termination factor 3, mitochondrial

Gene

Mterf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds promoter DNA and regulates initiation of transcription (By similarity). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes (PubMed:17662942, PubMed:23300484). Required for normal mitochondrial function (PubMed:17662942, PubMed:23300484). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (PubMed:17662942, PubMed:23300484).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • developmental process Source: GO_Central
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • ribosome assembly Source: GO_Central
  • RNA splicing Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processRibosome biogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-5205685. Pink/Parkin Mediated Mitophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor 3, mitochondrial
Alternative name(s):
Mitochondrial transcription termination factor 3
Short name:
mTERF3
mTERF domain-containing protein 1, mitochondrial
Gene namesi
Name:Mterf3
Synonyms:Mterfd1
Ordered Locus Names:CGI-12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913660. Mterf3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality, due to severe mitochondrial dysfunction. Embryos are much smaller than normal and none survive past E10.5.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 67MitochondrionBy similarityAdd BLAST67
ChainiPRO_000025545868 – 412Transcription termination factor 3, mitochondrialAdd BLAST345

Proteomic databases

EPDiQ8R3J4.
MaxQBiQ8R3J4.
PaxDbiQ8R3J4.
PeptideAtlasiQ8R3J4.
PRIDEiQ8R3J4.

PTM databases

iPTMnetiQ8R3J4.
PhosphoSitePlusiQ8R3J4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021519.
CleanExiMM_MTERFD1.
ExpressionAtlasiQ8R3J4. baseline and differential.
GenevisibleiQ8R3J4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021991.

Structurei

3D structure databases

ProteinModelPortaliQ8R3J4.
SMRiQ8R3J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Contains seven structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a superhelical structure with a solenoid shape.By similarity

Sequence similaritiesi

Belongs to the mTERF family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1267. Eukaryota.
ENOG410XT49. LUCA.
GeneTreeiENSGT00390000005801.
HOGENOMiHOG000044443.
HOVERGENiHBG062577.
InParanoidiQ8R3J4.
KOiK15032.
OMAiNNFYFVR.
OrthoDBiEOG091G0AZ7.
PhylomeDBiQ8R3J4.
TreeFamiTF317943.

Family and domain databases

InterProiView protein in InterPro
IPR003690. MTERF.
PfamiView protein in Pfam
PF02536. mTERF. 1 hit.
SMARTiView protein in SMART
SM00733. Mterf. 6 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R3J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLAQQLPR RFNSVKLTSF IKAKQVTKRS ARAGKAVLPG FSAQPLLSSD
60 70 80 90 100
TSFLRRGIKT YRTLFWNRFH SASTNRTKSS AESTLLPSVA EQQERILSLE
110 120 130 140 150
SELPLEEVDD LPPLSPLQSV SEEEAIQIAA YSPLPISSFT LADYVDHSKT
160 170 180 190 200
LQKLVQLGVD LSKIEKHPDA ANLLLRLDFE KHIKQILLFL KDLGLEDNQL
210 220 230 240 250
GPFLTKNYAI FSEDLENLKT RVAYLQSKNF SKTDIARMVK NAPFLLSFSV
260 270 280 290 300
ERLDNRLGFF QKELELNVKK TRDLVVRLPR LLTGSLEPVK ENMKVYHLEL
310 320 330 340 350
GFKHNEIQHM VIKIPKMLTA NKRKLTEIFD YVHNVMNIPH HIIVKFPQLF
360 370 380 390 400
NTRVFKIKER HLFLAYLGRA QYDPAKPNYV SLDKFVSFPD KIFCKEIAKA
410
SLNDFEKFLK TL
Length:412
Mass (Da):47,357
Last modified:June 1, 2002 - v1
Checksum:iE85FAACAA83E1C59
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201 – 203GPF → DTY in BAB27006 (PubMed:16141072).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010525 mRNA. Translation: BAB27006.1.
AK011934 mRNA. Translation: BAB27924.3.
BC025173 mRNA. Translation: AAH25173.1.
BC085282 mRNA. Translation: AAH85282.1.
CCDSiCCDS26611.1.
RefSeqiNP_079823.2. NM_025547.3.
XP_006517384.1. XM_006517321.2.
XP_011242850.1. XM_011244548.2.
XP_017171052.1. XM_017315563.1.
UniGeneiMm.347939.

Genome annotation databases

EnsembliENSMUST00000021991; ENSMUSP00000021991; ENSMUSG00000021519.
GeneIDi66410.
KEGGimmu:66410.
UCSCiuc007qzw.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiMTEF3_MOUSE
AccessioniPrimary (citable) accession number: Q8R3J4
Secondary accession number(s): Q9CSV1, Q9CWM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2002
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families