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Protein

Conserved oligomeric Golgi complex subunit 6

Gene

Cog6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal Golgi function.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 6
Short name:
COG complex subunit 6
Alternative name(s):
Component of oligomeric Golgi complex 6
Gene namesi
Name:Cog6
Synonyms:Kiaa1134
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1914792. Cog6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002135141 – 657Conserved oligomeric Golgi complex subunit 6Add BLAST657

Proteomic databases

EPDiQ8R3I3.
MaxQBiQ8R3I3.
PaxDbiQ8R3I3.
PeptideAtlasiQ8R3I3.
PRIDEiQ8R3I3.

PTM databases

PhosphoSitePlusiQ8R3I3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027742.
CleanExiMM_COG6.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048603.

Structurei

3D structure databases

ProteinModelPortaliQ8R3I3.
SMRiQ8R3I3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG6 family.Curated

Phylogenomic databases

eggNOGiKOG3758. Eukaryota.
ENOG410Y72M. LUCA.
HOGENOMiHOG000265767.
HOVERGENiHBG025711.
InParanoidiQ8R3I3.
KOiK20293.
PhylomeDBiQ8R3I3.
TreeFamiTF314527.

Family and domain databases

InterProiIPR010490. COG6.
[Graphical view]
PANTHERiPTHR21506. PTHR21506. 1 hit.
SMARTiSM01087. COG6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R3I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADASGEVAA VPASGAANGF SNGAGATPAQ PNNPLSRKLH KILETRLEND
60 70 80 90 100
KEMLEALKAL SAFFVENSLR TRRNLRGDIE RRSLAINEEF VNIFKDVKEE
110 120 130 140 150
LESINEDVQA MSSCCQDMTS RLQAAKEQTQ DLIVKTTKLQ AENQRLEIRA
160 170 180 190 200
QVVDAFLAKF QLTSDEMSLL RGTRGGPVTE DFFKALGRVK QIHNDVKVLL
210 220 230 240 250
RTNQQTAGLE IMEQMALLQE TAYERLYRWA QSECRALTQE SCDVSAVLSQ
260 270 280 290 300
AMEALQDRPV LYKYTLDEFG TARRSTVVRG FIDALTRGGP GGTPRPIEMH
310 320 330 340 350
SHDPLRYVGD MLAWLHQATA SEKEHLEALL KHVTAQGVKE NIQEVVGHIT
360 370 380 390 400
EGVCRPLKVR IEQVILAEPG AVLLYKISNL LKFYHHTISG IVGNSAATLL
410 420 430 440 450
TTIEEMHLLS KKIFFTSLSL HANKLMDKVE LPPPDLGPSS ALSQTLTLLR
460 470 480 490 500
DILASHDSSV VPLDARQADF VQVLSCALDP LLQMCTVSAS NLGTADMATF
510 520 530 540 550
MVNSLYMMKT TLALFEFTDR RLEMLQFQIE AHLDTLINEQ ASYVLTRVGL
560 570 580 590 600
SYIYNTIQQH RPDQGSLANM PNLDAVALKA AMAQFDRYLS APDHLLMPQL
610 620 630 640 650
NSLLSATVKE QIIKQSTELI CRAYAEVHAA VMNPDNAYKD PENILHRSPE

QVKTLLS
Length:657
Mass (Da):73,040
Last modified:April 8, 2008 - v2
Checksum:iD305C8E5F623122C
GO

Sequence cautioni

The sequence AAH25427 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288G → E in AAH25427 (PubMed:15489334).Curated1
Sequence conflicti461V → I in BAE31900 (PubMed:16141072).Curated1
Sequence conflicti461V → I in BAC27280 (PubMed:16141072).Curated1
Sequence conflicti620I → V in BAB23168 (PubMed:16141072).Curated1
Sequence conflicti620I → V in BAE31900 (PubMed:16141072).Curated1
Sequence conflicti620I → V in BAC27280 (PubMed:16141072).Curated1
Sequence conflicti643N → S in BAB23168 (PubMed:16141072).Curated1
Sequence conflicti643N → S in BAE31900 (PubMed:16141072).Curated1
Sequence conflicti643N → S in BAC27280 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004100 mRNA. Translation: BAB23168.1.
AK031149 mRNA. Translation: BAC27280.1.
AK153320 mRNA. Translation: BAE31900.1.
AB093286 mRNA. Translation: BAC41470.1.
BC025427 mRNA. Translation: AAH25427.1. Different initiation.
CCDSiCCDS50905.1.
RefSeqiNP_080501.2. NM_026225.3.
UniGeneiMm.249548.

Genome annotation databases

GeneIDi67542.
KEGGimmu:67542.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004100 mRNA. Translation: BAB23168.1.
AK031149 mRNA. Translation: BAC27280.1.
AK153320 mRNA. Translation: BAE31900.1.
AB093286 mRNA. Translation: BAC41470.1.
BC025427 mRNA. Translation: AAH25427.1. Different initiation.
CCDSiCCDS50905.1.
RefSeqiNP_080501.2. NM_026225.3.
UniGeneiMm.249548.

3D structure databases

ProteinModelPortaliQ8R3I3.
SMRiQ8R3I3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048603.

PTM databases

PhosphoSitePlusiQ8R3I3.

Proteomic databases

EPDiQ8R3I3.
MaxQBiQ8R3I3.
PaxDbiQ8R3I3.
PeptideAtlasiQ8R3I3.
PRIDEiQ8R3I3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi67542.
KEGGimmu:67542.

Organism-specific databases

CTDi57511.
MGIiMGI:1914792. Cog6.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3758. Eukaryota.
ENOG410Y72M. LUCA.
HOGENOMiHOG000265767.
HOVERGENiHBG025711.
InParanoidiQ8R3I3.
KOiK20293.
PhylomeDBiQ8R3I3.
TreeFamiTF314527.

Miscellaneous databases

ChiTaRSiCog6. mouse.
PROiQ8R3I3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027742.
CleanExiMM_COG6.

Family and domain databases

InterProiIPR010490. COG6.
[Graphical view]
PANTHERiPTHR21506. PTHR21506. 1 hit.
SMARTiSM01087. COG6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOG6_MOUSE
AccessioniPrimary (citable) accession number: Q8R3I3
Secondary accession number(s): Q8BSN7, Q8CHB1, Q9CTA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.