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Q8R3G9

- TSN8_MOUSE

UniProt

Q8R3G9 - TSN8_MOUSE

Protein

Tetraspanin-8

Gene

Tspan8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. negative regulation of blood coagulation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-8
    Short name:
    Tspan-8
    Gene namesi
    Name:Tspan8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:2384918. Tspan8.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Tetraspanin-8PRO_0000415811Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8R3G9.
    PaxDbiQ8R3G9.
    PRIDEiQ8R3G9.

    PTM databases

    PhosphoSiteiQ8R3G9.

    Expressioni

    Gene expression databases

    BgeeiQ8R3G9.
    GenevestigatoriQ8R3G9.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8R3G9. 1 interaction.
    STRINGi10090.ENSMUSP00000049243.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini34 – 5219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini74 – 8411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini106 – 20398ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini225 – 23511CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG312327.
    GeneTreeiENSGT00740000115399.
    HOGENOMiHOG000230651.
    HOVERGENiHBG002324.
    InParanoidiQ8R3G9.
    KOiK17349.
    OMAiYKSCECS.
    OrthoDBiEOG7PGDRZ.
    PhylomeDBiQ8R3G9.
    TreeFamiTF352895.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R3G9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGVSSCLKY SMFFFNFLFW VCGTLILGLA IWVRVSKDGK EIITSGDSST    50
    NPFIAVNILI AVGSIIMVLG FLGCCGAVKE SRCMLLLFFI GLLLILILQV 100
    AAGILGAAFK PEYNRILNET LYENAKLLSD NTDEAKDFQK AMIVFQSEFK 150
    CCGLENGAAD WGNNFVEAKE SCQCTGTDCA TYQGSSVYPK TCLSLIKDLF 200
    EKNIIIVIGI AFGLAVIEIL GLVFSMVLYC QIGSK 235
    Length:235
    Mass (Da):25,582
    Last modified:June 1, 2002 - v1
    Checksum:i1660D73299D7B2EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126270 Genomic DNA. No translation available.
    AC153364 Genomic DNA. No translation available.
    CH466539 Genomic DNA. Translation: EDL21777.1.
    CH466539 Genomic DNA. Translation: EDL21778.1.
    CH466539 Genomic DNA. Translation: EDL21779.1.
    CH466539 Genomic DNA. Translation: EDL21780.1.
    BC025461 mRNA. Translation: AAH25461.1.
    BC027777 mRNA. Translation: AAH27777.1.
    BC029068 mRNA. Translation: AAH29068.1.
    BC029808 mRNA. Translation: AAH29808.1.
    BC034198 mRNA. Translation: AAH34198.1.
    CCDSiCCDS24181.1.
    RefSeqiNP_001162150.1. NM_001168679.1.
    NP_001162151.1. NM_001168680.1.
    NP_666122.1. NM_146010.2.
    XP_006513605.1. XM_006513542.1.
    UniGeneiMm.22270.

    Genome annotation databases

    EnsembliENSMUST00000035563; ENSMUSP00000049243; ENSMUSG00000034127.
    ENSMUST00000080630; ENSMUSP00000079463; ENSMUSG00000034127.
    ENSMUST00000179196; ENSMUSP00000136645; ENSMUSG00000034127.
    GeneIDi216350.
    KEGGimmu:216350.
    UCSCiuc007hbm.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126270 Genomic DNA. No translation available.
    AC153364 Genomic DNA. No translation available.
    CH466539 Genomic DNA. Translation: EDL21777.1 .
    CH466539 Genomic DNA. Translation: EDL21778.1 .
    CH466539 Genomic DNA. Translation: EDL21779.1 .
    CH466539 Genomic DNA. Translation: EDL21780.1 .
    BC025461 mRNA. Translation: AAH25461.1 .
    BC027777 mRNA. Translation: AAH27777.1 .
    BC029068 mRNA. Translation: AAH29068.1 .
    BC029808 mRNA. Translation: AAH29808.1 .
    BC034198 mRNA. Translation: AAH34198.1 .
    CCDSi CCDS24181.1.
    RefSeqi NP_001162150.1. NM_001168679.1.
    NP_001162151.1. NM_001168680.1.
    NP_666122.1. NM_146010.2.
    XP_006513605.1. XM_006513542.1.
    UniGenei Mm.22270.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8R3G9. 1 interaction.
    STRINGi 10090.ENSMUSP00000049243.

    PTM databases

    PhosphoSitei Q8R3G9.

    Proteomic databases

    MaxQBi Q8R3G9.
    PaxDbi Q8R3G9.
    PRIDEi Q8R3G9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035563 ; ENSMUSP00000049243 ; ENSMUSG00000034127 .
    ENSMUST00000080630 ; ENSMUSP00000079463 ; ENSMUSG00000034127 .
    ENSMUST00000179196 ; ENSMUSP00000136645 ; ENSMUSG00000034127 .
    GeneIDi 216350.
    KEGGi mmu:216350.
    UCSCi uc007hbm.2. mouse.

    Organism-specific databases

    CTDi 7103.
    MGIi MGI:2384918. Tspan8.

    Phylogenomic databases

    eggNOGi NOG312327.
    GeneTreei ENSGT00740000115399.
    HOGENOMi HOG000230651.
    HOVERGENi HBG002324.
    InParanoidi Q8R3G9.
    KOi K17349.
    OMAi YKSCECS.
    OrthoDBi EOG7PGDRZ.
    PhylomeDBi Q8R3G9.
    TreeFami TF352895.

    Miscellaneous databases

    NextBioi 375119.
    PROi Q8R3G9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R3G9.
    Genevestigatori Q8R3G9.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon and Mammary tumor.

    Entry informationi

    Entry nameiTSN8_MOUSE
    AccessioniPrimary (citable) accession number: Q8R3G9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2012
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3