Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8R3G9 (TSN8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetraspanin-8

Short name=Tspan-8
Gene names
Name:Tspan8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of blood coagulation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Tetraspanin-8
PRO_0000415811

Regions

Topological domain1 – 1212Cytoplasmic Potential
Transmembrane13 – 3321Helical; Potential
Topological domain34 – 5219Extracellular Potential
Transmembrane53 – 7321Helical; Potential
Topological domain74 – 8411Cytoplasmic Potential
Transmembrane85 – 10521Helical; Potential
Topological domain106 – 20398Extracellular Potential
Transmembrane204 – 22421Helical; Potential
Topological domain225 – 23511Cytoplasmic Potential

Amino acid modifications

Glycosylation1181N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8R3G9 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 1660D73299D7B2EB

FASTA23525,582
        10         20         30         40         50         60 
MAGVSSCLKY SMFFFNFLFW VCGTLILGLA IWVRVSKDGK EIITSGDSST NPFIAVNILI 

        70         80         90        100        110        120 
AVGSIIMVLG FLGCCGAVKE SRCMLLLFFI GLLLILILQV AAGILGAAFK PEYNRILNET 

       130        140        150        160        170        180 
LYENAKLLSD NTDEAKDFQK AMIVFQSEFK CCGLENGAAD WGNNFVEAKE SCQCTGTDCA 

       190        200        210        220        230 
TYQGSSVYPK TCLSLIKDLF EKNIIIVIGI AFGLAVIEIL GLVFSMVLYC QIGSK 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC126270 Genomic DNA. No translation available.
AC153364 Genomic DNA. No translation available.
CH466539 Genomic DNA. Translation: EDL21777.1.
CH466539 Genomic DNA. Translation: EDL21778.1.
CH466539 Genomic DNA. Translation: EDL21779.1.
CH466539 Genomic DNA. Translation: EDL21780.1.
BC025461 mRNA. Translation: AAH25461.1.
BC027777 mRNA. Translation: AAH27777.1.
BC029068 mRNA. Translation: AAH29068.1.
BC029808 mRNA. Translation: AAH29808.1.
BC034198 mRNA. Translation: AAH34198.1.
RefSeqNP_001162150.1. NM_001168679.1.
NP_001162151.1. NM_001168680.1.
NP_666122.1. NM_146010.2.
XP_006513605.1. XM_006513542.1.
UniGeneMm.22270.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8R3G9. 1 interaction.
STRING10090.ENSMUSP00000049243.

PTM databases

PhosphoSiteQ8R3G9.

Proteomic databases

PaxDbQ8R3G9.
PRIDEQ8R3G9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000035563; ENSMUSP00000049243; ENSMUSG00000034127.
ENSMUST00000080630; ENSMUSP00000079463; ENSMUSG00000034127.
ENSMUST00000179196; ENSMUSP00000136645; ENSMUSG00000034127.
GeneID216350.
KEGGmmu:216350.
UCSCuc007hbm.2. mouse.

Organism-specific databases

CTD7103.
MGIMGI:2384918. Tspan8.

Phylogenomic databases

eggNOGNOG312327.
GeneTreeENSGT00740000115399.
HOGENOMHOG000230651.
HOVERGENHBG002324.
InParanoidQ8R3G9.
KOK17349.
OMAYENTKLL.
OrthoDBEOG7PGDRZ.
PhylomeDBQ8R3G9.
TreeFamTF352895.

Gene expression databases

BgeeQ8R3G9.
GenevestigatorQ8R3G9.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio375119.
PROQ8R3G9.
SOURCESearch...

Entry information

Entry nameTSN8_MOUSE
AccessionPrimary (citable) accession number: Q8R3G9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot