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Protein

Tetraspanin-8

Gene

Tspan8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-8
Short name:
Tspan-8
Gene namesi
Name:Tspan8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2384918. Tspan8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Topological domaini34 – 5219ExtracellularSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Topological domaini74 – 8411CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Topological domaini106 – 20398ExtracellularSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Topological domaini225 – 23511CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Tetraspanin-8PRO_0000415811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8R3G9.
PaxDbiQ8R3G9.
PRIDEiQ8R3G9.

PTM databases

PhosphoSiteiQ8R3G9.

Expressioni

Gene expression databases

BgeeiQ8R3G9.
GenevisibleiQ8R3G9. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8R3G9. 1 interaction.
STRINGi10090.ENSMUSP00000049243.

Structurei

3D structure databases

ProteinModelPortaliQ8R3G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG312327.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ8R3G9.
KOiK17349.
OMAiNYKSCEC.
OrthoDBiEOG7PGDRZ.
PhylomeDBiQ8R3G9.
TreeFamiTF352895.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R3G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVSSCLKY SMFFFNFLFW VCGTLILGLA IWVRVSKDGK EIITSGDSST
60 70 80 90 100
NPFIAVNILI AVGSIIMVLG FLGCCGAVKE SRCMLLLFFI GLLLILILQV
110 120 130 140 150
AAGILGAAFK PEYNRILNET LYENAKLLSD NTDEAKDFQK AMIVFQSEFK
160 170 180 190 200
CCGLENGAAD WGNNFVEAKE SCQCTGTDCA TYQGSSVYPK TCLSLIKDLF
210 220 230
EKNIIIVIGI AFGLAVIEIL GLVFSMVLYC QIGSK
Length:235
Mass (Da):25,582
Last modified:June 1, 2002 - v1
Checksum:i1660D73299D7B2EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126270 Genomic DNA. No translation available.
AC153364 Genomic DNA. No translation available.
CH466539 Genomic DNA. Translation: EDL21777.1.
CH466539 Genomic DNA. Translation: EDL21778.1.
CH466539 Genomic DNA. Translation: EDL21779.1.
CH466539 Genomic DNA. Translation: EDL21780.1.
BC025461 mRNA. Translation: AAH25461.1.
BC027777 mRNA. Translation: AAH27777.1.
BC029068 mRNA. Translation: AAH29068.1.
BC029808 mRNA. Translation: AAH29808.1.
BC034198 mRNA. Translation: AAH34198.1.
CCDSiCCDS24181.1.
RefSeqiNP_001162150.1. NM_001168679.1.
NP_001162151.1. NM_001168680.1.
NP_666122.1. NM_146010.2.
XP_006513605.1. XM_006513542.1.
UniGeneiMm.22270.

Genome annotation databases

EnsembliENSMUST00000035563; ENSMUSP00000049243; ENSMUSG00000034127.
ENSMUST00000080630; ENSMUSP00000079463; ENSMUSG00000034127.
ENSMUST00000179196; ENSMUSP00000136645; ENSMUSG00000034127.
GeneIDi216350.
KEGGimmu:216350.
UCSCiuc007hbm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126270 Genomic DNA. No translation available.
AC153364 Genomic DNA. No translation available.
CH466539 Genomic DNA. Translation: EDL21777.1.
CH466539 Genomic DNA. Translation: EDL21778.1.
CH466539 Genomic DNA. Translation: EDL21779.1.
CH466539 Genomic DNA. Translation: EDL21780.1.
BC025461 mRNA. Translation: AAH25461.1.
BC027777 mRNA. Translation: AAH27777.1.
BC029068 mRNA. Translation: AAH29068.1.
BC029808 mRNA. Translation: AAH29808.1.
BC034198 mRNA. Translation: AAH34198.1.
CCDSiCCDS24181.1.
RefSeqiNP_001162150.1. NM_001168679.1.
NP_001162151.1. NM_001168680.1.
NP_666122.1. NM_146010.2.
XP_006513605.1. XM_006513542.1.
UniGeneiMm.22270.

3D structure databases

ProteinModelPortaliQ8R3G9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R3G9. 1 interaction.
STRINGi10090.ENSMUSP00000049243.

PTM databases

PhosphoSiteiQ8R3G9.

Proteomic databases

MaxQBiQ8R3G9.
PaxDbiQ8R3G9.
PRIDEiQ8R3G9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035563; ENSMUSP00000049243; ENSMUSG00000034127.
ENSMUST00000080630; ENSMUSP00000079463; ENSMUSG00000034127.
ENSMUST00000179196; ENSMUSP00000136645; ENSMUSG00000034127.
GeneIDi216350.
KEGGimmu:216350.
UCSCiuc007hbm.2. mouse.

Organism-specific databases

CTDi7103.
MGIiMGI:2384918. Tspan8.

Phylogenomic databases

eggNOGiNOG312327.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ8R3G9.
KOiK17349.
OMAiNYKSCEC.
OrthoDBiEOG7PGDRZ.
PhylomeDBiQ8R3G9.
TreeFamiTF352895.

Miscellaneous databases

NextBioi375119.
PROiQ8R3G9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R3G9.
GenevisibleiQ8R3G9. MM.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Mammary tumor.

Entry informationi

Entry nameiTSN8_MOUSE
AccessioniPrimary (citable) accession number: Q8R3G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: June 1, 2002
Last modified: July 22, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.