Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8R3G9

- TSN8_MOUSE

UniProt

Q8R3G9 - TSN8_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Tetraspanin-8

Gene

Tspan8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. negative regulation of blood coagulation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-8
Short name:
Tspan-8
Gene namesi
Name:Tspan8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:2384918. Tspan8.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Tetraspanin-8PRO_0000415811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8R3G9.
PaxDbiQ8R3G9.
PRIDEiQ8R3G9.

PTM databases

PhosphoSiteiQ8R3G9.

Expressioni

Gene expression databases

BgeeiQ8R3G9.
GenevestigatoriQ8R3G9.

Interactioni

Protein-protein interaction databases

IntActiQ8R3G9. 1 interaction.
STRINGi10090.ENSMUSP00000049243.

Structurei

3D structure databases

ProteinModelPortaliQ8R3G9.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini34 – 5219ExtracellularSequence AnalysisAdd
BLAST
Topological domaini74 – 8411CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini106 – 20398ExtracellularSequence AnalysisAdd
BLAST
Topological domaini225 – 23511CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG312327.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ8R3G9.
KOiK17349.
OMAiYKSCECS.
OrthoDBiEOG7PGDRZ.
PhylomeDBiQ8R3G9.
TreeFamiTF352895.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R3G9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGVSSCLKY SMFFFNFLFW VCGTLILGLA IWVRVSKDGK EIITSGDSST
60 70 80 90 100
NPFIAVNILI AVGSIIMVLG FLGCCGAVKE SRCMLLLFFI GLLLILILQV
110 120 130 140 150
AAGILGAAFK PEYNRILNET LYENAKLLSD NTDEAKDFQK AMIVFQSEFK
160 170 180 190 200
CCGLENGAAD WGNNFVEAKE SCQCTGTDCA TYQGSSVYPK TCLSLIKDLF
210 220 230
EKNIIIVIGI AFGLAVIEIL GLVFSMVLYC QIGSK
Length:235
Mass (Da):25,582
Last modified:June 1, 2002 - v1
Checksum:i1660D73299D7B2EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126270 Genomic DNA. No translation available.
AC153364 Genomic DNA. No translation available.
CH466539 Genomic DNA. Translation: EDL21777.1.
CH466539 Genomic DNA. Translation: EDL21778.1.
CH466539 Genomic DNA. Translation: EDL21779.1.
CH466539 Genomic DNA. Translation: EDL21780.1.
BC025461 mRNA. Translation: AAH25461.1.
BC027777 mRNA. Translation: AAH27777.1.
BC029068 mRNA. Translation: AAH29068.1.
BC029808 mRNA. Translation: AAH29808.1.
BC034198 mRNA. Translation: AAH34198.1.
CCDSiCCDS24181.1.
RefSeqiNP_001162150.1. NM_001168679.1.
NP_001162151.1. NM_001168680.1.
NP_666122.1. NM_146010.2.
XP_006513605.1. XM_006513542.1.
UniGeneiMm.22270.

Genome annotation databases

EnsembliENSMUST00000035563; ENSMUSP00000049243; ENSMUSG00000034127.
ENSMUST00000080630; ENSMUSP00000079463; ENSMUSG00000034127.
ENSMUST00000179196; ENSMUSP00000136645; ENSMUSG00000034127.
GeneIDi216350.
KEGGimmu:216350.
UCSCiuc007hbm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126270 Genomic DNA. No translation available.
AC153364 Genomic DNA. No translation available.
CH466539 Genomic DNA. Translation: EDL21777.1 .
CH466539 Genomic DNA. Translation: EDL21778.1 .
CH466539 Genomic DNA. Translation: EDL21779.1 .
CH466539 Genomic DNA. Translation: EDL21780.1 .
BC025461 mRNA. Translation: AAH25461.1 .
BC027777 mRNA. Translation: AAH27777.1 .
BC029068 mRNA. Translation: AAH29068.1 .
BC029808 mRNA. Translation: AAH29808.1 .
BC034198 mRNA. Translation: AAH34198.1 .
CCDSi CCDS24181.1.
RefSeqi NP_001162150.1. NM_001168679.1.
NP_001162151.1. NM_001168680.1.
NP_666122.1. NM_146010.2.
XP_006513605.1. XM_006513542.1.
UniGenei Mm.22270.

3D structure databases

ProteinModelPortali Q8R3G9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8R3G9. 1 interaction.
STRINGi 10090.ENSMUSP00000049243.

PTM databases

PhosphoSitei Q8R3G9.

Proteomic databases

MaxQBi Q8R3G9.
PaxDbi Q8R3G9.
PRIDEi Q8R3G9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035563 ; ENSMUSP00000049243 ; ENSMUSG00000034127 .
ENSMUST00000080630 ; ENSMUSP00000079463 ; ENSMUSG00000034127 .
ENSMUST00000179196 ; ENSMUSP00000136645 ; ENSMUSG00000034127 .
GeneIDi 216350.
KEGGi mmu:216350.
UCSCi uc007hbm.2. mouse.

Organism-specific databases

CTDi 7103.
MGIi MGI:2384918. Tspan8.

Phylogenomic databases

eggNOGi NOG312327.
GeneTreei ENSGT00760000118983.
HOGENOMi HOG000230651.
HOVERGENi HBG002324.
InParanoidi Q8R3G9.
KOi K17349.
OMAi YKSCECS.
OrthoDBi EOG7PGDRZ.
PhylomeDBi Q8R3G9.
TreeFami TF352895.

Miscellaneous databases

NextBioi 375119.
PROi Q8R3G9.
SOURCEi Search...

Gene expression databases

Bgeei Q8R3G9.
Genevestigatori Q8R3G9.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Mammary tumor.

Entry informationi

Entry nameiTSN8_MOUSE
AccessioniPrimary (citable) accession number: Q8R3G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3