Q8R3F5 (FABD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial
Short name=MCT
EC=2.3.1.39

Alternative name(s):
Mitochondrial malonyltransferase
[Acyl-carrier-protein] malonyltransferase

Gene names

Name:	Mcat
Synonyms:	Mt

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias By similarity.
Catalytic activity	Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the type II malonyltransferase family.
Sequence caution	The sequence AAH25519.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from direct assay. Source: MGI
Molecular function	[acyl-carrier-protein] S-malonyltransferase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 381		Malonyl-CoA-acyl carrier protein transacylase, mitochondrial		PRO_0000042239
Sites
	Active site	151	1	By similarity
	Active site	268	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8R3F5 [UniParc]. Last modified October 11, 2005. Version 3. Checksum: 7024C1EBAF95B1EE	FASTA	381	41,928
	10 20 30 40 50 60 MSARVARAGW AWRSWGRRAA SSLREPPPDA VDVAELLRDS SVAEEGAQEA VARRRPPSQC 70 80 90 100 110 120 SVLLFPGQGC QAVGMGSGLL HLPRVRQLYE AAHRVLGYDL LELCLRGPQE DLDRTVHCQP 130 140 150 160 170 180 AVFVASLAAV EKLHHLQPAV IDNCVAAAGF SVGEFAALVF AGAMDFSEGL YAVKARAEAM 190 200 210 220 230 240 QEASEAVPSG MLSVLGQRQS NFSFACLEAQ EHCKSLGIEN PVCQVSNYLF PDCRVISGHL 250 260 270 280 290 300 EALQFLRRNS AKYHFRRTKM LPVSGGFHTC LMEPAVDPLM KVLGSINIKK PLVAVHSNVS 310 320 330 340 350 360 GQKYTHPQHI RKLLGQQVVS PVKWEQTMHS IYERKKGMEF PSTYEVGPGQ QLGSILKCCN 370 380 RQAWKSYSHV DVMQNIMDPD P

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thyroid.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC099494 mRNA. Translation: AAH99494.1. BC025519 mRNA. Translation: AAH25519.1. Different initiation.
IPI	IPI00342938.
RefSeq	NP_001025185.1. NM_001030014.2.
UniGene	Mm.37560.
3D structure databases
ProteinModelPortal	Q8R3F5.
SMR	Q8R3F5. Positions 59-373.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8R3F5.
PTM databases
PhosphoSite	Q8R3F5.
Proteomic databases
PRIDE	Q8R3F5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000061882; ENSMUSP00000051569; ENSMUSG00000048755.
GeneID	223722.
KEGG	mmu:223722.
UCSC	uc007xbf.1. mouse.
Organism-specific databases
CTD	27349.
MGI	MGI:2388651. Mcat.
Phylogenomic databases
eggNOG	roNOG16466.
GeneTree	ENSGT00390000013715.
HOGENOM	HBG687898.
HOVERGEN	HBG051540.
InParanoid	Q8R3F5.
OMA	EAQEHCK.
OrthoDB	EOG4X6C8N.
Gene expression databases
ArrayExpress	Q8R3F5.
Bgee	Q8R3F5.
CleanEx	MM_MCAT.
Genevestigator	Q8R3F5.
GermOnline	ENSMUSG00000048755. Mus musculus.
Family and domain databases
InterPro	IPR001227. Ac_transferase_dom. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR016036. Malonyl_transacylase_ACP-bd. [Graphical view]
Gene3D	G3DSA:3.40.366.10. Ac_transferase_reg. 2 hits.
KO	K00645.
Pfam	PF00698. Acyl_transf_1. 1 hit. [Graphical view]
SUPFAM	SSF52151. Acyl_Trfase/lysoPlipase. 1 hit. SSF55048. Malonyl_transacylase_ACP-bd. 1 hit.
ProtoNet	Search...
Other
NextBio	376844.
SOURCE	Search...

Entry information

Entry name

FABD_MOUSE

Accession

Primary (citable) accession number: Q8R3F5
Secondary accession number(s): Q4FZH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	October 11, 2005
Last modified:	November 16, 2011
This is version 69 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program