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Q8R3F5

- FABD_MOUSE

UniProt

Q8R3F5 - FABD_MOUSE

Protein

Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

Gene

Mcat

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 3 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias By similarity.By similarity

    Catalytic activityi

    Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei151 – 1511By similarity
    Active sitei268 – 2681By similarity

    GO - Molecular functioni

    1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (EC:2.3.1.39)
    Short name:
    MCT
    Alternative name(s):
    Mitochondrial malonyltransferase
    [Acyl-carrier-protein] malonyltransferase
    Gene namesi
    Name:Mcat
    Synonyms:Mt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2388651. Mcat.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 381Malonyl-CoA-acyl carrier protein transacylase, mitochondrialPRO_0000042239
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei312 – 3121N6-succinyllysine1 Publication

    Proteomic databases

    MaxQBiQ8R3F5.
    PaxDbiQ8R3F5.
    PRIDEiQ8R3F5.

    PTM databases

    PhosphoSiteiQ8R3F5.

    Expressioni

    Gene expression databases

    BgeeiQ8R3F5.
    CleanExiMM_MCAT.
    GenevestigatoriQ8R3F5.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8R3F5. 1 interaction.
    MINTiMINT-4094897.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R3F5.
    SMRiQ8R3F5. Positions 3-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type II malonyltransferase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0331.
    GeneTreeiENSGT00390000013715.
    HOGENOMiHOG000036504.
    HOVERGENiHBG051540.
    InParanoidiQ8R3F5.
    KOiK00645.
    OMAiDIMFSGS.
    OrthoDBiEOG7D85X6.
    PhylomeDBiQ8R3F5.
    TreeFamiTF313401.

    Family and domain databases

    Gene3Di3.40.366.10. 2 hits.
    InterProiIPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8R3F5-1 [UniParc]FASTAAdd to Basket

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    MSARVARAGW AWRSWGRRAA SSLREPPPDA VDVAELLRDS SVAEEGAQEA    50
    VARRRPPSQC SVLLFPGQGC QAVGMGSGLL HLPRVRQLYE AAHRVLGYDL 100
    LELCLRGPQE DLDRTVHCQP AVFVASLAAV EKLHHLQPAV IDNCVAAAGF 150
    SVGEFAALVF AGAMDFSEGL YAVKARAEAM QEASEAVPSG MLSVLGQRQS 200
    NFSFACLEAQ EHCKSLGIEN PVCQVSNYLF PDCRVISGHL EALQFLRRNS 250
    AKYHFRRTKM LPVSGGFHTC LMEPAVDPLM KVLGSINIKK PLVAVHSNVS 300
    GQKYTHPQHI RKLLGQQVVS PVKWEQTMHS IYERKKGMEF PSTYEVGPGQ 350
    QLGSILKCCN RQAWKSYSHV DVMQNIMDPD P 381
    Length:381
    Mass (Da):41,928
    Last modified:October 11, 2005 - v3
    Checksum:i7024C1EBAF95B1EE
    GO

    Sequence cautioni

    The sequence AAH25519.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099494 mRNA. Translation: AAH99494.1.
    BC025519 mRNA. Translation: AAH25519.1. Different initiation.
    CCDSiCCDS27704.1.
    RefSeqiNP_001025185.1. NM_001030014.2.
    UniGeneiMm.37560.

    Genome annotation databases

    EnsembliENSMUST00000061882; ENSMUSP00000051569; ENSMUSG00000048755.
    GeneIDi223722.
    KEGGimmu:223722.
    UCSCiuc007xbf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099494 mRNA. Translation: AAH99494.1 .
    BC025519 mRNA. Translation: AAH25519.1 . Different initiation.
    CCDSi CCDS27704.1.
    RefSeqi NP_001025185.1. NM_001030014.2.
    UniGenei Mm.37560.

    3D structure databases

    ProteinModelPortali Q8R3F5.
    SMRi Q8R3F5. Positions 3-377.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8R3F5. 1 interaction.
    MINTi MINT-4094897.

    PTM databases

    PhosphoSitei Q8R3F5.

    Proteomic databases

    MaxQBi Q8R3F5.
    PaxDbi Q8R3F5.
    PRIDEi Q8R3F5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061882 ; ENSMUSP00000051569 ; ENSMUSG00000048755 .
    GeneIDi 223722.
    KEGGi mmu:223722.
    UCSCi uc007xbf.1. mouse.

    Organism-specific databases

    CTDi 27349.
    MGIi MGI:2388651. Mcat.

    Phylogenomic databases

    eggNOGi COG0331.
    GeneTreei ENSGT00390000013715.
    HOGENOMi HOG000036504.
    HOVERGENi HBG051540.
    InParanoidi Q8R3F5.
    KOi K00645.
    OMAi DIMFSGS.
    OrthoDBi EOG7D85X6.
    PhylomeDBi Q8R3F5.
    TreeFami TF313401.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Miscellaneous databases

    ChiTaRSi MCAT. mouse.
    NextBioi 376844.
    PROi Q8R3F5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R3F5.
    CleanExi MM_MCAT.
    Genevestigatori Q8R3F5.

    Family and domain databases

    Gene3Di 3.40.366.10. 2 hits.
    InterProi IPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thyroid.
    2. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-312, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiFABD_MOUSE
    AccessioniPrimary (citable) accession number: Q8R3F5
    Secondary accession number(s): Q4FZH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 93 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3