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Q8R3F5

- FABD_MOUSE

UniProt

Q8R3F5 - FABD_MOUSE

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Protein

Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

Gene

Mcat

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias (By similarity).By similarity

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei151 – 1511By similarity
Active sitei268 – 2681By similarity

GO - Molecular functioni

  1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC
  2. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (EC:2.3.1.39)
Short name:
MCT
Alternative name(s):
Mitochondrial malonyltransferase
[Acyl-carrier-protein] malonyltransferase
Gene namesi
Name:Mcat
Synonyms:Mt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2388651. Mcat.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 381Malonyl-CoA-acyl carrier protein transacylase, mitochondrialPRO_0000042239
Transit peptidei1 – ?MitochondrionSequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei312 – 3121N6-succinyllysine1 Publication

Proteomic databases

MaxQBiQ8R3F5.
PaxDbiQ8R3F5.
PRIDEiQ8R3F5.

PTM databases

PhosphoSiteiQ8R3F5.

Expressioni

Gene expression databases

BgeeiQ8R3F5.
CleanExiMM_MCAT.
GenevestigatoriQ8R3F5.

Interactioni

Protein-protein interaction databases

IntActiQ8R3F5. 1 interaction.
MINTiMINT-4094897.

Structurei

3D structure databases

ProteinModelPortaliQ8R3F5.
SMRiQ8R3F5. Positions 59-373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II malonyltransferase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0331.
GeneTreeiENSGT00390000013715.
HOGENOMiHOG000036504.
HOVERGENiHBG051540.
InParanoidiQ8R3F5.
KOiK00645.
OMAiDIMFSGS.
OrthoDBiEOG7D85X6.
PhylomeDBiQ8R3F5.
TreeFamiTF313401.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R3F5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSARVARAGW AWRSWGRRAA SSLREPPPDA VDVAELLRDS SVAEEGAQEA
60 70 80 90 100
VARRRPPSQC SVLLFPGQGC QAVGMGSGLL HLPRVRQLYE AAHRVLGYDL
110 120 130 140 150
LELCLRGPQE DLDRTVHCQP AVFVASLAAV EKLHHLQPAV IDNCVAAAGF
160 170 180 190 200
SVGEFAALVF AGAMDFSEGL YAVKARAEAM QEASEAVPSG MLSVLGQRQS
210 220 230 240 250
NFSFACLEAQ EHCKSLGIEN PVCQVSNYLF PDCRVISGHL EALQFLRRNS
260 270 280 290 300
AKYHFRRTKM LPVSGGFHTC LMEPAVDPLM KVLGSINIKK PLVAVHSNVS
310 320 330 340 350
GQKYTHPQHI RKLLGQQVVS PVKWEQTMHS IYERKKGMEF PSTYEVGPGQ
360 370 380
QLGSILKCCN RQAWKSYSHV DVMQNIMDPD P
Length:381
Mass (Da):41,928
Last modified:October 11, 2005 - v3
Checksum:i7024C1EBAF95B1EE
GO

Sequence cautioni

The sequence AAH25519.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC099494 mRNA. Translation: AAH99494.1.
BC025519 mRNA. Translation: AAH25519.1. Different initiation.
CCDSiCCDS27704.1.
RefSeqiNP_001025185.1. NM_001030014.2.
UniGeneiMm.37560.

Genome annotation databases

EnsembliENSMUST00000061882; ENSMUSP00000051569; ENSMUSG00000048755.
GeneIDi223722.
KEGGimmu:223722.
UCSCiuc007xbf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC099494 mRNA. Translation: AAH99494.1 .
BC025519 mRNA. Translation: AAH25519.1 . Different initiation.
CCDSi CCDS27704.1.
RefSeqi NP_001025185.1. NM_001030014.2.
UniGenei Mm.37560.

3D structure databases

ProteinModelPortali Q8R3F5.
SMRi Q8R3F5. Positions 59-373.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8R3F5. 1 interaction.
MINTi MINT-4094897.

PTM databases

PhosphoSitei Q8R3F5.

Proteomic databases

MaxQBi Q8R3F5.
PaxDbi Q8R3F5.
PRIDEi Q8R3F5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000061882 ; ENSMUSP00000051569 ; ENSMUSG00000048755 .
GeneIDi 223722.
KEGGi mmu:223722.
UCSCi uc007xbf.1. mouse.

Organism-specific databases

CTDi 27349.
MGIi MGI:2388651. Mcat.

Phylogenomic databases

eggNOGi COG0331.
GeneTreei ENSGT00390000013715.
HOGENOMi HOG000036504.
HOVERGENi HBG051540.
InParanoidi Q8R3F5.
KOi K00645.
OMAi DIMFSGS.
OrthoDBi EOG7D85X6.
PhylomeDBi Q8R3F5.
TreeFami TF313401.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Miscellaneous databases

ChiTaRSi MCAT. mouse.
NextBioi 376844.
PROi Q8R3F5.
SOURCEi Search...

Gene expression databases

Bgeei Q8R3F5.
CleanExi MM_MCAT.
Genevestigatori Q8R3F5.

Family and domain databases

Gene3Di 3.40.366.10. 2 hits.
InterProi IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thyroid.
  2. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-312, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiFABD_MOUSE
AccessioniPrimary (citable) accession number: Q8R3F5
Secondary accession number(s): Q4FZH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3