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Protein

Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

Gene

Mcat

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria (By similarity).By similarity

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei151By similarity1
Active sitei268By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-77289 Mitochondrial Fatty Acid Beta-Oxidation
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (EC:2.3.1.39)
Short name:
MCT
Alternative name(s):
Mitochondrial malonyltransferase
[Acyl-carrier-protein] malonyltransferase
Gene namesi
Name:Mcat
Synonyms:Mt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2388651 Mcat

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000042239? – 381Malonyl-CoA-acyl carrier protein transacylase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei312N6-succinyllysineCombined sources1

Proteomic databases

EPDiQ8R3F5
MaxQBiQ8R3F5
PaxDbiQ8R3F5
PeptideAtlasiQ8R3F5
PRIDEiQ8R3F5

PTM databases

iPTMnetiQ8R3F5
PhosphoSitePlusiQ8R3F5
SwissPalmiQ8R3F5

Expressioni

Gene expression databases

BgeeiENSMUSG00000048755
CleanExiMM_MCAT
GenevisibleiQ8R3F5 MM

Interactioni

Protein-protein interaction databases

IntActiQ8R3F5, 1 interactor
MINTiQ8R3F5
STRINGi10090.ENSMUSP00000051569

Structurei

3D structure databases

ProteinModelPortaliQ8R3F5
SMRiQ8R3F5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II malonyltransferase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2926 Eukaryota
COG0331 LUCA
GeneTreeiENSGT00390000013715
HOGENOMiHOG000036504
HOVERGENiHBG051540
InParanoidiQ8R3F5
KOiK00645
OMAiAANYNCP
OrthoDBiEOG091G09QO
PhylomeDBiQ8R3F5
TreeFamiTF313401

Family and domain databases

Gene3Di3.40.366.10, 2 hits
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR016036 Malonyl_transacylase_ACP-bd
IPR020801 PKS_acyl_transferase
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SUPFAMiSSF52151 SSF52151, 2 hits
SSF55048 SSF55048, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R3F5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSARVARAGW AWRSWGRRAA SSLREPPPDA VDVAELLRDS SVAEEGAQEA
60 70 80 90 100
VARRRPPSQC SVLLFPGQGC QAVGMGSGLL HLPRVRQLYE AAHRVLGYDL
110 120 130 140 150
LELCLRGPQE DLDRTVHCQP AVFVASLAAV EKLHHLQPAV IDNCVAAAGF
160 170 180 190 200
SVGEFAALVF AGAMDFSEGL YAVKARAEAM QEASEAVPSG MLSVLGQRQS
210 220 230 240 250
NFSFACLEAQ EHCKSLGIEN PVCQVSNYLF PDCRVISGHL EALQFLRRNS
260 270 280 290 300
AKYHFRRTKM LPVSGGFHTC LMEPAVDPLM KVLGSINIKK PLVAVHSNVS
310 320 330 340 350
GQKYTHPQHI RKLLGQQVVS PVKWEQTMHS IYERKKGMEF PSTYEVGPGQ
360 370 380
QLGSILKCCN RQAWKSYSHV DVMQNIMDPD P
Length:381
Mass (Da):41,928
Last modified:October 11, 2005 - v3
Checksum:i7024C1EBAF95B1EE
GO

Sequence cautioni

The sequence AAH25519 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099494 mRNA Translation: AAH99494.1
BC025519 mRNA Translation: AAH25519.1 Different initiation.
CCDSiCCDS27704.1
RefSeqiNP_001025185.1, NM_001030014.2
UniGeneiMm.37560

Genome annotation databases

EnsembliENSMUST00000061882; ENSMUSP00000051569; ENSMUSG00000048755
GeneIDi223722
KEGGimmu:223722
UCSCiuc007xbf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFABD_MOUSE
AccessioniPrimary (citable) accession number: Q8R3F5
Secondary accession number(s): Q4FZH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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