Q8R3C0 (MCMBP_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
September 21, 2011.
Version 63.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Mini-chromosome maintenance complex-binding protein Short name=MCM-BP Short name=MCM-binding protein | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 642 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion By similarity. |
| Subunit structure | Interacts with the MCM complex: associates with the MCM3-7 complex which lacks MCM2, while it does not interact with the MCM complex when MCM2 is present (MCM2-7 complex). Interacts with the RPA complex, when composed of all RPA1, RPA2 and RPA3 components, but not with RPA1 or RPA2 alone By similarity. |
| Subcellular location | Nucleus By similarity. Note: Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex By similarity. |
| Sequence similarities | Belongs to the MCMBP family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle Cell division DNA replication Mitosis |
| Cellular component | Nucleus |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | DNA-dependent DNA replication Inferred from sequence or structural similarity. Source: UniProtKB S phase of mitotic cell cycleInferred from sequence or structural similarity. Source: UniProtKB cell divisionInferred from electronic annotation. Source: UniProtKB-KW mitosisInferred from electronic annotation. Source: UniProtKB-KW sister chromatid cohesionInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | chromatin binding Inferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 642 | 642 | Mini-chromosome maintenance complex-binding protein | PRO_0000089828 | |||||
Amino acid modifications | |||||||||
| Modified residue | 154 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 160 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 298 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
| [1] | "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor and Salivary gland. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AC122767 Genomic DNA. No translation available. AC136741 Genomic DNA. No translation available. BC025641 mRNA. Translation: AAH25641.1. BC038342 mRNA. Translation: AAH38342.1. |
| IPI | IPI00153724. |
| RefSeq | NP_666067.1. NM_145955.3. |
| UniGene | Mm.464029. Mm.58882. |
3D structure databases | |
| ProteinModelPortal | Q8R3C0. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8R3C0. |
PTM databases | |
| PhosphoSite | Q8R3C0. |
Proteomic databases | |
| PRIDE | Q8R3C0. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000057557; ENSMUSP00000062843; ENSMUSG00000048170. |
| GeneID | 210711. |
| KEGG | mmu:210711. |
| UCSC | uc009jzh.1. mouse. |
Organism-specific databases | |
| CTD | 79892. |
| MGI | MGI:1920977. Mcmbp. |
Phylogenomic databases | |
| eggNOG | roNOG08053. |
| GeneTree | ENSGT00390000017265. |
| HOVERGEN | HBG059839. |
| OMA | NNAPKWV. |
| OrthoDB | EOG4WM4T5. |
Gene expression databases | |
| ArrayExpress | Q8R3C0. |
| Bgee | Q8R3C0. |
| CleanEx | MM_1110007A13RIK. |
| Genevestigator | Q8R3C0. |
| GermOnline | ENSMUSG00000048170. Mus musculus. |
Family and domain databases | |
| InterPro | IPR019140. MCM_complex-bd. [Graphical view] |
| PANTHER | PTHR13489. PTHR13489. 1 hit. |
| Pfam | PF09739. DUF2044. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 373028. |
| SOURCE | Search... |
Entry information
| Entry name | MCMBP_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8R3C0 Secondary accession number(s): D3Z3G1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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