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Protein

Mini-chromosome maintenance complex-binding protein

Gene

Mcmbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA replication, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Mini-chromosome maintenance complex-binding protein
Short name:
MCM-BP
Short name:
MCM-binding protein
Gene namesi
Name:Mcmbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1920977. Mcmbp.

Subcellular locationi

  • Nucleus By similarity

  • Note: Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Mini-chromosome maintenance complex-binding proteinPRO_0000089828Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei154 – 1541PhosphoserineBy similarity
Modified residuei160 – 1601PhosphothreonineBy similarity
Modified residuei167 – 1671PhosphoserineBy similarity
Modified residuei298 – 2981PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R3C0.
MaxQBiQ8R3C0.
PaxDbiQ8R3C0.
PeptideAtlasiQ8R3C0.
PRIDEiQ8R3C0.

PTM databases

iPTMnetiQ8R3C0.
PhosphoSiteiQ8R3C0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048170.
CleanExiMM_1110007A13RIK.
ExpressionAtlasiQ8R3C0. baseline and differential.
GenevisibleiQ8R3C0. MM.

Interactioni

Subunit structurei

Interacts with the MCM complex: associates with the MCM3-7 complex which lacks MCM2, while it does not interact with the MCM complex when MCM2 is present (MCM2-7 complex). Interacts with the RPA complex, when composed of all RPA1, RPA2 and RPA3 components, but not with RPA1 or RPA2 alone (By similarity).By similarity

Protein-protein interaction databases

BioGridi229174. 1 interaction.
IntActiQ8R3C0. 1 interaction.
MINTiMINT-8178510.
STRINGi10090.ENSMUSP00000062843.

Structurei

3D structure databases

ProteinModelPortaliQ8R3C0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MCMBP family.Curated

Phylogenomic databases

eggNOGiKOG2545. Eukaryota.
ENOG410XNU0. LUCA.
GeneTreeiENSGT00390000017265.
HOGENOMiHOG000237536.
HOVERGENiHBG059839.
InParanoidiQ8R3C0.
PhylomeDBiQ8R3C0.
TreeFamiTF324793.

Family and domain databases

InterProiIPR019140. MCM_complex-bd.
[Graphical view]
PANTHERiPTHR13489. PTHR13489. 1 hit.
PfamiPF09739. MCM_bind. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R3C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPCGEDWLSH PLGIVQGFFA QNGVNPDWEK KVIEYFKEKL KENNAPKWVP
60 70 80 90 100
SLNEVPLHYL KPNSFVKFRC MIQDMFDPEF YMGIYETVNQ NTKARVLHFG
110 120 130 140 150
KYRDVAECGP QQELDLSSPR STTSERQTFY CVPVPGESSW VKEAYVNANQ
160 170 180 190 200
ARVSPSTSYT PSRHKRSYED DEDMDLQPSK QKEQHPGSRQ AGGLGGLHWC
210 220 230 240 250
GEPKRLETEA SSGQQLNTLN LSSPFDLNFP LPGEKGPACL VKVYEDWDCF
260 270 280 290 300
KVNDVLELYG VLSVDPVLSV LNSEERDASA LLDPMECTDM AEEQRVHSPP
310 320 330 340 350
ASLVPRIHVI LAQKLQHINP LLPTCLNKEE SRSCQFVSNF MSELSPVRAE
360 370 380 390 400
LLGFLTHALL GDSLAAEYLI LHLISTVYTR RDVLPLGKFT VNLSGCPQNS
410 420 430 440 450
TFTEHLYRII QHLVPASFRL QMTIENMNQL KLIPHKDYTA NRLVSGLLQL
460 470 480 490 500
PNNTSLVIDE TLLEQGQLDT PGVHNVTALS NLITWQKVDY DFSYHQMEFP
510 520 530 540 550
CNINVLITSE GRSLLPADCQ IHLQPQLIPP NMEEYMNGLL SAVLPSVLNK
560 570 580 590 600
FRIYLTLLRF LDYNLSDDIT KAVEDDFVEM RKDDPQSITA DDLHQLLVVA
610 620 630 640
RFLSLSVGQT TLSRERWLRA KQLELSRKAR LQQQKSVNGN EL
Length:642
Mass (Da):72,891
Last modified:June 1, 2002 - v1
Checksum:iFD5E282DFCC4A5F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122767 Genomic DNA. No translation available.
AC136741 Genomic DNA. No translation available.
BC025641 mRNA. Translation: AAH25641.1.
BC038342 mRNA. Translation: AAH38342.1.
CCDSiCCDS40153.1.
RefSeqiNP_666067.1. NM_145955.3.
UniGeneiMm.490344.
Mm.58882.

Genome annotation databases

EnsembliENSMUST00000057557; ENSMUSP00000062843; ENSMUSG00000048170.
GeneIDi210711.
KEGGimmu:210711.
UCSCiuc009jzh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122767 Genomic DNA. No translation available.
AC136741 Genomic DNA. No translation available.
BC025641 mRNA. Translation: AAH25641.1.
BC038342 mRNA. Translation: AAH38342.1.
CCDSiCCDS40153.1.
RefSeqiNP_666067.1. NM_145955.3.
UniGeneiMm.490344.
Mm.58882.

3D structure databases

ProteinModelPortaliQ8R3C0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229174. 1 interaction.
IntActiQ8R3C0. 1 interaction.
MINTiMINT-8178510.
STRINGi10090.ENSMUSP00000062843.

PTM databases

iPTMnetiQ8R3C0.
PhosphoSiteiQ8R3C0.

Proteomic databases

EPDiQ8R3C0.
MaxQBiQ8R3C0.
PaxDbiQ8R3C0.
PeptideAtlasiQ8R3C0.
PRIDEiQ8R3C0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057557; ENSMUSP00000062843; ENSMUSG00000048170.
GeneIDi210711.
KEGGimmu:210711.
UCSCiuc009jzh.1. mouse.

Organism-specific databases

CTDi79892.
MGIiMGI:1920977. Mcmbp.

Phylogenomic databases

eggNOGiKOG2545. Eukaryota.
ENOG410XNU0. LUCA.
GeneTreeiENSGT00390000017265.
HOGENOMiHOG000237536.
HOVERGENiHBG059839.
InParanoidiQ8R3C0.
PhylomeDBiQ8R3C0.
TreeFamiTF324793.

Miscellaneous databases

ChiTaRSiMcmbp. mouse.
PROiQ8R3C0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048170.
CleanExiMM_1110007A13RIK.
ExpressionAtlasiQ8R3C0. baseline and differential.
GenevisibleiQ8R3C0. MM.

Family and domain databases

InterProiIPR019140. MCM_complex-bd.
[Graphical view]
PANTHERiPTHR13489. PTHR13489. 1 hit.
PfamiPF09739. MCM_bind. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCMBP_MOUSE
AccessioniPrimary (citable) accession number: Q8R3C0
Secondary accession number(s): D3Z3G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.