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Protein

Ras-related and estrogen-regulated growth inhibitor

Gene

Rerg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20GTPBy similarity8
Nucleotide bindingi60 – 64GTPBy similarity5
Nucleotide bindingi118 – 121GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related and estrogen-regulated growth inhibitor
Gene namesi
Name:Rerg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2665139. Rerg.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827241 – 199Ras-related and estrogen-regulated growth inhibitorAdd BLAST199

Proteomic databases

MaxQBiQ8R367.
PaxDbiQ8R367.
PRIDEiQ8R367.

PTM databases

iPTMnetiQ8R367.
PhosphoSitePlusiQ8R367.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030222.
CleanExiMM_RERG.
ExpressionAtlasiQ8R367. baseline and differential.
GenevisibleiQ8R367. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032347.

Structurei

3D structure databases

ProteinModelPortaliQ8R367.
SMRiQ8R367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi168 – 171Poly-Arg4

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133696.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ8R367.
KOiK07855.
OMAiHVRQVPT.
OrthoDBiEOG091G0M6D.
PhylomeDBiQ8R367.
TreeFamiTF318030.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSAEVKLA IFGRAGVGKS AIVVRFLTKR FIWEYDPTLE STYRHQATID
60 70 80 90 100
DEVVSMEILD TAGQEDTIQR EGHMRWGEGF VLVYDITDRG SFEEVLPLKN
110 120 130 140 150
ILDEVKKPKN VTLILVGNKA DLDHSRQVST EEGEKLATEL ACAFYECSAC
160 170 180 190
TGEGNITEVF YELCREVRRR RMVQGKTRRR SSTTHVKQAI NKMLTKISS
Length:199
Mass (Da):22,580
Last modified:June 1, 2002 - v1
Checksum:iB733BC187A9F29A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133734 mRNA. Translation: BAE21810.1.
BC026463 mRNA. Translation: AAH26463.1.
CCDSiCCDS20663.1.
RefSeqiNP_001157684.1. NM_001164212.1.
NP_001157686.1. NM_001164214.1.
NP_871788.1. NM_181988.2.
UniGeneiMm.46233.

Genome annotation databases

EnsembliENSMUST00000032347; ENSMUSP00000032347; ENSMUSG00000030222.
ENSMUST00000117919; ENSMUSP00000113105; ENSMUSG00000030222.
GeneIDi232441.
KEGGimmu:232441.
UCSCiuc009emr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133734 mRNA. Translation: BAE21810.1.
BC026463 mRNA. Translation: AAH26463.1.
CCDSiCCDS20663.1.
RefSeqiNP_001157684.1. NM_001164212.1.
NP_001157686.1. NM_001164214.1.
NP_871788.1. NM_181988.2.
UniGeneiMm.46233.

3D structure databases

ProteinModelPortaliQ8R367.
SMRiQ8R367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032347.

PTM databases

iPTMnetiQ8R367.
PhosphoSitePlusiQ8R367.

Proteomic databases

MaxQBiQ8R367.
PaxDbiQ8R367.
PRIDEiQ8R367.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032347; ENSMUSP00000032347; ENSMUSG00000030222.
ENSMUST00000117919; ENSMUSP00000113105; ENSMUSG00000030222.
GeneIDi232441.
KEGGimmu:232441.
UCSCiuc009emr.2. mouse.

Organism-specific databases

CTDi85004.
MGIiMGI:2665139. Rerg.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133696.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ8R367.
KOiK07855.
OMAiHVRQVPT.
OrthoDBiEOG091G0M6D.
PhylomeDBiQ8R367.
TreeFamiTF318030.

Miscellaneous databases

ChiTaRSiRerg. mouse.
PROiQ8R367.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030222.
CleanExiMM_RERG.
ExpressionAtlasiQ8R367. baseline and differential.
GenevisibleiQ8R367. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRERG_MOUSE
AccessioniPrimary (citable) accession number: Q8R367
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.