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Protein

Rab11 family-interacting protein 5

Gene

Rab11fip5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to acidic pH Source: MGI
  • insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
  • negative regulation of adiponectin secretion Source: MGI
  • regulated exocytosis Source: UniProtKB
  • regulation of protein localization to cell surface Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Rab11 family-interacting protein 5
Short name:
Rab11-FIP5
Alternative name(s):
Rab11-interacting protein Rip11
Gene namesi
Name:Rab11fip5
Synonyms:D6Ertd32e, Rip11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1098586. Rab11fip5.

Subcellular locationi

GO - Cellular componenti

  • early endosome Source: UniProtKB
  • early endosome membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • intracellular membrane-bounded organelle Source: MGI
  • microtubule organizing center Source: MGI
  • mitochondrial outer membrane Source: UniProtKB
  • mitochondrion Source: MGI
  • recycling endosome Source: UniProtKB
  • recycling endosome membrane Source: UniProtKB-SubCell
  • secretory granule Source: UniProtKB
  • transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 645645Rab11 family-interacting protein 5PRO_0000097308Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei176 – 1761PhosphoserineCombined sources
Modified residuei283 – 2831PhosphoserineCombined sources
Modified residuei307 – 3071PhosphoserineCombined sources
Modified residuei357 – 3571Phosphoserine1 Publication
Modified residuei486 – 4861PhosphoserineBy similarity
Modified residuei530 – 5301PhosphoserineCombined sources
Modified residuei539 – 5391PhosphoserineCombined sources
Modified residuei545 – 5451PhosphoserineCombined sources
Modified residuei640 – 6401PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated on serine and threonine residues. Phosphorylation at Ser-357 is PKA-dependent.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8R361.
PaxDbiQ8R361.
PRIDEiQ8R361.

PTM databases

iPTMnetiQ8R361.
PhosphoSiteiQ8R361.

Expressioni

Gene expression databases

BgeeiQ8R361.
CleanExiMM_RAB11FIP5.
ExpressionAtlasiQ8R361. baseline and differential.
GenevisibleiQ8R361. MM.

Interactioni

Subunit structurei

Forms a heterooligomeric complex with RAB11FIP4. Binds NAPG and TROVE2. Binds RAB11A that has been activated by GTP binding (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206353. 3 interactions.
IntActiQ8R361. 3 interactions.
MINTiMINT-4132498.
STRINGi10090.ENSMUSP00000058305.

Structurei

3D structure databases

ProteinModelPortaliQ8R361.
SMRiQ8R361. Positions 596-639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 128123C2PROSITE-ProRule annotationAdd
BLAST
Domaini578 – 64063FIP-RBDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi243 – 397155Ser-richAdd
BLAST

Domaini

Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg2+ rather than Ca2+ (By similarity).By similarity

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 FIP-RBD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJ70. Eukaryota.
ENOG410XQK9. LUCA.
GeneTreeiENSGT00530000063203.
HOGENOMiHOG000234700.
HOVERGENiHBG079127.
InParanoidiQ8R361.
KOiK12484.
OMAiVEKTHGC.
OrthoDBiEOG7WQ7SB.
TreeFamiTF326172.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR019018. Rab-bd_FIP-RBD.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF09457. RBD-FIP. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS51511. FIP_RBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVRDPEPA AGSSRWLPTH VQVTVLRASG LRGKSSGAGS TSDAYTVIQV
60 70 80 90 100
GREKYSTSVV EKTQGCPEWC EECSFELPPG ALDGLLRAQE ADAGPAPWAS
110 120 130 140 150
GPNAACELVL TTMHRSLIGV DKFLGRATVA LDEVFRAGRA QHTQWYRLHS
160 170 180 190 200
KPGKKEKERG EIQVTIQFTR NNLSASMFDL SMKDKPRSPF SKLKDRVKGK
210 220 230 240 250
KKYDLESASA ILPSSALEDP ELGSLGKMGK AKGFFLRNKL RKSSLTQSNT
260 270 280 290 300
SLGSDSTLSS TSGSLVYQGP GAELLTRSPS HSSWLSTEGG RDSIQSPKLL
310 320 330 340 350
THKRTYSDEA SQLRAAPPRA LLELQGHLDG ASRSSLCVNG SHVYNEEPQP
360 370 380 390 400
PLRHRSSISG PFPPSSSLHS VPPRSSEEGS RSSDDSWGRG SHGTSSSEAV
410 420 430 440 450
PGQEELSKQA KGASCSGEEE GARLPEGKPV QVATPMVASS EAVAAEKDRK
460 470 480 490 500
PRMGLFHHHH HQGLSRSEQG RRGSVGEKGS PSLGASPHHS STGEEKAKSS
510 520 530 540 550
WFGLRESKEP TQKPSPHPVK PLTAAPVEAS PDRKQPRTSL STALSSGLER
560 570 580 590 600
LKTVTSGGIQ SVLPASQLGS SVDTKRPKDS AVLDQSAKYY HLTHDELIGL
610 620 630 640
LLQRERELSQ RDEHVQELES YIDRLLVRIM ETSPTLLQIS PGPPK
Length:645
Mass (Da):69,553
Last modified:August 22, 2003 - v2
Checksum:iCBA713E9E68A042A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153605 Genomic DNA. No translation available.
AC155728 Genomic DNA. No translation available.
BC026473 mRNA. Translation: AAH26473.1.
BC044833 mRNA. Translation: AAH44833.2.
BC051063 mRNA. Translation: AAH51063.3.
BC141380 mRNA. Translation: AAI41381.1.
CCDSiCCDS20292.1.
RefSeqiNP_001003955.1. NM_001003955.2.
NP_803417.3. NM_177466.4.
UniGeneiMm.220334.

Genome annotation databases

EnsembliENSMUST00000060837; ENSMUSP00000058305; ENSMUSG00000051343.
GeneIDi52055.
KEGGimmu:52055.
UCSCiuc009cpo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153605 Genomic DNA. No translation available.
AC155728 Genomic DNA. No translation available.
BC026473 mRNA. Translation: AAH26473.1.
BC044833 mRNA. Translation: AAH44833.2.
BC051063 mRNA. Translation: AAH51063.3.
BC141380 mRNA. Translation: AAI41381.1.
CCDSiCCDS20292.1.
RefSeqiNP_001003955.1. NM_001003955.2.
NP_803417.3. NM_177466.4.
UniGeneiMm.220334.

3D structure databases

ProteinModelPortaliQ8R361.
SMRiQ8R361. Positions 596-639.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206353. 3 interactions.
IntActiQ8R361. 3 interactions.
MINTiMINT-4132498.
STRINGi10090.ENSMUSP00000058305.

PTM databases

iPTMnetiQ8R361.
PhosphoSiteiQ8R361.

Proteomic databases

MaxQBiQ8R361.
PaxDbiQ8R361.
PRIDEiQ8R361.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060837; ENSMUSP00000058305; ENSMUSG00000051343.
GeneIDi52055.
KEGGimmu:52055.
UCSCiuc009cpo.1. mouse.

Organism-specific databases

CTDi26056.
MGIiMGI:1098586. Rab11fip5.

Phylogenomic databases

eggNOGiENOG410IJ70. Eukaryota.
ENOG410XQK9. LUCA.
GeneTreeiENSGT00530000063203.
HOGENOMiHOG000234700.
HOVERGENiHBG079127.
InParanoidiQ8R361.
KOiK12484.
OMAiVEKTHGC.
OrthoDBiEOG7WQ7SB.
TreeFamiTF326172.

Miscellaneous databases

ChiTaRSiRab11fip5. mouse.
NextBioi308438.
PROiQ8R361.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R361.
CleanExiMM_RAB11FIP5.
ExpressionAtlasiQ8R361. baseline and differential.
GenevisibleiQ8R361. MM.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR019018. Rab-bd_FIP-RBD.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF09457. RBD-FIP. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS51511. FIP_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Brain and Mammary tumor.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 382-389, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  4. "Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis."
    Sugawara K., Shibasaki T., Mizoguchi A., Saito T., Seino S.
    Genes Cells 14:445-456(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN EXOCYTOSIS, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-357.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539; SER-545 AND SER-640, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-176; SER-283; SER-307 AND SER-530, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiRFIP5_MOUSE
AccessioniPrimary (citable) accession number: Q8R361
Secondary accession number(s): C4IXU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: August 22, 2003
Last modified: May 11, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.