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Q8R322

- GLE1_MOUSE

UniProt

Q8R322 - GLE1_MOUSE

Protein

Nucleoporin GLE1

Gene

Gle1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) By similarity.By similarity

    GO - Biological processi

    1. poly(A)+ mRNA export from nucleus Source: InterPro
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA transport, Protein transport, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoporin GLE1
    Alternative name(s):
    GLE1-like protein
    Gene namesi
    Name:Gle1
    Synonyms:Gle1l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1921662. Gle1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Nucleusnuclear pore complex By similarity
    Note: Shuttles between the nucleus and the cytoplasm. Localizes to the nuclear pore complex and nuclear envelope. Shuttling is essential for its mRNA export function By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nuclear pore Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nuclear pore complex, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 699699Nucleoporin GLE1PRO_0000204823Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei91 – 911PhosphoserineBy similarity
    Modified residuei101 – 1011PhosphoserineBy similarity
    Modified residuei352 – 3521Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8R322.
    PaxDbiQ8R322.
    PRIDEiQ8R322.

    PTM databases

    PhosphoSiteiQ8R322.

    Expressioni

    Gene expression databases

    BgeeiQ8R322.
    CleanExiMM_GLE1.
    GenevestigatoriQ8R322.

    Interactioni

    Subunit structurei

    Associated with the NPC, it however may not be a stable component of the NPC complex since it shuttles between the nucleus and the cytoplasm. Interacts with nuclear pore complex proteins NUP155 and NUPL2 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ8R322. 1 interaction.
    MINTiMINT-4126988.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R322.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2929Interaction with NUP155By similarityAdd
    BLAST
    Regioni445 – 48440Mediates the shuttling between the nucleus and the cytoplasmBy similarityAdd
    BLAST
    Regioni657 – 69943Interaction with NUPL2By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili154 – 274121Sequence AnalysisAdd
    BLAST
    Coiled coili306 – 35651Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi67 – 10438Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GLE1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG330485.
    GeneTreeiENSGT00390000012903.
    HOVERGENiHBG081558.
    InParanoidiA3KGV8.
    OMAiSQHTESM.
    OrthoDBiEOG7FFMRB.
    PhylomeDBiQ8R322.
    TreeFamiTF324158.

    Family and domain databases

    InterProiIPR012476. GLE1.
    [Graphical view]
    PANTHERiPTHR12960. PTHR12960. 1 hit.
    PfamiPF07817. GLE1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R322-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSDGRCWET LRALRNTSKG RLRYDREWLL RYEDVLEECM SLPKLSSYSG    50
    WVVDHILPNT SGHTQESAPS SDNSPSSGSA SGLYQSSLLK SPVRSSPQSP 100
    SPSSPNGTQS THESPFTEPI APQSSRAIKV EGCIRMYELA HRMRGTEGLR 150
    QWQEEQERKV RALSEMASEQ LKRFDELKEL KLHKEFQDLQ EVMEKSTREA 200
    LGHQEKLKEE HRHRAKILNL KLREAEQQRV KQAEQEQLRK EEGQVRLRSL 250
    YSLQEEVLQL NQQLDASSQH KELLSVDLAA FQTRGNQLCG LISSIIRTTL 300
    ESGYPTAENQ AEAERALQEM RDLLSDLEQE ITRASQVKKK HEEEAKVKRQ 350
    ESQVQQGPAP PTQTSAPSPS PVGAQNEDLQ VKVQDSTMQW YQQLQDASAK 400
    CVLAFEDLTS SKDSQTKKIK MDLQKAATIP VSQISTIAGS KLKEIFDKIH 450
    SLLSGKPVQS GGRSVSVTLN PQGLDFVQYK LAEKFVKQGE EEVASHHEAA 500
    FPIAVVASGI WMLHPKVGDL ILAHLHKKCP YSVPFYPAFK EGMALEDYQR 550
    MLGYQVTDSK VEQQDNFLKR MSGMIRLYAA IIQLQWPYGN RQEAHPHGLN 600
    HGWRWLAQVL NMEPLSDVTA TLLFDFLEVC GNALMKQYQV QFWKMILLIK 650
    EDYFPRIEAI TSSGQMGSFI RLKQFLEKCL QRREIPVPRG FLTTSFWRS 699
    Length:699
    Mass (Da):79,574
    Last modified:December 6, 2005 - v2
    Checksum:i5403C38F9DC7ED75
    GO

    Sequence cautioni

    The sequence BAC25796.1 differs from that shown. Reason: Frameshift at positions 92 and 166.
    The sequence BAE36515.1 differs from that shown. Reason: Frameshift at positions 1 and 31.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti70 – 701Missing in AAH26797. (PubMed:15489334)Curated
    Sequence conflicti88 – 881L → R in BAC25796. (PubMed:16141072)Curated
    Sequence conflicti115 – 1151P → Q in AAH26797. (PubMed:15489334)Curated
    Sequence conflicti206 – 2061K → E in BAE36148. (PubMed:15489334)Curated
    Sequence conflicti359 – 3591A → G in AAH26797. (PubMed:15489334)Curated
    Sequence conflicti368 – 3681S → I in AAH26797. (PubMed:15489334)Curated
    Sequence conflicti374 – 3741A → T in AAH26797. (PubMed:15489334)Curated
    Sequence conflicti535 – 5351F → L in BAC25796. (PubMed:16141072)Curated
    Sequence conflicti598 – 5981G → S in BAC25796. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016671 mRNA. Translation: BAB30371.1.
    AK028183 mRNA. Translation: BAC25796.1. Frameshift.
    AK133888 mRNA. Translation: BAE21914.1.
    AK145748 mRNA. Translation: BAE26625.1.
    AK150230 mRNA. Translation: BAE29396.1.
    AK161015 mRNA. Translation: BAE36148.1.
    AK161659 mRNA. Translation: BAE36515.1. Frameshift.
    AL928926 Genomic DNA. Translation: CAM46233.1.
    BC026797 mRNA. Translation: AAH26797.1.
    CCDSiCCDS15862.1.
    RefSeqiNP_083199.1. NM_028923.3.
    UniGeneiMm.275121.

    Genome annotation databases

    EnsembliENSMUST00000019859; ENSMUSP00000019859; ENSMUSG00000019715.
    GeneIDi74412.
    KEGGimmu:74412.
    UCSCiuc008jaq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016671 mRNA. Translation: BAB30371.1 .
    AK028183 mRNA. Translation: BAC25796.1 . Frameshift.
    AK133888 mRNA. Translation: BAE21914.1 .
    AK145748 mRNA. Translation: BAE26625.1 .
    AK150230 mRNA. Translation: BAE29396.1 .
    AK161015 mRNA. Translation: BAE36148.1 .
    AK161659 mRNA. Translation: BAE36515.1 . Frameshift.
    AL928926 Genomic DNA. Translation: CAM46233.1 .
    BC026797 mRNA. Translation: AAH26797.1 .
    CCDSi CCDS15862.1.
    RefSeqi NP_083199.1. NM_028923.3.
    UniGenei Mm.275121.

    3D structure databases

    ProteinModelPortali Q8R322.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8R322. 1 interaction.
    MINTi MINT-4126988.

    PTM databases

    PhosphoSitei Q8R322.

    Proteomic databases

    MaxQBi Q8R322.
    PaxDbi Q8R322.
    PRIDEi Q8R322.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019859 ; ENSMUSP00000019859 ; ENSMUSG00000019715 .
    GeneIDi 74412.
    KEGGi mmu:74412.
    UCSCi uc008jaq.2. mouse.

    Organism-specific databases

    CTDi 2733.
    MGIi MGI:1921662. Gle1.

    Phylogenomic databases

    eggNOGi NOG330485.
    GeneTreei ENSGT00390000012903.
    HOVERGENi HBG081558.
    InParanoidi A3KGV8.
    OMAi SQHTESM.
    OrthoDBi EOG7FFMRB.
    PhylomeDBi Q8R322.
    TreeFami TF324158.

    Miscellaneous databases

    ChiTaRSi GLE1. mouse.
    NextBioi 340689.
    PROi Q8R322.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R322.
    CleanExi MM_GLE1.
    Genevestigatori Q8R322.

    Family and domain databases

    InterProi IPR012476. GLE1.
    [Graphical view ]
    PANTHERi PTHR12960. PTHR12960. 1 hit.
    Pfami PF07817. GLE1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow, Head and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiGLE1_MOUSE
    AccessioniPrimary (citable) accession number: Q8R322
    Secondary accession number(s): A3KGV8
    , Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3