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Protein

Nucleoporin GLE1

Gene

Gle1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin GLE1
Alternative name(s):
GLE1-like protein
Gene namesi
Name:Gle1
Synonyms:Gle1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1921662. Gle1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Nucleusnuclear pore complex By similarity

  • Note: Shuttles between the nucleus and the cytoplasm. Shuttling is essential for its mRNA export function.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048231 – 699Nucleoporin GLE1Add BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineBy similarity1
Modified residuei91PhosphoserineBy similarity1
Modified residuei101PhosphoserineBy similarity1
Modified residuei352PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R322.
MaxQBiQ8R322.
PaxDbiQ8R322.
PeptideAtlasiQ8R322.
PRIDEiQ8R322.

PTM databases

iPTMnetiQ8R322.
PhosphoSitePlusiQ8R322.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019715.
CleanExiMM_GLE1.
GenevisibleiQ8R322. MM.

Interactioni

Subunit structurei

Associated with the NPC, it however may not be a stable component of the NPC complex since it shuttles between the nucleus and the cytoplasm. Interacts with nuclear pore complex proteins NUP155 and NUPL2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8R322. 1 interactor.
MINTiMINT-4126988.
STRINGi10090.ENSMUSP00000019859.

Structurei

3D structure databases

ProteinModelPortaliQ8R322.
SMRiQ8R322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29Interaction with NUP155By similarityAdd BLAST29
Regioni445 – 484Mediates the shuttling between the nucleus and the cytoplasmBy similarityAdd BLAST40
Regioni657 – 699Interaction with NUPL2By similarityAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili154 – 274Sequence analysisAdd BLAST121
Coiled coili306 – 356Sequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 104Ser-richAdd BLAST38

Sequence similaritiesi

Belongs to the GLE1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2412. Eukaryota.
ENOG410XT57. LUCA.
GeneTreeiENSGT00390000012903.
HOVERGENiHBG081558.
InParanoidiQ8R322.
KOiK18723.
OMAiGNQLCSQ.
OrthoDBiEOG091G0AZV.
PhylomeDBiQ8R322.
TreeFamiTF324158.

Family and domain databases

InterProiIPR012476. GLE1.
[Graphical view]
PANTHERiPTHR12960. PTHR12960. 1 hit.
PfamiPF07817. GLE1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSDGRCWET LRALRNTSKG RLRYDREWLL RYEDVLEECM SLPKLSSYSG
60 70 80 90 100
WVVDHILPNT SGHTQESAPS SDNSPSSGSA SGLYQSSLLK SPVRSSPQSP
110 120 130 140 150
SPSSPNGTQS THESPFTEPI APQSSRAIKV EGCIRMYELA HRMRGTEGLR
160 170 180 190 200
QWQEEQERKV RALSEMASEQ LKRFDELKEL KLHKEFQDLQ EVMEKSTREA
210 220 230 240 250
LGHQEKLKEE HRHRAKILNL KLREAEQQRV KQAEQEQLRK EEGQVRLRSL
260 270 280 290 300
YSLQEEVLQL NQQLDASSQH KELLSVDLAA FQTRGNQLCG LISSIIRTTL
310 320 330 340 350
ESGYPTAENQ AEAERALQEM RDLLSDLEQE ITRASQVKKK HEEEAKVKRQ
360 370 380 390 400
ESQVQQGPAP PTQTSAPSPS PVGAQNEDLQ VKVQDSTMQW YQQLQDASAK
410 420 430 440 450
CVLAFEDLTS SKDSQTKKIK MDLQKAATIP VSQISTIAGS KLKEIFDKIH
460 470 480 490 500
SLLSGKPVQS GGRSVSVTLN PQGLDFVQYK LAEKFVKQGE EEVASHHEAA
510 520 530 540 550
FPIAVVASGI WMLHPKVGDL ILAHLHKKCP YSVPFYPAFK EGMALEDYQR
560 570 580 590 600
MLGYQVTDSK VEQQDNFLKR MSGMIRLYAA IIQLQWPYGN RQEAHPHGLN
610 620 630 640 650
HGWRWLAQVL NMEPLSDVTA TLLFDFLEVC GNALMKQYQV QFWKMILLIK
660 670 680 690
EDYFPRIEAI TSSGQMGSFI RLKQFLEKCL QRREIPVPRG FLTTSFWRS
Length:699
Mass (Da):79,574
Last modified:December 6, 2005 - v2
Checksum:i5403C38F9DC7ED75
GO

Sequence cautioni

The sequence BAC25796 differs from that shown. Reason: Frameshift at positions 92 and 166.Curated
The sequence BAE36515 differs from that shown. Reason: Frameshift at positions 1 and 31.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70Missing in AAH26797 (PubMed:15489334).Curated1
Sequence conflicti88L → R in BAC25796 (PubMed:16141072).Curated1
Sequence conflicti115P → Q in AAH26797 (PubMed:15489334).Curated1
Sequence conflicti206K → E in BAE36148 (PubMed:15489334).Curated1
Sequence conflicti359A → G in AAH26797 (PubMed:15489334).Curated1
Sequence conflicti368S → I in AAH26797 (PubMed:15489334).Curated1
Sequence conflicti374A → T in AAH26797 (PubMed:15489334).Curated1
Sequence conflicti535F → L in BAC25796 (PubMed:16141072).Curated1
Sequence conflicti598G → S in BAC25796 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016671 mRNA. Translation: BAB30371.1.
AK028183 mRNA. Translation: BAC25796.1. Frameshift.
AK133888 mRNA. Translation: BAE21914.1.
AK145748 mRNA. Translation: BAE26625.1.
AK150230 mRNA. Translation: BAE29396.1.
AK161015 mRNA. Translation: BAE36148.1.
AK161659 mRNA. Translation: BAE36515.1. Frameshift.
AL928926 Genomic DNA. Translation: CAM46233.1.
BC026797 mRNA. Translation: AAH26797.1.
CCDSiCCDS15862.1.
RefSeqiNP_083199.1. NM_028923.3.
UniGeneiMm.275121.

Genome annotation databases

EnsembliENSMUST00000019859; ENSMUSP00000019859; ENSMUSG00000019715.
GeneIDi74412.
KEGGimmu:74412.
UCSCiuc008jaq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016671 mRNA. Translation: BAB30371.1.
AK028183 mRNA. Translation: BAC25796.1. Frameshift.
AK133888 mRNA. Translation: BAE21914.1.
AK145748 mRNA. Translation: BAE26625.1.
AK150230 mRNA. Translation: BAE29396.1.
AK161015 mRNA. Translation: BAE36148.1.
AK161659 mRNA. Translation: BAE36515.1. Frameshift.
AL928926 Genomic DNA. Translation: CAM46233.1.
BC026797 mRNA. Translation: AAH26797.1.
CCDSiCCDS15862.1.
RefSeqiNP_083199.1. NM_028923.3.
UniGeneiMm.275121.

3D structure databases

ProteinModelPortaliQ8R322.
SMRiQ8R322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R322. 1 interactor.
MINTiMINT-4126988.
STRINGi10090.ENSMUSP00000019859.

PTM databases

iPTMnetiQ8R322.
PhosphoSitePlusiQ8R322.

Proteomic databases

EPDiQ8R322.
MaxQBiQ8R322.
PaxDbiQ8R322.
PeptideAtlasiQ8R322.
PRIDEiQ8R322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019859; ENSMUSP00000019859; ENSMUSG00000019715.
GeneIDi74412.
KEGGimmu:74412.
UCSCiuc008jaq.2. mouse.

Organism-specific databases

CTDi2733.
MGIiMGI:1921662. Gle1.

Phylogenomic databases

eggNOGiKOG2412. Eukaryota.
ENOG410XT57. LUCA.
GeneTreeiENSGT00390000012903.
HOVERGENiHBG081558.
InParanoidiQ8R322.
KOiK18723.
OMAiGNQLCSQ.
OrthoDBiEOG091G0AZV.
PhylomeDBiQ8R322.
TreeFamiTF324158.

Miscellaneous databases

ChiTaRSiGle1. mouse.
PROiQ8R322.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019715.
CleanExiMM_GLE1.
GenevisibleiQ8R322. MM.

Family and domain databases

InterProiIPR012476. GLE1.
[Graphical view]
PANTHERiPTHR12960. PTHR12960. 1 hit.
PfamiPF07817. GLE1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLE1_MOUSE
AccessioniPrimary (citable) accession number: Q8R322
Secondary accession number(s): A3KGV8
, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.