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Q8R322

- GLE1_MOUSE

UniProt

Q8R322 - GLE1_MOUSE

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Protein

Nucleoporin GLE1

Gene
Gle1, Gle1l
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) By similarity.

GO - Biological processi

  1. poly(A)+ mRNA export from nucleus Source: InterPro
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin GLE1
Alternative name(s):
GLE1-like protein
Gene namesi
Name:Gle1
Synonyms:Gle1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1921662. Gle1.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Nucleusnuclear pore complex By similarity
Note: Shuttles between the nucleus and the cytoplasm. Localizes to the nuclear pore complex and nuclear envelope. Shuttling is essential for its mRNA export function By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nuclear pore Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 699699Nucleoporin GLE1PRO_0000204823Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei91 – 911Phosphoserine By similarity
Modified residuei101 – 1011Phosphoserine By similarity
Modified residuei352 – 3521Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8R322.
PaxDbiQ8R322.
PRIDEiQ8R322.

PTM databases

PhosphoSiteiQ8R322.

Expressioni

Gene expression databases

BgeeiQ8R322.
CleanExiMM_GLE1.
GenevestigatoriQ8R322.

Interactioni

Subunit structurei

Associated with the NPC, it however may not be a stable component of the NPC complex since it shuttles between the nucleus and the cytoplasm. Interacts with nuclear pore complex proteins NUP155 and NUPL2 By similarity.

Protein-protein interaction databases

IntActiQ8R322. 1 interaction.
MINTiMINT-4126988.

Structurei

3D structure databases

ProteinModelPortaliQ8R322.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929Interaction with NUP155 By similarityAdd
BLAST
Regioni445 – 48440Mediates the shuttling between the nucleus and the cytoplasm By similarityAdd
BLAST
Regioni657 – 69943Interaction with NUPL2 By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili154 – 274121 Reviewed predictionAdd
BLAST
Coiled coili306 – 35651 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi67 – 10438Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the GLE1 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG330485.
GeneTreeiENSGT00390000012903.
HOVERGENiHBG081558.
InParanoidiA3KGV8.
OMAiSQHTESM.
OrthoDBiEOG7FFMRB.
PhylomeDBiQ8R322.
TreeFamiTF324158.

Family and domain databases

InterProiIPR012476. GLE1.
[Graphical view]
PANTHERiPTHR12960. PTHR12960. 1 hit.
PfamiPF07817. GLE1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R322-1 [UniParc]FASTAAdd to Basket

« Hide

MPSDGRCWET LRALRNTSKG RLRYDREWLL RYEDVLEECM SLPKLSSYSG    50
WVVDHILPNT SGHTQESAPS SDNSPSSGSA SGLYQSSLLK SPVRSSPQSP 100
SPSSPNGTQS THESPFTEPI APQSSRAIKV EGCIRMYELA HRMRGTEGLR 150
QWQEEQERKV RALSEMASEQ LKRFDELKEL KLHKEFQDLQ EVMEKSTREA 200
LGHQEKLKEE HRHRAKILNL KLREAEQQRV KQAEQEQLRK EEGQVRLRSL 250
YSLQEEVLQL NQQLDASSQH KELLSVDLAA FQTRGNQLCG LISSIIRTTL 300
ESGYPTAENQ AEAERALQEM RDLLSDLEQE ITRASQVKKK HEEEAKVKRQ 350
ESQVQQGPAP PTQTSAPSPS PVGAQNEDLQ VKVQDSTMQW YQQLQDASAK 400
CVLAFEDLTS SKDSQTKKIK MDLQKAATIP VSQISTIAGS KLKEIFDKIH 450
SLLSGKPVQS GGRSVSVTLN PQGLDFVQYK LAEKFVKQGE EEVASHHEAA 500
FPIAVVASGI WMLHPKVGDL ILAHLHKKCP YSVPFYPAFK EGMALEDYQR 550
MLGYQVTDSK VEQQDNFLKR MSGMIRLYAA IIQLQWPYGN RQEAHPHGLN 600
HGWRWLAQVL NMEPLSDVTA TLLFDFLEVC GNALMKQYQV QFWKMILLIK 650
EDYFPRIEAI TSSGQMGSFI RLKQFLEKCL QRREIPVPRG FLTTSFWRS 699
Length:699
Mass (Da):79,574
Last modified:December 6, 2005 - v2
Checksum:i5403C38F9DC7ED75
GO

Sequence cautioni

The sequence BAC25796.1 differs from that shown. Reason: Frameshift at positions 92 and 166.
The sequence BAE36515.1 differs from that shown. Reason: Frameshift at positions 1 and 31.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701Missing in AAH26797. 1 Publication
Sequence conflicti88 – 881L → R in BAC25796. 1 Publication
Sequence conflicti115 – 1151P → Q in AAH26797. 1 Publication
Sequence conflicti206 – 2061K → E in BAE36148. 1 Publication
Sequence conflicti359 – 3591A → G in AAH26797. 1 Publication
Sequence conflicti368 – 3681S → I in AAH26797. 1 Publication
Sequence conflicti374 – 3741A → T in AAH26797. 1 Publication
Sequence conflicti535 – 5351F → L in BAC25796. 1 Publication
Sequence conflicti598 – 5981G → S in BAC25796. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK016671 mRNA. Translation: BAB30371.1.
AK028183 mRNA. Translation: BAC25796.1. Frameshift.
AK133888 mRNA. Translation: BAE21914.1.
AK145748 mRNA. Translation: BAE26625.1.
AK150230 mRNA. Translation: BAE29396.1.
AK161015 mRNA. Translation: BAE36148.1.
AK161659 mRNA. Translation: BAE36515.1. Frameshift.
AL928926 Genomic DNA. Translation: CAM46233.1.
BC026797 mRNA. Translation: AAH26797.1.
CCDSiCCDS15862.1.
RefSeqiNP_083199.1. NM_028923.3.
UniGeneiMm.275121.

Genome annotation databases

EnsembliENSMUST00000019859; ENSMUSP00000019859; ENSMUSG00000019715.
GeneIDi74412.
KEGGimmu:74412.
UCSCiuc008jaq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK016671 mRNA. Translation: BAB30371.1 .
AK028183 mRNA. Translation: BAC25796.1 . Frameshift.
AK133888 mRNA. Translation: BAE21914.1 .
AK145748 mRNA. Translation: BAE26625.1 .
AK150230 mRNA. Translation: BAE29396.1 .
AK161015 mRNA. Translation: BAE36148.1 .
AK161659 mRNA. Translation: BAE36515.1 . Frameshift.
AL928926 Genomic DNA. Translation: CAM46233.1 .
BC026797 mRNA. Translation: AAH26797.1 .
CCDSi CCDS15862.1.
RefSeqi NP_083199.1. NM_028923.3.
UniGenei Mm.275121.

3D structure databases

ProteinModelPortali Q8R322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8R322. 1 interaction.
MINTi MINT-4126988.

PTM databases

PhosphoSitei Q8R322.

Proteomic databases

MaxQBi Q8R322.
PaxDbi Q8R322.
PRIDEi Q8R322.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019859 ; ENSMUSP00000019859 ; ENSMUSG00000019715 .
GeneIDi 74412.
KEGGi mmu:74412.
UCSCi uc008jaq.2. mouse.

Organism-specific databases

CTDi 2733.
MGIi MGI:1921662. Gle1.

Phylogenomic databases

eggNOGi NOG330485.
GeneTreei ENSGT00390000012903.
HOVERGENi HBG081558.
InParanoidi A3KGV8.
OMAi SQHTESM.
OrthoDBi EOG7FFMRB.
PhylomeDBi Q8R322.
TreeFami TF324158.

Miscellaneous databases

ChiTaRSi GLE1. mouse.
NextBioi 340689.
PROi Q8R322.
SOURCEi Search...

Gene expression databases

Bgeei Q8R322.
CleanExi MM_GLE1.
Genevestigatori Q8R322.

Family and domain databases

InterProi IPR012476. GLE1.
[Graphical view ]
PANTHERi PTHR12960. PTHR12960. 1 hit.
Pfami PF07817. GLE1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Head and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGLE1_MOUSE
AccessioniPrimary (citable) accession number: Q8R322
Secondary accession number(s): A3KGV8
, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi