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Q8R322 (GLE1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoporin GLE1
Alternative name(s):
GLE1-like protein
Gene names
Name:Gle1
Synonyms:Gle1l
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length699 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) By similarity.

Subunit structure

Associated with the NPC, it however may not be a stable component of the NPC complex since it shuttles between the nucleus and the cytoplasm. Interacts with nuclear pore complex proteins NUP155 and NUPL2 By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Nucleusnuclear pore complex By similarity. Note: Shuttles between the nucleus and the cytoplasm. Localizes to the nuclear pore complex and nuclear envelope. Shuttling is essential for its mRNA export function By similarity.

Sequence similarities

Belongs to the GLE1 family.

Sequence caution

The sequence BAC25796.1 differs from that shown. Reason: Frameshift at positions 92 and 166.

The sequence BAE36515.1 differs from that shown. Reason: Frameshift at positions 1 and 31.

Ontologies

Keywords
   Biological processmRNA transport
Protein transport
Translocation
Transport
   Cellular componentCytoplasm
Nuclear pore complex
Nucleus
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpoly(A)+ mRNA export from nucleus

Inferred from electronic annotation. Source: InterPro

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nuclear pore

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 699699Nucleoporin GLE1
PRO_0000204823

Regions

Region1 – 2929Interaction with NUP155 By similarity
Region445 – 48440Mediates the shuttling between the nucleus and the cytoplasm By similarity
Region657 – 69943Interaction with NUPL2 By similarity
Coiled coil154 – 274121 Potential
Coiled coil306 – 35651 Potential
Compositional bias67 – 10438Ser-rich

Amino acid modifications

Modified residue911Phosphoserine By similarity
Modified residue1011Phosphoserine By similarity
Modified residue3521Phosphoserine Ref.4

Experimental info

Sequence conflict701Missing in AAH26797. Ref.3
Sequence conflict881L → R in BAC25796. Ref.1
Sequence conflict1151P → Q in AAH26797. Ref.3
Sequence conflict2061K → E in BAE36148. Ref.3
Sequence conflict3591A → G in AAH26797. Ref.3
Sequence conflict3681S → I in AAH26797. Ref.3
Sequence conflict3741A → T in AAH26797. Ref.3
Sequence conflict5351F → L in BAC25796. Ref.1
Sequence conflict5981G → S in BAC25796. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8R322 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 5403C38F9DC7ED75

FASTA69979,574
        10         20         30         40         50         60 
MPSDGRCWET LRALRNTSKG RLRYDREWLL RYEDVLEECM SLPKLSSYSG WVVDHILPNT 

        70         80         90        100        110        120 
SGHTQESAPS SDNSPSSGSA SGLYQSSLLK SPVRSSPQSP SPSSPNGTQS THESPFTEPI 

       130        140        150        160        170        180 
APQSSRAIKV EGCIRMYELA HRMRGTEGLR QWQEEQERKV RALSEMASEQ LKRFDELKEL 

       190        200        210        220        230        240 
KLHKEFQDLQ EVMEKSTREA LGHQEKLKEE HRHRAKILNL KLREAEQQRV KQAEQEQLRK 

       250        260        270        280        290        300 
EEGQVRLRSL YSLQEEVLQL NQQLDASSQH KELLSVDLAA FQTRGNQLCG LISSIIRTTL 

       310        320        330        340        350        360 
ESGYPTAENQ AEAERALQEM RDLLSDLEQE ITRASQVKKK HEEEAKVKRQ ESQVQQGPAP 

       370        380        390        400        410        420 
PTQTSAPSPS PVGAQNEDLQ VKVQDSTMQW YQQLQDASAK CVLAFEDLTS SKDSQTKKIK 

       430        440        450        460        470        480 
MDLQKAATIP VSQISTIAGS KLKEIFDKIH SLLSGKPVQS GGRSVSVTLN PQGLDFVQYK 

       490        500        510        520        530        540 
LAEKFVKQGE EEVASHHEAA FPIAVVASGI WMLHPKVGDL ILAHLHKKCP YSVPFYPAFK 

       550        560        570        580        590        600 
EGMALEDYQR MLGYQVTDSK VEQQDNFLKR MSGMIRLYAA IIQLQWPYGN RQEAHPHGLN 

       610        620        630        640        650        660 
HGWRWLAQVL NMEPLSDVTA TLLFDFLEVC GNALMKQYQV QFWKMILLIK EDYFPRIEAI 

       670        680        690 
TSSGQMGSFI RLKQFLEKCL QRREIPVPRG FLTTSFWRS 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow, Head and Testis.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary tumor.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK016671 mRNA. Translation: BAB30371.1.
AK028183 mRNA. Translation: BAC25796.1. Frameshift.
AK133888 mRNA. Translation: BAE21914.1.
AK145748 mRNA. Translation: BAE26625.1.
AK150230 mRNA. Translation: BAE29396.1.
AK161015 mRNA. Translation: BAE36148.1.
AK161659 mRNA. Translation: BAE36515.1. Frameshift.
AL928926 Genomic DNA. Translation: CAM46233.1.
BC026797 mRNA. Translation: AAH26797.1.
RefSeqNP_083199.1. NM_028923.3.
UniGeneMm.275121.

3D structure databases

ProteinModelPortalQ8R322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8R322. 1 interaction.
MINTMINT-4126988.

PTM databases

PhosphoSiteQ8R322.

Proteomic databases

PaxDbQ8R322.
PRIDEQ8R322.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019859; ENSMUSP00000019859; ENSMUSG00000019715.
GeneID74412.
KEGGmmu:74412.
UCSCuc008jaq.2. mouse.

Organism-specific databases

CTD2733.
MGIMGI:1921662. Gle1.

Phylogenomic databases

eggNOGNOG330485.
GeneTreeENSGT00390000012903.
HOVERGENHBG081558.
InParanoidA3KGV8.
OMASQHTESM.
OrthoDBEOG7FFMRB.
PhylomeDBQ8R322.
TreeFamTF324158.

Gene expression databases

BgeeQ8R322.
CleanExMM_GLE1.
GenevestigatorQ8R322.

Family and domain databases

InterProIPR012476. GLE1.
[Graphical view]
PANTHERPTHR12960. PTHR12960. 1 hit.
PfamPF07817. GLE1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGLE1. mouse.
NextBio340689.
PROQ8R322.
SOURCESearch...

Entry information

Entry nameGLE1_MOUSE
AccessionPrimary (citable) accession number: Q8R322
Secondary accession number(s): A3KGV8 expand/collapse secondary AC list , Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: April 16, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot