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Protein

HMG box-containing protein 1

Gene

Hbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi436 – 504HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HMG box-containing protein 1
Alternative name(s):
HMG box transcription factor 1
High mobility group box transcription factor 1
Gene namesi
Name:Hbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:894659. Hbp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi370L → D: Strongly reduces Sin3A binding. 1 Publication1
Mutagenesisi373M → D: Strongly reduces Sin3A binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485471 – 516HMG box-containing protein 1Add BLAST516

Proteomic databases

PaxDbiQ8R316.
PRIDEiQ8R316.

PTM databases

iPTMnetiQ8R316.
PhosphoSitePlusiQ8R316.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002996.
CleanExiMM_HBP1.

Interactioni

Subunit structurei

Binds TCF4 (By similarity). Binds RB1. Binds the second PAH repeat of SIN3A.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131158.

Structurei

Secondary structure

1516
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi220 – 223Combined sources4
Helixi234 – 240Combined sources7
Turni247 – 249Combined sources3
Turni255 – 258Combined sources4
Beta strandi262 – 272Combined sources11
Beta strandi275 – 283Combined sources9
Helixi287 – 289Combined sources3
Beta strandi292 – 296Combined sources5
Beta strandi302 – 304Combined sources3
Turni305 – 307Combined sources3
Beta strandi308 – 313Combined sources6
Helixi314 – 321Combined sources8
Beta strandi363 – 365Combined sources3
Helixi366 – 375Combined sources10
Turni376 – 378Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S5RNMR-A358-380[»]
1V06NMR-A208-345[»]
ProteinModelPortaliQ8R316.
SMRiQ8R316.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8R316.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 345AXHPROSITE-ProRule annotationAdd BLAST143

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi156 – 161Poly-Ser6
Compositional biasi197 – 200Poly-Asp4
Compositional biasi394 – 432Ser-richAdd BLAST39

Sequence similaritiesi

Contains 1 AXH domain.PROSITE-ProRule annotation
Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFNF. Eukaryota.
ENOG410XPPV. LUCA.
HOGENOMiHOG000065753.
HOVERGENiHBG052810.
InParanoidiQ8R316.
PhylomeDBiQ8R316.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR003652. Ataxin_AXH_dom.
IPR009071. HMG_box_dom.
[Graphical view]
PfamiPF08517. AXH. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00536. AXH. 1 hit.
SM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF102031. SSF102031. 1 hit.
SSF47095. SSF47095. 1 hit.
PROSITEiPS51148. AXH. 1 hit.
PS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R316-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVWEVKTNQM PNAVQKLLLV MDKRAPGMSD SLELLQCNEN LPSSPGYNSC
60 70 80 90 100
DEHMELDDLP ELQAVQSDPT QSAIYQLSSD VSHQEYPRSS WSQNTSDIPE
110 120 130 140 150
NTHREDEVDW LTELANIATS PQSPLMQCSF YNRSSPVHII ATSKSLHSYA
160 170 180 190 200
RPPPVSSSSK SGPAFPHDHW KEETPVRHER ANSESESGIF CMSSLSDDDD
210 220 230 240 250
LGWCNSWPST IWHCFLKGTR LCFHKESNKE WQDVEDFARA ASCDNEEEIQ
260 270 280 290 300
MGTHKGYGSD GLKLLSHEES VSFGESVLKL TFDPGTVEDG LLTVECKLDH
310 320 330 340 350
PFYVKNKGWS SFYPSLTVVQ HGIPCCEIHI GDVCLPPGHP DAINFDDSGV
360 370 380 390 400
FDTFKSYDFT PMDSSAVYVL SSMARQRRAS LSCGGGPGTG QEFSGSEFSK
410 420 430 440 450
SCGSPGSSQL SSSSLYAKAV KSHSSGTVSA TSPNKCKRPM NAFMLFAKKY
460 470 480 490 500
RVEYTQMYPG KDNRAISVIL GDRWKKMKNE ERRMYTLEAK ALAEEQKRLN
510
PDCWKRKRTN SGSQQH
Length:516
Mass (Da):57,645
Last modified:June 1, 2002 - v1
Checksum:i2DC6D40FE41543B0
GO
Isoform 2 (identifier: Q8R316-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-516: Missing.

Note: No experimental confirmation available.
Show »
Length:464
Mass (Da):51,433
Checksum:iB40F04F670C60E19
GO

Sequence cautioni

The sequence BAC38611 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014657465 – 516Missing in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026853 mRNA. Translation: AAH26853.1.
AK028674 mRNA. Translation: BAC26060.1.
AK082770 mRNA. Translation: BAC38611.1. Different initiation.
AK133127 mRNA. Translation: BAE21520.1.
RefSeqiNP_694878.2. NM_153198.2.
NP_818774.2. NM_177993.3.
XP_017170701.1. XM_017315212.1. [Q8R316-1]
UniGeneiMm.390461.
Mm.458534.

Genome annotation databases

GeneIDi73389.
KEGGimmu:73389.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026853 mRNA. Translation: AAH26853.1.
AK028674 mRNA. Translation: BAC26060.1.
AK082770 mRNA. Translation: BAC38611.1. Different initiation.
AK133127 mRNA. Translation: BAE21520.1.
RefSeqiNP_694878.2. NM_153198.2.
NP_818774.2. NM_177993.3.
XP_017170701.1. XM_017315212.1. [Q8R316-1]
UniGeneiMm.390461.
Mm.458534.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S5RNMR-A358-380[»]
1V06NMR-A208-345[»]
ProteinModelPortaliQ8R316.
SMRiQ8R316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131158.

PTM databases

iPTMnetiQ8R316.
PhosphoSitePlusiQ8R316.

Proteomic databases

PaxDbiQ8R316.
PRIDEiQ8R316.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi73389.
KEGGimmu:73389.

Organism-specific databases

CTDi26959.
MGIiMGI:894659. Hbp1.

Phylogenomic databases

eggNOGiENOG410IFNF. Eukaryota.
ENOG410XPPV. LUCA.
HOGENOMiHOG000065753.
HOVERGENiHBG052810.
InParanoidiQ8R316.
PhylomeDBiQ8R316.

Miscellaneous databases

EvolutionaryTraceiQ8R316.
PROiQ8R316.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002996.
CleanExiMM_HBP1.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR003652. Ataxin_AXH_dom.
IPR009071. HMG_box_dom.
[Graphical view]
PfamiPF08517. AXH. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00536. AXH. 1 hit.
SM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF102031. SSF102031. 1 hit.
SSF47095. SSF47095. 1 hit.
PROSITEiPS51148. AXH. 1 hit.
PS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBP1_MOUSE
AccessioniPrimary (citable) accession number: Q8R316
Secondary accession number(s): Q3V0I4, Q8BUS3, Q8C199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.