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Q8R316

- HBP1_MOUSE

UniProt

Q8R316 - HBP1_MOUSE

Protein

HMG box-containing protein 1

Gene

Hbp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi436 – 50469HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. RNA binding Source: InterPro

    GO - Biological processi

    1. positive regulation of potassium ion transport Source: Ensembl
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW
    4. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation, Wnt signaling pathway

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HMG box-containing protein 1
    Alternative name(s):
    HMG box transcription factor 1
    High mobility group box transcription factor 1
    Gene namesi
    Name:Hbp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:894659. Hbp1.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi370 – 3701L → D: Strongly reduces Sin3A binding. 1 Publication
    Mutagenesisi373 – 3731M → D: Strongly reduces Sin3A binding. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 516516HMG box-containing protein 1PRO_0000048547Add
    BLAST

    Proteomic databases

    PRIDEiQ8R316.

    PTM databases

    PhosphoSiteiQ8R316.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8R316.
    BgeeiQ8R316.
    CleanExiMM_HBP1.
    GenevestigatoriQ8R316.

    Interactioni

    Subunit structurei

    Binds TCF4 By similarity. Binds RB1. Binds the second PAH repeat of SIN3A.By similarity

    Structurei

    Secondary structure

    1
    516
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi220 – 2234
    Helixi234 – 2407
    Turni247 – 2493
    Turni255 – 2584
    Beta strandi262 – 27211
    Beta strandi275 – 2839
    Helixi287 – 2893
    Beta strandi292 – 2965
    Beta strandi302 – 3043
    Turni305 – 3073
    Beta strandi308 – 3136
    Helixi314 – 3218
    Beta strandi363 – 3653
    Helixi366 – 37510
    Turni376 – 3783

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1S5RNMR-A358-380[»]
    1V06NMR-A208-345[»]
    ProteinModelPortaliQ8R316.
    SMRiQ8R316. Positions 208-345, 427-505.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8R316.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini203 – 345143AXHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi156 – 1616Poly-Ser
    Compositional biasi197 – 2004Poly-Asp
    Compositional biasi394 – 43239Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 AXH domain.PROSITE-ProRule annotation
    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG149693.
    HOGENOMiHOG000065753.
    HOVERGENiHBG052810.
    InParanoidiQ8R316.
    PhylomeDBiQ8R316.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR013723. Ataxin-1_HBP1.
    IPR003652. Ataxin_AXH_dom.
    IPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF08517. AXH. 1 hit.
    PF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00536. AXH. 1 hit.
    SM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF102031. SSF102031. 1 hit.
    SSF47095. SSF47095. 1 hit.
    PROSITEiPS51148. AXH. 1 hit.
    PS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8R316-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVWEVKTNQM PNAVQKLLLV MDKRAPGMSD SLELLQCNEN LPSSPGYNSC    50
    DEHMELDDLP ELQAVQSDPT QSAIYQLSSD VSHQEYPRSS WSQNTSDIPE 100
    NTHREDEVDW LTELANIATS PQSPLMQCSF YNRSSPVHII ATSKSLHSYA 150
    RPPPVSSSSK SGPAFPHDHW KEETPVRHER ANSESESGIF CMSSLSDDDD 200
    LGWCNSWPST IWHCFLKGTR LCFHKESNKE WQDVEDFARA ASCDNEEEIQ 250
    MGTHKGYGSD GLKLLSHEES VSFGESVLKL TFDPGTVEDG LLTVECKLDH 300
    PFYVKNKGWS SFYPSLTVVQ HGIPCCEIHI GDVCLPPGHP DAINFDDSGV 350
    FDTFKSYDFT PMDSSAVYVL SSMARQRRAS LSCGGGPGTG QEFSGSEFSK 400
    SCGSPGSSQL SSSSLYAKAV KSHSSGTVSA TSPNKCKRPM NAFMLFAKKY 450
    RVEYTQMYPG KDNRAISVIL GDRWKKMKNE ERRMYTLEAK ALAEEQKRLN 500
    PDCWKRKRTN SGSQQH 516
    Length:516
    Mass (Da):57,645
    Last modified:June 1, 2002 - v1
    Checksum:i2DC6D40FE41543B0
    GO
    Isoform 2 (identifier: Q8R316-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         465-516: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:464
    Mass (Da):51,433
    Checksum:iB40F04F670C60E19
    GO

    Sequence cautioni

    The sequence BAC38611.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei465 – 51652Missing in isoform 2. 1 PublicationVSP_014657Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC026853 mRNA. Translation: AAH26853.1.
    AK028674 mRNA. Translation: BAC26060.1.
    AK082770 mRNA. Translation: BAC38611.1. Different initiation.
    AK133127 mRNA. Translation: BAE21520.1.
    RefSeqiNP_694878.2. NM_153198.2.
    NP_818774.2. NM_177993.3.
    UniGeneiMm.390461.
    Mm.458534.

    Genome annotation databases

    GeneIDi73389.
    KEGGimmu:73389.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC026853 mRNA. Translation: AAH26853.1 .
    AK028674 mRNA. Translation: BAC26060.1 .
    AK082770 mRNA. Translation: BAC38611.1 . Different initiation.
    AK133127 mRNA. Translation: BAE21520.1 .
    RefSeqi NP_694878.2. NM_153198.2.
    NP_818774.2. NM_177993.3.
    UniGenei Mm.390461.
    Mm.458534.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1S5R NMR - A 358-380 [» ]
    1V06 NMR - A 208-345 [» ]
    ProteinModelPortali Q8R316.
    SMRi Q8R316. Positions 208-345, 427-505.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8R316.

    Proteomic databases

    PRIDEi Q8R316.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 73389.
    KEGGi mmu:73389.

    Organism-specific databases

    CTDi 26959.
    MGIi MGI:894659. Hbp1.

    Phylogenomic databases

    eggNOGi NOG149693.
    HOGENOMi HOG000065753.
    HOVERGENi HBG052810.
    InParanoidi Q8R316.
    PhylomeDBi Q8R316.

    Miscellaneous databases

    EvolutionaryTracei Q8R316.
    NextBioi 338141.
    PROi Q8R316.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R316.
    Bgeei Q8R316.
    CleanExi MM_HBP1.
    Genevestigatori Q8R316.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR013723. Ataxin-1_HBP1.
    IPR003652. Ataxin_AXH_dom.
    IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF08517. AXH. 1 hit.
    PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00536. AXH. 1 hit.
    SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF102031. SSF102031. 1 hit.
    SSF47095. SSF47095. 1 hit.
    PROSITEi PS51148. AXH. 1 hit.
    PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Skin and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A."
      Lavender P., Vandel L., Bannister A.J., Kouzarides T.
      Oncogene 14:2721-2728(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RB1, FUNCTION.
    4. "Assignment of the 1H, 13C, and 15N resonances of the AXH domain of the transcription factor HBP1."
      de Chiara C., Kelly G., Frenkiel T.A., Pastore A.
      J. Biomol. NMR 28:411-412(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 208-345.
    5. "HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations."
      Swanson K.A., Knoepfler P.S., Huang K., Kang R.S., Cowley S.M., Laherty C.D., Eisenman R.N., Radhakrishnan I.
      Nat. Struct. Mol. Biol. 11:738-746(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 233-255, SUBCELLULAR LOCATION, MUTAGENESIS OF LEU-370 AND MET-373, INTERACTION WITH SIN3A.

    Entry informationi

    Entry nameiHBP1_MOUSE
    AccessioniPrimary (citable) accession number: Q8R316
    Secondary accession number(s): Q3V0I4, Q8BUS3, Q8C199
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3