Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8R316

- HBP1_MOUSE

UniProt

Q8R316 - HBP1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

HMG box-containing protein 1

Gene

Hbp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi436 – 50469HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro

GO - Biological processi

  1. positive regulation of potassium ion transport Source: Ensembl
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
  4. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HMG box-containing protein 1
Alternative name(s):
HMG box transcription factor 1
High mobility group box transcription factor 1
Gene namesi
Name:Hbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:894659. Hbp1.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi370 – 3701L → D: Strongly reduces Sin3A binding. 1 Publication
Mutagenesisi373 – 3731M → D: Strongly reduces Sin3A binding. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516HMG box-containing protein 1PRO_0000048547Add
BLAST

Proteomic databases

PRIDEiQ8R316.

PTM databases

PhosphoSiteiQ8R316.

Expressioni

Gene expression databases

BgeeiQ8R316.
CleanExiMM_HBP1.
ExpressionAtlasiQ8R316. baseline and differential.
GenevestigatoriQ8R316.

Interactioni

Subunit structurei

Binds TCF4 (By similarity). Binds RB1. Binds the second PAH repeat of SIN3A.By similarity

Structurei

Secondary structure

1
516
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi220 – 2234
Helixi234 – 2407
Turni247 – 2493
Turni255 – 2584
Beta strandi262 – 27211
Beta strandi275 – 2839
Helixi287 – 2893
Beta strandi292 – 2965
Beta strandi302 – 3043
Turni305 – 3073
Beta strandi308 – 3136
Helixi314 – 3218
Beta strandi363 – 3653
Helixi366 – 37510
Turni376 – 3783

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S5RNMR-A358-380[»]
1V06NMR-A208-345[»]
ProteinModelPortaliQ8R316.
SMRiQ8R316. Positions 208-345, 427-505.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8R316.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini203 – 345143AXHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 1616Poly-Ser
Compositional biasi197 – 2004Poly-Asp
Compositional biasi394 – 43239Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 AXH domain.PROSITE-ProRule annotation
Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG149693.
HOGENOMiHOG000065753.
HOVERGENiHBG052810.
InParanoidiQ8R316.
PhylomeDBiQ8R316.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR013723. Ataxin-1_HBP1.
IPR003652. Ataxin_AXH_dom.
IPR009071. HMG_box_dom.
[Graphical view]
PfamiPF08517. AXH. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00536. AXH. 1 hit.
SM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF102031. SSF102031. 1 hit.
SSF47095. SSF47095. 1 hit.
PROSITEiPS51148. AXH. 1 hit.
PS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8R316-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVWEVKTNQM PNAVQKLLLV MDKRAPGMSD SLELLQCNEN LPSSPGYNSC
60 70 80 90 100
DEHMELDDLP ELQAVQSDPT QSAIYQLSSD VSHQEYPRSS WSQNTSDIPE
110 120 130 140 150
NTHREDEVDW LTELANIATS PQSPLMQCSF YNRSSPVHII ATSKSLHSYA
160 170 180 190 200
RPPPVSSSSK SGPAFPHDHW KEETPVRHER ANSESESGIF CMSSLSDDDD
210 220 230 240 250
LGWCNSWPST IWHCFLKGTR LCFHKESNKE WQDVEDFARA ASCDNEEEIQ
260 270 280 290 300
MGTHKGYGSD GLKLLSHEES VSFGESVLKL TFDPGTVEDG LLTVECKLDH
310 320 330 340 350
PFYVKNKGWS SFYPSLTVVQ HGIPCCEIHI GDVCLPPGHP DAINFDDSGV
360 370 380 390 400
FDTFKSYDFT PMDSSAVYVL SSMARQRRAS LSCGGGPGTG QEFSGSEFSK
410 420 430 440 450
SCGSPGSSQL SSSSLYAKAV KSHSSGTVSA TSPNKCKRPM NAFMLFAKKY
460 470 480 490 500
RVEYTQMYPG KDNRAISVIL GDRWKKMKNE ERRMYTLEAK ALAEEQKRLN
510
PDCWKRKRTN SGSQQH
Length:516
Mass (Da):57,645
Last modified:June 1, 2002 - v1
Checksum:i2DC6D40FE41543B0
GO
Isoform 2 (identifier: Q8R316-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-516: Missing.

Note: No experimental confirmation available.

Show »
Length:464
Mass (Da):51,433
Checksum:iB40F04F670C60E19
GO

Sequence cautioni

The sequence BAC38611.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei465 – 51652Missing in isoform 2. 1 PublicationVSP_014657Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC026853 mRNA. Translation: AAH26853.1.
AK028674 mRNA. Translation: BAC26060.1.
AK082770 mRNA. Translation: BAC38611.1. Different initiation.
AK133127 mRNA. Translation: BAE21520.1.
RefSeqiNP_694878.2. NM_153198.2.
NP_818774.2. NM_177993.3.
UniGeneiMm.390461.
Mm.458534.

Genome annotation databases

GeneIDi73389.
KEGGimmu:73389.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC026853 mRNA. Translation: AAH26853.1 .
AK028674 mRNA. Translation: BAC26060.1 .
AK082770 mRNA. Translation: BAC38611.1 . Different initiation.
AK133127 mRNA. Translation: BAE21520.1 .
RefSeqi NP_694878.2. NM_153198.2.
NP_818774.2. NM_177993.3.
UniGenei Mm.390461.
Mm.458534.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1S5R NMR - A 358-380 [» ]
1V06 NMR - A 208-345 [» ]
ProteinModelPortali Q8R316.
SMRi Q8R316. Positions 208-345, 427-505.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8R316.

Proteomic databases

PRIDEi Q8R316.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 73389.
KEGGi mmu:73389.

Organism-specific databases

CTDi 26959.
MGIi MGI:894659. Hbp1.

Phylogenomic databases

eggNOGi NOG149693.
HOGENOMi HOG000065753.
HOVERGENi HBG052810.
InParanoidi Q8R316.
PhylomeDBi Q8R316.

Miscellaneous databases

EvolutionaryTracei Q8R316.
NextBioi 338141.
PROi Q8R316.
SOURCEi Search...

Gene expression databases

Bgeei Q8R316.
CleanExi MM_HBP1.
ExpressionAtlasi Q8R316. baseline and differential.
Genevestigatori Q8R316.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR013723. Ataxin-1_HBP1.
IPR003652. Ataxin_AXH_dom.
IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF08517. AXH. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00536. AXH. 1 hit.
SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF102031. SSF102031. 1 hit.
SSF47095. SSF47095. 1 hit.
PROSITEi PS51148. AXH. 1 hit.
PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Skin and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A."
    Lavender P., Vandel L., Bannister A.J., Kouzarides T.
    Oncogene 14:2721-2728(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RB1, FUNCTION.
  4. "Assignment of the 1H, 13C, and 15N resonances of the AXH domain of the transcription factor HBP1."
    de Chiara C., Kelly G., Frenkiel T.A., Pastore A.
    J. Biomol. NMR 28:411-412(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 208-345.
  5. "HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations."
    Swanson K.A., Knoepfler P.S., Huang K., Kang R.S., Cowley S.M., Laherty C.D., Eisenman R.N., Radhakrishnan I.
    Nat. Struct. Mol. Biol. 11:738-746(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 233-255, SUBCELLULAR LOCATION, MUTAGENESIS OF LEU-370 AND MET-373, INTERACTION WITH SIN3A.

Entry informationi

Entry nameiHBP1_MOUSE
AccessioniPrimary (citable) accession number: Q8R316
Secondary accession number(s): Q3V0I4, Q8BUS3, Q8C199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3