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Protein

Exocyst complex component 6

Gene

Exoc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.By similarity

GO - Biological processi

  • erythrocyte differentiation Source: MGI
  • protein transport Source: UniProtKB-KW
  • vesicle docking involved in exocytosis Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 6
Alternative name(s):
Exocyst complex component Sec15A
SEC15-like protein 1
Gene namesi
Name:Exoc6
Synonyms:Sec15a, Sec15l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1351611. Exoc6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Exocyst complex component 6PRO_0000118952Add
BLAST

Proteomic databases

EPDiQ8R313.
MaxQBiQ8R313.
PaxDbiQ8R313.
PRIDEiQ8R313.

PTM databases

iPTMnetiQ8R313.
PhosphoSiteiQ8R313.

Expressioni

Gene expression databases

CleanExiMM_EXOC6.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with CNTRL (By similarity). Interacts with RAB11A in a GTP-dependent manner.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Rab3ipQ627392EBI-9202179,EBI-2028671From a different organism.

Protein-protein interaction databases

IntActiQ8R313. 1 interaction.
STRINGi10090.ENSMUSP00000064332.

Structurei

3D structure databases

ProteinModelPortaliQ8R313.
SMRiQ8R313. Positions 409-728.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC15 family.Curated

Phylogenomic databases

eggNOGiKOG2176. Eukaryota.
ENOG410XQAE. LUCA.
HOVERGENiHBG057543.
InParanoidiQ8R313.

Family and domain databases

InterProiIPR007225. Sec15.
[Graphical view]
PANTHERiPTHR12702. PTHR12702. 1 hit.
PfamiPF04091. Sec15. 1 hit.
[Graphical view]
PIRSFiPIRSF025007. Sec15. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R313-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESCEALGT VPEHERILQE IESTDTACVG PTLRSVYDDQ PNAHKKFMEK
60 70 80 90 100
LDACIRNHDK EIEKMCNFHH QGFVDAITEL LKVRADAEKL KVTDTNRRFQ
110 120 130 140 150
DAGKEVIIQT EDIIRCRIQQ RNITTVVEKL QLCLPVLEMY SKLKEQMSMK
160 170 180 190 200
RYYSALKTME QLENVYFPRV SQYRFCQLMM ETLPKLREDM MNYCMSDLTY
210 220 230 240 250
GLESIRKHSD KIGEAAMKQA QQQKSFSVAL QKQNNMRFGK NMHVNNDRIL
260 270 280 290 300
EEKSDVIPKH ALEEEAENDE EVLTVQDLVD FSPVYRCLHI YSALGDEETF
310 320 330 340 350
ENYYRKQRKK QARLVLQPQS SVHETVDGYR RYFTQIVGFF VVEDHILHVT
360 370 380 390 400
QGLVTRVYTE ELWNMALSKI IAVLRAHSSY CTDPDLVLEL KNLIVIFADT
410 420 430 440 450
LQGYGFPVNR LFDLLFEIRD QYNETLLKKW AGIFRDIFEE DNYSPIPIGS
460 470 480 490 500
EEEYKVVISR FPFQDPDLEK QSFPKKFPMS QSVPLIYIQV KEFIYASLKF
510 520 530 540 550
SESLHRSSTE IDDMLRKSTN LLLTRILSSC LLNLIRKPHI GLTELVQIII
560 570 580 590 600
NTTHLEQACK YLEDFITNIT NISQETVHTT RLYGLSTFKD ARHAAEGEIY
610 620 630 640 650
TKLNQKIDEF VQLADYDWTM AESDGRASGY LMDLINFLRS IFQVFTHLPG
660 670 680 690 700
KVAQTACMSA CQHLSTSLMQ MLLDSELKQI SMGAVQQFNL DVIQCELFAS
710 720 730 740 750
SEPVPGFQGD TLQLAFIDLR QLLDLFMVWD WSTYLADYGQ PASKYLRVNP
760 770 780 790 800
HAALTLLEKM KDTSKKNNIF AQFRKNDRDR QKLIETVVRQ LRGLVTGMSQ

HT
Length:802
Mass (Da):93,077
Last modified:October 25, 2002 - v2
Checksum:i7AA82DCADBCD8E8B
GO

Sequence cautioni

The sequence AAH26859.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026859 mRNA. Translation: AAH26859.1. Different initiation.
UniGeneiMm.24865.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026859 mRNA. Translation: AAH26859.1. Different initiation.
UniGeneiMm.24865.

3D structure databases

ProteinModelPortaliQ8R313.
SMRiQ8R313. Positions 409-728.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R313. 1 interaction.
STRINGi10090.ENSMUSP00000064332.

PTM databases

iPTMnetiQ8R313.
PhosphoSiteiQ8R313.

Proteomic databases

EPDiQ8R313.
MaxQBiQ8R313.
PaxDbiQ8R313.
PRIDEiQ8R313.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1351611. Exoc6.

Phylogenomic databases

eggNOGiKOG2176. Eukaryota.
ENOG410XQAE. LUCA.
HOVERGENiHBG057543.
InParanoidiQ8R313.

Miscellaneous databases

ChiTaRSiExoc6. mouse.
PROiQ8R313.
SOURCEiSearch...

Gene expression databases

CleanExiMM_EXOC6.

Family and domain databases

InterProiIPR007225. Sec15.
[Graphical view]
PANTHERiPTHR12702. PTHR12702. 1 hit.
PfamiPF04091. Sec15. 1 hit.
[Graphical view]
PIRSFiPIRSF025007. Sec15. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Sec15 is an effector for the Rab11 GTPase in mammalian cells."
    Zhang X.-M., Ellis S., Sriratana A., Mitchell C.A., Rowe T.
    J. Biol. Chem. 279:43027-43034(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAB11A.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Spleen and Testis.

Entry informationi

Entry nameiEXOC6_MOUSE
AccessioniPrimary (citable) accession number: Q8R313
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: March 16, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.