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Protein

Endoplasmic reticulum export factor CTAGE5

Gene

Ctage5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum export factor CTAGE5Curated
Alternative name(s):
cTAGE family member 5Imported
Gene namesi
Name:Ctage5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1346056. Ctage5.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein Sequence analysis

  • Note: Endoplasmic reticulum exit sites.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9LumenalCurated9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 779CytoplasmicCuratedAdd BLAST749

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895421 – 779Endoplasmic reticulum export factor CTAGE5Add BLAST779

Proteomic databases

EPDiQ8R311.
MaxQBiQ8R311.
PaxDbiQ8R311.
PeptideAtlasiQ8R311.
PRIDEiQ8R311.

PTM databases

iPTMnetiQ8R311.
PhosphoSitePlusiQ8R311.

Expressioni

Gene expression databases

CleanExiMM_CTAGE5.

Interactioni

Subunit structurei

Interacts with MIA3. Interacts with the COPII coat subunits SEC23A, SEC23B and maybe SEC24C. Interacts with PREB; recruits PREB to endoplasmic reticulum exit sites. May interact with APOB.By similarity

Protein-protein interaction databases

IntActiQ8R311. 4 interactors.
MINTiMINT-4092511.
STRINGi10090.ENSMUSP00000070572.

Structurei

3D structure databases

ProteinModelPortaliQ8R311.
SMRiQ8R311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 626Mediates interaction with MIA3By similarityAdd BLAST595
Regioni627 – 779Proline-rich domain (PRD); mediates interaction with the COPII coat subunits SEC23A and SEC23BBy similarityAdd BLAST153

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili74 – 248Sequence analysisAdd BLAST175
Coiled coili297 – 465Sequence analysisAdd BLAST169

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi652 – 774Pro-richPROSITE-ProRule annotationAdd BLAST123

Domaini

The proline-rich domain (PRD) contains repeated PPP motifs. A single PPP motif is necessary and sufficient to mediate interaction with the COPII coat subunits SEC23A and SEC23B.By similarity
The coiled coil domains mediate interaction with MIA3. The first coiled coil domain mediates interaction with PREB.By similarity

Sequence similaritiesi

Belongs to the cTAGE family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJV2. Eukaryota.
ENOG410ZUJU. LUCA.
HOGENOMiHOG000112043.
HOVERGENiHBG051216.
InParanoidiQ8R311.
PhylomeDBiQ8R311.

Sequencei

Sequence statusi: Complete.

Q8R311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRADFNPSGF SLELAVCVLS VGLLAVVLFL WRGFRSIRSR FYVGREKKLA
60 70 80 90 100
LELSALIEEK CKLLDKVSIV QKEYEGLESS LKEASFEKES TEAQSLEFVE
110 120 130 140 150
GSQISEATYE NLEQSKSKLE DEILLLEEKL EEERAKHSEQ DELMADISKR
160 170 180 190 200
IQSLEDESKS LKSQVAEAKT TFRIFEINEE RLKGAIKDAL NENSQLQESQ
210 220 230 240 250
KQLLQETEMM KEQVNDLDKQ KVALEESRAQ AEQALSEKES QIETLVTSLL
260 270 280 290 300
KMKDWAAVLG EDIADDGNLD LDMKSGLENT AALDNQPKGA LKKLIYAAKL
310 320 330 340 350
NASLKALEGE RNQVYTQLSE VDQVKEDLTE HIKSLESKQA SLQSEKTEFE
360 370 380 390 400
SESQKLQQKL KVITELYQEN EMKLHRKLTV EENYRLEKEE KLSKVDEKIS
410 420 430 440 450
HATEELETCR QRAKDLEEEL ERTIHSYQGQ VISHEKKAHD NWLAARTLER
460 470 480 490 500
NLNDLRKENA HNRQKLTETE FKFELLEKDP YALDVPNTAF GREHSPYGPS
510 520 530 540 550
PLGRPPSETR AFLSPPTLLE GPLRLSPLLP GGGGRGSRGP ENLLDHQMNT
560 570 580 590 600
ERGESSYDRL SDAPRAPSDR SLSPPWEQDR RMTAHPPPGQ PYSDPALQRQ
610 620 630 640 650
DRFYPNSGRL SGPAELRSYN MPSLDKVDGP VPSEMESSGN GTKDNLGNSN
660 670 680 690 700
VPDSPIPAEC EAAGRGFFPP PFPPVRDPLF PVDPRSQFMR RGPSFPPPPP
710 720 730 740 750
GSIYAAPRDY FPPRDFPGPP LPPFPGRTVY APRGFPPYLP PRAGFFPPPP
760 770
HPESRSELPP DLIPPSKEPA ADPPETQEA
Length:779
Mass (Da):87,718
Last modified:June 1, 2002 - v1
Checksum:i77F6FC898BA833D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024076 mRNA. Translation: AAH24076.1.
BC026864 mRNA. Translation: AAH26864.1.
UniGeneiMm.213215.
Mm.244118.
Mm.438038.

Similar proteinsi

Entry informationi

Entry nameiCTGE5_MOUSE
AccessioniPrimary (citable) accession number: Q8R311
Secondary accession number(s): Q8CIE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is unclear whether MIA2 and CTAGE5 constitute 2 distinct genes or a single one similar to MIA3.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families