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Q8R2Z3

- S26A7_MOUSE

UniProt

Q8R2Z3 - S26A7_MOUSE

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Protein

Anion exchange transporter

Gene
Slc26a7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion.By similarity3 Publications

GO - Molecular functioni

  1. anion:anion antiporter activity Source: UniProtKB-KW
  2. anion channel activity Source: MGI
  3. bicarbonate transmembrane transporter activity Source: UniProtKB
  4. chloride channel activity Source: MGI
  5. oxalate transmembrane transporter activity Source: Ensembl
  6. sulfate transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. anion transport Source: MGI
  2. bicarbonate transport Source: UniProtKB
  3. chloride transmembrane transport Source: GOC
  4. chloride transport Source: MGI
  5. gastric acid secretion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange transporter
Alternative name(s):
Solute carrier family 26 member 7
Gene namesi
Name:Slc26a7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2384791. Slc26a7.

Subcellular locationi

Basolateral cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein
Note: Expressed on the basolateral membrane of acid-secreting gastric parietal cells, distal nephron segments and apical domains of proximal tubules and in the glomerulus. Expressed in the cytoplasm in recycling endosomes of kidney outer medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion.3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei76 – 9621Helical; Reviewed predictionAdd
BLAST
Topological domaini97 – 14448Extracellular Reviewed predictionAdd
BLAST
Transmembranei145 – 16521Helical; Reviewed predictionAdd
BLAST
Topological domaini166 – 1661Cytoplasmic Reviewed prediction
Transmembranei167 – 18721Helical; Reviewed predictionAdd
BLAST
Topological domaini188 – 19912Extracellular Reviewed predictionAdd
BLAST
Transmembranei200 – 22021Helical; Reviewed predictionAdd
BLAST
Topological domaini221 – 2222Cytoplasmic Reviewed prediction
Transmembranei223 – 24321Helical; Reviewed predictionAdd
BLAST
Topological domaini244 – 25411Extracellular Reviewed predictionAdd
BLAST
Transmembranei255 – 27521Helical; Reviewed predictionAdd
BLAST
Topological domaini276 – 30631Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei307 – 32721Helical; Reviewed predictionAdd
BLAST
Topological domaini328 – 34316Extracellular Reviewed predictionAdd
BLAST
Transmembranei344 – 36421Helical; Reviewed predictionAdd
BLAST
Topological domaini365 – 38319Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei384 – 40421Helical; Reviewed predictionAdd
BLAST
Transmembranei405 – 42521Helical; Reviewed predictionAdd
BLAST
Topological domaini426 – 44823Extracellular Reviewed predictionAdd
BLAST
Transmembranei449 – 46921Helical; Reviewed predictionAdd
BLAST
Topological domaini470 – 656187Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB
  2. integral component of membrane Source: MGI
  3. recycling endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Anion exchange transporterPRO_0000320682Add
BLAST

Proteomic databases

PaxDbiQ8R2Z3.
PRIDEiQ8R2Z3.

PTM databases

PhosphoSiteiQ8R2Z3.

Expressioni

Tissue specificityi

Abundantly expressed in parietal cells on the glandular portion of the stomach. Lower levels are observed in the kidney, with expression in the proximal tubule and thick ascending limb of the loop of Henle. Also expressed in distal segments of nephron, in extraglomerular mesagial cells and a subpopulation of intercalated cells of outer medullary collecting ducts.3 Publications

Gene expression databases

ArrayExpressiQ8R2Z3.
BgeeiQ8R2Z3.
CleanExiMM_SLC26A7.
GenevestigatoriQ8R2Z3.

Structurei

3D structure databases

ProteinModelPortaliQ8R2Z3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini492 – 641150STASAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni641 – 65616Membrane targeting By similarityBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00750000117294.
HOGENOMiHOG000049231.
HOVERGENiHBG108442.
InParanoidiB1AWS0.
KOiK13962.
OMAiCLISCIF.
OrthoDBiEOG76T9QT.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR002645. STAS_dom.
IPR011547. Sulph_transpt.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R2Z3-1 [UniParc]FASTAAdd to Basket

« Hide

MTGAKRKKRS VLWGKMHTPH REDIKQWCKR RLPILEWAPQ YNLKENLLPD    50
TVSGIMLAVQ QVAQGLSFAM LSSVHPVFGL YGSLFPAIIY AIFGMGRHVA 100
TGTFALTSLI SANAVERLVP QSSRNLTTQS NSSVLGLSEF ELQRIGVAAA 150
VSFLGGVIQL VMFVLQLGSA TFLLTEPVIS AMTTGAATHV VTSQVKYLLG 200
IKMPYISGPL GFFYIYAYVF ENIKSVQLEA LLFSLLSIIV LVLVKELNEQ 250
FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PNGIPPPRAP 300
PMNILSAVLT EAFGVALVGY VASLALAQGS AKKFKYSVDD NQEFLAHGLS 350
NVIPSFLFCI PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL 400
LYWLPMCVLA SIIVVGLKGM LIQFRDLKKY WNVDKIDWGI WISTYIFTIC 450
FAANVGLLFG VICTIAIVLG RFPRAKTLSI TDMKEMELKV KTEMHDETSQ 500
QIKIISINNP LVFLNAKKFS ADLMKIILKE SDSNQPLDDV SKCEQNTLLS 550
SLSNGNCNEE ASQPCSSEKC SLVLNCSGLT FFDYTGVSTL VELYLDCKSR 600
SVDVFLANCT ASLIKAMTYY GDLDTEKPIF FDSVPAAISI IQSNKNLSKA 650
SDHSEV 656
Length:656
Mass (Da):71,829
Last modified:July 27, 2011 - v3
Checksum:i321924A9BE7A1D0A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti233 – 2331F → L in AAO49172. 1 Publication
Sequence conflicti233 – 2331F → L in AAH26928. 1 Publication
Sequence conflicti639 – 6391S → T in AAO49172. 1 Publication
Sequence conflicti639 – 6391S → T in AAH26928. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF345194 mRNA. Translation: AAO49172.1.
AL772270, AL772236 Genomic DNA. Translation: CAM19223.1.
AL772236, AL772270 Genomic DNA. Translation: CAM27494.1.
CH466538 Genomic DNA. Translation: EDL05611.1.
BC026928 mRNA. Translation: AAH26928.1.
CCDSiCCDS17979.1.
RefSeqiNP_666059.2. NM_145947.2.
UniGeneiMm.483839.

Genome annotation databases

EnsembliENSMUST00000042221; ENSMUSP00000041789; ENSMUSG00000040569.
GeneIDi208890.
KEGGimmu:208890.
UCSCiuc008saz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF345194 mRNA. Translation: AAO49172.1 .
AL772270 , AL772236 Genomic DNA. Translation: CAM19223.1 .
AL772236 , AL772270 Genomic DNA. Translation: CAM27494.1 .
CH466538 Genomic DNA. Translation: EDL05611.1 .
BC026928 mRNA. Translation: AAH26928.1 .
CCDSi CCDS17979.1.
RefSeqi NP_666059.2. NM_145947.2.
UniGenei Mm.483839.

3D structure databases

ProteinModelPortali Q8R2Z3.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8R2Z3.

Proteomic databases

PaxDbi Q8R2Z3.
PRIDEi Q8R2Z3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042221 ; ENSMUSP00000041789 ; ENSMUSG00000040569 .
GeneIDi 208890.
KEGGi mmu:208890.
UCSCi uc008saz.2. mouse.

Organism-specific databases

CTDi 115111.
MGIi MGI:2384791. Slc26a7.

Phylogenomic databases

eggNOGi COG0659.
GeneTreei ENSGT00750000117294.
HOGENOMi HOG000049231.
HOVERGENi HBG108442.
InParanoidi B1AWS0.
KOi K13962.
OMAi CLISCIF.
OrthoDBi EOG76T9QT.
TreeFami TF313784.

Miscellaneous databases

NextBioi 372447.
PROi Q8R2Z3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8R2Z3.
Bgeei Q8R2Z3.
CleanExi MM_SLC26A7.
Genevestigatori Q8R2Z3.

Family and domain databases

Gene3Di 3.30.750.24. 2 hits.
InterProi IPR002645. STAS_dom.
IPR011547. Sulph_transpt.
[Graphical view ]
Pfami PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 2 hits.
PROSITEi PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of Mus musculus Slc26a7, a novel putative anion exchanger."
    Mount D.B.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  5. "Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells."
    Petrovic S., Ju X., Barone S., Seidler U., Alper S.L., Lohi H., Kere J., Soleimani M.
    Am. J. Physiol. 284:G1093-G1103(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "SLC26A7 is a Cl- channel regulated by intracellular pH."
    Kim K.H., Shcheynikov N., Wang Y., Muallem S.
    J. Biol. Chem. 280:6463-6470(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INHIBITION.
  7. "Immunolocalization of anion transporter Slc26a7 in mouse kidney."
    Dudas P.L., Mentone S., Greineder C.F., Biemesderfer D., Aronson P.S.
    Am. J. Physiol. 290:F937-F945(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion."
    Xu J., Worrell R.T., Li H.C., Barone S.L., Petrovic S., Amlal H., Soleimani M.
    J. Am. Soc. Nephrol. 17:956-967(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS26A7_MOUSE
AccessioniPrimary (citable) accession number: Q8R2Z3
Secondary accession number(s): A2AJZ4, B1AWS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Regulated by pH. Activity inhibited by all inhibitors of several anion channels and transporters, including 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS), diphenylamine-2-carboxylic acid and glybenclamide.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi