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Q8R2Z3

- S26A7_MOUSE

UniProt

Q8R2Z3 - S26A7_MOUSE

Protein

Anion exchange transporter

Gene

Slc26a7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion.By similarity3 Publications

    GO - Molecular functioni

    1. anion:anion antiporter activity Source: UniProtKB-KW
    2. anion channel activity Source: MGI
    3. bicarbonate transmembrane transporter activity Source: UniProtKB
    4. chloride channel activity Source: MGI
    5. oxalate transmembrane transporter activity Source: Ensembl
    6. sulfate transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. anion transport Source: MGI
    2. bicarbonate transport Source: UniProtKB
    3. chloride transmembrane transport Source: GOC
    4. chloride transport Source: MGI
    5. gastric acid secretion Source: UniProtKB

    Keywords - Biological processi

    Anion exchange, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anion exchange transporter
    Alternative name(s):
    Solute carrier family 26 member 7
    Gene namesi
    Name:Slc26a7Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2384791. Slc26a7.

    Subcellular locationi

    Basolateral cell membrane; Multi-pass membrane protein 3 Publications. Recycling endosome membrane; Multi-pass membrane protein 3 Publications
    Note: Expressed on the basolateral membrane of acid-secreting gastric parietal cells, distal nephron segments and apical domains of proximal tubules and in the glomerulus. Expressed in the cytoplasm in recycling endosomes of kidney outer medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion.By similarity3 Publications

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB
    2. integral component of membrane Source: MGI
    3. recycling endosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 656656Anion exchange transporterPRO_0000320682Add
    BLAST

    Proteomic databases

    PaxDbiQ8R2Z3.
    PRIDEiQ8R2Z3.

    PTM databases

    PhosphoSiteiQ8R2Z3.

    Expressioni

    Tissue specificityi

    Abundantly expressed in parietal cells on the glandular portion of the stomach. Lower levels are observed in the kidney, with expression in the proximal tubule and thick ascending limb of the loop of Henle. Also expressed in distal segments of nephron, in extraglomerular mesagial cells and a subpopulation of intercalated cells of outer medullary collecting ducts.3 Publications

    Gene expression databases

    ArrayExpressiQ8R2Z3.
    BgeeiQ8R2Z3.
    CleanExiMM_SLC26A7.
    GenevestigatoriQ8R2Z3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R2Z3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini97 – 14448ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini166 – 1661CytoplasmicSequence Analysis
    Topological domaini188 – 19912ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 2222CytoplasmicSequence Analysis
    Topological domaini244 – 25411ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini276 – 30631CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini328 – 34316ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini365 – 38319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini426 – 44823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini470 – 656187CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei223 – 24321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei307 – 32721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei344 – 36421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei384 – 40421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei405 – 42521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei449 – 46921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini492 – 641150STASPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni641 – 65616Membrane targetingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 STAS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0659.
    GeneTreeiENSGT00750000117294.
    HOGENOMiHOG000049231.
    HOVERGENiHBG108442.
    InParanoidiB1AWS0.
    KOiK13962.
    OMAiCLISCIF.
    OrthoDBiEOG76T9QT.
    TreeFamiTF313784.

    Family and domain databases

    Gene3Di3.30.750.24. 2 hits.
    InterProiIPR002645. STAS_dom.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PfamiPF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 2 hits.
    PROSITEiPS50801. STAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R2Z3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGAKRKKRS VLWGKMHTPH REDIKQWCKR RLPILEWAPQ YNLKENLLPD    50
    TVSGIMLAVQ QVAQGLSFAM LSSVHPVFGL YGSLFPAIIY AIFGMGRHVA 100
    TGTFALTSLI SANAVERLVP QSSRNLTTQS NSSVLGLSEF ELQRIGVAAA 150
    VSFLGGVIQL VMFVLQLGSA TFLLTEPVIS AMTTGAATHV VTSQVKYLLG 200
    IKMPYISGPL GFFYIYAYVF ENIKSVQLEA LLFSLLSIIV LVLVKELNEQ 250
    FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PNGIPPPRAP 300
    PMNILSAVLT EAFGVALVGY VASLALAQGS AKKFKYSVDD NQEFLAHGLS 350
    NVIPSFLFCI PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL 400
    LYWLPMCVLA SIIVVGLKGM LIQFRDLKKY WNVDKIDWGI WISTYIFTIC 450
    FAANVGLLFG VICTIAIVLG RFPRAKTLSI TDMKEMELKV KTEMHDETSQ 500
    QIKIISINNP LVFLNAKKFS ADLMKIILKE SDSNQPLDDV SKCEQNTLLS 550
    SLSNGNCNEE ASQPCSSEKC SLVLNCSGLT FFDYTGVSTL VELYLDCKSR 600
    SVDVFLANCT ASLIKAMTYY GDLDTEKPIF FDSVPAAISI IQSNKNLSKA 650
    SDHSEV 656
    Length:656
    Mass (Da):71,829
    Last modified:July 27, 2011 - v3
    Checksum:i321924A9BE7A1D0A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti233 – 2331F → L in AAO49172. 1 PublicationCurated
    Sequence conflicti233 – 2331F → L in AAH26928. (PubMed:15489334)Curated
    Sequence conflicti639 – 6391S → T in AAO49172. 1 PublicationCurated
    Sequence conflicti639 – 6391S → T in AAH26928. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF345194 mRNA. Translation: AAO49172.1.
    AL772270, AL772236 Genomic DNA. Translation: CAM19223.1.
    AL772236, AL772270 Genomic DNA. Translation: CAM27494.1.
    CH466538 Genomic DNA. Translation: EDL05611.1.
    BC026928 mRNA. Translation: AAH26928.1.
    CCDSiCCDS17979.1.
    RefSeqiNP_666059.2. NM_145947.2.
    UniGeneiMm.483839.

    Genome annotation databases

    EnsembliENSMUST00000042221; ENSMUSP00000041789; ENSMUSG00000040569.
    GeneIDi208890.
    KEGGimmu:208890.
    UCSCiuc008saz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF345194 mRNA. Translation: AAO49172.1 .
    AL772270 , AL772236 Genomic DNA. Translation: CAM19223.1 .
    AL772236 , AL772270 Genomic DNA. Translation: CAM27494.1 .
    CH466538 Genomic DNA. Translation: EDL05611.1 .
    BC026928 mRNA. Translation: AAH26928.1 .
    CCDSi CCDS17979.1.
    RefSeqi NP_666059.2. NM_145947.2.
    UniGenei Mm.483839.

    3D structure databases

    ProteinModelPortali Q8R2Z3.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8R2Z3.

    Proteomic databases

    PaxDbi Q8R2Z3.
    PRIDEi Q8R2Z3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042221 ; ENSMUSP00000041789 ; ENSMUSG00000040569 .
    GeneIDi 208890.
    KEGGi mmu:208890.
    UCSCi uc008saz.2. mouse.

    Organism-specific databases

    CTDi 115111.
    MGIi MGI:2384791. Slc26a7.

    Phylogenomic databases

    eggNOGi COG0659.
    GeneTreei ENSGT00750000117294.
    HOGENOMi HOG000049231.
    HOVERGENi HBG108442.
    InParanoidi B1AWS0.
    KOi K13962.
    OMAi CLISCIF.
    OrthoDBi EOG76T9QT.
    TreeFami TF313784.

    Miscellaneous databases

    NextBioi 372447.
    PROi Q8R2Z3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R2Z3.
    Bgeei Q8R2Z3.
    CleanExi MM_SLC26A7.
    Genevestigatori Q8R2Z3.

    Family and domain databases

    Gene3Di 3.30.750.24. 2 hits.
    InterProi IPR002645. STAS_dom.
    IPR011547. Sulph_transpt.
    [Graphical view ]
    Pfami PF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 2 hits.
    PROSITEi PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of Mus musculus Slc26a7, a novel putative anion exchanger."
      Mount D.B.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6JImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech IIImported.
      Tissue: Mammary tumorImported.
    5. "Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells."
      Petrovic S., Ju X., Barone S., Seidler U., Alper S.L., Lohi H., Kere J., Soleimani M.
      Am. J. Physiol. 284:G1093-G1103(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    6. "SLC26A7 is a Cl- channel regulated by intracellular pH."
      Kim K.H., Shcheynikov N., Wang Y., Muallem S.
      J. Biol. Chem. 280:6463-6470(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INHIBITION.
    7. "Immunolocalization of anion transporter Slc26a7 in mouse kidney."
      Dudas P.L., Mentone S., Greineder C.F., Biemesderfer D., Aronson P.S.
      Am. J. Physiol. 290:F937-F945(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    8. "Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion."
      Xu J., Worrell R.T., Li H.C., Barone S.L., Petrovic S., Amlal H., Soleimani M.
      J. Am. Soc. Nephrol. 17:956-967(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiS26A7_MOUSE
    AccessioniPrimary (citable) accession number: Q8R2Z3
    Secondary accession number(s): A2AJZ4, B1AWS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 86 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Regulated by pH. Activity inhibited by all inhibitors of several anion channels and transporters, including 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS), diphenylamine-2-carboxylic acid and glybenclamide.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3