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Q8R2Z3 (S26A7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anion exchange transporter
Alternative name(s):
Solute carrier family 26 member 7
Gene names
Name:Slc26a7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length656 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion. Ref.5 Ref.6 Ref.7 UniProtKB Q8TE54

Subcellular location

Basolateral cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note: Expressed on the basolateral membrane of acid-secreting gastric parietal cells, distal nephron segments and apical domains of proximal tubules and in the glomerulus. Expressed in the cytoplasm in recycling endosomes of kidney outer medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. Ref.5 Ref.7 Ref.8

Tissue specificity

Abundantly expressed in parietal cells on the glandular portion of the stomach. Lower levels are observed in the kidney, with expression in the proximal tubule and thick ascending limb of the loop of Henle. Also expressed in distal segments of nephron, in extraglomerular mesagial cells and a subpopulation of intercalated cells of outer medullary collecting ducts. Ref.5 Ref.7 Ref.8

Miscellaneous

Regulated by pH. Activity inhibited by all inhibitors of several anion channels and transporters, including 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS), diphenylamine-2-carboxylic acid and glybenclamide. Ref.6

Sequence similarities

Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification]

Contains 1 STAS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 656656Anion exchange transporter
PRO_0000320682

Regions

Topological domain1 – 7575Cytoplasmic Potential
Transmembrane76 – 9621Helical; Potential
Topological domain97 – 14448Extracellular Potential
Transmembrane145 – 16521Helical; Potential
Topological domain1661Cytoplasmic Potential
Transmembrane167 – 18721Helical; Potential
Topological domain188 – 19912Extracellular Potential
Transmembrane200 – 22021Helical; Potential
Topological domain221 – 2222Cytoplasmic Potential
Transmembrane223 – 24321Helical; Potential
Topological domain244 – 25411Extracellular Potential
Transmembrane255 – 27521Helical; Potential
Topological domain276 – 30631Cytoplasmic Potential
Transmembrane307 – 32721Helical; Potential
Topological domain328 – 34316Extracellular Potential
Transmembrane344 – 36421Helical; Potential
Topological domain365 – 38319Cytoplasmic Potential
Transmembrane384 – 40421Helical; Potential
Transmembrane405 – 42521Helical; Potential
Topological domain426 – 44823Extracellular Potential
Transmembrane449 – 46921Helical; Potential
Topological domain470 – 656187Cytoplasmic Potential
Domain492 – 641150STAS
Region641 – 65616Membrane targeting By similarity UniProtKB Q8TE54

Experimental info

Sequence conflict2331F → L in AAO49172. Ref.1
Sequence conflict2331F → L in AAH26928. Ref.4
Sequence conflict6391S → T in AAO49172. Ref.1
Sequence conflict6391S → T in AAH26928. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q8R2Z3 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 321924A9BE7A1D0A

FASTA65671,829
        10         20         30         40         50         60 
MTGAKRKKRS VLWGKMHTPH REDIKQWCKR RLPILEWAPQ YNLKENLLPD TVSGIMLAVQ 

        70         80         90        100        110        120 
QVAQGLSFAM LSSVHPVFGL YGSLFPAIIY AIFGMGRHVA TGTFALTSLI SANAVERLVP 

       130        140        150        160        170        180 
QSSRNLTTQS NSSVLGLSEF ELQRIGVAAA VSFLGGVIQL VMFVLQLGSA TFLLTEPVIS 

       190        200        210        220        230        240 
AMTTGAATHV VTSQVKYLLG IKMPYISGPL GFFYIYAYVF ENIKSVQLEA LLFSLLSIIV 

       250        260        270        280        290        300 
LVLVKELNEQ FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PNGIPPPRAP 

       310        320        330        340        350        360 
PMNILSAVLT EAFGVALVGY VASLALAQGS AKKFKYSVDD NQEFLAHGLS NVIPSFLFCI 

       370        380        390        400        410        420 
PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL LYWLPMCVLA SIIVVGLKGM 

       430        440        450        460        470        480 
LIQFRDLKKY WNVDKIDWGI WISTYIFTIC FAANVGLLFG VICTIAIVLG RFPRAKTLSI 

       490        500        510        520        530        540 
TDMKEMELKV KTEMHDETSQ QIKIISINNP LVFLNAKKFS ADLMKIILKE SDSNQPLDDV 

       550        560        570        580        590        600 
SKCEQNTLLS SLSNGNCNEE ASQPCSSEKC SLVLNCSGLT FFDYTGVSTL VELYLDCKSR 

       610        620        630        640        650 
SVDVFLANCT ASLIKAMTYY GDLDTEKPIF FDSVPAAISI IQSNKNLSKA SDHSEV 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of Mus musculus Slc26a7, a novel putative anion exchanger."
Mount D.B.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary tumor.
[5]"Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells."
Petrovic S., Ju X., Barone S., Seidler U., Alper S.L., Lohi H., Kere J., Soleimani M.
Am. J. Physiol. 284:G1093-G1103(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[6]"SLC26A7 is a Cl- channel regulated by intracellular pH."
Kim K.H., Shcheynikov N., Wang Y., Muallem S.
J. Biol. Chem. 280:6463-6470(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INHIBITION.
[7]"Immunolocalization of anion transporter Slc26a7 in mouse kidney."
Dudas P.L., Mentone S., Greineder C.F., Biemesderfer D., Aronson P.S.
Am. J. Physiol. 290:F937-F945(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[8]"Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion."
Xu J., Worrell R.T., Li H.C., Barone S.L., Petrovic S., Amlal H., Soleimani M.
J. Am. Soc. Nephrol. 17:956-967(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF345194 mRNA. Translation: AAO49172.1.
AL772270, AL772236 Genomic DNA. Translation: CAM19223.1.
AL772236, AL772270 Genomic DNA. Translation: CAM27494.1.
CH466538 Genomic DNA. Translation: EDL05611.1.
BC026928 mRNA. Translation: AAH26928.1.
RefSeqNP_666059.2. NM_145947.2.
UniGeneMm.483839.

3D structure databases

ProteinModelPortalQ8R2Z3.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8R2Z3.

Proteomic databases

PaxDbQ8R2Z3.
PRIDEQ8R2Z3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000042221; ENSMUSP00000041789; ENSMUSG00000040569.
GeneID208890.
KEGGmmu:208890.
UCSCuc008saz.2. mouse.

Organism-specific databases

CTD115111.
MGIMGI:2384791. Slc26a7.

Phylogenomic databases

eggNOGCOG0659.
GeneTreeENSGT00750000117294.
HOGENOMHOG000049231.
HOVERGENHBG108442.
InParanoidB1AWS0.
KOK13962.
OMACLISCIF.
OrthoDBEOG76T9QT.
TreeFamTF313784.

Gene expression databases

ArrayExpressQ8R2Z3.
BgeeQ8R2Z3.
CleanExMM_SLC26A7.
GenevestigatorQ8R2Z3.

Family and domain databases

Gene3D3.30.750.24. 2 hits.
InterProIPR002645. STAS_dom.
IPR011547. Sulph_transpt.
[Graphical view]
PfamPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMSSF52091. SSF52091. 2 hits.
PROSITEPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio372447.
PROQ8R2Z3.
SOURCESearch...

Entry information

Entry nameS26A7_MOUSE
AccessionPrimary (citable) accession number: Q8R2Z3
Secondary accession number(s): A2AJZ4, B1AWS0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot