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Protein

Anion exchange transporter

Gene

Slc26a7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion.By similarity3 Publications

GO - Molecular functioni

  • anion:anion antiporter activity Source: UniProtKB-KW
  • anion channel activity Source: MGI
  • bicarbonate transmembrane transporter activity Source: UniProtKB
  • chloride channel activity Source: MGI
  • oxalate transmembrane transporter activity Source: MGI
  • secondary active sulfate transmembrane transporter activity Source: InterPro
  • sulfate transmembrane transporter activity Source: MGI

GO - Biological processi

  • anion transport Source: MGI
  • bicarbonate transport Source: UniProtKB
  • chloride transmembrane transport Source: GOC
  • chloride transport Source: MGI
  • gastric acid secretion Source: UniProtKB
  • oxalate transport Source: MGI
  • sulfate transmembrane transport Source: MGI
  • sulfate transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_350869. Multifunctional anion exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange transporter
Alternative name(s):
Solute carrier family 26 member 7
Gene namesi
Name:Slc26a7Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2384791. Slc26a7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Topological domaini97 – 14448ExtracellularSequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST
Topological domaini166 – 1661CytoplasmicSequence Analysis
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Topological domaini188 – 19912ExtracellularSequence AnalysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence AnalysisAdd
BLAST
Topological domaini221 – 2222CytoplasmicSequence Analysis
Transmembranei223 – 24321HelicalSequence AnalysisAdd
BLAST
Topological domaini244 – 25411ExtracellularSequence AnalysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST
Topological domaini276 – 30631CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei307 – 32721HelicalSequence AnalysisAdd
BLAST
Topological domaini328 – 34316ExtracellularSequence AnalysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence AnalysisAdd
BLAST
Topological domaini365 – 38319CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence AnalysisAdd
BLAST
Transmembranei405 – 42521HelicalSequence AnalysisAdd
BLAST
Topological domaini426 – 44823ExtracellularSequence AnalysisAdd
BLAST
Transmembranei449 – 46921HelicalSequence AnalysisAdd
BLAST
Topological domaini470 – 656187CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: UniProtKB
  • cytoplasm Source: MGI
  • endosome Source: MGI
  • integral component of membrane Source: MGI
  • recycling endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Anion exchange transporterPRO_0000320682Add
BLAST

Proteomic databases

PaxDbiQ8R2Z3.
PRIDEiQ8R2Z3.

PTM databases

PhosphoSiteiQ8R2Z3.

Expressioni

Tissue specificityi

Abundantly expressed in parietal cells on the glandular portion of the stomach. Lower levels are observed in the kidney, with expression in the proximal tubule and thick ascending limb of the loop of Henle. Also expressed in distal segments of nephron, in extraglomerular mesagial cells and a subpopulation of intercalated cells of outer medullary collecting ducts.3 Publications

Gene expression databases

BgeeiQ8R2Z3.
CleanExiMM_SLC26A7.
ExpressionAtlasiQ8R2Z3. baseline and differential.
GenevisibleiQ8R2Z3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041789.

Structurei

3D structure databases

ProteinModelPortaliQ8R2Z3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini492 – 641150STASPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni641 – 65616Membrane targetingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000049231.
HOVERGENiHBG108442.
InParanoidiQ8R2Z3.
KOiK13962.
OMAiCLISCIF.
OrthoDBiEOG76T9QT.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR030329. SLC26A7.
IPR002645. STAS_dom.
IPR001902. Sul_anion_transpt.
IPR030402. Sulfate_tra_GLY.
IPR011547. Sulph_transpt.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PTHR11814:SF75. PTHR11814:SF75. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF13792. Sulfate_tra_GLY. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R2Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGAKRKKRS VLWGKMHTPH REDIKQWCKR RLPILEWAPQ YNLKENLLPD
60 70 80 90 100
TVSGIMLAVQ QVAQGLSFAM LSSVHPVFGL YGSLFPAIIY AIFGMGRHVA
110 120 130 140 150
TGTFALTSLI SANAVERLVP QSSRNLTTQS NSSVLGLSEF ELQRIGVAAA
160 170 180 190 200
VSFLGGVIQL VMFVLQLGSA TFLLTEPVIS AMTTGAATHV VTSQVKYLLG
210 220 230 240 250
IKMPYISGPL GFFYIYAYVF ENIKSVQLEA LLFSLLSIIV LVLVKELNEQ
260 270 280 290 300
FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PNGIPPPRAP
310 320 330 340 350
PMNILSAVLT EAFGVALVGY VASLALAQGS AKKFKYSVDD NQEFLAHGLS
360 370 380 390 400
NVIPSFLFCI PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL
410 420 430 440 450
LYWLPMCVLA SIIVVGLKGM LIQFRDLKKY WNVDKIDWGI WISTYIFTIC
460 470 480 490 500
FAANVGLLFG VICTIAIVLG RFPRAKTLSI TDMKEMELKV KTEMHDETSQ
510 520 530 540 550
QIKIISINNP LVFLNAKKFS ADLMKIILKE SDSNQPLDDV SKCEQNTLLS
560 570 580 590 600
SLSNGNCNEE ASQPCSSEKC SLVLNCSGLT FFDYTGVSTL VELYLDCKSR
610 620 630 640 650
SVDVFLANCT ASLIKAMTYY GDLDTEKPIF FDSVPAAISI IQSNKNLSKA

SDHSEV
Length:656
Mass (Da):71,829
Last modified:July 27, 2011 - v3
Checksum:i321924A9BE7A1D0A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti233 – 2331F → L in AAO49172 (Ref. 1) Curated
Sequence conflicti233 – 2331F → L in AAH26928 (PubMed:15489334).Curated
Sequence conflicti639 – 6391S → T in AAO49172 (Ref. 1) Curated
Sequence conflicti639 – 6391S → T in AAH26928 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345194 mRNA. Translation: AAO49172.1.
AL772270, AL772236 Genomic DNA. Translation: CAM19223.1.
AL772236, AL772270 Genomic DNA. Translation: CAM27494.1.
CH466538 Genomic DNA. Translation: EDL05611.1.
BC026928 mRNA. Translation: AAH26928.1.
CCDSiCCDS17979.1.
RefSeqiNP_666059.2. NM_145947.2.
UniGeneiMm.483839.

Genome annotation databases

EnsembliENSMUST00000042221; ENSMUSP00000041789; ENSMUSG00000040569.
GeneIDi208890.
KEGGimmu:208890.
UCSCiuc008saz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345194 mRNA. Translation: AAO49172.1.
AL772270, AL772236 Genomic DNA. Translation: CAM19223.1.
AL772236, AL772270 Genomic DNA. Translation: CAM27494.1.
CH466538 Genomic DNA. Translation: EDL05611.1.
BC026928 mRNA. Translation: AAH26928.1.
CCDSiCCDS17979.1.
RefSeqiNP_666059.2. NM_145947.2.
UniGeneiMm.483839.

3D structure databases

ProteinModelPortaliQ8R2Z3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041789.

PTM databases

PhosphoSiteiQ8R2Z3.

Proteomic databases

PaxDbiQ8R2Z3.
PRIDEiQ8R2Z3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042221; ENSMUSP00000041789; ENSMUSG00000040569.
GeneIDi208890.
KEGGimmu:208890.
UCSCiuc008saz.2. mouse.

Organism-specific databases

CTDi115111.
MGIiMGI:2384791. Slc26a7.

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000049231.
HOVERGENiHBG108442.
InParanoidiQ8R2Z3.
KOiK13962.
OMAiCLISCIF.
OrthoDBiEOG76T9QT.
TreeFamiTF313784.

Enzyme and pathway databases

ReactomeiREACT_350869. Multifunctional anion exchangers.

Miscellaneous databases

NextBioi372447.
PROiQ8R2Z3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R2Z3.
CleanExiMM_SLC26A7.
ExpressionAtlasiQ8R2Z3. baseline and differential.
GenevisibleiQ8R2Z3. MM.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR030329. SLC26A7.
IPR002645. STAS_dom.
IPR001902. Sul_anion_transpt.
IPR030402. Sulfate_tra_GLY.
IPR011547. Sulph_transpt.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PTHR11814:SF75. PTHR11814:SF75. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF13792. Sulfate_tra_GLY. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of Mus musculus Slc26a7, a novel putative anion exchanger."
    Mount D.B.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6JImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech IIImported.
    Tissue: Mammary tumorImported.
  5. "Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells."
    Petrovic S., Ju X., Barone S., Seidler U., Alper S.L., Lohi H., Kere J., Soleimani M.
    Am. J. Physiol. 284:G1093-G1103(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "SLC26A7 is a Cl- channel regulated by intracellular pH."
    Kim K.H., Shcheynikov N., Wang Y., Muallem S.
    J. Biol. Chem. 280:6463-6470(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INHIBITION.
  7. "Immunolocalization of anion transporter Slc26a7 in mouse kidney."
    Dudas P.L., Mentone S., Greineder C.F., Biemesderfer D., Aronson P.S.
    Am. J. Physiol. 290:F937-F945(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion."
    Xu J., Worrell R.T., Li H.C., Barone S.L., Petrovic S., Amlal H., Soleimani M.
    J. Am. Soc. Nephrol. 17:956-967(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS26A7_MOUSE
AccessioniPrimary (citable) accession number: Q8R2Z3
Secondary accession number(s): A2AJZ4, B1AWS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 27, 2011
Last modified: June 24, 2015
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Regulated by pH. Activity inhibited by all inhibitors of several anion channels and transporters, including 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS), diphenylamine-2-carboxylic acid and glybenclamide.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.