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Protein

Dolichol kinase

Gene

Dolk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors.By similarity

Catalytic activityi

CTP + dolichol = CDP + dolichyl phosphate.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-446199. Synthesis of Dolichyl-phosphate.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichol kinaseImported (EC:2.7.1.108)
Alternative name(s):
Transmembrane protein 15Imported
Gene namesi
Name:DolkImported
Synonyms:Tmem15Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2677836. Dolk.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16LumenalSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 72CytoplasmicSequence analysisAdd BLAST35
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 109LumenalSequence analysisAdd BLAST16
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 132CytoplasmicSequence analysis2
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 161LumenalSequence analysis8
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 186CytoplasmicSequence analysis4
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 220LumenalSequence analysisAdd BLAST13
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Topological domaini242 – 252CytoplasmicSequence analysisAdd BLAST11
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Topological domaini274 – 293LumenalSequence analysisAdd BLAST20
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 333CytoplasmicSequence analysisAdd BLAST19
Transmembranei334 – 350HelicalSequence analysisAdd BLAST17
Topological domaini351 – 355LumenalSequence analysis5
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377 – 397CytoplasmicSequence analysisAdd BLAST21
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 432LumenalSequence analysisAdd BLAST14
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Topological domaini454 – 468CytoplasmicSequence analysisAdd BLAST15
Transmembranei469 – 489HelicalSequence analysisAdd BLAST21
Topological domaini490 – 491LumenalSequence analysis2
Transmembranei492 – 512HelicalSequence analysisAdd BLAST21
Topological domaini513 – 534CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003555811 – 534Dolichol kinaseAdd BLAST534

Proteomic databases

MaxQBiQ8R2Y3.
PaxDbiQ8R2Y3.
PeptideAtlasiQ8R2Y3.
PRIDEiQ8R2Y3.

PTM databases

PhosphoSitePlusiQ8R2Y3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000075419.
GenevisibleiQ8R2Y3. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8R2Y3. 1 interactor.
STRINGi10090.ENSMUSP00000097792.

Structurei

3D structure databases

ProteinModelPortaliQ8R2Y3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni455 – 470CTP-bindingBy similarityAdd BLAST16

Sequence similaritiesi

Belongs to the polyprenol kinase family.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2468. Eukaryota.
COG0170. LUCA.
GeneTreeiENSGT00390000004067.
HOGENOMiHOG000036052.
HOVERGENiHBG054655.
InParanoidiQ8R2Y3.
KOiK00902.
OMAiWLVPRPC.
OrthoDBiEOG091G0J56.
PhylomeDBiQ8R2Y3.
TreeFamiTF323379.

Family and domain databases

InterProiIPR032974. Polypren_kinase.
[Graphical view]
PANTHERiPTHR13205. PTHR13205. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R2Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRQCPPQES GAALSGSVLA EAAVVFAVVL SIHAAVWDRY SWCAVALAVQ
60 70 80 90 100
AFYVQYKWDR LLQQGNAVFQ FRMSANSGLL PASMVMPLLG LVMKERCQTA
110 120 130 140 150
GNPYFERFGI VVAATGMAVA LFSSVLALGI TRPVPTNTCA ISGLAGGVII
160 170 180 190 200
YIMRHSLSVG EVIEVLEVLL IFVYLNMILL YLLPRCFTPG EALLVLGGIS
210 220 230 240 250
FVLNQLIKRS LTESQGDPVD FFLLVVVVGM VLMGVFFSTL FVFMDSGTWA
260 270 280 290 300
SSIFFHLMTC VLGLGVVLPW LHWLIRRNPL LWLLQFLFYT ETRIYLLAYW
310 320 330 340 350
SLLASVACLV VLYQNAKRSS SESKKHRAPT ITRKYFHFIV VATYIPGIIF
360 370 380 390 400
DRPLLYVAAT VCLAVFIFLE YVRYFRIKPL GHTLRSLLSL FLDERDSGPL
410 420 430 440 450
ILTHIYLLLG MSLPIWLIPR PCTQKDSLEG ARALVPYAGV LAVGVGDTVA
460 470 480 490 500
SIFGSTMGEI RWPGTKKTFE GTMTSIFAQI ISVALILIFD SGVDLNYSYA
510 520 530
WILGSISTVS LLEAYTTQID NLLLPLYLLI LLMA
Length:534
Mass (Da):59,145
Last modified:June 1, 2002 - v1
Checksum:i3DCFD916081B3443
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073968 mRNA. Translation: BAF82000.1.
AK144705 mRNA. Translation: BAE26024.1.
AL954388 Genomic DNA. Translation: CAM23161.1.
CH466542 Genomic DNA. Translation: EDL08455.1.
BC026973 mRNA. Translation: AAH26973.1.
CCDSiCCDS15877.1.
RefSeqiNP_808316.1. NM_177648.3.
UniGeneiMm.26690.

Genome annotation databases

EnsembliENSMUST00000100219; ENSMUSP00000097792; ENSMUSG00000075419.
GeneIDi227697.
KEGGimmu:227697.
UCSCiuc008jby.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073968 mRNA. Translation: BAF82000.1.
AK144705 mRNA. Translation: BAE26024.1.
AL954388 Genomic DNA. Translation: CAM23161.1.
CH466542 Genomic DNA. Translation: EDL08455.1.
BC026973 mRNA. Translation: AAH26973.1.
CCDSiCCDS15877.1.
RefSeqiNP_808316.1. NM_177648.3.
UniGeneiMm.26690.

3D structure databases

ProteinModelPortaliQ8R2Y3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R2Y3. 1 interactor.
STRINGi10090.ENSMUSP00000097792.

PTM databases

PhosphoSitePlusiQ8R2Y3.

Proteomic databases

MaxQBiQ8R2Y3.
PaxDbiQ8R2Y3.
PeptideAtlasiQ8R2Y3.
PRIDEiQ8R2Y3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100219; ENSMUSP00000097792; ENSMUSG00000075419.
GeneIDi227697.
KEGGimmu:227697.
UCSCiuc008jby.1. mouse.

Organism-specific databases

CTDi22845.
MGIiMGI:2677836. Dolk.

Phylogenomic databases

eggNOGiKOG2468. Eukaryota.
COG0170. LUCA.
GeneTreeiENSGT00390000004067.
HOGENOMiHOG000036052.
HOVERGENiHBG054655.
InParanoidiQ8R2Y3.
KOiK00902.
OMAiWLVPRPC.
OrthoDBiEOG091G0J56.
PhylomeDBiQ8R2Y3.
TreeFamiTF323379.

Enzyme and pathway databases

ReactomeiR-MMU-446199. Synthesis of Dolichyl-phosphate.

Miscellaneous databases

PROiQ8R2Y3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075419.
GenevisibleiQ8R2Y3. MM.

Family and domain databases

InterProiIPR032974. Polypren_kinase.
[Graphical view]
PANTHERiPTHR13205. PTHR13205. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDOLK_MOUSE
AccessioniPrimary (citable) accession number: Q8R2Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.