Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8R2Y0

- ABHD6_MOUSE

UniProt

Q8R2Y0 - ABHD6_MOUSE

Protein

Monoacylglycerol lipase ABHD6

Gene

Abhd6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Has 2-arachidonoylglycerol hydrolase activity. May be a regulator of endocannabinoid signaling pathways.1 Publication

    Catalytic activityi

    Hydrolyzes glycerol monoesters of long-chain fatty acids.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei148 – 1481Charge relay systemBy similarity
    Active sitei278 – 2781Charge relay systemBy similarity
    Active sitei306 – 3061Charge relay systemBy similarity

    GO - Molecular functioni

    1. acylglycerol lipase activity Source: MGI

    GO - Biological processi

    1. long term synaptic depression Source: MGI
    2. metabolic process Source: GOC
    3. negative regulation of cell migration Source: MGI
    4. regulation of endocannabinoid signaling pathway Source: MGI

    Keywords - Molecular functioni

    Hydrolase

    Protein family/group databases

    MEROPSiS33.977.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monoacylglycerol lipase ABHD6 (EC:3.1.1.23)
    Alternative name(s):
    2-arachidonoylglycerol hydrolase
    Abhydrolase domain-containing protein 6
    Gene namesi
    Name:Abhd6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1913332. Abhd6.

    Subcellular locationi

    Membrane 1 Publication; Single-pass type II membrane protein 1 Publication

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: MGI
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 336336Monoacylglycerol lipase ABHD6PRO_0000281576Add
    BLAST

    Proteomic databases

    MaxQBiQ8R2Y0.
    PaxDbiQ8R2Y0.
    PRIDEiQ8R2Y0.

    PTM databases

    PhosphoSiteiQ8R2Y0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8R2Y0.
    BgeeiQ8R2Y0.
    CleanExiMM_ABHD6.
    GenevestigatoriQ8R2Y0.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8R2Y0. 1 interaction.
    MINTiMINT-4118823.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R2Y0.
    SMRiQ8R2Y0. Positions 43-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88ExtracellularSequence Analysis
    Topological domaini30 – 336307CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0596.
    GeneTreeiENSGT00510000047225.
    HOGENOMiHOG000008016.
    HOVERGENiHBG059524.
    InParanoidiQ8R2Y0.
    KOiK13700.
    OMAiNSFYRKL.
    OrthoDBiEOG786H3D.
    PhylomeDBiQ8R2Y0.
    TreeFamiTF331946.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    [Graphical view]
    PRINTSiPR00111. ABHYDROLASE.
    PR00412. EPOXHYDRLASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8R2Y0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV    50
    RYAHHEDYQF CYSFRGRPGH KPSILMLHGF SAHKDMWLSV VKFLPKNLHL 100
    VCVDMPGHEG TTRSSLDDLS IVGQVKRIHQ FVECLKLNKK PFHLIGTSMG 150
    GHVAGVYAAY YPSDVCSLSL VCPAGLQYST DNPFVQRLKE LEESAAIQKI 200
    PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN SFYRKLFLEI 250
    VNEKSRYSLH ENMDKIKVPT QIIWGKQDQV LDVSGADILA KSISNSQVEV 300
    LENCGHSVVM ERPRKTAKLI VDFLASVHNT DNKKLN 336
    Length:336
    Mass (Da):38,205
    Last modified:June 1, 2002 - v1
    Checksum:i4C207C66DBE41FE4
    GO
    Isoform 2 (identifier: Q8R2Y0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-47: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:289
    Mass (Da):32,788
    Checksum:i1A55E8CD1C0B71A6
    GO

    Sequence cautioni

    The sequence BAE40616.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti85 – 851D → G in BAB22430. (PubMed:16141072)Curated
    Sequence conflicti173 – 1731P → A in BAB22430. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4747Missing in isoform 2. 1 PublicationVSP_024012Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002883 mRNA. Translation: BAB22430.1.
    AK076105 mRNA. Translation: BAC36186.1.
    AK090076 mRNA. Translation: BAC41081.1.
    AK168782 mRNA. Translation: BAE40616.1. Different initiation.
    BC027011 mRNA. Translation: AAH27011.1.
    CCDSiCCDS26808.1. [Q8R2Y0-1]
    RefSeqiNP_079617.2. NM_025341.3. [Q8R2Y0-1]
    XP_006518136.1. XM_006518073.1. [Q8R2Y0-1]
    XP_006518137.1. XM_006518074.1. [Q8R2Y0-1]
    UniGeneiMm.181473.

    Genome annotation databases

    EnsembliENSMUST00000026313; ENSMUSP00000026313; ENSMUSG00000025277. [Q8R2Y0-1]
    ENSMUST00000166497; ENSMUSP00000129169; ENSMUSG00000025277. [Q8R2Y0-1]
    GeneIDi66082.
    KEGGimmu:66082.
    UCSCiuc007sen.1. mouse. [Q8R2Y0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002883 mRNA. Translation: BAB22430.1 .
    AK076105 mRNA. Translation: BAC36186.1 .
    AK090076 mRNA. Translation: BAC41081.1 .
    AK168782 mRNA. Translation: BAE40616.1 . Different initiation.
    BC027011 mRNA. Translation: AAH27011.1 .
    CCDSi CCDS26808.1. [Q8R2Y0-1 ]
    RefSeqi NP_079617.2. NM_025341.3. [Q8R2Y0-1 ]
    XP_006518136.1. XM_006518073.1. [Q8R2Y0-1 ]
    XP_006518137.1. XM_006518074.1. [Q8R2Y0-1 ]
    UniGenei Mm.181473.

    3D structure databases

    ProteinModelPortali Q8R2Y0.
    SMRi Q8R2Y0. Positions 43-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8R2Y0. 1 interaction.
    MINTi MINT-4118823.

    Chemistry

    BindingDBi Q8R2Y0.
    ChEMBLi CHEMBL5010.

    Protein family/group databases

    MEROPSi S33.977.

    PTM databases

    PhosphoSitei Q8R2Y0.

    Proteomic databases

    MaxQBi Q8R2Y0.
    PaxDbi Q8R2Y0.
    PRIDEi Q8R2Y0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026313 ; ENSMUSP00000026313 ; ENSMUSG00000025277 . [Q8R2Y0-1 ]
    ENSMUST00000166497 ; ENSMUSP00000129169 ; ENSMUSG00000025277 . [Q8R2Y0-1 ]
    GeneIDi 66082.
    KEGGi mmu:66082.
    UCSCi uc007sen.1. mouse. [Q8R2Y0-1 ]

    Organism-specific databases

    CTDi 57406.
    MGIi MGI:1913332. Abhd6.

    Phylogenomic databases

    eggNOGi COG0596.
    GeneTreei ENSGT00510000047225.
    HOGENOMi HOG000008016.
    HOVERGENi HBG059524.
    InParanoidi Q8R2Y0.
    KOi K13700.
    OMAi NSFYRKL.
    OrthoDBi EOG786H3D.
    PhylomeDBi Q8R2Y0.
    TreeFami TF331946.

    Miscellaneous databases

    NextBioi 320572.
    PROi Q8R2Y0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R2Y0.
    Bgeei Q8R2Y0.
    CleanExi MM_ABHD6.
    Genevestigatori Q8R2Y0.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    [Graphical view ]
    PRINTSi PR00111. ABHYDROLASE.
    PR00412. EPOXHYDRLASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Amnion, Embryo and Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N-3.
      Tissue: Mammary tumor.
    3. "A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol."
      Blankman J.L., Simon G.M., Cravatt B.F.
      Chem. Biol. 14:1347-1356(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiABHD6_MOUSE
    AccessioniPrimary (citable) accession number: Q8R2Y0
    Secondary accession number(s): Q3TGD2, Q9DCD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3