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Protein

Arf-GAP with dual PH domain-containing protein 2

Gene

Adap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity (By similarity).By similarityCurated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri25 – 4824C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • heart development Source: UniProtKB
  • inositol lipid-mediated signaling Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with dual PH domain-containing protein 2
Alternative name(s):
Centaurin-alpha-2
Short name:
Cnt-a2
Gene namesi
Name:Adap2
Synonyms:Centa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2663075. Adap2.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell membrane By similarity

  • Note: Constitutively associated with the plasma membrane. Excluded from the nucleus (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Arf-GAP with dual PH domain-containing protein 2PRO_0000074207Add
BLAST

Proteomic databases

EPDiQ8R2V5.
MaxQBiQ8R2V5.
PaxDbiQ8R2V5.
PRIDEiQ8R2V5.

PTM databases

iPTMnetiQ8R2V5.
PhosphoSiteiQ8R2V5.

Expressioni

Gene expression databases

BgeeiQ8R2V5.
ExpressionAtlasiQ8R2V5. baseline and differential.
GenevisibleiQ8R2V5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021050.

Structurei

3D structure databases

ProteinModelPortaliQ8R2V5.
SMRiQ8R2V5. Positions 4-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 132124Arf-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini132 – 233102PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini255 – 361107PH 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri25 – 4824C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0703. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00820000127006.
HOVERGENiHBG050888.
InParanoidiQ8R2V5.
OMAiPQANDCL.
OrthoDBiEOG71K62W.
TreeFamiTF324540.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 2 hits.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R2V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDRERNKKR LLELLQAAGT GNGHCADCGA ADPDWASYKL GIFICLHCSG
60 70 80 90 100
VHRNFPDISK VKSVRLDFWD DSMVEFMTHH GNLNVKAKFE ARVPAFYYVP
110 120 130 140 150
QANDCLVLKE QWIRAKYERQ EFTAIDKAVS HPGNREGFLW KRGRDNAQFL
160 170 180 190 200
RRRFVLLSRE GLLKYYTKEE GKAPKAVISI KDLNATFQTE KIGHPHGLQI
210 220 230 240 250
TYRKEGHTRN LFVYHDSGKE IVDWFNALRA ARLQYLKLAF PDLPESELVP
260 270 280 290 300
LITRNYLKQG FMEKTGPKHR EPFKKRWFAL DPQERRLLYY KNPLDAFELG
310 320 330 340 350
QVFLGSNEQG YEVWEDLPKG IRGNRWKAGL TVITPERKFI FTCPTEKEQR
360 370 380
EWLESLRGVL SSPLSPLHLL TTSAETGCGL G
Length:381
Mass (Da):43,989
Last modified:June 1, 2002 - v1
Checksum:i2E504CEF0ACD84D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027165 mRNA. Translation: AAH27165.1.
CCDSiCCDS25128.1.
RefSeqiNP_742145.1. NM_172133.1.
UniGeneiMm.341520.

Genome annotation databases

EnsembliENSMUST00000021050; ENSMUSP00000021050; ENSMUSG00000020709.
GeneIDi216991.
KEGGimmu:216991.
UCSCiuc007klk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027165 mRNA. Translation: AAH27165.1.
CCDSiCCDS25128.1.
RefSeqiNP_742145.1. NM_172133.1.
UniGeneiMm.341520.

3D structure databases

ProteinModelPortaliQ8R2V5.
SMRiQ8R2V5. Positions 4-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021050.

PTM databases

iPTMnetiQ8R2V5.
PhosphoSiteiQ8R2V5.

Proteomic databases

EPDiQ8R2V5.
MaxQBiQ8R2V5.
PaxDbiQ8R2V5.
PRIDEiQ8R2V5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021050; ENSMUSP00000021050; ENSMUSG00000020709.
GeneIDi216991.
KEGGimmu:216991.
UCSCiuc007klk.1. mouse.

Organism-specific databases

CTDi55803.
MGIiMGI:2663075. Adap2.

Phylogenomic databases

eggNOGiKOG0703. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00820000127006.
HOVERGENiHBG050888.
InParanoidiQ8R2V5.
OMAiPQANDCL.
OrthoDBiEOG71K62W.
TreeFamiTF324540.

Miscellaneous databases

ChiTaRSiAdap2. mouse.
PROiQ8R2V5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R2V5.
ExpressionAtlasiQ8R2V5. baseline and differential.
GenevisibleiQ8R2V5. MM.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 2 hits.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiADAP2_MOUSE
AccessioniPrimary (citable) accession number: Q8R2V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.