Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arf-GAP with dual PH domain-containing protein 2

Gene

Adap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity (By similarity).By similarityCurated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 48C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • heart development Source: UniProtKB
  • inositol lipid-mediated signaling Source: MGI

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with dual PH domain-containing protein 2
Alternative name(s):
Centaurin-alpha-2
Short name:
Cnt-a2
Gene namesi
Name:Adap2
Synonyms:Centa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2663075 Adap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000742071 – 381Arf-GAP with dual PH domain-containing protein 2Add BLAST381

Proteomic databases

EPDiQ8R2V5
MaxQBiQ8R2V5
PaxDbiQ8R2V5
PRIDEiQ8R2V5

PTM databases

iPTMnetiQ8R2V5
PhosphoSitePlusiQ8R2V5

Expressioni

Gene expression databases

BgeeiENSMUSG00000020709
ExpressionAtlasiQ8R2V5 baseline and differential
GenevisibleiQ8R2V5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021050

Structurei

3D structure databases

ProteinModelPortaliQ8R2V5
SMRiQ8R2V5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 132Arf-GAPPROSITE-ProRule annotationAdd BLAST124
Domaini132 – 233PH 1PROSITE-ProRule annotationAdd BLAST102
Domaini255 – 361PH 2PROSITE-ProRule annotationAdd BLAST107

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 48C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0703 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00900000140892
HOVERGENiHBG050888
InParanoidiQ8R2V5
OMAiPQANDCL
OrthoDBiEOG091G0789
TreeFamiTF324540

Family and domain databases

CDDicd13252 PH1_ADAP, 1 hit
cd01251 PH2_ADAP, 1 hit
Gene3Di2.30.29.30, 2 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR037849 PH1_ADAP
IPR037851 PH2_ADAP
IPR001849 PH_domain
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 2 hits
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 2 hits

Sequencei

Sequence statusi: Complete.

Q8R2V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDRERNKKR LLELLQAAGT GNGHCADCGA ADPDWASYKL GIFICLHCSG
60 70 80 90 100
VHRNFPDISK VKSVRLDFWD DSMVEFMTHH GNLNVKAKFE ARVPAFYYVP
110 120 130 140 150
QANDCLVLKE QWIRAKYERQ EFTAIDKAVS HPGNREGFLW KRGRDNAQFL
160 170 180 190 200
RRRFVLLSRE GLLKYYTKEE GKAPKAVISI KDLNATFQTE KIGHPHGLQI
210 220 230 240 250
TYRKEGHTRN LFVYHDSGKE IVDWFNALRA ARLQYLKLAF PDLPESELVP
260 270 280 290 300
LITRNYLKQG FMEKTGPKHR EPFKKRWFAL DPQERRLLYY KNPLDAFELG
310 320 330 340 350
QVFLGSNEQG YEVWEDLPKG IRGNRWKAGL TVITPERKFI FTCPTEKEQR
360 370 380
EWLESLRGVL SSPLSPLHLL TTSAETGCGL G
Length:381
Mass (Da):43,989
Last modified:June 1, 2002 - v1
Checksum:i2E504CEF0ACD84D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027165 mRNA Translation: AAH27165.1
CCDSiCCDS25128.1
RefSeqiNP_742145.1, NM_172133.1
UniGeneiMm.341520

Genome annotation databases

EnsembliENSMUST00000021050; ENSMUSP00000021050; ENSMUSG00000020709
GeneIDi216991
KEGGimmu:216991
UCSCiuc007klk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiADAP2_MOUSE
AccessioniPrimary (citable) accession number: Q8R2V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health