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Q8R2U8

- Q8R2U8_MOUSE

UniProt

Q8R2U8 - Q8R2U8_MOUSE

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Protein
Submitted name: Pdk1 protein
Gene
Pdk1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. pyruvate dehydrogenase (acetyl-transferring) kinase activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. cell proliferation Source: Ensembl
  2. hypoxia-inducible factor-1alpha signaling pathway Source: Ensembl
  3. intracellular signal transduction Source: MGI
  4. intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
  5. regulation of glucose metabolic process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Pdk1 proteinImported
Gene namesi
Name:Pdk1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1926119. Pdk1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
  2. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiQ8R2U8.
BgeeiQ8R2U8.
GenevestigatoriQ8R2U8.

Structurei

3D structure databases

ProteinModelPortaliQ8R2U8.
SMRiQ8R2U8. Positions 39-419.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000511.
InParanoidiQ8R2U8.

Family and domain databases

Gene3Di1.20.140.20. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR018955. BCDHK/PDK_N.
IPR003594. HATPase_ATP-bd.
IPR005467. Sig_transdc_His_kinase_core.
[Graphical view]
PfamiPF10436. BCDHK_Adom3. 1 hit.
PF02518. HATPase_c. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
SSF69012. SSF69012. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R2U8-1 [UniParc]FASTAAdd to Basket

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MRLARLLRGG TSVRPLCAVP CASRSLASAS GSGPASELGV PGQVDFYARF    50
SPSPLSMKQF LDFGSVNACE KTSFMFLRQE LPVRLANIMK EISLLPDNLL 100
RTPSVQLVQS WYIQSLQELL DFKDKSAEDA KTIYEFTDTV IRIRNRHNDV 150
IPTMAQGVTE YKESFGVDPV TSQNVQYFLD RFYMSRISIR MLLNQHSLLF 200
GGKGSPSHRK HIGSINPNCD VVEVIKDGYE NARRLCDLYY VNSPELELEE 250
LNAKSPGQTI QVVYVPSHLY HMVFELFKNA MRATMEHHAD KGVYPPIQVH 300
VTLGEEDLTV KMSDRGGGVP LRKIDRLFNY MYSTAPRPRV ETSRAVPLAG 350
FGYGLPISRL YAQYFQGDLK LYSLEGYGTD AVIYIKALST ESVERLPVYN 400
KAAWKHYKAN HEADDWCVPS REPKDMTTFR SS 432
Length:432
Mass (Da):48,837
Last modified:June 1, 2002 - v1
Checksum:i6682B5DEE68E62AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC027196 mRNA. Translation: AAH27196.1.
UniGeneiMm.34411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC027196 mRNA. Translation: AAH27196.1 .
UniGenei Mm.34411.

3D structure databases

ProteinModelPortali Q8R2U8.
SMRi Q8R2U8. Positions 39-419.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1926119. Pdk1.

Phylogenomic databases

HOVERGENi HBG000511.
InParanoidi Q8R2U8.

Miscellaneous databases

ChiTaRSi Pdk1. mouse.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8R2U8.
Bgeei Q8R2U8.
Genevestigatori Q8R2U8.

Family and domain databases

Gene3Di 1.20.140.20. 1 hit.
3.30.565.10. 1 hit.
InterProi IPR018955. BCDHK/PDK_N.
IPR003594. HATPase_ATP-bd.
IPR005467. Sig_transdc_His_kinase_core.
[Graphical view ]
Pfami PF10436. BCDHK_Adom3. 1 hit.
PF02518. HATPase_c. 1 hit.
[Graphical view ]
SMARTi SM00387. HATPase_c. 1 hit.
[Graphical view ]
SUPFAMi SSF55874. SSF55874. 1 hit.
SSF69012. SSF69012. 1 hit.
PROSITEi PS50109. HIS_KIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.

Entry informationi

Entry nameiQ8R2U8_MOUSE
AccessioniPrimary (citable) accession number: Q8R2U8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: March 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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