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Q8R2U8

- Q8R2U8_MOUSE

UniProt

Q8R2U8 - Q8R2U8_MOUSE

Protein
Submitted name:

Pdk1 protein

Gene

Pdk1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. pyruvate dehydrogenase (acetyl-transferring) kinase activity Source: Ensembl

    GO - Biological processi

    1. cell proliferation Source: Ensembl
    2. hypoxia-inducible factor-1alpha signaling pathway Source: Ensembl
    3. intracellular signal transduction Source: MGI
    4. intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
    5. regulation of glucose metabolic process Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Pdk1 proteinImported
    Gene namesi
    Name:Pdk1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1926119. Pdk1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI
    2. plasma membrane Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiQ8R2U8.
    BgeeiQ8R2U8.
    GenevestigatoriQ8R2U8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R2U8.
    SMRiQ8R2U8. Positions 39-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG000511.
    InParanoidiQ8R2U8.

    Family and domain databases

    Gene3Di1.20.140.20. 1 hit.
    3.30.565.10. 1 hit.
    InterProiIPR018955. BCDHK/PDK_N.
    IPR003594. HATPase_ATP-bd.
    IPR005467. Sig_transdc_His_kinase_core.
    [Graphical view]
    PfamiPF10436. BCDHK_Adom3. 1 hit.
    PF02518. HATPase_c. 1 hit.
    [Graphical view]
    SMARTiSM00387. HATPase_c. 1 hit.
    [Graphical view]
    SUPFAMiSSF55874. SSF55874. 1 hit.
    SSF69012. SSF69012. 1 hit.
    PROSITEiPS50109. HIS_KIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R2U8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLARLLRGG TSVRPLCAVP CASRSLASAS GSGPASELGV PGQVDFYARF    50
    SPSPLSMKQF LDFGSVNACE KTSFMFLRQE LPVRLANIMK EISLLPDNLL 100
    RTPSVQLVQS WYIQSLQELL DFKDKSAEDA KTIYEFTDTV IRIRNRHNDV 150
    IPTMAQGVTE YKESFGVDPV TSQNVQYFLD RFYMSRISIR MLLNQHSLLF 200
    GGKGSPSHRK HIGSINPNCD VVEVIKDGYE NARRLCDLYY VNSPELELEE 250
    LNAKSPGQTI QVVYVPSHLY HMVFELFKNA MRATMEHHAD KGVYPPIQVH 300
    VTLGEEDLTV KMSDRGGGVP LRKIDRLFNY MYSTAPRPRV ETSRAVPLAG 350
    FGYGLPISRL YAQYFQGDLK LYSLEGYGTD AVIYIKALST ESVERLPVYN 400
    KAAWKHYKAN HEADDWCVPS REPKDMTTFR SS 432
    Length:432
    Mass (Da):48,837
    Last modified:June 1, 2002 - v1
    Checksum:i6682B5DEE68E62AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC027196 mRNA. Translation: AAH27196.1.
    UniGeneiMm.34411.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC027196 mRNA. Translation: AAH27196.1 .
    UniGenei Mm.34411.

    3D structure databases

    ProteinModelPortali Q8R2U8.
    SMRi Q8R2U8. Positions 39-419.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1926119. Pdk1.

    Phylogenomic databases

    HOVERGENi HBG000511.
    InParanoidi Q8R2U8.

    Miscellaneous databases

    ChiTaRSi Pdk1. mouse.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R2U8.
    Bgeei Q8R2U8.
    Genevestigatori Q8R2U8.

    Family and domain databases

    Gene3Di 1.20.140.20. 1 hit.
    3.30.565.10. 1 hit.
    InterProi IPR018955. BCDHK/PDK_N.
    IPR003594. HATPase_ATP-bd.
    IPR005467. Sig_transdc_His_kinase_core.
    [Graphical view ]
    Pfami PF10436. BCDHK_Adom3. 1 hit.
    PF02518. HATPase_c. 1 hit.
    [Graphical view ]
    SMARTi SM00387. HATPase_c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55874. SSF55874. 1 hit.
    SSF69012. SSF69012. 1 hit.
    PROSITEi PS50109. HIS_KIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.

    Entry informationi

    Entry nameiQ8R2U8_MOUSE
    AccessioniPrimary (citable) accession number: Q8R2U8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)