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Q8R2T8 (TF3C5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
General transcription factor 3C polypeptide 5
Alternative name(s):
TF3C-epsilon
Transcription factor IIIC 63 kDa subunit
Short name=TFIIIC 63 kDa subunit
Short name=TFIIIC63
Transcription factor IIIC subunit epsilon
Gene names
Name:Gtf3c5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters By similarity.

Subunit structure

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the TFIIIC subunit 5 family.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   LigandDNA-binding
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processskeletal muscle cell differentiation

Inferred from mutant phenotype PubMed 22147266. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenttranscription factor TFIIIC complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8R2T8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8R2T8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     465-470: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 520519General transcription factor 3C polypeptide 5
PRO_0000209716

Regions

Compositional bias87 – 9610Poly-Arg
Compositional bias478 – 51538Glu-rich
Compositional bias486 – 50015Poly-Glu

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Natural variations

Alternative sequence465 – 4706Missing in isoform 2.
VSP_010356

Experimental info

Sequence conflict1451M → T in AAH27247. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: 02687D323638FD0B

FASTA52060,502
        10         20         30         40         50         60 
MAAAEPDADP KAAIPVDLRR ERRLVCVEYP GVVRNEAKML QTLGGEESVS RIYTDPTKRL 

        70         80         90        100        110        120 
ELYFRPKDPY CHPVCANRFS TSSLLLRIRK RTRRRRGVLG DEAHPQVTFN LEIIGIISTI 

       130        140        150        160        170        180 
YKFQGMSDFQ YLAVHTEAGG KHVSMYDRVL MRKPEKEEFF HQELPLYIPP PIFSRLDTPV 

       190        200        210        220        230        240 
DYFYRPETQH REGYHNPTIS GENLIGLSRA RRPHNAIFVN FEDTEVPEQP LEAAVQTWKK 

       250        260        270        280        290        300 
ACTNPIDQKV EEELRKLFDI RPVWSRNAVK SNVSVHPDKL KILLPYMAYY MITGPWRSLW 

       310        320        330        340        350        360 
IRFGYDPRKH PDAKIYQVLD FRIRCGMKYG YGSRDMPVKA KRSTYNYSLP ITVKKTSNQP 

       370        380        390        400        410        420 
GTMHDLKQGL GPSGTDGPRK LTYNKYKLKD SVYIFREGAL PPYRQMFYQL CDLNVEELQK 

       430        440        450        460        470        480 
IVHRNDGTET VCTERDGWCL PKTTDHLRDT MSLMILQTIR SERPALFSNT GKADRGKEQL 

       490        500        510        520 
MFESGEEEEE EEEEEEEEEE DFKPSDGSEN EMETEILDYV 

« Hide

Isoform 2 [UniParc].

Checksum: 39806677F99F4765
Show »

FASTA51459,868

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Eye.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-520 (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC027055 mRNA. Translation: AAH27055.1.
BC027247 mRNA. Translation: AAH27247.1.
BC039171 mRNA. Translation: AAH39171.1.
AK045419 mRNA. Translation: BAC32354.1.
RefSeqNP_683730.1. NM_148928.2.
XP_006498376.1. XM_006498313.1.
UniGeneMm.274120.

3D structure databases

ProteinModelPortalQ8R2T8.
SMRQ8R2T8. Positions 27-131, 213-465.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid213934. 1 interaction.
STRING10090.ENSMUSP00000109521.

PTM databases

PhosphoSiteQ8R2T8.

Proteomic databases

PaxDbQ8R2T8.
PRIDEQ8R2T8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028157; ENSMUSP00000028157; ENSMUSG00000026816. [Q8R2T8-2]
ENSMUST00000113889; ENSMUSP00000109521; ENSMUSG00000026816. [Q8R2T8-1]
GeneID70239.
KEGGmmu:70239.
UCSCuc012bsz.1. mouse. [Q8R2T8-1]

Organism-specific databases

CTD9328.
MGIMGI:1917489. Gtf3c5.

Phylogenomic databases

eggNOGNOG311463.
GeneTreeENSGT00390000004458.
HOGENOMHOG000220825.
HOVERGENHBG058445.
InParanoidQ8R2T8.
KOK15202.
OMARDTMSLM.
OrthoDBEOG780RMW.
PhylomeDBQ8R2T8.
TreeFamTF313581.

Gene expression databases

ArrayExpressQ8R2T8.
BgeeQ8R2T8.
CleanExMM_GTF3C5.
GenevestigatorQ8R2T8.

Family and domain databases

InterProIPR019136. TF_IIIC_su-5.
[Graphical view]
PfamPF09734. Tau95. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio331234.
PROQ8R2T8.
SOURCESearch...

Entry information

Entry nameTF3C5_MOUSE
AccessionPrimary (citable) accession number: Q8R2T8
Secondary accession number(s): Q8BLE3, Q8R0D0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: April 16, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot