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Q8R2T8

- TF3C5_MOUSE

UniProt

Q8R2T8 - TF3C5_MOUSE

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Protein

General transcription factor 3C polypeptide 5

Gene

Gtf3c5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. skeletal muscle cell differentiation Source: MGI
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_250309. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
REACT_251592. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_261233. RNA Polymerase III Abortive And Retractive Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 5
Alternative name(s):
TF3C-epsilon
Transcription factor IIIC 63 kDa subunit
Short name:
TFIIIC 63 kDa subunit
Short name:
TFIIIC63
Transcription factor IIIC subunit epsilon
Gene namesi
Name:Gtf3c5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1917489. Gtf3c5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. transcription factor TFIIIC complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 520519General transcription factor 3C polypeptide 5PRO_0000209716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8R2T8.
PaxDbiQ8R2T8.
PRIDEiQ8R2T8.

PTM databases

PhosphoSiteiQ8R2T8.

Expressioni

Gene expression databases

BgeeiQ8R2T8.
CleanExiMM_GTF3C5.
ExpressionAtlasiQ8R2T8. baseline.
GenevestigatoriQ8R2T8.

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP (By similarity).By similarity

Protein-protein interaction databases

BioGridi213934. 1 interaction.
STRINGi10090.ENSMUSP00000109521.

Structurei

3D structure databases

ProteinModelPortaliQ8R2T8.
SMRiQ8R2T8. Positions 27-131, 248-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi87 – 9610Poly-Arg
Compositional biasi478 – 51538Glu-richAdd
BLAST
Compositional biasi486 – 50015Poly-GluAdd
BLAST

Sequence similaritiesi

Belongs to the TFIIIC subunit 5 family.Curated

Phylogenomic databases

eggNOGiNOG311463.
GeneTreeiENSGT00390000004458.
HOGENOMiHOG000220825.
HOVERGENiHBG058445.
InParanoidiQ8R2T8.
KOiK15202.
OMAiDTMSLMI.
OrthoDBiEOG780RMW.
PhylomeDBiQ8R2T8.
TreeFamiTF313581.

Family and domain databases

InterProiIPR019136. TF_IIIC_su-5.
[Graphical view]
PfamiPF09734. Tau95. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8R2T8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAEPDADP KAAIPVDLRR ERRLVCVEYP GVVRNEAKML QTLGGEESVS
60 70 80 90 100
RIYTDPTKRL ELYFRPKDPY CHPVCANRFS TSSLLLRIRK RTRRRRGVLG
110 120 130 140 150
DEAHPQVTFN LEIIGIISTI YKFQGMSDFQ YLAVHTEAGG KHVSMYDRVL
160 170 180 190 200
MRKPEKEEFF HQELPLYIPP PIFSRLDTPV DYFYRPETQH REGYHNPTIS
210 220 230 240 250
GENLIGLSRA RRPHNAIFVN FEDTEVPEQP LEAAVQTWKK ACTNPIDQKV
260 270 280 290 300
EEELRKLFDI RPVWSRNAVK SNVSVHPDKL KILLPYMAYY MITGPWRSLW
310 320 330 340 350
IRFGYDPRKH PDAKIYQVLD FRIRCGMKYG YGSRDMPVKA KRSTYNYSLP
360 370 380 390 400
ITVKKTSNQP GTMHDLKQGL GPSGTDGPRK LTYNKYKLKD SVYIFREGAL
410 420 430 440 450
PPYRQMFYQL CDLNVEELQK IVHRNDGTET VCTERDGWCL PKTTDHLRDT
460 470 480 490 500
MSLMILQTIR SERPALFSNT GKADRGKEQL MFESGEEEEE EEEEEEEEEE
510 520
DFKPSDGSEN EMETEILDYV
Length:520
Mass (Da):60,502
Last modified:May 24, 2004 - v2
Checksum:i02687D323638FD0B
GO
Isoform 2 (identifier: Q8R2T8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-470: Missing.

Note: No experimental confirmation available.

Show »
Length:514
Mass (Da):59,868
Checksum:i39806677F99F4765
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451M → T in AAH27247. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei465 – 4706Missing in isoform 2. 2 PublicationsVSP_010356

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027055 mRNA. Translation: AAH27055.1.
BC027247 mRNA. Translation: AAH27247.1.
BC039171 mRNA. Translation: AAH39171.1.
AK045419 mRNA. Translation: BAC32354.1.
CCDSiCCDS15842.1. [Q8R2T8-2]
CCDS71012.1. [Q8R2T8-1]
RefSeqiNP_001277413.1. NM_001290484.1. [Q8R2T8-1]
NP_683730.1. NM_148928.3. [Q8R2T8-2]
UniGeneiMm.274120.

Genome annotation databases

EnsembliENSMUST00000028157; ENSMUSP00000028157; ENSMUSG00000026816. [Q8R2T8-2]
ENSMUST00000113889; ENSMUSP00000109521; ENSMUSG00000026816. [Q8R2T8-1]
GeneIDi70239.
KEGGimmu:70239.
UCSCiuc012bsz.1. mouse. [Q8R2T8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027055 mRNA. Translation: AAH27055.1 .
BC027247 mRNA. Translation: AAH27247.1 .
BC039171 mRNA. Translation: AAH39171.1 .
AK045419 mRNA. Translation: BAC32354.1 .
CCDSi CCDS15842.1. [Q8R2T8-2 ]
CCDS71012.1. [Q8R2T8-1 ]
RefSeqi NP_001277413.1. NM_001290484.1. [Q8R2T8-1 ]
NP_683730.1. NM_148928.3. [Q8R2T8-2 ]
UniGenei Mm.274120.

3D structure databases

ProteinModelPortali Q8R2T8.
SMRi Q8R2T8. Positions 27-131, 248-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 213934. 1 interaction.
STRINGi 10090.ENSMUSP00000109521.

PTM databases

PhosphoSitei Q8R2T8.

Proteomic databases

MaxQBi Q8R2T8.
PaxDbi Q8R2T8.
PRIDEi Q8R2T8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028157 ; ENSMUSP00000028157 ; ENSMUSG00000026816 . [Q8R2T8-2 ]
ENSMUST00000113889 ; ENSMUSP00000109521 ; ENSMUSG00000026816 . [Q8R2T8-1 ]
GeneIDi 70239.
KEGGi mmu:70239.
UCSCi uc012bsz.1. mouse. [Q8R2T8-1 ]

Organism-specific databases

CTDi 9328.
MGIi MGI:1917489. Gtf3c5.

Phylogenomic databases

eggNOGi NOG311463.
GeneTreei ENSGT00390000004458.
HOGENOMi HOG000220825.
HOVERGENi HBG058445.
InParanoidi Q8R2T8.
KOi K15202.
OMAi DTMSLMI.
OrthoDBi EOG780RMW.
PhylomeDBi Q8R2T8.
TreeFami TF313581.

Enzyme and pathway databases

Reactomei REACT_250309. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
REACT_251592. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_261233. RNA Polymerase III Abortive And Retractive Initiation.

Miscellaneous databases

NextBioi 331234.
PROi Q8R2T8.
SOURCEi Search...

Gene expression databases

Bgeei Q8R2T8.
CleanExi MM_GTF3C5.
ExpressionAtlasi Q8R2T8. baseline.
Genevestigatori Q8R2T8.

Family and domain databases

InterProi IPR019136. TF_IIIC_su-5.
[Graphical view ]
Pfami PF09734. Tau95. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-520 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiTF3C5_MOUSE
AccessioniPrimary (citable) accession number: Q8R2T8
Secondary accession number(s): Q8BLE3, Q8R0D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 26, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3