Q8R2T8 (TF3C5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
General transcription factor 3C polypeptide 5

Alternative name(s):
TF3C-epsilon
Transcription factor IIIC 63 kDa subunit
Short name=TFIIIC 63 kDa subunit
Short name=TFIIIC63
Transcription factor IIIC subunit epsilon

Gene names

Name:

Gtf3c5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	520 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters By similarity.
Subunit structure	Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the TFIIIC subunit 5 family.

Ontologies

Keywords
Biological process	Transcription
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	skeletal muscle cell differentiation Inferred from mutant phenotype PubMed 22147266. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	transcription factor TFIIIC complex Inferred from electronic annotation. Source: Compara
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8R2T8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8R2T8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     465-470: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 520	520	General transcription factor 3C polypeptide 5		PRO_0000209716
Regions
	Compositional bias	87 – 96	10	Poly-Arg
	Compositional bias	478 – 515	38	Glu-rich
	Compositional bias	486 – 500	15	Poly-Glu
Natural variations
	Alternative sequence	465 – 470	6	Missing in isoform 2.		VSP_010356
Experimental info
	Sequence conflict	145	1	M → T in AAH27247. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 24, 2004. Version 2. Checksum: 02687D323638FD0B	FASTA	520	60,502
	10 20 30 40 50 60 MAAAEPDADP KAAIPVDLRR ERRLVCVEYP GVVRNEAKML QTLGGEESVS RIYTDPTKRL 70 80 90 100 110 120 ELYFRPKDPY CHPVCANRFS TSSLLLRIRK RTRRRRGVLG DEAHPQVTFN LEIIGIISTI 130 140 150 160 170 180 YKFQGMSDFQ YLAVHTEAGG KHVSMYDRVL MRKPEKEEFF HQELPLYIPP PIFSRLDTPV 190 200 210 220 230 240 DYFYRPETQH REGYHNPTIS GENLIGLSRA RRPHNAIFVN FEDTEVPEQP LEAAVQTWKK 250 260 270 280 290 300 ACTNPIDQKV EEELRKLFDI RPVWSRNAVK SNVSVHPDKL KILLPYMAYY MITGPWRSLW 310 320 330 340 350 360 IRFGYDPRKH PDAKIYQVLD FRIRCGMKYG YGSRDMPVKA KRSTYNYSLP ITVKKTSNQP 370 380 390 400 410 420 GTMHDLKQGL GPSGTDGPRK LTYNKYKLKD SVYIFREGAL PPYRQMFYQL CDLNVEELQK 430 440 450 460 470 480 IVHRNDGTET VCTERDGWCL PKTTDHLRDT MSLMILQTIR SERPALFSNT GKADRGKEQL 490 500 510 520 MFESGEEEEE EEEEEEEEEE DFKPSDGSEN EMETEILDYV
	Isoform 2 [UniParc]. Checksum: 39806677F99F4765	FASTA	514	59,868
	10 20 30 40 50 60 MAAAEPDADP KAAIPVDLRR ERRLVCVEYP GVVRNEAKML QTLGGEESVS RIYTDPTKRL 70 80 90 100 110 120 ELYFRPKDPY CHPVCANRFS TSSLLLRIRK RTRRRRGVLG DEAHPQVTFN LEIIGIISTI 130 140 150 160 170 180 YKFQGMSDFQ YLAVHTEAGG KHVSMYDRVL MRKPEKEEFF HQELPLYIPP PIFSRLDTPV 190 200 210 220 230 240 DYFYRPETQH REGYHNPTIS GENLIGLSRA RRPHNAIFVN FEDTEVPEQP LEAAVQTWKK 250 260 270 280 290 300 ACTNPIDQKV EEELRKLFDI RPVWSRNAVK SNVSVHPDKL KILLPYMAYY MITGPWRSLW 310 320 330 340 350 360 IRFGYDPRKH PDAKIYQVLD FRIRCGMKYG YGSRDMPVKA KRSTYNYSLP ITVKKTSNQP 370 380 390 400 410 420 GTMHDLKQGL GPSGTDGPRK LTYNKYKLKD SVYIFREGAL PPYRQMFYQL CDLNVEELQK 430 440 450 460 470 480 IVHRNDGTET VCTERDGWCL PKTTDHLRDT MSLMILQTIR SERPGKADRG KEQLMFESGE 490 500 510 EEEEEEEEEE EEEEDFKPSD GSENEMETEI LDYV

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Eye.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-520 (ISOFORM 2). Strain: C57BL/6J. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC027055 mRNA. Translation: AAH27055.1. BC027247 mRNA. Translation: AAH27247.1. BC039171 mRNA. Translation: AAH39171.1. AK045419 mRNA. Translation: BAC32354.1.
IPI	IPI00277858. IPI00417173.
RefSeq	NP_683730.1. NM_148928.2.
UniGene	Mm.274120.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000109521.
PTM databases
PhosphoSite	Q8R2T8.
Proteomic databases
PaxDb	Q8R2T8.
PRIDE	Q8R2T8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000028157; ENSMUSP00000028157; ENSMUSG00000026816. ENSMUST00000113889; ENSMUSP00000109521; ENSMUSG00000026816.
GeneID	70239.
KEGG	mmu:70239.
Organism-specific databases
CTD	9328.
MGI	MGI:1917489. Gtf3c5.
Phylogenomic databases
eggNOG	NOG311463.
GeneTree	ENSGT00390000004458.
HOGENOM	HOG000220825.
HOVERGEN	HBG058445.
InParanoid	Q8R2T8.
KO	K15202.
OMA	PNDMPVK.
OrthoDB	EOG4VDPZX.
Gene expression databases
ArrayExpress	Q8R2T8.
Bgee	Q8R2T8.
CleanEx	MM_GTF3C5.
Genevestigator	Q8R2T8.
GermOnline	ENSMUSG00000026816. Mus musculus.
Family and domain databases
InterPro	IPR019136. TF_IIIC_su-5. [Graphical view]
Pfam	PF09734. Tau95. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	331234.
SOURCE	Search...

Entry information

Entry name

TF3C5_MOUSE

Accession

Primary (citable) accession number: Q8R2T8
Secondary accession number(s): Q8BLE3, Q8R0D0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	May 24, 2004
Last modified:	April 3, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program