Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8R2T8

- TF3C5_MOUSE

UniProt

Q8R2T8 - TF3C5_MOUSE

Protein

General transcription factor 3C polypeptide 5

Gene

Gtf3c5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (24 May 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. skeletal muscle cell differentiation Source: MGI
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor 3C polypeptide 5
    Alternative name(s):
    TF3C-epsilon
    Transcription factor IIIC 63 kDa subunit
    Short name:
    TFIIIC 63 kDa subunit
    Short name:
    TFIIIC63
    Transcription factor IIIC subunit epsilon
    Gene namesi
    Name:Gtf3c5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1917489. Gtf3c5.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. transcription factor TFIIIC complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 520519General transcription factor 3C polypeptide 5PRO_0000209716Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8R2T8.
    PaxDbiQ8R2T8.
    PRIDEiQ8R2T8.

    PTM databases

    PhosphoSiteiQ8R2T8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8R2T8.
    BgeeiQ8R2T8.
    CleanExiMM_GTF3C5.
    GenevestigatoriQ8R2T8.

    Interactioni

    Subunit structurei

    Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi213934. 1 interaction.
    STRINGi10090.ENSMUSP00000109521.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R2T8.
    SMRiQ8R2T8. Positions 27-131, 248-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi87 – 9610Poly-Arg
    Compositional biasi478 – 51538Glu-richAdd
    BLAST
    Compositional biasi486 – 50015Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TFIIIC subunit 5 family.Curated

    Phylogenomic databases

    eggNOGiNOG311463.
    GeneTreeiENSGT00390000004458.
    HOGENOMiHOG000220825.
    HOVERGENiHBG058445.
    InParanoidiQ8R2T8.
    KOiK15202.
    OMAiDTMSLMI.
    OrthoDBiEOG780RMW.
    PhylomeDBiQ8R2T8.
    TreeFamiTF313581.

    Family and domain databases

    InterProiIPR019136. TF_IIIC_su-5.
    [Graphical view]
    PfamiPF09734. Tau95. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8R2T8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAEPDADP KAAIPVDLRR ERRLVCVEYP GVVRNEAKML QTLGGEESVS    50
    RIYTDPTKRL ELYFRPKDPY CHPVCANRFS TSSLLLRIRK RTRRRRGVLG 100
    DEAHPQVTFN LEIIGIISTI YKFQGMSDFQ YLAVHTEAGG KHVSMYDRVL 150
    MRKPEKEEFF HQELPLYIPP PIFSRLDTPV DYFYRPETQH REGYHNPTIS 200
    GENLIGLSRA RRPHNAIFVN FEDTEVPEQP LEAAVQTWKK ACTNPIDQKV 250
    EEELRKLFDI RPVWSRNAVK SNVSVHPDKL KILLPYMAYY MITGPWRSLW 300
    IRFGYDPRKH PDAKIYQVLD FRIRCGMKYG YGSRDMPVKA KRSTYNYSLP 350
    ITVKKTSNQP GTMHDLKQGL GPSGTDGPRK LTYNKYKLKD SVYIFREGAL 400
    PPYRQMFYQL CDLNVEELQK IVHRNDGTET VCTERDGWCL PKTTDHLRDT 450
    MSLMILQTIR SERPALFSNT GKADRGKEQL MFESGEEEEE EEEEEEEEEE 500
    DFKPSDGSEN EMETEILDYV 520
    Length:520
    Mass (Da):60,502
    Last modified:May 24, 2004 - v2
    Checksum:i02687D323638FD0B
    GO
    Isoform 2 (identifier: Q8R2T8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         465-470: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:514
    Mass (Da):59,868
    Checksum:i39806677F99F4765
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti145 – 1451M → T in AAH27247. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei465 – 4706Missing in isoform 2. 2 PublicationsVSP_010356

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC027055 mRNA. Translation: AAH27055.1.
    BC027247 mRNA. Translation: AAH27247.1.
    BC039171 mRNA. Translation: AAH39171.1.
    AK045419 mRNA. Translation: BAC32354.1.
    CCDSiCCDS15842.1. [Q8R2T8-2]
    CCDS71012.1. [Q8R2T8-1]
    RefSeqiNP_001277413.1. NM_001290484.1. [Q8R2T8-1]
    NP_683730.1. NM_148928.3. [Q8R2T8-2]
    UniGeneiMm.274120.

    Genome annotation databases

    EnsembliENSMUST00000028157; ENSMUSP00000028157; ENSMUSG00000026816. [Q8R2T8-2]
    ENSMUST00000113889; ENSMUSP00000109521; ENSMUSG00000026816. [Q8R2T8-1]
    GeneIDi70239.
    KEGGimmu:70239.
    UCSCiuc012bsz.1. mouse. [Q8R2T8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC027055 mRNA. Translation: AAH27055.1 .
    BC027247 mRNA. Translation: AAH27247.1 .
    BC039171 mRNA. Translation: AAH39171.1 .
    AK045419 mRNA. Translation: BAC32354.1 .
    CCDSi CCDS15842.1. [Q8R2T8-2 ]
    CCDS71012.1. [Q8R2T8-1 ]
    RefSeqi NP_001277413.1. NM_001290484.1. [Q8R2T8-1 ]
    NP_683730.1. NM_148928.3. [Q8R2T8-2 ]
    UniGenei Mm.274120.

    3D structure databases

    ProteinModelPortali Q8R2T8.
    SMRi Q8R2T8. Positions 27-131, 248-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 213934. 1 interaction.
    STRINGi 10090.ENSMUSP00000109521.

    PTM databases

    PhosphoSitei Q8R2T8.

    Proteomic databases

    MaxQBi Q8R2T8.
    PaxDbi Q8R2T8.
    PRIDEi Q8R2T8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028157 ; ENSMUSP00000028157 ; ENSMUSG00000026816 . [Q8R2T8-2 ]
    ENSMUST00000113889 ; ENSMUSP00000109521 ; ENSMUSG00000026816 . [Q8R2T8-1 ]
    GeneIDi 70239.
    KEGGi mmu:70239.
    UCSCi uc012bsz.1. mouse. [Q8R2T8-1 ]

    Organism-specific databases

    CTDi 9328.
    MGIi MGI:1917489. Gtf3c5.

    Phylogenomic databases

    eggNOGi NOG311463.
    GeneTreei ENSGT00390000004458.
    HOGENOMi HOG000220825.
    HOVERGENi HBG058445.
    InParanoidi Q8R2T8.
    KOi K15202.
    OMAi DTMSLMI.
    OrthoDBi EOG780RMW.
    PhylomeDBi Q8R2T8.
    TreeFami TF313581.

    Miscellaneous databases

    NextBioi 331234.
    PROi Q8R2T8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R2T8.
    Bgeei Q8R2T8.
    CleanExi MM_GTF3C5.
    Genevestigatori Q8R2T8.

    Family and domain databases

    InterProi IPR019136. TF_IIIC_su-5.
    [Graphical view ]
    Pfami PF09734. Tau95. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Eye.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-520 (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Brain.

    Entry informationi

    Entry nameiTF3C5_MOUSE
    AccessioniPrimary (citable) accession number: Q8R2T8
    Secondary accession number(s): Q8BLE3, Q8R0D0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3