SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8R2T8

- TF3C5_MOUSE

UniProt

Q8R2T8 - TF3C5_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
General transcription factor 3C polypeptide 5
Gene
Gtf3c5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. skeletal muscle cell differentiation Source: MGI
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 5
Alternative name(s):
TF3C-epsilon
Transcription factor IIIC 63 kDa subunit
Short name:
TFIIIC 63 kDa subunit
Short name:
TFIIIC63
Transcription factor IIIC subunit epsilon
Gene namesi
Name:Gtf3c5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1917489. Gtf3c5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. transcription factor TFIIIC complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 520519General transcription factor 3C polypeptide 5
PRO_0000209716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8R2T8.
PaxDbiQ8R2T8.
PRIDEiQ8R2T8.

PTM databases

PhosphoSiteiQ8R2T8.

Expressioni

Gene expression databases

ArrayExpressiQ8R2T8.
BgeeiQ8R2T8.
CleanExiMM_GTF3C5.
GenevestigatoriQ8R2T8.

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP By similarity.

Protein-protein interaction databases

BioGridi213934. 1 interaction.
STRINGi10090.ENSMUSP00000109521.

Structurei

3D structure databases

ProteinModelPortaliQ8R2T8.
SMRiQ8R2T8. Positions 27-131, 248-324.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi87 – 9610Poly-Arg
Compositional biasi478 – 51538Glu-rich
Add
BLAST
Compositional biasi486 – 50015Poly-Glu
Add
BLAST

Sequence similaritiesi

Belongs to the TFIIIC subunit 5 family.

Phylogenomic databases

eggNOGiNOG311463.
GeneTreeiENSGT00390000004458.
HOGENOMiHOG000220825.
HOVERGENiHBG058445.
InParanoidiQ8R2T8.
KOiK15202.
OMAiDTMSLMI.
OrthoDBiEOG780RMW.
PhylomeDBiQ8R2T8.
TreeFamiTF313581.

Family and domain databases

InterProiIPR019136. TF_IIIC_su-5.
[Graphical view]
PfamiPF09734. Tau95. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8R2T8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAAEPDADP KAAIPVDLRR ERRLVCVEYP GVVRNEAKML QTLGGEESVS    50
RIYTDPTKRL ELYFRPKDPY CHPVCANRFS TSSLLLRIRK RTRRRRGVLG 100
DEAHPQVTFN LEIIGIISTI YKFQGMSDFQ YLAVHTEAGG KHVSMYDRVL 150
MRKPEKEEFF HQELPLYIPP PIFSRLDTPV DYFYRPETQH REGYHNPTIS 200
GENLIGLSRA RRPHNAIFVN FEDTEVPEQP LEAAVQTWKK ACTNPIDQKV 250
EEELRKLFDI RPVWSRNAVK SNVSVHPDKL KILLPYMAYY MITGPWRSLW 300
IRFGYDPRKH PDAKIYQVLD FRIRCGMKYG YGSRDMPVKA KRSTYNYSLP 350
ITVKKTSNQP GTMHDLKQGL GPSGTDGPRK LTYNKYKLKD SVYIFREGAL 400
PPYRQMFYQL CDLNVEELQK IVHRNDGTET VCTERDGWCL PKTTDHLRDT 450
MSLMILQTIR SERPALFSNT GKADRGKEQL MFESGEEEEE EEEEEEEEEE 500
DFKPSDGSEN EMETEILDYV 520
Length:520
Mass (Da):60,502
Last modified:May 24, 2004 - v2
Checksum:i02687D323638FD0B
GO
Isoform 2 (identifier: Q8R2T8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-470: Missing.

Note: No experimental confirmation available.

Show »
Length:514
Mass (Da):59,868
Checksum:i39806677F99F4765
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei465 – 4706Missing in isoform 2.
VSP_010356

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451M → T in AAH27247. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC027055 mRNA. Translation: AAH27055.1.
BC027247 mRNA. Translation: AAH27247.1.
BC039171 mRNA. Translation: AAH39171.1.
AK045419 mRNA. Translation: BAC32354.1.
CCDSiCCDS15842.1. [Q8R2T8-2]
CCDS71012.1. [Q8R2T8-1]
RefSeqiNP_001277413.1. NM_001290484.1. [Q8R2T8-1]
NP_683730.1. NM_148928.3. [Q8R2T8-2]
UniGeneiMm.274120.

Genome annotation databases

EnsembliENSMUST00000028157; ENSMUSP00000028157; ENSMUSG00000026816. [Q8R2T8-2]
ENSMUST00000113889; ENSMUSP00000109521; ENSMUSG00000026816. [Q8R2T8-1]
GeneIDi70239.
KEGGimmu:70239.
UCSCiuc012bsz.1. mouse. [Q8R2T8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC027055 mRNA. Translation: AAH27055.1 .
BC027247 mRNA. Translation: AAH27247.1 .
BC039171 mRNA. Translation: AAH39171.1 .
AK045419 mRNA. Translation: BAC32354.1 .
CCDSi CCDS15842.1. [Q8R2T8-2 ]
CCDS71012.1. [Q8R2T8-1 ]
RefSeqi NP_001277413.1. NM_001290484.1. [Q8R2T8-1 ]
NP_683730.1. NM_148928.3. [Q8R2T8-2 ]
UniGenei Mm.274120.

3D structure databases

ProteinModelPortali Q8R2T8.
SMRi Q8R2T8. Positions 27-131, 248-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 213934. 1 interaction.
STRINGi 10090.ENSMUSP00000109521.

PTM databases

PhosphoSitei Q8R2T8.

Proteomic databases

MaxQBi Q8R2T8.
PaxDbi Q8R2T8.
PRIDEi Q8R2T8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028157 ; ENSMUSP00000028157 ; ENSMUSG00000026816 . [Q8R2T8-2 ]
ENSMUST00000113889 ; ENSMUSP00000109521 ; ENSMUSG00000026816 . [Q8R2T8-1 ]
GeneIDi 70239.
KEGGi mmu:70239.
UCSCi uc012bsz.1. mouse. [Q8R2T8-1 ]

Organism-specific databases

CTDi 9328.
MGIi MGI:1917489. Gtf3c5.

Phylogenomic databases

eggNOGi NOG311463.
GeneTreei ENSGT00390000004458.
HOGENOMi HOG000220825.
HOVERGENi HBG058445.
InParanoidi Q8R2T8.
KOi K15202.
OMAi DTMSLMI.
OrthoDBi EOG780RMW.
PhylomeDBi Q8R2T8.
TreeFami TF313581.

Miscellaneous databases

NextBioi 331234.
PROi Q8R2T8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8R2T8.
Bgeei Q8R2T8.
CleanExi MM_GTF3C5.
Genevestigatori Q8R2T8.

Family and domain databases

InterProi IPR019136. TF_IIIC_su-5.
[Graphical view ]
Pfami PF09734. Tau95. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-520 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiTF3C5_MOUSE
AccessioniPrimary (citable) accession number: Q8R2T8
Secondary accession number(s): Q8BLE3, Q8R0D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: September 3, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi