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Protein

CD177 antigen

Gene

Cd177

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-140875. Common Pathway of Fibrin Clot Formation.

Names & Taxonomyi

Protein namesi
Recommended name:
CD177 antigen
Alternative name(s):
CD_antigen: CD177
Gene namesi
Name:Cd177
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1916141. Cd177.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 817Removed in mature formSequence analysisPRO_0000378450
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – ?CD177 antigenPRO_0000378449

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence analysis
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence analysis
Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ8R2S8.
PaxDbiQ8R2S8.
PRIDEiQ8R2S8.

Expressioni

Gene expression databases

BgeeiQ8R2S8.
GenevisibleiQ8R2S8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064934.

Structurei

3D structure databases

ProteinModelPortaliQ8R2S8.
SMRiQ8R2S8. Positions 47-203, 235-376, 425-572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 20370UPAR/Ly6 1Add
BLAST
Domaini322 – 39372UPAR/Ly6 2Add
BLAST
Domaini511 – 58171UPAR/Ly6 3Add
BLAST
Domaini705 – 77470UPAR/Ly6 4Add
BLAST

Sequence similaritiesi

Contains 4 UPAR/Ly6 domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J207. Eukaryota.
ENOG4111D7X. LUCA.
GeneTreeiENSGT00530000063351.
HOGENOMiHOG000111477.
InParanoidiQ8R2S8.
KOiK06552.
OMAiCASATEL.
OrthoDBiEOG74TWZ3.
PhylomeDBiQ8R2S8.
TreeFamiTF337286.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
[Graphical view]
PfamiPF00021. UPAR_LY6. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R2S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSIPVLTLL GVTALLPCVP ALTCQKSSAQ AVRNVAELPL RWWGAGEKTC
60 70 80 90 100
EVSEGCQDLI MLLYNGPKVN LVIIKGCTEV EDQEPKVIWL RTGPGLSVVS
110 120 130 140 150
YTRVCRHGDL CNDVNSTKIL EELPTPTVPG SLRCPLCLSN DSCENAPEQV
160 170 180 190 200
CPVGSTHCYD GVLRLRGDGI RTNLKVQGCM AQPDCNLLNG TQAIGTLYMS
210 220 230 240 250
ENCDLIGPQA LDCNSGSLET VRNVSDLHLS WTTGWQTCEA GEGCYETVML
260 270 280 290 300
IQNGHEFHMV LTKGCTRDMN KKARLTRHRT GPGISIVSYV HVCRDRDFCN
310 320 330 340 350
DLSTTDPLWT PPPDTELGTL RCRHCLSTGS CVSASELVCP AGSTHCYSGV
360 370 380 390 400
LSLRGGGVIS DLKVQGCISQ SQPGCNLLNG TQTIGPVDVR EDCGLQLDAL
410 420 430 440 450
KCQHGTLKTI QDISKLPLQW TAGQKICNVG EGCQDTLMLI ENGEQVNLVL
460 470 480 490 500
TKGCTTAKDQ EAKVTEHRTG PGLSVTSYTR VCRKKDFCND LSTTAPLWAP
510 520 530 540 550
PPVTAPGTTR CPLCFSEQAC ENAPEQVCPA GSTHCYSGVL SLRGGGIISD
560 570 580 590 600
LKVQGCMSQP GCNLLNGTQT IGPVDVSERC SPPSETTELS CYRGVMFELG
610 620 630 640 650
NGFAEEPVKW TAPGSQVCAP DEICQETLLL IDVGQKSAFL GSKGCSSPGA
660 670 680 690 700
QDNIGVSIFS RLPGMLVASY TKFCSSHLCN GADSSSVLLS ILPRPDVPPP
710 720 730 740 750
GDVQCPMCVE LFGSCKSTDS VTCPRGATHC YKGDIALQGG GLTTRVSIQG
760 770 780 790 800
CMAPPIKPLL GDSKTIGIFS AEESSNYRHE DDVTSAPSLA WTLRLSAWML
810
GLSALLSSLY AGICPLC
Length:817
Mass (Da):87,091
Last modified:June 1, 2002 - v1
Checksum:iF22A8B073D6F7C60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466593 Genomic DNA. Translation: EDL24318.1.
BC027283 mRNA. Translation: AAH27283.1.
CCDSiCCDS20962.1.
RefSeqiNP_081138.2. NM_026862.3.
UniGeneiMm.292848.

Genome annotation databases

EnsembliENSMUST00000063956; ENSMUSP00000064934; ENSMUSG00000052212.
GeneIDi68891.
KEGGimmu:68891.
UCSCiuc009fql.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466593 Genomic DNA. Translation: EDL24318.1.
BC027283 mRNA. Translation: AAH27283.1.
CCDSiCCDS20962.1.
RefSeqiNP_081138.2. NM_026862.3.
UniGeneiMm.292848.

3D structure databases

ProteinModelPortaliQ8R2S8.
SMRiQ8R2S8. Positions 47-203, 235-376, 425-572.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064934.

Proteomic databases

MaxQBiQ8R2S8.
PaxDbiQ8R2S8.
PRIDEiQ8R2S8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063956; ENSMUSP00000064934; ENSMUSG00000052212.
GeneIDi68891.
KEGGimmu:68891.
UCSCiuc009fql.1. mouse.

Organism-specific databases

CTDi57126.
MGIiMGI:1916141. Cd177.

Phylogenomic databases

eggNOGiENOG410J207. Eukaryota.
ENOG4111D7X. LUCA.
GeneTreeiENSGT00530000063351.
HOGENOMiHOG000111477.
InParanoidiQ8R2S8.
KOiK06552.
OMAiCASATEL.
OrthoDBiEOG74TWZ3.
PhylomeDBiQ8R2S8.
TreeFamiTF337286.

Enzyme and pathway databases

ReactomeiR-MMU-140875. Common Pathway of Fibrin Clot Formation.

Miscellaneous databases

ChiTaRSiCd177. mouse.
NextBioi328125.
PROiQ8R2S8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R2S8.
GenevisibleiQ8R2S8. MM.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
[Graphical view]
PfamiPF00021. UPAR_LY6. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCD177_MOUSE
AccessioniPrimary (citable) accession number: Q8R2S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: June 1, 2002
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.