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Protein

Ribosomal protein S6 kinase-like 1

Gene

Rps6kl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei177ATPPROSITE-ProRule annotation1
Active sitei407Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi151 – 159ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ribonucleoprotein, Ribosomal protein, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinase-like 1 (EC:2.7.11.1)
Gene namesi
Name:Rps6kl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2443413. Rps6kl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002326421 – 544Ribosomal protein S6 kinase-like 1Add BLAST544

Proteomic databases

PaxDbiQ8R2S1.
PRIDEiQ8R2S1.

PTM databases

iPTMnetiQ8R2S1.
PhosphoSitePlusiQ8R2S1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019235.
CleanExiMM_RPS6KL1.
GenevisibleiQ8R2S1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019379.

Structurei

3D structure databases

ProteinModelPortaliQ8R2S1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 115MITAdd BLAST29
Domaini145 – 534Protein kinasePROSITE-ProRule annotationAdd BLAST390

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.PROSITE-ProRule annotation
Contains 1 MIT domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0603. Eukaryota.
ENOG410ZH1N. LUCA.
GeneTreeiENSGT00530000063268.
HOGENOMiHOG000154183.
HOVERGENiHBG084136.
InParanoidiQ8R2S1.
KOiK20839.
OMAiHPGQLEL.
OrthoDBiEOG091G0CNL.
PhylomeDBiQ8R2S1.
TreeFamiTF323964.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR007330. MIT.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R2S1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLVACECPP GPGLEPEPCS RARSQACMYL EQIRNRVATG TADVTKRDYL
60 70 80 90 100
VDAATQIHLA LERDVSEDYE AAFNHYQNGV DVLLRGVHVD PNKERREAVK
110 120 130 140 150
LKITKYLRRA EEIFNCHLQR TLGSGASPNT GFSSLRLRPI RTLSSALEQL
160 170 180 190 200
KGCRVVGIIK KVQVVQDPAT GGTFIVKSLP RCHMVSRERL TIIPHGVPYM
210 220 230 240 250
TKLLRYFVSE DSIFLHLEHV QGGTLWSHLL SQDHFQYSGL NSGSVQEKSQ
260 270 280 290 300
AQLSTRLSLM TPAELTPGHT LRQNRIPMEP PRTSQSLPPA LQLQKEADAE
310 320 330 340 350
PSSRPSAVFS SDPTEAPCGH SHSQVRRAGQ SSNPAPTQRL HWVREGADRV
360 370 380 390 400
LGAYGRGRGR NPPSANRASL GSGRAAWSLR EGQVKQWAAE MLLALEALHQ
410 420 430 440 450
QGVLCRDLNP QNLLLDQAGH IQLTYFGQWS EVEPRCSQEA VDCLYSAPEV
460 470 480 490 500
GGISELTEAC DWWSYGSLLY ELLTGMALSQ SHPSGFQAHT QLQLPEWLSH
510 520 530 540
PAASLLTELL QFEPQRRLGA GGGGTSRLKS HPFFSTIQWS RLMG
Length:544
Mass (Da):60,193
Last modified:June 1, 2002 - v1
Checksum:i05E16F8B4C33799B
GO
Isoform 2 (identifier: Q8R2S1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-88: Missing.
     162-177: Missing.
     449-467: EVGGISELTEACDWWSYGS → GTVPEPPFRIPGPHPTPAA
     468-544: Missing.

Show »
Length:441
Mass (Da):48,856
Checksum:i05531D498704D4BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti418A → AE in AAH24798 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01793579 – 88Missing in isoform 2. 1 Publication10
Alternative sequenceiVSP_017936162 – 177Missing in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_017937449 – 467EVGGI…WSYGS → GTVPEPPFRIPGPHPTPAA in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_017938468 – 544Missing in isoform 2. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044050 mRNA. Translation: BAC31753.1.
BC024798 mRNA. Translation: AAH24798.1.
BC027298 mRNA. Translation: AAH27298.1.
CCDSiCCDS36496.1. [Q8R2S1-1]
RefSeqiNP_666356.2. NM_146244.4. [Q8R2S1-1]
UniGeneiMm.44829.

Genome annotation databases

EnsembliENSMUST00000019379; ENSMUSP00000019379; ENSMUSG00000019235. [Q8R2S1-1]
GeneIDi238323.
KEGGimmu:238323.
UCSCiuc007ogm.2. mouse. [Q8R2S1-1]
uc007ogp.2. mouse. [Q8R2S1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044050 mRNA. Translation: BAC31753.1.
BC024798 mRNA. Translation: AAH24798.1.
BC027298 mRNA. Translation: AAH27298.1.
CCDSiCCDS36496.1. [Q8R2S1-1]
RefSeqiNP_666356.2. NM_146244.4. [Q8R2S1-1]
UniGeneiMm.44829.

3D structure databases

ProteinModelPortaliQ8R2S1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019379.

PTM databases

iPTMnetiQ8R2S1.
PhosphoSitePlusiQ8R2S1.

Proteomic databases

PaxDbiQ8R2S1.
PRIDEiQ8R2S1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019379; ENSMUSP00000019379; ENSMUSG00000019235. [Q8R2S1-1]
GeneIDi238323.
KEGGimmu:238323.
UCSCiuc007ogm.2. mouse. [Q8R2S1-1]
uc007ogp.2. mouse. [Q8R2S1-2]

Organism-specific databases

CTDi83694.
MGIiMGI:2443413. Rps6kl1.

Phylogenomic databases

eggNOGiKOG0603. Eukaryota.
ENOG410ZH1N. LUCA.
GeneTreeiENSGT00530000063268.
HOGENOMiHOG000154183.
HOVERGENiHBG084136.
InParanoidiQ8R2S1.
KOiK20839.
OMAiHPGQLEL.
OrthoDBiEOG091G0CNL.
PhylomeDBiQ8R2S1.
TreeFamiTF323964.

Miscellaneous databases

PROiQ8R2S1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019235.
CleanExiMM_RPS6KL1.
GenevisibleiQ8R2S1. MM.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR007330. MIT.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPKL1_MOUSE
AccessioniPrimary (citable) accession number: Q8R2S1
Secondary accession number(s): Q8R1D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.