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Protein

Ribosomal protein S6 kinase-like 1

Gene

Rps6kl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei177 – 1771ATPPROSITE-ProRule annotation
Active sitei407 – 4071Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi151 – 1599ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ribonucleoprotein, Ribosomal protein, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinase-like 1 (EC:2.7.11.1)
Gene namesi
Name:Rps6kl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2443413. Rps6kl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 544544Ribosomal protein S6 kinase-like 1PRO_0000232642Add
BLAST

Proteomic databases

PaxDbiQ8R2S1.
PRIDEiQ8R2S1.

PTM databases

iPTMnetiQ8R2S1.
PhosphoSiteiQ8R2S1.

Expressioni

Gene expression databases

BgeeiQ8R2S1.
CleanExiMM_RPS6KL1.
GenevisibleiQ8R2S1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019379.

Structurei

3D structure databases

ProteinModelPortaliQ8R2S1.
SMRiQ8R2S1. Positions 48-113, 381-542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini87 – 11529MITAdd
BLAST
Domaini145 – 534390Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.PROSITE-ProRule annotation
Contains 1 MIT domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0603. Eukaryota.
ENOG410ZH1N. LUCA.
GeneTreeiENSGT00530000063268.
HOGENOMiHOG000154183.
HOVERGENiHBG084136.
InParanoidiQ8R2S1.
OMAiECPPGPG.
OrthoDBiEOG78PV8C.
PhylomeDBiQ8R2S1.
TreeFamiTF323964.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR007330. MIT.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R2S1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLVACECPP GPGLEPEPCS RARSQACMYL EQIRNRVATG TADVTKRDYL
60 70 80 90 100
VDAATQIHLA LERDVSEDYE AAFNHYQNGV DVLLRGVHVD PNKERREAVK
110 120 130 140 150
LKITKYLRRA EEIFNCHLQR TLGSGASPNT GFSSLRLRPI RTLSSALEQL
160 170 180 190 200
KGCRVVGIIK KVQVVQDPAT GGTFIVKSLP RCHMVSRERL TIIPHGVPYM
210 220 230 240 250
TKLLRYFVSE DSIFLHLEHV QGGTLWSHLL SQDHFQYSGL NSGSVQEKSQ
260 270 280 290 300
AQLSTRLSLM TPAELTPGHT LRQNRIPMEP PRTSQSLPPA LQLQKEADAE
310 320 330 340 350
PSSRPSAVFS SDPTEAPCGH SHSQVRRAGQ SSNPAPTQRL HWVREGADRV
360 370 380 390 400
LGAYGRGRGR NPPSANRASL GSGRAAWSLR EGQVKQWAAE MLLALEALHQ
410 420 430 440 450
QGVLCRDLNP QNLLLDQAGH IQLTYFGQWS EVEPRCSQEA VDCLYSAPEV
460 470 480 490 500
GGISELTEAC DWWSYGSLLY ELLTGMALSQ SHPSGFQAHT QLQLPEWLSH
510 520 530 540
PAASLLTELL QFEPQRRLGA GGGGTSRLKS HPFFSTIQWS RLMG
Length:544
Mass (Da):60,193
Last modified:June 1, 2002 - v1
Checksum:i05E16F8B4C33799B
GO
Isoform 2 (identifier: Q8R2S1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-88: Missing.
     162-177: Missing.
     449-467: EVGGISELTEACDWWSYGS → GTVPEPPFRIPGPHPTPAA
     468-544: Missing.

Show »
Length:441
Mass (Da):48,856
Checksum:i05531D498704D4BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti418 – 4181A → AE in AAH24798 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei79 – 8810Missing in isoform 2. 1 PublicationVSP_017935
Alternative sequencei162 – 17716Missing in isoform 2. 1 PublicationVSP_017936Add
BLAST
Alternative sequencei449 – 46719EVGGI…WSYGS → GTVPEPPFRIPGPHPTPAA in isoform 2. 1 PublicationVSP_017937Add
BLAST
Alternative sequencei468 – 54477Missing in isoform 2. 1 PublicationVSP_017938Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044050 mRNA. Translation: BAC31753.1.
BC024798 mRNA. Translation: AAH24798.1.
BC027298 mRNA. Translation: AAH27298.1.
CCDSiCCDS36496.1. [Q8R2S1-1]
RefSeqiNP_666356.2. NM_146244.4. [Q8R2S1-1]
UniGeneiMm.44829.

Genome annotation databases

EnsembliENSMUST00000019379; ENSMUSP00000019379; ENSMUSG00000019235. [Q8R2S1-1]
GeneIDi238323.
KEGGimmu:238323.
UCSCiuc007ogm.2. mouse. [Q8R2S1-1]
uc007ogp.2. mouse. [Q8R2S1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044050 mRNA. Translation: BAC31753.1.
BC024798 mRNA. Translation: AAH24798.1.
BC027298 mRNA. Translation: AAH27298.1.
CCDSiCCDS36496.1. [Q8R2S1-1]
RefSeqiNP_666356.2. NM_146244.4. [Q8R2S1-1]
UniGeneiMm.44829.

3D structure databases

ProteinModelPortaliQ8R2S1.
SMRiQ8R2S1. Positions 48-113, 381-542.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019379.

PTM databases

iPTMnetiQ8R2S1.
PhosphoSiteiQ8R2S1.

Proteomic databases

PaxDbiQ8R2S1.
PRIDEiQ8R2S1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019379; ENSMUSP00000019379; ENSMUSG00000019235. [Q8R2S1-1]
GeneIDi238323.
KEGGimmu:238323.
UCSCiuc007ogm.2. mouse. [Q8R2S1-1]
uc007ogp.2. mouse. [Q8R2S1-2]

Organism-specific databases

CTDi83694.
MGIiMGI:2443413. Rps6kl1.

Phylogenomic databases

eggNOGiKOG0603. Eukaryota.
ENOG410ZH1N. LUCA.
GeneTreeiENSGT00530000063268.
HOGENOMiHOG000154183.
HOVERGENiHBG084136.
InParanoidiQ8R2S1.
OMAiECPPGPG.
OrthoDBiEOG78PV8C.
PhylomeDBiQ8R2S1.
TreeFamiTF323964.

Miscellaneous databases

PROiQ8R2S1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R2S1.
CleanExiMM_RPS6KL1.
GenevisibleiQ8R2S1. MM.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR007330. MIT.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain cortex.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Eye and Mammary tumor.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 361-374, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiRPKL1_MOUSE
AccessioniPrimary (citable) accession number: Q8R2S1
Secondary accession number(s): Q8R1D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.