Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

AP-3 complex subunit mu-2

Gene

Ap3m2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Ap47 is a subunit of the plasma membrane adaptor (By similarity). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.By similarity1 Publication

GO - Biological processi

  • anterograde axonal transport Source: UniProtKB
  • anterograde synaptic vesicle transport Source: UniProtKB
  • intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit mu-2
Alternative name(s):
Adaptor-related protein complex 3 subunit mu-2
Clathrin assembly protein assembly protein complex 3 mu-2 medium chain
Clathrin coat assembly protein AP47 homolog 2
Clathrin coat-associated protein AP47 homolog 2
Golgi adaptor AP-1 47 kDa protein homolog 2
HA1 47 kDa subunit homolog 2
Mu3B-adaptin
Short name:
m3B
P47B
Gene namesi
Name:Ap3m2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1929214. Ap3m2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418AP-3 complex subunit mu-2PRO_0000193785Add
BLAST

Proteomic databases

MaxQBiQ8R2R9.
PaxDbiQ8R2R9.
PeptideAtlasiQ8R2R9.
PRIDEiQ8R2R9.

PTM databases

iPTMnetiQ8R2R9.
PhosphoSiteiQ8R2R9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031539.
CleanExiMM_AP3M2.
GenevisibleiQ8R2R9. MM.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). AP-3 associates with the BLOC-1 complex.By similarity

Protein-protein interaction databases

IntActiQ8R2R9. 1 interaction.
STRINGi10090.ENSMUSP00000128446.

Structurei

3D structure databases

ProteinModelPortaliQ8R2R9.
SMRiQ8R2R9. Positions 4-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 417242MHDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2740. Eukaryota.
ENOG410XT7B. LUCA.
GeneTreeiENSGT00530000062779.
HOGENOMiHOG000234366.
HOVERGENiHBG104910.
InParanoidiQ8R2R9.
KOiK12398.
OMAiEDYFSEC.
OrthoDBiEOG091G088V.
PhylomeDBiQ8R2R9.
TreeFamiTF315187.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R2R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHSLFLINS SGDIFLEKHW KSVVSRSVCD YFFEAQERAT EAENVPPVIP
60 70 80 90 100
TPHHYLLSVY RHKIFFVAVI QTEVPPLFVI EFLHRVVDTF QDYFGVCSEP
110 120 130 140 150
VIKDNVVVVY EVLEEMLDNG FPLATESNIL KELIKPPTIL RTVVNTITGS
160 170 180 190 200
TNVGDQLPTG QLSVVPWRRT GVKYTNNEAY FDVVEEIDAI IDKSGSTVTA
210 220 230 240 250
EIQGVIDACV KLTGMPDLTL SFMNPRLLDD VSFHPCVRFK RWESERILSF
260 270 280 290 300
IPPDGNFRLL AYHVSAQNLV AIPVYVKHSI SFRDSSSLGR FEITVGPKQT
310 320 330 340 350
MGKTIEGVIV TSQMPKGVLN MSLTPSQGTH TFDPVTKMLS WDVGKINPQK
360 370 380 390 400
LPSLKGTMGL QVGASKPDEN PTINLQFKIQ QLAISGLKVN RLDMYGEKYK
410
PFKGIKYMTK AGKFQVRT
Length:418
Mass (Da):46,916
Last modified:June 1, 2002 - v1
Checksum:iBE72859A36889C9C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti346 – 3483INP → LNQ in AAK73278 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039763 mRNA. Translation: AAK73278.1.
AK077365 mRNA. Translation: BAC36770.1.
AK081220 mRNA. Translation: BAC38169.1.
AK082988 mRNA. Translation: BAC38723.1.
AK134634 mRNA. Translation: BAE22219.1.
BC027301 mRNA. Translation: AAH27301.1.
BC030484 mRNA. Translation: AAH30484.1.
CCDSiCCDS22184.1.
RefSeqiNP_001116292.1. NM_001122820.1.
NP_083781.2. NM_029505.3.
UniGeneiMm.390023.

Genome annotation databases

EnsembliENSMUST00000163739; ENSMUSP00000128446; ENSMUSG00000031539.
GeneIDi64933.
KEGGimmu:64933.
UCSCiuc009ldy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039763 mRNA. Translation: AAK73278.1.
AK077365 mRNA. Translation: BAC36770.1.
AK081220 mRNA. Translation: BAC38169.1.
AK082988 mRNA. Translation: BAC38723.1.
AK134634 mRNA. Translation: BAE22219.1.
BC027301 mRNA. Translation: AAH27301.1.
BC030484 mRNA. Translation: AAH30484.1.
CCDSiCCDS22184.1.
RefSeqiNP_001116292.1. NM_001122820.1.
NP_083781.2. NM_029505.3.
UniGeneiMm.390023.

3D structure databases

ProteinModelPortaliQ8R2R9.
SMRiQ8R2R9. Positions 4-418.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R2R9. 1 interaction.
STRINGi10090.ENSMUSP00000128446.

PTM databases

iPTMnetiQ8R2R9.
PhosphoSiteiQ8R2R9.

Proteomic databases

MaxQBiQ8R2R9.
PaxDbiQ8R2R9.
PeptideAtlasiQ8R2R9.
PRIDEiQ8R2R9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163739; ENSMUSP00000128446; ENSMUSG00000031539.
GeneIDi64933.
KEGGimmu:64933.
UCSCiuc009ldy.2. mouse.

Organism-specific databases

CTDi10947.
MGIiMGI:1929214. Ap3m2.

Phylogenomic databases

eggNOGiKOG2740. Eukaryota.
ENOG410XT7B. LUCA.
GeneTreeiENSGT00530000062779.
HOGENOMiHOG000234366.
HOVERGENiHBG104910.
InParanoidiQ8R2R9.
KOiK12398.
OMAiEDYFSEC.
OrthoDBiEOG091G088V.
PhylomeDBiQ8R2R9.
TreeFamiTF315187.

Miscellaneous databases

PROiQ8R2R9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031539.
CleanExiMM_AP3M2.
GenevisibleiQ8R2R9. MM.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP3M2_MOUSE
AccessioniPrimary (citable) accession number: Q8R2R9
Secondary accession number(s): Q3UYJ3, Q923G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.