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Protein

Alpha- and gamma-adaptin-binding protein p34

Gene

Aagab

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in endocytic recycling of growth factor receptors such as EGFR.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha- and gamma-adaptin-binding protein p34
Gene namesi
Name:Aagab
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914189. Aagab.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Alpha- and gamma-adaptin-binding protein p34PRO_0000058135Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei311 – 3111PhosphoserineCombined sources
Modified residuei312 – 3121PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R2R3.
MaxQBiQ8R2R3.
PaxDbiQ8R2R3.
PRIDEiQ8R2R3.

PTM databases

PhosphoSiteiQ8R2R3.

Expressioni

Gene expression databases

BgeeiQ8R2R3.
CleanExiMM_2310007F21RIK.
GenevisibleiQ8R2R3. MM.

Interactioni

Subunit structurei

Associated with AP-1 and AP-2 complexes.By similarity

Protein-protein interaction databases

BioGridi211824. 1 interaction.
STRINGi10090.ENSMUSP00000048595.

Structurei

3D structure databases

ProteinModelPortaliQ8R2R3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4273. Eukaryota.
ENOG410XRVH. LUCA.
GeneTreeiENSGT00390000007218.
HOGENOMiHOG000115322.
HOVERGENiHBG053397.
InParanoidiQ8R2R3.
OMAiVMKNDRN.
OrthoDBiEOG7DZ8PB.
TreeFamiTF328856.

Family and domain databases

InterProiIPR019341. Alpha/Gamma-adaptin-bd_p34.
[Graphical view]
PfamiPF10199. Adaptin_binding. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R2R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGVPCALV TSCSATFTGD RLVQHILGTE DAVVEATSSD AVRFYPWTID
60 70 80 90 100
NKYYSAEINL CVVPSKFLVT AEIAESVQAF VVYFDSTQKS GLDSVSSWLP
110 120 130 140 150
LAEAWLAEVM ILVCDRVCDD GINRQQAQEW CIKHGFELVE LNPEELPEED
160 170 180 190 200
DDFPESTGVK RIVQALNANV WSNVVMKSDR SQGFSLLNSL AGANRRVASA
210 220 230 240 250
ESCHSEQQEP SPTAERTESL PGHHSGACGS AGAQVDSIVD PMLDLDIQEL
260 270 280 290 300
ASLTTGGGDL ENFERLFSKL KEMKDKAATL PHEQRKLHAE KVAKAFWMAI
310
GGDRDEIEGL SSDDEH
Length:316
Mass (Da):34,511
Last modified:July 27, 2011 - v2
Checksum:iF9AA6274ECAD8C21
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511D → N in AAH27311 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK159897 mRNA. Translation: BAE35463.1.
AK009203 mRNA. Translation: BAB26137.1.
CH466522 Genomic DNA. Translation: EDL26044.1.
BC027311 mRNA. Translation: AAH27311.1.
CCDSiCCDS23271.1.
RefSeqiNP_080133.1. NM_025857.2.
UniGeneiMm.34338.

Genome annotation databases

EnsembliENSMUST00000041551; ENSMUSP00000048595; ENSMUSG00000037257.
GeneIDi66939.
KEGGimmu:66939.
UCSCiuc009qbf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK159897 mRNA. Translation: BAE35463.1.
AK009203 mRNA. Translation: BAB26137.1.
CH466522 Genomic DNA. Translation: EDL26044.1.
BC027311 mRNA. Translation: AAH27311.1.
CCDSiCCDS23271.1.
RefSeqiNP_080133.1. NM_025857.2.
UniGeneiMm.34338.

3D structure databases

ProteinModelPortaliQ8R2R3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211824. 1 interaction.
STRINGi10090.ENSMUSP00000048595.

PTM databases

PhosphoSiteiQ8R2R3.

Proteomic databases

EPDiQ8R2R3.
MaxQBiQ8R2R3.
PaxDbiQ8R2R3.
PRIDEiQ8R2R3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041551; ENSMUSP00000048595; ENSMUSG00000037257.
GeneIDi66939.
KEGGimmu:66939.
UCSCiuc009qbf.1. mouse.

Organism-specific databases

CTDi79719.
MGIiMGI:1914189. Aagab.

Phylogenomic databases

eggNOGiKOG4273. Eukaryota.
ENOG410XRVH. LUCA.
GeneTreeiENSGT00390000007218.
HOGENOMiHOG000115322.
HOVERGENiHBG053397.
InParanoidiQ8R2R3.
OMAiVMKNDRN.
OrthoDBiEOG7DZ8PB.
TreeFamiTF328856.

Miscellaneous databases

NextBioi323075.
PROiQ8R2R3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R2R3.
CleanExiMM_2310007F21RIK.
GenevisibleiQ8R2R3. MM.

Family and domain databases

InterProiIPR019341. Alpha/Gamma-adaptin-bd_p34.
[Graphical view]
PfamiPF10199. Adaptin_binding. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311 AND SER-312, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiAAGAB_MOUSE
AccessioniPrimary (citable) accession number: Q8R2R3
Secondary accession number(s): Q3TW04, Q9CV78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 27, 2011
Last modified: March 16, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.