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Q8R2R1

- POMT1_MOUSE

UniProt

Q8R2R1 - POMT1_MOUSE

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Protein
Protein O-mannosyl-transferase 1
Gene
Pomt1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues By similarity.

Catalytic activityi

Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

Cofactori

Magnesium By similarity.

Pathwayi

GO - Molecular functioni

  1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. extracellular matrix organization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT39. Glycosyltransferase Family 39.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein O-mannosyl-transferase 1 (EC:2.4.1.109)
Alternative name(s):
Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Gene namesi
Name:Pomt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2138994. Pomt1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021Helical; Reviewed prediction
Add
BLAST
Transmembranei90 – 11021Helical; Reviewed prediction
Add
BLAST
Transmembranei121 – 14121Helical; Reviewed prediction
Add
BLAST
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST
Transmembranei176 – 19621Helical; Reviewed prediction
Add
BLAST
Transmembranei228 – 24821Helical; Reviewed prediction
Add
BLAST
Transmembranei266 – 28621Helical; Reviewed prediction
Add
BLAST
Transmembranei597 – 61721Helical; Reviewed prediction
Add
BLAST
Transmembranei636 – 65621Helical; Reviewed prediction
Add
BLAST
Transmembranei660 – 68021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. acrosomal vesicle Source: MGI
  2. endoplasmic reticulum membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. sarcoplasmic reticulum Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice suffer of developmental arrest around E7.5 and die between E7.5 and E9.5. Defects are observed in the formation of Reichert's membrane that are probably due to abnormal glycosylation and maturation of dystroglycan and impaired recruitment of laminin.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 746746Protein O-mannosyl-transferase 1
PRO_0000121485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi435 – 4351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi471 – 4711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi539 – 5391N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8R2R1.
PRIDEiQ8R2R1.

PTM databases

PhosphoSiteiQ8R2R1.

Expressioni

Developmental stagei

Expressed ubiquitously at low level after E7.5. At E8.5 high levels of expression are detected throughout the neural tube, and in the dorsal aspects of the neural folds of the future midbrain region and the somites. At E9.0 high levels of expression are detected in the ventral domain of the neural tube, developing eye, floor plate, notochord, and gut endothelium. At E10.5 expression high levels of expression are detected in the dermomyotome of the somites, limb-bud mesenchyme, mantle layer of the dorsal neural tube, and developing trigeminal ganglion.1 Publication

Gene expression databases

ArrayExpressiQ8R2R1.
BgeeiQ8R2R1.
CleanExiMM_POMT1.
GenevestigatoriQ8R2R1.

Structurei

3D structure databases

ProteinModelPortaliQ8R2R1.
SMRiQ8R2R1. Positions 319-476.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini318 – 38164MIR 1
Add
BLAST
Domaini392 – 44958MIR 2
Add
BLAST
Domaini453 – 51361MIR 3
Add
BLAST

Sequence similaritiesi

Contains 3 MIR domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1928.
GeneTreeiENSGT00740000115531.
HOGENOMiHOG000157526.
HOVERGENiHBG053637.
InParanoidiQ8R2R1.
KOiK00728.
OMAiLLFFYVH.
OrthoDBiEOG79KPDP.
PhylomeDBiQ8R2R1.
TreeFamiTF300552.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R2R1-1 [UniParc]FASTAAdd to Basket

« Hide

MGSHSTGLEE TLGVLPSWLF CKMLRFLKRP LVVTVDINLN LVALTGLGLL    50
TRLWQLSYPR AVVFDEVYYG QYISFYMKRI FFLDDSGPPF GHMLLALGGW 100
LGGFDGNFLW NRIGAEYSSN VPIWSLRLLP ALAGALSVPM AYQIVLELHF 150
SHGAAIGAAL LMLIENALIT QSRLMLLESI LIFFNLLAVL SYLKFFNSQT 200
HSPFSVHWWL WLLLTGVSCS CAVGIKYMGI FTYLLVLGIA AVHAWNLIGD 250
QTLSNMRVLS HLLARIVALL VVPVFLYLLF FYVHLMLLYR SGPHDQIMSS 300
AFQASLEGGL ARITQGQPLE VAFGSQVTLK SVSGKPLPCW LHSHKNTYPM 350
IYENGRGSSH QQQVTCYPFK DINNWWIVKD PGRHQLVVNN PPRPVRHGDI 400
VQLVHGMTTR LLNTHDVAAP LSPHSQEVSC YIDYNISMPA QNLWKLDIVN 450
RESNRDTWKT ILSEVRFVHV NTSAILKLSG AHLPDWGFRQ LEVVGEKLSP 500
GYHESMVWNV EEHRYGKSHE QKERELELHS PTQLDISRNL SFMARFSELQ 550
WKMLTLKNED LEHQYSSTPL EWLTLDTNIA YWLHPRTSAQ IHLLGNIVIW 600
TSASLATVVY TLLFFWYLLR RRRSICDLPE DAWSRWVLAG ALCTGGWALN 650
YLPFFLMERV LFLYHYLPAL TFQILLLPIV LQHASDHLCR SQLQRNVFSA 700
LVVAWYSSAC HVSNMLRPLT YGDTSLSPGE LRALRWKDSW DILIRK 746
Length:746
Mass (Da):85,234
Last modified:June 1, 2002 - v1
Checksum:i05CB97DFC79BAE0A
GO

Sequence cautioni

The sequence BAC35577.1 differs from that shown. Reason: Frameshift at position 255.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21G → S in BAC35577. 1 Publication
Sequence conflicti257 – 2571R → P in AAG15588. 1 Publication
Sequence conflicti318 – 3181P → H in BAE22274. 1 Publication
Sequence conflicti330 – 3301K → E in AAG15588. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY007238 mRNA. Translation: AAG15588.1.
AY494857 mRNA. Translation: AAS76201.1.
AK053889 mRNA. Translation: BAC35577.1. Frameshift.
AK134770 mRNA. Translation: BAE22274.1.
AK153984 mRNA. Translation: BAE32295.1.
BC027325 mRNA. Translation: AAH27325.1.
CCDSiCCDS15908.1.
RefSeqiNP_660127.1. NM_145145.1.
UniGeneiMm.31192.

Genome annotation databases

EnsembliENSMUST00000036473; ENSMUSP00000038722; ENSMUSG00000039254.
GeneIDi99011.
KEGGimmu:99011.
UCSCiuc008jeq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY007238 mRNA. Translation: AAG15588.1 .
AY494857 mRNA. Translation: AAS76201.1 .
AK053889 mRNA. Translation: BAC35577.1 . Frameshift.
AK134770 mRNA. Translation: BAE22274.1 .
AK153984 mRNA. Translation: BAE32295.1 .
BC027325 mRNA. Translation: AAH27325.1 .
CCDSi CCDS15908.1.
RefSeqi NP_660127.1. NM_145145.1.
UniGenei Mm.31192.

3D structure databases

ProteinModelPortali Q8R2R1.
SMRi Q8R2R1. Positions 319-476.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT39. Glycosyltransferase Family 39.

PTM databases

PhosphoSitei Q8R2R1.

Proteomic databases

PaxDbi Q8R2R1.
PRIDEi Q8R2R1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036473 ; ENSMUSP00000038722 ; ENSMUSG00000039254 .
GeneIDi 99011.
KEGGi mmu:99011.
UCSCi uc008jeq.1. mouse.

Organism-specific databases

CTDi 10585.
MGIi MGI:2138994. Pomt1.

Phylogenomic databases

eggNOGi COG1928.
GeneTreei ENSGT00740000115531.
HOGENOMi HOG000157526.
HOVERGENi HBG053637.
InParanoidi Q8R2R1.
KOi K00728.
OMAi LLFFYVH.
OrthoDBi EOG79KPDP.
PhylomeDBi Q8R2R1.
TreeFami TF300552.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

NextBioi 353755.
PROi Q8R2R1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8R2R1.
Bgeei Q8R2R1.
CleanExi MM_POMT1.
Genevestigatori Q8R2R1.

Family and domain databases

InterProi IPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view ]
PANTHERi PTHR10050. PTHR10050. 1 hit.
Pfami PF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view ]
SMARTi SM00472. MIR. 3 hits.
[Graphical view ]
SUPFAMi SSF82109. SSF82109. 1 hit.
PROSITEi PS50919. MIR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A putative mouse O-mannosyltransferase mPOMT1."
    Wang X., Jigami Y.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    Strain: Swiss Webster / NIH.
    Tissue: Embryo.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Eye, Medulla oblongata and Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiPOMT1_MOUSE
AccessioniPrimary (citable) accession number: Q8R2R1
Secondary accession number(s): Q3UYD8
, Q64J18, Q8BPJ6, Q8BPU1, Q8R474
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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