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Protein

Tectonic-3

Gene

Tctn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation (By similarity). Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.By similarity1 Publication

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cilium morphogenesis Source: UniProtKB
  • smoothened signaling pathway Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-5620912. Anchoring of the basal body to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Tectonic-3
Gene namesi
Name:Tctn3
Synonyms:Tect3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1914840. Tctn3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 575553ExtracellularSequence analysisAdd
BLAST
Transmembranei576 – 59419HelicalSequence analysisAdd
BLAST
Topological domaini595 – 5951CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 595573Tectonic-3PRO_0000229802Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence analysis
Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8R2Q6.
PaxDbiQ8R2Q6.
PRIDEiQ8R2Q6.

PTM databases

iPTMnetiQ8R2Q6.
PhosphoSiteiQ8R2Q6.

Expressioni

Gene expression databases

BgeeiQ8R2Q6.
CleanExiMM_TCTN3.
GenevisibleiQ8R2Q6. MM.

Interactioni

Subunit structurei

Part of the tectonic-like complex (also named B9 complex).1 Publication

Protein-protein interaction databases

BioGridi212298. 1 interaction.
IntActiQ8R2Q6. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8R2Q6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi78 – 9720Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the tectonic family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFR0. Eukaryota.
ENOG4111GX2. LUCA.
GeneTreeiENSGT00570000079101.
HOGENOMiHOG000070061.
HOVERGENiHBG094032.
InParanoidiQ8R2Q6.
KOiK19382.
OMAiFPENAQP.
OrthoDBiEOG7S4X62.
PhylomeDBiQ8R2Q6.
TreeFamiTF329169.

Family and domain databases

InterProiIPR011677. DUF1619.
[Graphical view]
PfamiPF07773. DUF1619. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R2Q6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCTLQLHLLL LVVLMLSETA RPQPSSTARA FPTSWGLEPV TPEVPTSAPP
60 70 80 90 100
DSSESPTPWT LSMPVNATTD PFPALPICVC DLTPGTCDLN CCCDKDCDLL
110 120 130 140 150
HPRTVFSFCL PGSVRSSSWV CVDNSLMFRS NSPFPSRVFT DSSGTTQFCV
160 170 180 190 200
RVNNSKANYF QKLQTVNATN FQALAAEFGG QSFPSMPPET QPPVLFYRAG
210 220 230 240 250
DPILTYYPSW SVVSLLRQPA AVGAGGLCAE SNPAGFLESK STTCPRFFRD
260 270 280 290 300
LASSCTSEPA LDAASYYNFR VLKVPRGVTD LQNMKFQVPV TLASQASPPL
310 320 330 340 350
LAGNTCQNIV SQVVYEIETN GTFGIQKVSV SFRQTNLTVK PGVSLQQDFI
360 370 380 390 400
VHFRAFQQRK AAAPAAPRSG NPGYLTGKPL LVLTGDTSHS MTLLQSEGNG
410 420 430 440 450
LCSAKRHAVQ FGVNAVSGCQ LRPREVNCSH LQEEVYQTLH GRPRPEHVAV
460 470 480 490 500
FGNADPAQRG GWTRILSRDC SVSAVNCTSC CLIPVSLEIQ VLWAHLGLQS
510 520 530 540 550
NPQAHVAGAR FLYQCKSVQE HQRGIEVSLT TLVNFVDITQ KPEPPRDQPR
560 570 580 590
IDWKLPFDFF FPFKAALSRG ASVQKDSLVL ILCVLLLGLL NSQTK
Length:595
Mass (Da):64,824
Last modified:June 1, 2002 - v1
Checksum:iB317AF1E20F4CDF1
GO
Isoform 2 (identifier: Q8R2Q6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-492: AVNCTSCCLIPVSLEIQVL → VRKEATTAWWLVFHLCNYA
     493-595: Missing.

Note: No experimental confirmation available.
Show »
Length:492
Mass (Da):53,516
Checksum:i02EC9F6914E2B929
GO
Isoform 3 (identifier: Q8R2Q6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     355-392: AFQQRKAAAP...LTGDTSHSMT → VSSLPSERVQ...VCLSEYLLFL
     393-595: Missing.

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):42,801
Checksum:i351EFB18E48406D4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei355 – 39238AFQQR…SHSMT → VSSLPSERVQRLSPRNSTLQ SQYPHCLSVCLSEYLLFL in isoform 3. 1 PublicationVSP_017767Add
BLAST
Alternative sequencei393 – 595203Missing in isoform 3. 1 PublicationVSP_017768Add
BLAST
Alternative sequencei474 – 49219AVNCT…EIQVL → VRKEATTAWWLVFHLCNYA in isoform 2. 1 PublicationVSP_017769Add
BLAST
Alternative sequencei493 – 595103Missing in isoform 2. 1 PublicationVSP_017770Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ278871 mRNA. Translation: ABB90563.1.
AK015861 mRNA. Translation: BAB30004.1.
AK016982 mRNA. Translation: BAB30537.1.
AK030156 mRNA. Translation: BAC26813.1.
BC027335 mRNA. Translation: AAH27335.1.
BC080805 mRNA. Translation: AAH80805.1.
CCDSiCCDS29804.1. [Q8R2Q6-1]
RefSeqiNP_080536.2. NM_026260.2. [Q8R2Q6-1]
UniGeneiMm.374056.
Mm.60758.

Genome annotation databases

EnsembliENSMUST00000025981; ENSMUSP00000025981; ENSMUSG00000025008. [Q8R2Q6-1]
ENSMUST00000135795; ENSMUSP00000123461; ENSMUSG00000025008. [Q8R2Q6-2]
GeneIDi67590.
KEGGimmu:67590.
UCSCiuc008hla.1. mouse. [Q8R2Q6-1]
uc008hlb.1. mouse. [Q8R2Q6-2]
uc008hlc.1. mouse. [Q8R2Q6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ278871 mRNA. Translation: ABB90563.1.
AK015861 mRNA. Translation: BAB30004.1.
AK016982 mRNA. Translation: BAB30537.1.
AK030156 mRNA. Translation: BAC26813.1.
BC027335 mRNA. Translation: AAH27335.1.
BC080805 mRNA. Translation: AAH80805.1.
CCDSiCCDS29804.1. [Q8R2Q6-1]
RefSeqiNP_080536.2. NM_026260.2. [Q8R2Q6-1]
UniGeneiMm.374056.
Mm.60758.

3D structure databases

ProteinModelPortaliQ8R2Q6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212298. 1 interaction.
IntActiQ8R2Q6. 1 interaction.

PTM databases

iPTMnetiQ8R2Q6.
PhosphoSiteiQ8R2Q6.

Proteomic databases

MaxQBiQ8R2Q6.
PaxDbiQ8R2Q6.
PRIDEiQ8R2Q6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025981; ENSMUSP00000025981; ENSMUSG00000025008. [Q8R2Q6-1]
ENSMUST00000135795; ENSMUSP00000123461; ENSMUSG00000025008. [Q8R2Q6-2]
GeneIDi67590.
KEGGimmu:67590.
UCSCiuc008hla.1. mouse. [Q8R2Q6-1]
uc008hlb.1. mouse. [Q8R2Q6-2]
uc008hlc.1. mouse. [Q8R2Q6-3]

Organism-specific databases

CTDi26123.
MGIiMGI:1914840. Tctn3.

Phylogenomic databases

eggNOGiENOG410IFR0. Eukaryota.
ENOG4111GX2. LUCA.
GeneTreeiENSGT00570000079101.
HOGENOMiHOG000070061.
HOVERGENiHBG094032.
InParanoidiQ8R2Q6.
KOiK19382.
OMAiFPENAQP.
OrthoDBiEOG7S4X62.
PhylomeDBiQ8R2Q6.
TreeFamiTF329169.

Enzyme and pathway databases

ReactomeiR-MMU-5620912. Anchoring of the basal body to the plasma membrane.

Miscellaneous databases

PROiQ8R2Q6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R2Q6.
CleanExiMM_TCTN3.
GenevisibleiQ8R2Q6. MM.

Family and domain databases

InterProiIPR011677. DUF1619.
[Graphical view]
PfamiPF07773. DUF1619. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition."
    Reiter J.F., Skarnes W.C.
    Genes Dev. 20:22-27(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: INTERACTION WITH MKS1.
  5. Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE TECTONIC-LIKE COMPLEX.

Entry informationi

Entry nameiTECT3_MOUSE
AccessioniPrimary (citable) accession number: Q8R2Q6
Secondary accession number(s): Q8CDF3, Q9CRC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.