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Protein

U3 small nucleolar RNA-associated protein 4 homolog

Gene

Utp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1.By similarity

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis, rRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 4 homolog
Alternative name(s):
Cirhin
Testis-expressed gene 292 protein
Gene namesi
Name:Utp4
Synonyms:Cirh1a, Kiaa1988, Tex292
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1096573 Utp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509091 – 686U3 small nucleolar RNA-associated protein 4 homologAdd BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki321Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

May be phosphorylated during mitosis; may control the association of this protein with WRD43 and UTP15.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8R2N2
MaxQBiQ8R2N2
PaxDbiQ8R2N2
PeptideAtlasiQ8R2N2
PRIDEiQ8R2N2

PTM databases

iPTMnetiQ8R2N2
PhosphoSitePlusiQ8R2N2
SwissPalmiQ8R2N2

Expressioni

Tissue specificityi

Expressed in liver.2 Publications

Developmental stagei

In 11.5 day embryos, highly and predominantly expressed in liver, with lower expression in somites, brain and craniofacial structures. Expression significantly decreases in 12.5 day embryos and in the newborn.2 Publications

Gene expression databases

BgeeiENSMUSG00000041438
CleanExiMM_CIRH1A
ExpressionAtlasiQ8R2N2 baseline and differential
GenevisibleiQ8R2N2 MM

Interactioni

Subunit structurei

Interacts with HIVEP1. Interacts with NOL11. Interacts directly with UTP15 and WDR43. May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75.By similarity

Protein-protein interaction databases

BioGridi204134, 1 interactor
IntActiQ8R2N2, 1 interactor
STRINGi10090.ENSMUSP00000048377

Structurei

3D structure databases

ProteinModelPortaliQ8R2N2
SMRiQ8R2N2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 53WD 1Add BLAST40
Repeati57 – 96WD 2Add BLAST40
Repeati99 – 138WD 3Add BLAST40
Repeati143 – 181WD 4Add BLAST39
Repeati193 – 231WD 5Add BLAST39
Repeati234 – 273WD 6Add BLAST40
Repeati285 – 322WD 7Add BLAST38
Repeati324 – 359WD 8Add BLAST36
Repeati435 – 474WD 9Add BLAST40
Repeati482 – 521WD 10Add BLAST40
Repeati524 – 563WD 11Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2048 Eukaryota
ENOG410XQNR LUCA
GeneTreeiENSGT00390000008662
HOGENOMiHOG000095656
HOVERGENiHBG050963
InParanoidiQ8R2N2
KOiK14548
OMAiVQKQGFH
OrthoDBiEOG091G06F9
PhylomeDBiQ8R2N2
TreeFamiTF313159

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 10 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R2N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEFKVHRVR FFNYVPSGIR CVAYNNQSNR LAVSRTDGTV EIYNLSANYF
60 70 80 90 100
QEKFFPGHES RGTEALCWAG GQRLFSAGLN GEILEYDLQA LNIKYTLDAF
110 120 130 140 150
GGPIWSMTAS PSGSQLLVGC EDGSVKLFEV TPEKIQFARN FDRQKSRILS
160 170 180 190 200
LCWHPAGTHV AAGSLDYISV FDVKSGSIIR KMVLDRQHLG VTKSRCIVWG
210 220 230 240 250
VAFLSDGTVI SVDSVGKVQL WDSATGTLVK SHLVANADVQ SIAVADQEDS
260 270 280 290 300
FVVGTAEGTV FHFQLVSMTS NSSEKQWVRT KPFQHHTHDV RAVAHSPTAL
310 320 330 340 350
ISGGTDTHLV IRPLMERVEV KNYDAALRKI TFPHRRLISC SKRRQLLLFQ
360 370 380 390 400
FAHHLELWRL GSTSATGKNG DTLPLSKNAD HLLHLKTKGP ENIICSCVSP
410 420 430 440 450
CGSWIAYSTA SRFFLYRLKY ERDNISLQRV SKLPSFLRSA LHILFSEDST
460 470 480 490 500
KLLVASNQGS LHIVHLSEGS FKHLHTFQPQ SGTVEAMCLL AVSPDGNWLA
510 520 530 540 550
ASGTSAGVHV YDLHHLKLHC TVPAYNFPVT ALAIAPNTNN LVIAHSDQQV
560 570 580 590 600
FEFSIPEKQY TEWSRSLQKQ GFHQLWLQRD TPITHISFHP KRPMHILLHD
610 620 630 640 650
AYMFCIIDKS LPLPNEKTVL YNPLPPKNES DVFLRRTTHG FKMSKIYKPL
660 670 680
LFMDLLDERT LVAVERPLDD IIAQLPPPIK KKKFGT
Length:686
Mass (Da):76,909
Last modified:August 16, 2005 - v3
Checksum:iE927C1338E948BD7
GO

Sequence cautioni

The sequence AAH27399 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD32596 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA56628 differs from that shown. Reason: Frameshift at positions 648, 645, 668 and 679.Curated
The sequence CAA56629 differs from that shown. Reason: Frameshift at positions 6, 7 and 11.Curated
The sequence CAA56629 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173318 mRNA Translation: BAD32596.1 Different initiation.
BC018262 mRNA Translation: AAH18262.1
BC027399 mRNA Translation: AAH27399.1 Different initiation.
BC068113 mRNA Translation: AAH68113.1
X80433 mRNA Translation: CAA56628.1 Frameshift.
X80434 mRNA Translation: CAA56629.1 Sequence problems.
CCDSiCCDS52664.1
PIRiS46930
RefSeqiNP_035704.2, NM_011574.2
XP_006530905.1, XM_006530842.3
UniGeneiMm.10665

Genome annotation databases

EnsembliENSMUST00000047629; ENSMUSP00000048377; ENSMUSG00000041438
GeneIDi21771
KEGGimmu:21771
UCSCiuc009ngr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiUTP4_MOUSE
AccessioniPrimary (citable) accession number: Q8R2N2
Secondary accession number(s): Q62306
, Q62307, Q69Z48, Q6NVG9, Q8VEL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: August 16, 2005
Last modified: May 23, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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